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DonepezilDosage,SideEffect|MIMS.comPhilippines
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Donepezil
>Indications
>Dosage
>DosageDetails
>Administration

>Contraindications
>SpecialPrecaution
>AdverseDrugReactions
>PregnancyCategory(USFDA)
>Overdosage

>DrugInteractions
>FoodInteraction
>MechanismofAction
>Storage
>MIMSClass

AvailableBrands
AriceptEv...
Done10
Dopezil
Servonex
Torpezil5...
OtherKnownBrands
Aricept
Arizil5/A...
Donezel

DrugUpdates
NewMolecules
Inspra

Indications
Dosage
DosageDetails

Administration
Contraindications
SpecialPrecautions

AdverseDrugReactions

PregnancyCategory(US
FDA)

Overdosage

DrugInteractions

MildtomoderatelyseveredementiainAlzheimer'sdisease.
Adult:POInitial:5mg/dayintheevening,upto10mg/dayafter46wk.
Oral
MildtomoderatelyseveredementiainAlzheimer'sdisease
Adult:Initially,5mgdailyatbedtime,increaseifnecessaryupto10mgoncedailyatbedtimeafter46
wk.
Elderly:Initially,5mgdailyatbedtime,increaseifnecessaryupto10mgoncedailyatbedtimeafter4
6wk.
Maybetakenwithorwithoutfood.
Hypersensitivity.
Cautionwhenusedinpatientswithsicksinussyndromeorcardiacconductionabnormalities.May
increasesecretionofgastricacidcautionwhenusedinpatientsatriskofulcerdisease.Patientswith
COPD,asthma,historyofepilepsy,bladderobstruction,prostatichypertrophy.Maycausedoserelated
diarrhoea,nauseaand/orvomitingwhichusuallyresolvesafter13wk.Safetyandefficacyhavenotbeen
establishedinchildren.Pregnancy,lactation.
Nausea,vomiting,anorexia,wtloss,diarrhoea,insomnia,fatigue,musclecrampsheadacheand
dizzinesssyncope,bradycardiaconvulsionsincreasedlivertransaminasessinoatrialand
atrioventricularblockhallucinations,agitationandaggressivebehaviorminorincreasesinplasma
creatinekinasepotentiallybladderoutflowobstruction.
ROUTE(S):PO

CategoryC:Eitherstudiesinanimalshaverevealedadverseeffectsonthefoetus(teratogenicor
embryocidalorother)andtherearenocontrolledstudiesinwomenorstudiesinwomenandanimalsare
notavailable.Drugsshouldbegivenonlyifthepotentialbenefitjustifiesthepotentialrisktothefoetus.
Overdosemayresultincholinergiccrisissymptomsincludeseverenausea,vomiting,salivation,
hypotension,bradycardia,respdepression,collapseandseizures.Muscleweaknessmayincreaseand
deathmayoccurifrespmusclesareinvolved.Treatmentincludessupportivemeasuresanduseoftertiary
anticholinergics(suchasatropine).
Mayincreasetheneurotoxiceffectofantipsychotics.Concurrentusewithsystemiccorticosteroidsmay
increasetheadverseeffectsofdonepezil.Mayincreasetheneuromuscularblockingeffectof
succinylcholine.Mayincreasetheadverseeffectsofcholinergicagonists.Mayincreasethebradycardic

http://www.mims.com/philippines/drug/info/donepezil?mtype=generic

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effectofblockers.
FoodInteraction
MechanismofAction

Storage
MIMSClass

Ginkgobilobamayincreasetheadverseeffectsofdonepezil.
Description:Donepezilreversiblyandnoncompetitivelyinhibitscentrallyactiveacetylcholinesterase.Itis
usedforthesymptomatictreatmentofAlzheimer'sdisease.
Pharmacokinetics:
Absorption:WellabsorbedintheGItract.Plasmalevelspeakwithin34hrafteroraladmin.
Distribution:Proteinbinding:About95%(mainlyalbumin).
Metabolism:PartiallymetabolisedinthelivermainlybyCYP3A4to4majormetabolites.
Excretion:Eliminationhalflife:About70hr.Steadystateconcentrationsareachievedwithin3wkof
treatmentinitiation.
Storebelow30C.
NeurodegenerativeDiseaseDrugs

Disclaimer:ThisinformationisindependentlydevelopedbyMIMSbasedonDonepezilfromvariousreferencesandisprovidedforyourreferenceonly.
Therapeuticusesandprescribinginformationmayvarybetweencountries.PleaserefertoMIMSProductMonographsforspecificandlocallyapproved
prescribinginformation.Althoughgreatefforthasbeenmadetoensurecontentaccuracy,MIMSshallnotbeheldresponsibleorliableforanyclaimsor
damagesarisingfromtheuseormisuseoftheinformationcontainedherein,itscontentsoromissions,orotherwise.Copyright2016MIMS.Allrightsreserved.
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