Management of Pediatric Ulcerative Colitis Joint.24

CLINICAL GUIDELINES
Management of Pediatric Ulcerative Colitis: Joint ECCO

and ESPGHAN Evidence-based Consensus Guidelines
Dan Turner, yArie Levine, zJohanna C. Escher, Anne M. Griffiths, jjRichard K. Russell,
Axel Dignass, #Jorge Amil Dias, Jiri Bronsky, yyChristian P. Braegger, zzSalvatore Cucchiara,
z
Lissy de Ridder, Ulrika L. Fagerberg, jjjjSeamus Hussey, Jean-Pierre Hugot,
##
Sanja Kolacek, Kaija Leena Kolho, yyyPaolo Lionetti, zzzAnders Prregaard,
Alexander Potapov, Risto Rintala, jjjjjjjjjjDaniela E. Serban, Annamaria Staiano,

jjjj
Brian Sweeny, ###Gigi Veerman, Gabor Veres, yyyyDavid C. Wilson, and
zzzz
Frank M. Ruemmele
ABSTRACT
Background and Aims: Pediatric ulcerative colitis (UC) shares many
features with adult-onset disease but there are some unique
considerations; therefore, therapeutic approaches have to be adapted to
these particular needs. We aimed to formulate guidelines for managing
UC in children based on a systematic review (SR) of the literature and
a robust consensus process. The present article is a product of a joint
effort of the European Crohns and Colitis Organization (ECCO) and
the European Society for Paediatric Gastroenterology, Hepatology, and
Nutrition (ESPGHAN).
Methods: A group of 27 experts in pediatric IBD participated in an
iterative consensus process including 2 face-to-face meetings, following
an open call to ESPGHAN and ECCO members. A list of 23 predefined
questions were addressed by working subgroups based on a SR of the

literature.
Results: A total of 40 formal recommendations and 68 practice points were
endorsed with a consensus rate of at least 89% regarding initial evaluation,
how to monitor disease activity, the role of endoscopic evaluation, medical
and surgical therapy, timing and choice of each medication, the role of
combined therapy, and when to stop medications. A management flowchart,
based on the Pediatric Ulcerative Colitis Activity Index (PUCAI), is
presented.
Conclusions: These guidelines provide clinically useful points to guide the
management of UC in children. Taken together, the recommendations offer
a standardized protocol that allows effective, timely management and
Received June 15, 2012; accepted June 22, 2012.

From the Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, and the yWolfson Medical Center, Tel-Aviv University, Tel-Aviv,
Israel, the zErasmusMC-Sophia Childrens Hospital, Rotterdam, The Netherlands, the The Hospital for Sick Children, University of Toronto, Toronto,
Canada, the jjYorkhill Hospital, Glasgow, UK, the Agaplesion Markus Hospital, Frankfurt/Main, Germany, the #Hospital S. Joao, Porto, Portugal, the
2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic, the yyUniversity Childrens Hospital, Zurich,
Switzerland, the zzPediatric Gastroenterology and Liver Unit, La Sapienza University, Rome, Italy, the Centre for Clinical Research, Vastmanland
County Hospital, Vasteras, Karolinska Institutet, Stockholm, Sweden, jjjjOur Ladys Childrens Hospital, Crumlin Dublin, Ireland, the Univ ParisDiderot-Sorbonne Paris-Cite, Hopital Robert Debre, Paris, France, the ##Childrens Hospital, Medical Center Sestre Milosrdnice, Zagreb University
Medical School, Croatia, the Childrens Hospital, Helsinki, University Central Hospital and University of Helsinki, Finland, the yyyUniversity of
Florence, Meyer Hospital, Florence, Italy, the zzzHvidovre University Hospital, Copenhagen, Denmark, the Childrens Health Russian Academy of
Medical Sciences, Moscow, Russia, the jjjjjjjjjjUniversity of Medicine and Pharmacy Iuliu Hatieganu, ClujNapoca, Romania, the University
of Naples Federico II, Italy, ###UZ Brussels, Belgium, the Semmelweis University, Budapest, Hungary, yyyyChild Life and Health, University of
Edinburgh, UK, and the zzzzUniversite Paris Descartes, Sorbonne Paris Cite, APHP, Hopital Necker Enfants Malades, Paris, France.
Address correspondence and reprint requests to Dan Turner, MD, PhD, Shaare Zedek Medical Center, Jerusalem, Israel (e-mail: turnerjd2001@gmail.com).
All authors contributed equally to this work.
R.K.R. is supported by a NHS Research Scotland career fellowship award. The work of the IBD team at Yorkhill, Glasgow, was supported by the Catherine
McEwan Foundation and the Yorkhill IBD fund. R.K.R. received consultation fee, research grant, or honorarium, from MSD, Abbott, Dr Falk, Ferring, and
Nestle; A.M.G. received consultation fee, research support, or speaking fee from Centocor, Janssen, Merck, Abbott, and Shire; J.C.E. received consultation
fee and research grant from MSD and Janssen Biologics; J.A.D. received consultation fee from Advisory Boards for MSD, Abbott; L.d.R. received
consultation fee from MSD and Shire; J.B. received consultation fee from MSD; U.L.F. received lecture fee or travel grant from Tillotts AB, Otsuka Pharma
Scandinavia AB, and Schering-Plough AB; A.P. received speakers fee from MSD, and is a consultant for Swedish Orphan Biovitrum (Shire); K.L.K.
received consultation fee from Abbott, MSD, and Tillotts Pharma; A.D. served as scientific advisory member for Ferring, MSD, Centocor, Abbott, UCB,
PDL, Shire, and received lecture honoraria from Ferring, Falk Foundation, MSD, Merckle Recordati, Abbott, UCB, Shire, Otsuka, Vifor, and
Immundiagnostik; S.K. received honorarium from MSD, Abbott, Nestle, and Nutricia; D.T. received consultation fee, research grant, or honorarium,
from MSD, Shire, Janssen, Hospital for Sick Children (PUCAI royalties), Proctor & Gamble, and Johnson & Johnson; A.L. received consultation fee,
research grants, or honoraria, from MSD, Falk, Janssen, and Nestle; G.V. is a consultant to MSD, Shire, and Danone; D.C.W. received consultation fees or
honoraria from MSD, Abbott, Ferring, and Nestle; F.M.R. received consultation fees, research grants, or lecture honoraria from Abbott, Biocodex,
Centocor, Danone, Falk Foundation, Ferring, Johnson & Johnson, Meadjohnson, MSD, Nestle, and Shire.
The other authors report no conflicts of interest.
Copyright # 2012 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric
Gastroenterology, Hepatology, and Nutrition
DOI: 10.1097/MPG.0b013e3182662233
340
JPGN Volume 55, Number 3, September 2012
Copyright 2012 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.
JPGN
Volume 55, Number 3, September 2012
monitoring of the disease course, while acknowledging that each patient is

unique.
Key Words: children, clinical guidelines, European Crohns and Colitis
Organization, European Society for Paediatric Gastroenterology,
Hepatology, and Nutrition, management, Pediatric Ulcerative Colitis
Activity Index, ulcerative colitis
(JPGN 2012;55: 340361)
lcerative colitis (UC) is a chronic relapsing inflammatory

condition of the colon, extending continuously from the
rectum proximally to a varying degree. No single criterion can
accurately diagnose UC. Typically, UC is suspected in a patient
presenting with bloody diarrhea, tenesmus, abdominal pain, and,
when symptoms become severe, weight loss, fatigue, and vomiting.
The incidence of pediatric-onset UC, which forms roughly 15%
to 20% of patients of all ages with UC, ranges between 1 and 4 of
100,000/year in most North American and European regions (13).
Childhood-onset UC is extensive in 60% to 80% of all cases,
twice as often as in adults (4). Because disease extent has been
consistently associated with disease severity, it is not surprising that
pediatric-onset UC has a worse disease course, with a 30% to 40%
colectomy rate at 10 years, as compared with 20% in adults (4,5),
although rates as low as 10% also have been reported in other
pediatric studies (6,7). Approximately 25% to 30% of children
with UC will require admission for an acute exacerbation before
transitioning to adult care, almost twice as often as seen in adultonset disease during a similar period (8,9). Children also have
unique age-related considerations, such as growth, puberty,
nutrition, and bone mineral density (BMD) accretion during adolescence, as well as differing psychosocial needs and development.
We aimed to develop guidelines for managing UC in children
based on a systematic review (SR) of the literature and a robust
consensus process of an international working group of specialists
in pediatric IBD from the European Society for Paediatric
Gastroenterology, Hepatology, and Nutrition (ESPGHAN) and
the European Crohns and Colitis Organization (ECCO), following
an open call. These consensus guidelines focus on the principles,
pitfalls, and pediatric considerations related to the diagnosis and
care of children and adolescents with UC. These guidelines
supplement those published for adults (10) and similar topics are
covered here only briefly, referencing the extensive ECCO review.
These guidelines relate only to ambulatory children and not
to the management of children hospitalized with acute severe
colitis, which was covered in the pediatric ESPGHAN and ECCO
guidelines on acute severe colitis (11).
METHODS
A list of 23 questions addressing the management of UC
in children was first developed, each appraised independently based
on review of the evidence by 2 group members (Appendix 1).
The subgroups recommendations were iterated by e-mail with
the steering committee until refined. The review of the evidence
included both pediatric and adult data because pediatric data were
often scarce (12). Electronic searches were performed in early 2011
using MEDLINE, Embase, CINAHL, and the Cochrane Controlled
Trials Register, and updated in early 2012. The search strategies
used are available upon request. Clinical guidelines, SRs, clinical
trials, cohort studies, case-control studies, diagnostic studies,
surveys, letters, narrative reviews, and case series were used.
The grading of evidence was performed according to the Oxford
Centre for Evidence-based Medicine (Appendix 2).
www.jpgn.org
Guidelines for Management of Pediatric Ulcerative Colitis

Recommendations were discussed by the working group at
2 face-to-face meetings during ESPGHAN annual meeting
(Sorrento, May 2011) and during UEGW (Stockholm, October
2011). The meetings were complemented by an e-mail Delphi
process with the entire group until agreement was reached.
All statements and practice points were supported by at least
89% of the group and, in most cases, reflect almost full consensus.
The guidelines include recommendations (boxed in the text) and
practice points that reflect common practice in which evidence
is lacking.
MONITORING AND PREDICTION

Baseline Investigations at Diagnosis and Differential
Diagnosis (Table 1) (96% consensus)
1. The diagnosis of pediatric UC should be based on
a combination of history, physical examination, and
ileocolonoscopy with histology on multiple biopsies,
performed by a gastroenterologist with pediatric expertise [EL5, RG D]
2. Upper endoscopy is recommended in all cases to exclude
Crohn disease [EL2b, RG C]
3. Initial laboratory investigations should include a full
blood count, liver enzymes, albumin, erythrocyte
sedimentation rate (ESR), iron status, and C-reactive
protein (CRP) [EL5, RG D; adults EL2b, RG B]
4. Stool culture is mandatory to exclude infectious
diarrhea; testing for Clostridium difficile toxin is recommended on at least 3 independent stool samples [EL4, RG
C]; additional stool tests may be necessary for patients
who report recent travels [EL5, RG D]
5. In children younger than 2 years, additional immunological investigations and allergy testing may be necessary to
exclude colitis related to primary immunodeficiency or
allergic conditions [EL5, RG D]
Practice Points:
1. Imaging of the small bowel is recommended to exclude Crohn
disease (CD) and should be performed particularly in patients
with atypical phenotypes.
2. Blood inflammatory markers in children with active colitis may
be normal, especially in mild disease.
3. Fecal inflammatory parameters, most notably calprotectin but
also lactoferrin and S100A12, effectively differentiate colitis
from noninflammatory diarrhea; however, in the vast majority
of cases, bloody diarrhea is present, which indicates colonic
inflammation. Therefore, fecal markers are not usually
necessary as part of the diagnostic workup of UC, unless used
to determine baseline values for future reference.
4. Serological markers (eg, anti-neutrophil cytoplasmic antibody,
anti-saccharomyces cerevisiae antibody) can be useful for
differentiating UC from CD; the diagnosis of UC should be
reevaluated in cases of positive anti-saccharomyces cerevisiae
antibody.
5. Immunological testing for atypical presentation and for
children younger than 2 years includes lymphocyte phenotyping (T, B, NK, NK-T cells), immunoglobulin levels, as well
as functional analyses of lymphocytic responses to antigens/
mitogens and neutrophils, including chronic granulomatous
disease (CGD). Allergic testing in infants is based mainly on a
trial of food withdrawal. Testing for the interleukin (IL)-10 axis
should be considered for those younger than 1 year, and may be
based on functional or genetic analyses.
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Turner et al
JPGN
TABLE 1. Main differential diagnosis of pediatric UC

Differential diagnosis
Clinical presentation
Investigation
Infectious colitis (frequent)
Acute onset, often with fever and occasionally

with vomiting. Rarely lasts >3 wk
Allergic colitis (frequent in

young infants)
Eczema, history of milk protein allergy,

family history of atopy
Vasculitis (rare)
Associated extraintestinal inflammation

(eg, skin, joints and eyes)
Onset of colitis within the first months of life,
often with perianal involvement; skin folliculitis
or eczema; other fungal or bacterial infections
Immunodeficiency
states (rare)
Stool samples for microbial investigations including

C difficile and parasites; tuberculosis and Yersinia
testing when indicated
Specific/total IgE, skin prick testing, colonic biopsies
(eosinophilic infiltration, lymphonodular hyperplasia),
trial of elimination of cows-milk protein and other
allergens
HLA-B5, skin biopsies, serological markers
Consult an immunologist in every case of early onset colitis
(eg, IL-10R and IL-10 genotyping and/or functional
testing, NBT testing or chemotaxis testing or genetic
testing (CGD), CVID, Wiskott-Aldrich syndrome,
and others)
CGD chronic granulomatous disease; CVID common variable immune deficiency; NBT nitroblue-tetrazolium test; UC ulcerative colitis.
It is beyond the scope of the present article to review all of

the evidence for the diagnosis and classification of UC, which
was addressed in the Porto criteria for the diagnosis of pediatric
IBD (13), the Paris pediatric modification of the Montreal classification of IBD (14), and a NASPGHAN working group review
(15). Briefly, the historical perception that considered UC as a
superficial inflammatory disease uniformly involving the rectum
and progressing contiguously to varying degrees of the colon only is
simplistic. Macroscopic rectal sparing may be seen in approximately 5% to 30% of patients, many of whom have relative
(mild patchy disease) rather than absolute macroscopic rectal
sparing (13,14,1618). Prospectively collected data from the large
ESPGHAN EuroKids registry demonstrated macroscopic rectal
sparing in 5% of children at diagnosis (19). Young children at
disease onset may show more rectal sparing, macroscopically
patchy disease, or have normal or minimally disturbed crypt
architecture (17), which occur primarily in children 10 years or
younger (20). Mild limited cecal erythema (ie, cecal patch) may be
present in both children and adults with UC (20,21). Mild nonerosive ileitis in the presence of severe pancolitis may be diagnosed
as backwash ileitis associated with UC and microscopically may
show villous atrophy, increased mononuclear cells, and scattered
crypt abscesses (22). Gastritis is commonly seen with UC whether
focal or diffuse, and erosions may be present (23); however,
frank gastric ulcers, erosive duodenitis, or esophagitis is rare in
UC, found in <1% of 261 children with newly diagnosed UC from
the EuroKids registry (19). In that registry, diagnostic yield of
upper gastrointestinal endoscopy was 7.5%, indicating that in 1 of
13 children with colitis, a diagnosis of CD could be made based
on the upper endoscopy findings (24).
Because there are multiple findings that may be inconsistent
with UC, it is important to complete a full ileocolonoscopy and
upper endoscopy with serial biopsies for diagnosing pediatric IBD.
In patients with acute severe colitis, a diagnostic sigmoidoscopy
may be used as the initial test for evaluation, but a follow-up
colonoscopy should be subsequently performed. Because histology
is atypical in a significant number of children, small bowel imaging
should be considered in pediatric patients to exclude CD.
Colonic inflammation in young infants (especially younger
than 1 year) may reflect allergic colitis or an immunodeficiency,
even as an isolated finding. Although these children should have an
allergic evaluation, only a trial of elimination diet can confirm the
diagnosis of allergic colitis (25). Before confirming the diagnosis of
342
early-onset IBD, classical and subtle immunodeficiencies should

be excluded (Table 1) (2628).
Assessing
Consensus)
and
Predicting
Disease
Activity
(96%
1. Endoscopic evaluation is recommended at diagnosis,

before major treatment changes and when the clinical
assessment is in question; endoscopic evaluation in
children is not routinely recommended during flares,
which are not severe or during clinical remission aside
from cancer surveillance [EL5, RG D]
Practice Points:
1. Achieving complete remission is associated with improved
long-term outcomes; however, there is no evidence to
suggest that endoscopic verification of mucosal healing is
significantly superior to clinical judgment of remission for
this purpose.
2. The Pediatric Ulcerative Colitis Activity Index (PUCAI;
Appendix 3) is a validated score of clinical disease activity
that does not include endoscopy or laboratory markers
and is easy to perform on a daily basis. Generally, a
PUCAI < 10 indicates remission, 10 to 34 mild disease activity,
35 to 64 moderate, and 65 points severe. A clinically
significant response is indicated by a drop in PUCAI of at least
20 points. In practice, clinicians may benchmark their decision
on response by these general cutoff values, but these can vary
individually.
3. In drug trials, the PUCAI score can be used as a noninvasive
primary outcome measure that has proven to be a valid and
responsive index, including high correlation with colonoscopy.
4. Before management changes in active disease, it must be
ensured that symptoms are the result of disease activity
and not of other clinical problems such as irritable bowel
syndrome [IBS], dysmotility, bacterial overgrowth, disease
complications (eg, stenosis), celiac, 5-aminosalicylic acid (5ASA) intolerance, or infection with C difficile or cytomegalovirus [CMV].
5. Complete blood cell count (CBC), albumin, liver enzymes,
and inflammatory markers should be performed periodically.
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JPGN
6. Calprotectin levels >100 to 150 mg/g indicate mucosal

inflammation. Its role in predicting clinical relapse needs
to be further studied prospectively head-to-head with
clinical variables, before it can be used to dictate a change
in therapy.
The ECCO adult guidelines recommend endoscopic
reassessment at relapse, for steroid-dependent or steroid-refractory
UC or when considering colectomy (29); however, endoscopic
assessment of disease activity has several major limitations.
First, endoscopic scoring depends on the subjective assessment
of mucosal properties with generally low interobserver reliability
(30). Second, endoscopic appearance lags behind clinical improvement, thereby underestimating response to treatment (31). Endoscopy in children is mostly performed under general anesthesia
and is considered more invasive than in adults. Finally, although
mucosal healing has been shown to predict favorable clinical
outcome in UC (3234), it has yet to be proven that endoscopy
is superior to clinical judgment for predicting clinically important
outcomes. Indeed, in the combined ACT cohorts (466 adults with
UC treated with either infliximab or placebo), endoscopic healing
had no predictive value among the subset of patients with clinical
remission after 8 weeks of therapy (32). Clinical judgment of
response to steroid treatment in UC has been shown to predict
long-term, clinically important outcomes, both in adults (35) and in
children (8,36). This probably stems from the strong correlation
between physicians clinical assessment of disease activity and
mucosal inflammation in UC, unlike that seen in CD (r 0.770.79
in76 children and 86 adults) ((37) and unpublished data from D.T.).
Treatment changes based on endoscopy were more frequent in
children with CD compared with UC (38). Taken together, and
incorporating the unique pediatric considerations, it does not
seem justified to recommend endoscopic assessment routinely
in pediatric UC solely for assessing disease activity or response
to treatment or at relapse. Endoscopic evaluation, however, is
indispensable in questionable clinical scenarios, before major treatment changes, and for diagnosing complications (eg, stenosis,
dysplasia) and superinfections.
The PUCAI is a noninvasive multi-item measure that
has been shown to be valid, reliable, and responsive to short-term
changes in several clinical trials and cohort studies (39,40). The
PUCAI has been proven to have excellent correlation with the
invasive Mayo score (r 0.95), physician global assessment
(r 0.91), and colonoscopic appearance (r 0.760.8) (37,39).
The PUCAI score ranges from 0 to 85 points and is the sum of
scores of daily abdominal pain, rectal bleeding, stool consistency,
number of stools, nocturnal stools, and activity level. Cutoff scores
for remission, mild, moderate, and severe disease have been
replicated in 3 independent cohorts with sensitivity and specificity
of >90% (37,39,40).
At the time of presentation, serum inflammatory markers are
higher in CD compared with UC (41,42). In a cohort of 512 children
newly diagnosed as having UC, 54% of those with mild disease had
normal results on all 4 common assays (ie, hemoglobin, albumin,
platelet, and ESR), compared with 21% of children with mild CD
(41). Both ESR and CRP were completely normal in 34% and 5% to
10% of 451 children with mild and moderate to severe disease
activity, respectively (43). Correlation with colonic inflammation
was only fair, with a slight superiority of CRP. In most patients,
either CRP or ESR alone was sufficient to reflect disease activity
over time, once it is determined which of the markers is elevated.
Fecal calprotectin levels above the cutoff of 100 mg/g
have been shown to correlate with mucosal inflammation on
endoscopy in UC in the range of 0.5 to 0.8 (4449). Although
www.jpgn.org

1 small study showed that the correlation of the Rachmilewitz index
was lower (44), most noninvasive clinical indices show similar
correlation with endoscopy, with r ranging from 0.65 to 0.8 (37).
Although fecal calprotectin is superior to markers of inflammation
in the blood (50), it is not known whether routine assessment of
calprotectin in all patients is superior to simple clinical assessment
in children; however, the authors stressed its importance because
they use calprotectin routinely. In the acute severe setting, the
clinical PUCAI predicted short-term clinical response better than
5 fecal biomarkers in children (51,52). Fecal biomarkers may
certainly be useful in some cases in which the association of
symptoms with mucosal inflammation is in question, such as with
nonbloody diarrhea. Further research is required to compare the
performance of fecal biomarkers to clinical judgment before
recommending the use of fecal biomarkers for routine monitoring
of disease activity in all patients.
MEDICAL MANAGEMENT
Oral 5-ASA and Rectal Therapy (93% consensus)
1. Oral 5-ASA regimens are recommended as first-line
induction therapy for mild to moderately active pediatric
UC [EL2b, RG B; adults EL1b, RG A] and for maintenance
of remission [EL5, RG D; adults EL1a, RG A] regardless of
other initial treatments
2. Monotherapy with topical 5-ASA may be effective
in selected children with mild to moderate proctitis;
however, this is a rare pediatric phenotype [EL 2b, RG
B; adults E1b, RG A]
3. Combining oral 5-ASA with topical 5-ASA is more effective than oral alone [EL5, RG D; adults EL1b, RG B].
Therefore, whenever tolerated, 5-ASA enemas (or rectal
steroids if 5-ASA is not tolerated) should be offered along
with oral therapy for induction of remission even in
extensive disease [EL5, RG D; adults EL1a, RG A]
4. Rectal 5-ASA is superior and should be preferred over
rectal steroid therapy [EL2b, RG B; adults EL1a, RG A]
Practice Points:
1. There is no evidence that any delivery system of mesalazine
(controlled release and pH dependent) is superior to the other.
2. Mesalazine and sulfasalazine are the 5-ASAs of choice. Oral
mesalazine is dosed 60 to 80 mg kg1 day1 in 2 daily doses up
to 4.8 g daily. Although not evidence based, doses of 100 mg/kg
are sometimes used. Rectal 5-ASA is dosed 25 mg/kg up to 1 g
once daily. Sulfasalazine is dosed 40 to 70 mg kg1 day1 oral
in 2 divided doses with a maximal dose of 4 g/day, and again,
higher doses are in use. The maximal combined oral and rectal
dose should not usually exceed the standard oral dose by >50% or
6.4 g/day in adults.
3. Although pediatric data are lacking, there are several adult trials
showing that once-daily dosing of 5-ASA is equally effective as
twice daily.
4. The maintenance dose should be similar to the dose used
for induction therapy, but lower doses may be considered after
a period of sustained remission (not lower than 40 mg/kg or
2.4 g/day; the minimum effective dose in adults is 1.2 g/day).
5. There is no firm evidence to support the superiority of
sulfasalazine over mesalazine. Sulfasalazine may be particularly helpful in patients with associated arthropathy; it is
considerably less expensive and is the only formulation
available in liquid form. It is, however, associated with
more adverse effects. Gradual dose increase of sulfasalazine
343
Turner et al
6.
7.
8.
9.
>7 to 14 days may decrease the rate of dose-dependent adverse

effects, such as headaches and gastrointestinal upset.
Lack of response to oral mesalazine within 2 weeks is an
indication to consider an alternative treatment as an addition of
topical therapy (if not started already) or oral corticosteroids.
Maintenance of 5-ASA should be continued indefinitely unless
intolerant, given its high effectiveness and excellent safety
profile.
Acute intolerance to 5-ASA may resemble a flare of colitis.
Response to withdrawal of 5-ASA and recurrence upon rechallenge provide the clue to this diagnosis, which precludes
further use of any 5-ASA-containing drug.
Rectal therapy should be offered to the child but cannot be
forced because effective alternatives exist. Single daily dosing
of rectal 5-ASA may enhance compliance without affecting
clinical outcomes.
5-ASA delivery systems can be divided into azo-compounds

(sulfasalazine, olsalazine, and balsalazide), controlled release
(Pentasa), pH dependent (either pH 6 [Salofalk, Mesasal, Claversal]
or pH 7 [Asacol, Mesren, Ipocol]), and a combination of pHdependent and controlled release (Mezavant and Lialda). Site of
delivery for the azo-compounds is the colon (cleavage by bacteria),
for the pH-dependent distal to the distal ileum, and for the
controlled release from the duodenum (53,54).
Two recent Cochrane reviews (55,56) and another metaanalysis (57) showed that 5-ASA compounds are effective in adults
for both induction and maintaining remission compared with
placebo. Eleven RCTs compared 5-ASA with placebo for induction
of remission (2086 patients), with relative risk (RR) of 0.79 (95%
confidence interval [CI] 0.730.85; number needed to treat [NNT]
6). Overall, 40% of patients achieved remission compared with 20%
in the placebo group. Eleven RCTs compared 5-ASA with placebo
(1502 patients) for maintenance of remission, with RR 0.65 (95%
CI 0.550.76; NNT 4). Overall, 40% of patients on 5-ASA relapsed
versus 63% with placebo >6 to 12 months (57). A recent metaanalysis showed that mucosal healing was achieved by 37% of
3977 patients using oral 5-ASA, and 50% of 2513 patients using
rectal 5-ASA (58). There was no difference in mucosal healing rate
between the various 5-ASA agents.
Four small pediatric clinical trials (5962) and a few
retrospective studies (6365) confirmed that 5-ASA is effective
for inducing remission in mild to moderate UC in children, achieving endoscopic remission in 27% after 12 weeks (59). There are no
pediatric trials evaluating combined oral and rectal 5-ASAs, nor of
the effectiveness of 5-ASA in maintaining remission.
The Cochrane meta-analysis showed a trend to benefit
the newer 5-ASA preparations (in terms of both efficacy and
minimizing adverse effects) over sulfasalazine for inducing remission, but sulfasalazine was superior for maintaining remission
(55,56). In contrast, the recent meta-analysis showed no difference
for both inducing and maintaining remission (57). One pediatric
double-blinded randomized clinical trial (RCT) showed that
olsalazine 30 mg kg1 day1 induced clinical response in 39%
versus 79% with sulfasalazine 60 mg kg1 day1 after 3 months in
56 children with mild to moderate UC (61). Results from another
pediatric trial suggested equivalent efficacy of mesalazine and
sulfasalazine in maintaining remission in either UC or Crohn
colitis (64). A dedicated meta-analysis comparing the efficacy of
sulfasalazine versus newer 5-ASA included 20 RCTs and showed
no major differences in efficacy and adverse events (66).
No pediatric dose-finding trials of aminosalicylates are
available. The pediatric dosing is extrapolated from adults
based on 3 studies showing that pharmacokinetics in children is
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JPGN
comparable with adults (63,65,67). Doses >2.4 g may be

beneficial for extensive colitis (68) and, as suggested in the
ASCEND trials, also in patients with more active disease (69
71). Because pediatric-onset UC is associated with a more severe
and extensive phenotype, higher doses on average may be needed
to treat children with UC. In adults, 2.4 g/day may be superior to
lower doses for maintaining remission, especially in extensive
disease (68), but no pediatric data are available. Wiersma et al
(67) have shown that a single mesalazine dose is probably safe and
this is well studied in adults (7275); however, trials to support
once-daily dosing in children, although under way, have not yet
been completed.
Although 5-ASA agents are considered safe (76), several
pediatric case reports described rare adverse effects, such as interstitial nephritis (77), pneumonitis (78), and pericarditis (owing to
hypersensitivity) (79). Interstitial nephritis is a rare but serious
complication of an aminosalicylate (77). Sulfasalazine may
inhibit the intestinal transport of folic acid (80). Acute intolerance
to 5-ASA is seen in 3% of adult patients and may resemble a flare of
colitis (10). Although not evidence based, many clinicians believe
that creatinine, full blood count, and urinalysis should be monitored
every 3 to 6 months during aminosalicylate therapy, and blood
folate levels annually (10,77).
Topical mesalazine induced remission in active proctitis and
distal colitis in 31% to 80% (median 67%) versus 7% to 11%
placebo, in a meta-analysis of 11 trials including 778 adult patients
(81). Mesalazine foam enemas, gel enemas, and liquid enemas
appear to achieve similar outcomes in terms of remission, tolerance,
and safety in adults, although the liquid enemas are perceived
to cover a larger part of the bowel (8284). 5-ASA suppositories
(up to 24 months) are superior to placebo for maintaining remission
in adults (8587). In pediatrics, 500 mg daily mesalazine
suppositories were effective in improving disease activity at
3 and 6 weeks in children with mild to moderate ulcerative proctitis
(62). Either 5-ASA or hydrocortisone enemas resulted in a higher
remission rate than placebo in 29 children with isolated left-sided
colitis (88). Unlike in adults, however, only 5% of children
present with isolated proctitis (4,19), and although higher rates
also have been reported (5), the risk for progressing to a more
extensive phenotype is higher than that in adults (4). Therefore,
rectal monotherapy is suitable for a few pediatric patients and, as a
general rule, should be used in combination with an oral medication.
Rectal 5-ASA was not significantly superior to oral 5-ASA
for symptomatic improvement in the Cochrane meta-analysis
(odds ratio [OR] 2.25, 95% CI 0.539.54, P 0.27), in contrast
to that suggested by previous meta-analyses (8991). No significant benefit of high-dose over low-dose rectal 5-ASA (mesalazine
500 mg daily up to 4 g/day) has been observed. Either single daily or
divided daily dosing of 5-ASA suppositories is equally effective for
inducing remission (92,93). Finally, rectal steroids are an effective
alternative to rectal 5-ASA in patients intolerant of 5-ASA (88).
Other rectal therapies proposed anecdotally include cyclosporine,
tacrolimus, short-chain fatty acids, probiotics, and beclomethasone
17,21-dipropionate (BDP).
A number of studies indicate that dual therapy with oral
and rectal 5-ASA is superior to either alone in patients with mild to
moderate UC (94). Adding 1 g daily mesalazine enemas enhanced
clinical improvement and remission at 4 and 8 weeks in adults
with mild to moderate UC treated with oral mesalazine 4 g daily
(95). Adjunctive intermittent 5-ASA enemas reduced frequency
of relapse compared with oral 5-ASA monotherapy in adults with
UC in remission (96).
For topical therapy to be successful, children and their
parents need extra support, education, and reassurance to allay
concerns and to ensure optimal compliance. The treatment of
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a given child with enemas should balance the clinical benefits,

psychological distress, and the viable oral alternatives.
Oral Steroids (96% consensus)
1. Oral steroids are effective for inducing remission in
pediatric UC [EL2a, RG C; adults EL1b, RG C] but not
for maintaining remission [EL5, RG D]
2. Oral steroids are recommended in moderate disease with
systemic symptoms and selected children with severe
disease without systemic symptoms, or in those failing
to achieve remission with optimal 5-ASA therapy. Most
of those with severe disease should be admitted for
intravenous steroid therapy [EL5, RG D; adults EL1b,
RG B]
3. The dose of prednisone/prednisolone should be 1 mg/kg
up to 40 mg once daily in most children [EL2a, RG B]
4. Steroid dependency in children should not be tolerated;
steroid-sparing strategies should be used [EL 4, GR C]
Practice Points:
1. Prednisone (the prodrug of prednisolone) or prednisolone
(the biologically active steroid) may be used orally with
comparable doses. Oral budesonide is not recommended for
UC. Recent data suggest that oral and rectally administered
BDP, a new corticosteroid with topical action, may be as
effective as prednisone in mild to moderate UC.
2. A single total dose in the morning is advisable to reduce
potential harmful suppression of growth.
3. In steroid refractoriness (ie, nonresponse to oral steroids within
714 days), optimal dosing and compliance with treatment
should be confirmed. Other explanations for the symptoms
(as outlined in the Assessing and Predicting Disease Activity
section) should be excluded.
4. Steroid dependency is defined as remission with corticosteroids
but recurrence of symptoms when the dose is lowered or
within 3 months following complete taper, or if steroids cannot
be stopped within 14 to 16 weeks. Steroid dependency should
be avoided by escalating the existing maintenance therapy or by
adding topical therapy.
5. We constructed a pediatric steroid tapering table (Table 2)
based on common practice and group consensus.
Steroids are introduced in up to 80% of children with UC
mainly within 3 months of diagnosis, with a 50% to 90% short-term
response rate (7,31,97). Mucosal healing with corticosteroids is
more often achieved in UC than in CD, but it lags behind clinical
improvement. After 8 weeks of steroid therapy in 20 children with
UC, mucosal healing has been achieved in 40%, whereas 90%
showed clinical improvement (31). The majority of adult patients
with UC respond to steroids within 2 to 3 weeks (98). In children, it
is particularly important to evaluate the response earlier to start
timely tapering and reduce the dose and duration of treatment. It is
imperative to avoid unnecessary steroid exposure to minimize
growth retardation and other steroid-related adverse effects.
Steroid therapy may lower calprotectin levels as disease activity
improves, but normalization is infrequent (99). Thus, an increased
level of calprotectin does not necessitate ongoing steroid therapy
if the patient is in clinical remission.
There are no dose-finding trials of steroids in pediatric UC.
In adults, a 20-mg daily dose of oral prednisone is less effective
than 40 mg in inducing remission; 60 mg was as effective as 40 mg
but with more adverse events (98). Splitting the daily dose is not
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more effective than a single dose (100). Children with UC may
have a higher steroid-related complication rate compared with
adults, including osteoporosis, glaucoma, and cataracts, even when
adjusted to weight-based steroid doses (101). Mood disorders and
sleep disturbance are common during steroid treatment. In most
asymptomatic cases, there is no need to add acid suppression during
standard steroid treatment. This should be considered in upper
gastrointestinal disease or when nonsteroidal anti-inflammatory
drugs (NSAIDs) are in use.
Steroid dependency implies initial clinical response to
systemic corticosteroid treatment, but the inability to achieve
and/or maintain a steroid-free clinical remission. Steroid dependency during a 1-year follow-up has been reported in 45% of
children with UC requiring corticosteroids at diagnosis, higher than
that reported in adults (7,97). Strategies to avoid steroid dependency
include optimization of 5-ASA, adjuvant therapy with enemas, and
consideration of escalating therapy to thiopurines or infliximab.
Adherence to therapy should be ensured, especially in adolescents.
Colectomy should be considered when medical strategies have not
resolved steroid dependency.
BDP is a new corticosteroid with topical action. RCTs
in adults showed its effectiveness in UC both in oral and topical
routes (102104). A pediatric trial showed that the week 12
remission rate among 15 children receiving 5 mg/day of BDP is
80% compared with only 33% in 15 children receiving 5-ASA (59).
There are preliminary data on the extended-release formulation of
budesonide inducing clinical improvement in adults with active
left-sided colitis but no pediatric data (105).
Antibiotics and Probiotics (Excluding Pouchitis) (96%
consensus)
1. There is insufficient evidence to recommend routine
antibiotic or probiotic therapy to ambulatory pediatric
patients with UC for induction or maintenance of remission [EL5, RG D; adults EL2b, RG B]
2. Probiotics, however, may be considered in children with
mild UC intolerant to 5-ASA, or as an adjuvant therapy
in those with mild residual activity despite standard
therapy [EL1b, RG B; adults EL1b, GR A]
Practice Points:
1. Efficacy of probiotics in pediatric and adult UC trials has been
demonstrated for VSL#3 (Table 3 for daily dosing) and
Escherichia coli Nissle.
2. Probiotics should be used with caution in severely immunocompromised patients or those with intravenous catheters
because sepsis has been reported. Bloating, flatulence, and
nausea may be associated with VSL#3.
There have been no controlled trials of adjunctive antibiotics
to induce or maintain remission in pediatric UC, but several
small adult studies suggested some benefit with differing regimens.
Oral tobramycin (107,108), oral rifaximin (109), and a combination
regimen of oral amoxicillin, metronidazole, and tetracycline
(110) had an adjunctive effect to successfully induce remission
in ambulatory adults with UC. Ciprofloxacin (<14 days) did
not induce remission in adults with mild to severe UC (111), but
6-month treatment seemed beneficial in maintaining remission in
adults with moderate to severe disease (112). Rifaximin increased
the remission rate in a small retrospective study of 11 children
(113).
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TABLE 2. Prednisone tapering plan (numbers reflect daily milligrams)

Week 1
60

50

45
40
35
30
25
20
15
Week 2
Week 3
Week 4
Week 5
Week 6
Week 7
Week 8
Week 9
Week 10
Week 11
50
40
40
40
35
30
25
20
15
40
40
40
30
30
30
25
20
15
35
35
35
30
30
25
20
15
12.5
30
30
30
25
25
20
20
15
10
25
25
25
25
20
15
15
12.5
10
20
20
20
20
15
15
15
10
7.5
15
15
15
15
15
10
10
7.5
7.5
10
10
10
10
10
10
5
5
5
5
5
5
5
5
5
5
2.5
2.5
0
0
0
0
0
0
0
0
0
First 2 to 3 weeks: Start prednisone at 1 mg/kg up to 40 mg once daily ( after discharge from acute severe colitis admission, the dose may be as high as
60 mg/day). If there is no significant clinical improvement in patients with moderate to severe colitis (ie, PUCAI decrease in <20 points) after 7 to 14 days, or an
increase in PUCAI 20 points at any time, then consider treatment escalation after excluding other causes for steroid-refractory disease (see text).
After the first 2 to 3 weeks: PUCAI 15 to 30: consider keeping the dose stable (while prolonging the total course by 1 week); PUCAI > 35, increase steroids to
the dose of the previous 1 to 2 steps for 1 week and then start weaning again more slowly; PUCAI > 60 or increase in PUCAI by at least 20 points at any time,
consider treatment escalation. In any case, avoid steroid dependency by timely escalation of maintenance therapy.
The risk for exacerbation is smaller with prednisone doses >20 mg, but the risk for adverse events is then higher. Thus, tapering should be instituted early
with larger decrements initially and slower decrements at lower doses. Shortening each stage from 7 to 5 days may be considered in selected cases. With lower
doses, alternate-day treatment may reduce the risk of adverse events. Consider the possibility of adrenal insufficiency, even many months after tapering off
steroids.
A recent SR of RCTs suggested an overall beneficial

effect of antibiotics for induction of remission in adult UC
(114). Nine RCTs, involving 662 patients with active UC (2 of
whom were in the acute severe setting), found a statistically
significant benefit of antibiotics for inducing remission (RR
0.64; 95% CI 0.430.96); however, a funnel plot suggested
publication bias, and a great variety of the antibiotics was used.
Pediatric trials are required to decipher the potential benefits,
if any, of antibiotics for UC in children before they can be
recommended.
Probiotics have been evaluated for induction and maintenance of remission in UC. One pediatric and 3 adult trials did
not find a significant difference between E coli Nissle 1917 and
mesalazine for maintaining remission in UC (10,115). Although
the ECCO guidelines in adults state that this probiotic may be
a viable alternative to 5-ASA for maintaining remission in
mild to moderate UC (10), a Cochrane review highlighted
major methodological limitations in these studies, preventing any
conclusion (116).
A small pediatric trial suggested that E coli Nissle is also
effective in inducing remission in UC (115). In an open pilot study,
remission was induced in 10 of 18 children with UC treated with
VSL#3 in conjunction with 5-ASA, low doses of corticosteroids, or
immunomodulators (117). A small trial of 29 children treated with
5-ASA showed that the combination with VSL#3 was superior to
placebo in inducing and maintaining 1-year remission (Table 3
tabulates the daily dosing) (106). These studies build on the adult
literature, which show a benefit for VSL#3 in inducing remission in
UC (117120).
In other small trials, different probiotics were suggested to be

effective in inducing remission (Saccharomyces boulardii (121),
Bifidobacterium longum plus the prebiotic Synergy (122), and
B breve, B bifidum plus Lactobacillus acidophilus (123)) and
maintaining remission (Lactobacillus GG (124), and Probio-Tec
AB-25 (125)). One recent pediatric trial showed that rectal enemas
of Lactobacillus reuteri were superior to placebo in facilitating
mesalazine-induced remission in UC (126).
Immunomodulators (89% consensus)
1. Thiopurines (azathioprine or mercaptopurine) are
recommended for maintaining remission in children with
5-ASA intolerance or those with frequently relapsing
(23 relapses per year) or steroid-dependent disease,
despite the use of maximal 5-ASA treatment [EL3b,
RG C; adults EL1b, RG B]; thiopurines are ineffective
for induction of remission [EL3b, RG C]
2. Thiopurines are recommended for maintenance treatment after inducing remission by steroids during acute
severe colitis because the likelihood for an aggressive
disease course is higher [EL4, RG C; adults: EL2b, RG B];
however, 5-ASA maintenance monotherapy may be
considered in 5-ASA-nave children with acute severe
colitis responding rapidly to steroids [EL5, RG D]
3. Cyclosporine or tacrolimus started during an episode
of acute severe colitis should be discontinued after
4 months, bridging to thiopurines [EL4, RG C]
4. The presently available evidence is insufficient to
recommend the use of methotrexate in pediatric UC
[EL5, RG D; adults EL4, RG C]
TABLE 3. Pediatric VSL#3 dosing by Miele et al (106)

Age, y
Weight, kg
Daily dose, bacteria/day
46
79
1114
1517
1723
2433
3453
5466
450 billion (1 sachet)

900 billion (2 sachets)
346
Practice Points:
1. The therapeutic effect of thiopurines may take up to 10 to
14 weeks after the start of treatment.
2. The dose may be adjusted to approximately 2.5 mg/kg of
azathioprine and 1 to 1.5 mg/kg of mercaptopurine, in a single
daily dose.
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3. The determination of thiopurine methyltransferase (TPMT)

genotype or phenotype (TPMT activity), if available, is
encouraged to identify patients at greater risk for early
profound myelosuppression. Dose should be reduced in
heterozygous patients or in those with low activity. Thiopurines
should not be used in children who are homozygous for
TPMT polymorphisms or those with extremely low TPMT
activity. Myelosuppression may still occur in the presence
of normal TPMT activity, and therefore regular monitoring of
blood counts and liver tests are recommended in all cases.
4. Thiopurines should be discontinued in clinically significant
myelosuppression or pancreatitis. Reintroduction of thiopurines
after leukopenia can be considered at a lower dose after
carefully assessing the risks and benefits and after measuring
TPMT activity/genotype and following metabolites. Switching
between azathioprine and mercaptopurine may be successful
in acute flu-like and gastrointestinal adverse events.
5. The measurement of metabolites of thiopurines (ie, 6-methyl
mercaptopurine [6-MMP] and 6-thioguanine [6-TG]) may be
helpful in patients failing therapy to assess compliance and to
assess the nature of possible toxicity (ie, leukopenia or elevated
liver enzymes).
6. Continuation of 5-ASA after introduction of thiopurines
may have some advantages, but there is insufficient evidence
to clearly recommend it.
7. Oral tacrolimus (FK-506) may be used in selected outpatient
children with UC as a bridge to thiopurines.
8. Methotrexate should be considered only in the rare patients
with UC who fail to respond or are intolerant of thiopurines,
when other alternatives are not available.
9. Vaccination status should be assessed in all children.
An attempt should be made to immunize with live vaccines
>6 weeks before starting immunosuppressive agents, but
immunization should not delay necessary medications to
control the disease.
A Cochrane review included 6 adult RCTs involving
286 patients and showed that azathioprine was superior to placebo
for the maintenance of remission in UC (OR 0.41, 95% CI 0.24
0.70) (127) with roughly 60% effectiveness (NNT 5) (128,129).
A prospective registry data of 133 children with UC reported a
1-year steroid-free remission rate of 49%, irrespective of whether
thiopurines were introduced at disease onset (130). Other retrospective studies in children confirmed the benefit of thiopurines in
maintaining remission and steroid sparing (131133), with a
median time to achieve steady state of thiopurine levels of 55 days
(134). An SR in adults including 2 RCTs on 130 patients with active
UC showed no statistically significant benefit of thiopurines for
inducing remission (129).
The superiority of AZA to maintain remission in UC
compared with 5-ASA has been documented in 2 small RCTs. In
the first, Ardizzone et al (135) enrolled 72 steroid-dependent adults
with UC to receive either 2 mg kg1 day1 of AZA or 3.2 g/day of
5-ASA, whereas prednisolone was tapered >8 weeks. Clinical and
endoscopic remission at 6 months was achieved in 53% of the AZA
group versus 19% in the 5-ASA group. In the second study, 34 adult
patients with UC were randomized to receive 1.5 mg/kg of mercaptopurine (n 15), 15 mg of methotrexate (n 12), or 3 g/day of
5-ASA (n 8) (136). Sustained remission rates at 30, 48, and 106
weeks were 79%, 64%, and 50% in the mercaptopurine group versus
25%, 0%, and 0% in the 5-ASA group, respectively. Nevertheless,
considering the efficacy and safety of aminosalicylates for the
maintenance of remission, thiopurines should be reserved for
patients intolerant of 5-ASA and children who developed an acute
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severe colitis episode for whom the risk of a more aggressive disease
course is higher.
One placebo-controlled trial in 70 adults with UC showed no
benefit for adding 1.5 g/day of olsalazine to 2.2 mg kg1 day1 of
azathioprine to maintain a 2-year remission, and there were more
adverse events and noncompliance in the 5-ASA-treated group
(137); however, the dose was small and olsalazine may have more
adverse effects than the other 5-ASA regimens and lower effectiveness (57). It cannot be stated whether there is an additional
advantage to combining 5-ASA with a thiopurine, but it is not
unreasonable to do so, given the excellent safety profile of 5-ASA
and its high effectiveness in UC, including cancer prevention.
Clinicians should be aware that 5-ASA may partially inhibit TMPT
activity and, therefore, may increase 6-TG levels (138,139).
Increasing the number of daily pills may also decrease compliance.
In a retrospective study of 107 children with IBD (of whom
30 had UC) a high discontinuation rate of 30% was noted when
using azathioprine at a dose of 3 mg kg1 day1, mainly because
of adverse events (140). In another study, treatment was discontinued because of an adverse effect in 17 (18%) of 95 treated
children (141). Dose-independent adverse reactions include fever,
pancreatitis, rash, arthralgias, nausea, vomiting, and diarrhea. Dosedependent toxicities include leukopenia, thrombocytopenia,
infections, and hepatitis (142). Pancreatitis is the most common
hypersensitivity reaction, occurring in 3% to 4% of adults and
children, and almost always within the first several weeks of
therapy. Infections are the main risk for immunosuppressed
adults (143,144) and children (145,146), although severe infections
are uncommon. Pediatricians should focus on immunizations at
diagnosis; guidelines for the prevention of infections in pediatric
IBD have been published (147). Once immunosuppressive therapy
has been initiated, inactivated vaccines should be administered,
including annual influenza, pneumococcal vaccine, and HPV.
Finally, thiopurines increase the risk for non-Hodgkin lymphoma
4-fold on average (148) but the risk is smaller at younger ages,
approximating 4.4 of 10,000 patient years (149). In contrast, the
rare but almost uniformly fatal hepatosplenic T-cell lymphoma
(HSTCL) has been recognized to occur in young adult or adolescent
boys with IBD, with roughly 50% having received thiopurine
therapy alone, and 50% thiopurines with anti-TNF (tumor necrosis
factor) (40 IBD cases reported by the end of 2010). Kotlyar et al
(150) have estimated the risks of this fatal neoplasm in men
younger than 35 years to be 1 in 7404 with thiopurines, and 1 in
3534 if receiving a combination of thiopurines and anti-TNF.
A meta-analysis involving adult and pediatric studies
suggests a strong association between 6-TG blood levels and
maintenance of remission (151). Mutations of the TMPT gene
influence the pharmacodynamics of thiopurines, but some studies
have failed to identify a clear benefit of TMPT genotyping (152).
Monitoring of metabolites may help to identify nonadherent
patients and optimize dose, although there is a large interindividual
variation that makes it difficult to define a single therapeutic
window (153). Concomitant use of allopurinol with reduced
dose of azathioprine may provide a valid therapeutic option in
cases of hyperactive TPMT resulting in high 6-MMP and low 6-TG
(154,155).
Studies on methotrexate for UC are small and have
inconsistent outcomes. In 2 adult trials, oral methotrexate at a dose
of 12.5 (156) or 15 mg/week (157) was ineffective in inducing
and maintaining remission in UC compared with placebo. Another
small RCT showed that methotrexate at a dose of 15 mg/week
was superior to 5-ASA but inferior to thiopurines in maintaining
2-year remission in UC (136). The 3-, 6-, and 12-month
remission rates determined by the PUCAI were 28% to 31% in
1 retrospective pediatric study including 32 children with UC
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Turner et al
(of whom 28 intolerant or refractory to thiopurines) treated
with intramuscular methotrexate at a mean dose of 13.7 3.6
mg m1 week1 (158). Two prospective placebo-controlled
studies regarding the efficacy of methotrexate in adult patients
with UC are under way.
Oral tacrolimus seems to achieve a short-term success
rate (ie, avoidance of colectomy) in the range of 60% to 80% in
pediatric acute severe colitis (159). Oral administration of
tacrolimus in an ambulatory child without acute severe colitis
seems to have steroid-sparing effects in steroid dependency
(160), but more studies are warranted. Oral tacrolimus is typically
used as a bridge to thiopurine therapy owing to its rapid onset of
action, and discontinued after 3 to 5 months to minimize adverse
effects (161).
Biological Agents (93% consensus)
1. Infliximab should be considered for treatment of
children with persistently active, or steroid-dependent
UC, uncontrolled by 5-ASA and thiopurines [EL1b, RG B;
adults EL1b, RG B]
2. Infliximab may be considered for steroid-refractory
(whether oral or intravenous) disease. If infliximab has
been initiated during an acute episode in a thiopurinenave patient, then it can be used as a bridge to thiopurine. In that case, infliximab may be discontinued after
approximately 4 to 8 months [EL4, RG C; adults EL1b,
RG B]
3. Adalimumab should only be used in those who lost
response or were intolerant of infliximab [EL4, RG C;
adults EL1b, RG B]
Practice Points:
1. Infliximab is presently the first-line biological agent in pediatric
UC and should be administered at 5 mg/kg (3 induction
doses >6 weeks followed by 5 mg/kg every 8 weeks for
maintenance); individualization of dosing may be needed.
2. Measuring infliximab levels and antibodies to infliximab can
optimize treatment when failing to maintain remission. If there
are low levels and negative antibodies, then dose escalation
may be indicated. Undetectable infliximab levels in the
presence of antibodies may indicate loss of response and the
need for dose escalation or switching to a different drug.
Normal infliximab level suggests primary nonresponse or
an alternative diagnosis as a cause of symptoms (as outlined
above).
3. Extrapolating from the adult literature and pediatric case series,
adalimumab should be started at 100 mg/m2 up to 160 mg,
followed by 50 mg/m2 up to 80 mg after 2 weeks and then
25 mg/m2 up to 40 mg every other week; dose individualization
may be needed.
4. There is no good evidence to support combining infliximab
with thiopurines in children with UC who failed thiopurine
treatment. Biological agents are, however, used by some
pediatric gastroenterologists in combination with thiopurines
for at least the first 4 to 8 months of therapy, even if the child
has been a nonresponder to thiopurines. The balance of safety
versus benefits of combination treatment needs to be fully
explained.
5. It is unknown whether 5-ASA offers an advantage in
combination with biological agents, but given the potential
benefit (including possible cancer chemoprevention) and the
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high safety, it is not unreasonable to recommend a combined

therapy.
A Cochrane review on adult UC trials concluded that
infliximab is effective in inducing clinical remission, promoting
mucosal healing, and reducing the need for colectomy in patients
with active UC whose disease has not responded to conventional
treatment (162). According to the randomized, double-blind,
placebo-controlled ACT-1 and ACT-2 trials, infliximab seems
to be effective for induction and maintenance of remission in
ambulatory adult patients with moderate to severe UC (163).
In both trials combined, 728 patients received placebo or infliximab
(5 or 10 mg/kg) intravenously at weeks 0, 2, and 6, then every
8 weeks and followed to week 54 (ACT-1) or 30 (ACT-2). Clinical
remission rates at weeks 8, 30, and 52 in the combined infliximab
arms compared with placebo were 33% versus 10%, 33% versus
13%, and 35% versus 17%, respectively. Steroid-free remission
at week 30 was 22% in the infliximab arms versus 13% in the
placebo arm.
Comparable results were found in a pediatric T-72 RCT
(164). Forty-five of 60 (75%) ambulatory children with moderate to
severe UC (excluding those hospitalized with acute severe UC)
responding to a standard 5 mg/kg 3-dose induction protocol were
randomized to continue to receive infliximab 5 mg/kg either every 8
or every 12 weeks. Dose was escalated to 10 mg/kg in 20 of 45
(44%) children who lost response during the 54-week follow-up
period in both arms, but such patients were considered treatment
failures in the primary analysis. The clinical (PUCAI < 10 points)
and complete mucosal healing rates (Mayo endoscopic subscore 0)
were both 33% at week 8; clinical remission rates in the q8 versus
q12 weeks were 8/20 (40%) versus 4/21 (19%) at week 30, and 8/21
(38%) versus 4/22 (18%) at week 54.
Other level 2 pediatric evidence exists to support infliximab
use in pediatric UC. A meta-analysis showed that the pooled longterm success rate of infliximab in 6 series including 126 children
with acute severe colitis was 64% (159). Of 53 infliximab-treated
children with UC in the North American registry (44% with
acute severe colitis), corticosteroid-free remission was observed
in 38% and 21% of patients at 12 and 24 months, respectively (165).
The likelihood of avoiding colectomy at 2 years was 61%.
One RCT of adalimumab to induce remission in adults with
UC has been published (ULTRA 1) (166). A total of 390 anti-TNF
nave ambulatory adult patients with moderate to severe UC
despite treatment with corticosteroids and/or immunosuppressants
were treated with a 4-dose induction protocol of 160/80/40/40 mg
versus 80/40/40/40 versus placebo every other week, subcutaneously. The 8-week clinical remission rate was 19% in the
high-dose arm compared with 10% in the low-dose arm and
9% with placebo (P 0.031). In the 52-week follow-up study
(ULTRA 2) of 494 adult patients with moderate to severe UC,
the use of adalimumab was shown to be safe and effective in
maintaining remission compared with placebo with remission rates
of 17% and 9%, respectively (167). Of note, the 52-week remission
rates in patients with prior anti-TNF exposure were only 10% and
3%, respectively. Adalimumab usage in pediatric UC has been
presented mainly as case reports (146).
Both the SONIC trial in adult CD (168) and its counterpart
in adult UC, the SUCCESS trial (169), included mainly thiopurinenave patients in whom the combination of infliximab and
azathioprine was shown to be superior to monotherapy with
azathioprine or infliximab alone. Combination therapy must be
weighed against the possible adverse effects, including the risk
of lymphoma (as discussed in the Immunomodulators section),
especially because there is no good evidence to support combination therapy after thiopurine failure. On the contrary, although
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concomitant immunomodulators reduced infusion reactions and

immunogenicity of infliximab in the combined ACCENT-1,
ACCENT-2, ACT-1, and ACT-2 trials, it did not improve
clinical outcomes or pharmacokinetics (170). Identical results of
lack of benefit to combined therapy have been reported in the
pediatric T72 trial of infliximab in UC (164). In an RCT in
adults with CD, stopping thiopurines after 6 months of combination therapy did not reduce the 2-year clinical or endoscopic
outcomes (171). Similarly, long-term colectomy rate did not
differ between monotherapy or combined therapy in 52 children
with UC treated with infliximab (165). In thiopurine-nave
children, infliximab can be used as a bridging agent for thiopurines
in steroid-refractory patients, and then combination therapy is
customarily given for 4 to 8 months (11). One pediatric study
reports on successful weaning of infliximab in 12 patients on
combination therapy (172).
Dose intensification (increasing infliximab dose to 10 mg/kg
or shortening dosing interval to 4 to 6 weeks) may be necessary
in those losing response over time (164,173). Optimizing use of
infliximab may be facilitated by access to drug levels and ability to
measure antibodies to infliximab (174). Most clinical trials have not
shown major safety issues, other than infusion reactions and allergic
responses. Uncommon adverse events including major infections,
demyelinating diseases, cutaneous eruptions, and lymphoma,
when used in conjunction with thiopurines (as discussed above),
however, have been reported (175). The discussion above for
immunomodulators regarding infections and vaccines applies also
to the biological agents and even more so when used in conjunction
with other immunomodulatory agents.
Other Investigational Interventions
Practice Points:
1. Granulocyte/monocyte apheresis remains a controversial treatment strategy and cannot be recommended routinely. It may be
a remote treatment option for induction and maintenance of
remission in children with ongoing mild to moderate active UC
when no other medical options exist.
2. Omega-3 supplement is not effective in inducing or maintaining
remission in UC even in large doses.
Treatments that act by removal of leukocytes and other
components of the immune system from the blood after filtering
(leukocytopheresis, granulocytapheresis, granulocyte/monocyte
apheresis) have been used to treat active UC, particularly in
Asia and Scandinavia. Two strategies have been used with 1 using
granulocyte/monocyte apheresis (Adacolumn) and 1 using leukocytapheresis (Cellsorba).
A meta-analysis including 7 adult clinical trials concluded
that granulocyte/monocyte apheresis was a useful treatment for
active UC, although specific methodological issues among most of
the RCTs limited the generalizability of the studies, and that higherquality RCTs were needed (176). A large adult RCT demonstrated
no benefit of apheresis compared with a sham infusion (177).
Six pediatric case series using heterogeneous methodology
have been published, including 71 children, most with mild to
moderate disease (178183), yielding remission in 32 of 71 (45%),
response in 20 of 71 (28%), and no response in 19 of 71 (27%)
usually (but not always) after an initial course of 5 cycles >5 weeks.
An open-label European pediatric trial is ongoing.
The use of leukocytapheresis has been limited thus far to
open-label studies in adults with almost no pediatric data (184). One
small adult study that randomized patients to either granulocyte/
monocyte apheresis or leukocytapheresis showed no significant
difference between the 2 treatments (185).
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The use of intravenous immunoglobulins to treat active
steroid-dependent UC (and CD) has been described in a small
pediatric case series with limited effect (186). A case report has
described amelioration of UC in a child infected with Enterobius
vermicularis (187). Initial small open-label studies suggested
that worm therapy was safe (188). There has been 1 RCT of worms
(Trichuris suis) in 54 adult patients with UC, which showed
a statistically significant benefit for treatment compared with
placebo at 12 weeks (189). More data are required before this
therapy can be considered, especially in children. A meta-analysis
found that omega-3 supplement is ineffective for maintaining
remission in UC (190). Fecal transplantation is an anecdotal therapy
without data to support its use in children.
SURGICAL CONSIDERATIONS
Elective Surgery for Pediatric UC (96% consensus)
1. Elective colectomy may be indicated in children with
active or steroid-dependent UC despite maximal treatment with 5-ASA, thiopurines, and anti-TNF therapy, or
the finding of colonic dysplasia [EL5, RG D; adults EL 4,
RG C]
2. In general, restorative proctocolectomy (ileoanal pouch
or ileal pouch-anal anastomosis), especially the J-pouch,
is preferred over straight pull-through (ileoanal) or
ileorectal anastomosis for elective surgery of pediatric
UC [EL2b, RG B]
3. The laparoscopic surgical approach can be used safely
in children with low complication rates and superior
cosmetic results [EL2b, RG B]
Practice Points:
1. The disease should be reevaluated thoroughly before referral to
colectomy, including repeated ileocolonoscopy and ruling out
other causes for the symptoms.
2. The role of ileorectal anastomosis is controversial but may be
considered in girls who are primarily concerned about the
reduced fecundity associated with restorative proctocolectomy.
High early failure rates have been reported and a lifelong
follow-up of the retained rectal stump is required.
3. A 2-stage operation (colectomy and pouch formation with
ileostomy in the first stage, and closure of the stoma at the
second stage) is the most common approach for elective surgery
for UC. A 3-stage operation (ie, splitting the first operation into
colectomy first and then pouch formation) should be considered
in patients with high-dose steroids or those experiencing
severe malnutrition, and when the diagnosis of CD has not been
excluded completely.
4. Restorative proctocolectomy without protecting ileostomy
(ie, 1-stage operation) may be safe in selected children without
any risk factors (eg, high-dose steroids). Anticipated tension at
the anastomosis site precludes this option.
5. There is no need for preoperative bowel preparation.
6. Preoperative high-dose steroids and questionably infliximab are
associated with increased surgical complications; thiopurines or
calcineurin inhibitors are probably not.
7. The risks of thromboembolic complications are low in
ambulatory pediatric patients with UC, and routine thromboembolic prophylaxis cannot be recommended.
Colectomy should be discussed as a viable alternative in
children who experience ongoing symptoms despite multiple
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Turner et al
immunosuppressive medications, especially if steroid dependent.
The most frequent indication for colectomy in ambulatory children
with UC is a chronic ongoing disease, at times steroid dependent; in
adults, dysplasia is also a common indication (191). In general,
effective doses of immunomodulatory agents and infliximab should
be attempted in most cases before referral to colectomy in ambulatory mild to moderate UC. In those losing response to infliximab,
adalimumab may be considered before colectomy.
Most pediatric surgeons treating patients with UC prefer
pouch surgery over straight pull-through, but there are few pediatric
data to support this. Most series report better continence after the
pouch procedure. A pediatric meta-analysis consisting of 5 studies
and 306 patients suggested that the straight ileoanal pull-through
was associated with a higher failure risk (15% for straight pullthrough vs 8% for pouch procedure), and perianal sepsis (20%
vs 10%), as well as a higher stool frequency (OR 2.63, 95% CI
1.343.92) (192). A multicenter study including 112 children with
straight ileoanal pull-through and 91 with a J-pouch showed similar
early and late complication rates (193). Stool frequency was higher
in the straight pull-through group, although the difference became
less apparent with longer follow-up (mean daily stool frequency at
24 months: 6.2 for the pouch procedure vs 8.4 for the straight pullthrough). Because the quality of life in children with restorative
proctocolectomy is inversely related to stool frequency and
continence (194), this difference is clinically important; however,
the pouch procedure is associated with risk for pouchitis
(see below).
A 2-stage operation is favored by most pediatric surgeons in
elective colectomy (192). One-stage repair may be feasible in
selected children with low disease activity, good nutritional status,
and not treated with steroids but it is associated with an increased
complication rate (195,196). A 3-stage surgery is performed
mainly in patients who require emergency colectomy for refractory
acute severe attack or in malnourished patients and those treated
with high-dose corticosteroids. With any chosen procedure,
a laparoscopic-assisted procedure is feasible and safe in adults
(197,198) and in children (199,200).
Ileorectal anastomosis is not often performed. Earlier
reports showed high failure rates, and there is a lifelong need for
endoscopic surveillance of the rectal stump. Adult studies have
shown that in selected cases, ileorectal anastomosis is safe, with
better continence function than pouch formation (201); however,
there was a higher urgency rate; the quality of life was similar and
approximately half required resection of the rectum in 20 years.
Nonetheless, this surgery may be considered, especially in young
female patients considering future fecundity. In a meta-analysis the
risk of female infertility was increased from 15% among 411 girls
with UC without ileal pouch-anal anastomosis (IPAA) to 48% in
481 girls after IPAA (202,203). It should be emphasized that
many of the infertile cases will eventually achieve pregnancy
with supportive treatments. It is unlikely that there would be a
difference in fertility problems between straight pull-through and
pouch procedures because the degree of pelvic dissection is similar;
however, fecundity is probably better preserved after ileorectal
anastomosis (204). An open discussion with a girl requiring
colectomy and her caregivers stating the pros and cons of each
procedure is mandatory before any surgical intervention.
Preoperative steroid therapy (>20 mg in adults), hypoalbuminemia, and malnutrition are associated with increased
surgical complication rates (205), but waiting for the reversal of
their effects before surgery is not recommended in the acute setting
(206). A meta-analysis of 5 studies found a higher postoperative
short-term complication rate in 706 adults treated with infliximab
before colectomy (207). In a population-based case-control study,
the risk of venous thromboembolic events in UC was increased
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across all age groups, but the absolute rate was much higher in the
older population (27 deep vein thrombosis [DVT] cases per 10,000
person-years in the 0- to 20-year-old group (odds ratio 10 [95% CI
3.429.3]) vs 207/10,000 in the older than 60-years-old group
(208)).
Pouchitis (100% consensus)
1. When pouchitis is suspected for the first time, endoscopy
with mucosal biopsies should be performed to confirm
the diagnosis [EL3b, RG C; adults EL3a, RG B]
2. The first-line therapy of pouchitis should be a 14-day
course of antibiotics; ciprofloxacin seems to be more
effective than metronidazole [EL5, RG C; adults EL1b,
RG A]; in persistent cases, combined metronidazole and
ciprofloxacin or oral budesonide can be given [EL5, RG
C; adults EL2b, RG B]
3. Probiotics may be used for maintaining antibioticinduced remission in recurrent pouchitis [EL5, RG C;
adults EL1b, RG B]
4. Topical mesalazine is an effective treatment for
inflammation of the residual rectal cuff, known as cuffitis
[EL 5, RG D; adults EL4, RGD]
Practice Points:
1. In chronic (>4 weeks) or refractory pouchitis-like symptoms,
other diagnoses should be sought, including cuffitis, missed
CD, anastomotic ulcer, irritable pouch syndrome, infectious
pouchitis, and anastomotic stenosis.
2. Fecal calprotectin can reflect the degree of pouch inflammation.
1
1
3. Metronidazole (2030 mg kg day in 3) divided doses
1
and/or ciprofloxacin (30 mg kg day1 up to 1 g/day in 2
divided doses) for 14 days are common dosing strategies for
pouchitis. Dosing of VSL#3 for recurrent pouchitis in 2 adult
RCT was 1800 billion bacteria once daily (4 sachets of
450 billion bacteria).
4. Although VSL#3 (900 billion bacteria daily) also may be
effective for preventing the first episode of pouchitis, this is not
justified because many children will never develop pouchitis.
5. Immunosupressants or infliximab may be considered in
refractory pouchitis.
Pouchitis, an idiopathic inflammation of the ileal reservoir, is

the most common complication of IPAA, occurring at least once in
pediatric series from 30% to 75% of patients (193,194,209211).
In a cohort of 151 children, 54 (36%) had no pouchitis, 73 (48%)
had 1 episode of acute pouchitis, 11 (7%) developed chronic
pouchitis, and 13 (9%) pouch failure for intractable disease or poor
pouch function (210). In children younger than 10 years, pouchitis
is reported in up to 75% of patients (212).
Clinical symptoms of pouchitis include looser and frequent
stools with or without blood, abdominal cramps, tenesmus, urgency,
abdominal discomfort, and seldom even fever (213). Symptoms of
pouch dysfunction are, however, not specific. Restorative proctocolectomy, especially with the stapling technique, leaves a remnant
of rectal mucosa between the dental line and the anastomosis.
Residual rectal cuff inflammation, known as cuffitis, may cause
symptoms similar to those of pouchitis, especially bleeding. In an
open trial performed in adults, mesalazine suppositories have
shown efficacy in cuffitis (214). Other pouchitis-mimickers include
missed CD and anastomotic ulcer or stenosis. Development of
terminal ileitis, also known as prepouch ileitis, can occur in children
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(215), and it does not necessarily confirm the diagnosis of CD.

Other differential diagnoses include ischemia and rare infections
such as CMV and C difficile. Moreover, irritable pouch syndrome is characterized by increased stool frequency and
cramping with normal endoscopy and histology of the pouch
(216). Therefore, initial clinical suspicion of pouchitis should be
confirmed by endoscopic evaluation of the pouch with mucosal
biopsies. Macroscopic findings include diffuse or patchy erythema,
edema, granularity, friability, loss of vascular pattern, spontaneous
or contact bleeding, erosion, and ulcerations. Unlike in UC, erosions and ulcerations of pouchitis may be discontinuous, and small
ulceration should not be overinterpreted as CD. Mucosal biopsies
should be obtained from the pouch and from the afferent ileal loop
but not from the staple line. Histology of pouchitis includes acute
and chronic inflammation, crypt abscesses, and ulcerations.
Risk factors for developing pouchitis reported in the adult
literature include extensive UC, backwash ileitis, extraintestinal
manifestations (EIMs; especially primary sclerosing cholangitis
[PSC]), being a nonsmoker, and the use of NSAIDs (217). Antineutrophil cytoplasmic antibody positivity has been associated with
pouchitis in adults but not in children (218).
Antibiotic treatment is considered the first-line treatment
for pouchitis. Metronidazole is associated with a rapid response,
but ciprofloxacin may be more effective, with fewer adverse
events (219). Combined antibiotic therapy is an option for chronic
pouchitis. Small adult trials suggested that chronic pouchitis may be
treated with combination of ciprofloxacin and imidazole or
rifaximin, or oral budesonide 9 mg daily for 8 weeks (217).
Infliximab has shown efficacy in refractory pouchitis and CDrelated complication of the pouch in an adult case series (220).
Two double-blind placebo-controlled trials performed in
adults showed effectiveness of the probiotic mixture VSL#3 in
maintaining remission in patients with chronic pouchitis (221,222).
VSL#3 was superior to placebo in 1 study for preventing pouchitis,
although in another it did not show added benefit (219).
OTHER MANAGEMENT CONSIDERATIONS

EIMs With a Focus on Arthritis and PSC (100% consensus)
1. A diagnosis of pauciarticular arthritis (type 1; affecting
<5 large joints) is made on clinical grounds, and treatment is primarily directed at inducing remission of
intestinal disease [EL 4, RG D; adults: EL3b, RG C]
2. When arthritis is present, sulfasalazine is the appropriate
5-ASA drug for maintenance treatment of UC [EL 4, RG
D; adults EL1a, RG B]
Practice Points:
1. A discussion regarding EIM other than arthritis and PSC is
similar to adults and may be found in the adult ECCO
guidelines, including recommendations for follow-up colonoscopies and cancer surveillance (217).
2. Magnetic resonance cholangiography is the first-line investigation for PSC in children, but the interpretation may be
difficult in young infants.
EIMs occur in up to 30% of pediatric patients with UC
potentially involving the skin, joints, hepatobiliary system, and
eyes. Some are clearly related to intestinal disease activity
(ie, erythema nodosum, peripheral arthritis), whereas others occur
independently (ie, pyoderma gangrenosum, uveitis, ankylosing
spondylitis, and PSC) (223). Data from 2 pediatric registries in
the United States (224,225) and Europe (223) indicate that 1 EIMs
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are present at diagnosis in 6% to 17% of pediatric patients with UC,
especially in children older than 5 years, with an increase of almost
50% with disease evolution (226229). EIMs are more likely to
occur in patients with extensive colitis (225).
Joint disease in IBD may be axial (sacroiliitis or ankylosing
spondylitis), causing inflammatory lower back pain or peripheral
arthritis (type 1: pauciarticular, large joints or type 2: polyarticular,
affecting particularly the metacarpophalangeal joints). In children
as in adults, peripheral arthritis is more common than axial arthritis,
which is usually acute and self-limiting, seronegative, and not
deforming. In children, the prevalence of arthritis seems to be
twice as high as in adults (224), with a clear female predominance.
There are some concerns about aggravating the bowel disease by
using NSAIDs; however, the risk seems to be low if prescribed for a
short course and at low doses (230). The sulfapyridine component
of sulfasalazine has an anti-inflammatory effect on both the colonic
mucosa and the joints (231).
PSC is 3 times more likely to occur in UC compared with CD
(225), and is associated with older age in children (225). PSC may
precede the onset of IBD symptoms by years but may also evolve in
patients with UC after colectomy. The cumulative incidence of PSC
in pediatric IBD was reported to be 1.6% at 10 years after diagnosis
(224). Although EIMs are generally associated with a more severe
course of disease, this is not true for PSC (225). ERCP is difficult to
perform, particularly in small children. MRCP may show a characteristic pattern of irregular bile ducts, with zones of both narrowing
and dilatation (232). PSC may progress to liver cirrhosis, ultimately
necessitating liver transplantation. Patients with PSC and UC have a
greater risk of malignancies such as colorectal cancer and cholangiocarcinoma (8%30% of patients with UC with long-standing
PSC) (233,234). Patients with a diagnosis of PSC during childhood
may have a more severe course of disease (234). In adults with
PSC, ursodeoxycholic acid is reported to improve abnormal liver
function tests (235) and may improve outcome. Recent recommendations for adult patients suggest ursodeoxycholic acid dose of
10 to 15 mg kg1 day1 and warn against high-dose treatment,
which may be harmful (236238). There are no studies of treatment
of PSC in children.
Growth, Bone, and Nutrition (100% consensus)
1. The nutritional status and growth of children with UC
must be monitored regularly; nutritional support should
be provided when required [EL 5, RG D]
2. Enteral or parenteral nutrition is inappropriate for
primary disease treatment in UC [Pediatric EL4, RG C;
Adult EL 2b, RG B]
3. Special diets or dietary supplementations are not effective to induce or maintain remission in pediatric UC, and
at times carry a risk of nutritional deficiencies [Pediatric
EL 5, RG D; Adult EL 3b, RG C]
4. Bone mineral status should be assessed using dual-energy
x-ray absorptiometry (DEXA), particularly in children
with highly active UC and who are receiving prolonged,
or repeated, treatment with corticosteroids [EL 2a, RG B].
Practice Points:
1. In children with UC without excessive steroid use, height
velocity is usually normal.
2. Continuation of regular diet is recommended during mild to
moderately active disease.
3. If oral intake is poor because of anorexia in active disease,
enteral nutrition or high-energy supplements may be indicated.
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4. Patients with UC are much less prone to impaired bone density
compared with patients with CD.
5. Adequate nutrition, weight-bearing exercise, adequate disease
control, avoidance of smoking, and steroid-sparing strategies
should all be used to promote bone health.
Undernutrition and particularly growth failure are less
common in children with UC compared with patients with CD,
but nutritional deficiencies can develop quickly during periods of
active disease (239). In newly diagnosed IBD, low BMI was seen in
8% of children with UC, whereas short stature was noted only in CD
(240). As a rule, children with UC reach their expected adult height
(241,242).
It has been documented that bowel rest or exclusive enteral
nutrition does not have any therapeutic role in acute UC (243245),
although bowel rest can alleviate abdominal pain, when severe.
For pediatric patients, there is a small retrospective study showing
that total parenteral nutrition and bowel rest did not improve the
outcome (246). In a pediatric prospective study, 74 of 128 (58%)
were not eating solid food by the third admission day for acute
severe colitis, but this was not associated with improved outcome
after controlling for disease activity (D.T., unpublished data).
There is no dietary approach proven to reduce the risk of either
developing or preventing a relapse of UC.
Peak bone mass attained during late childhood, adolescence,
and early adulthood is the most important determinant of lifelong skeletal health. Children with IBD are particularly prone
to disturbed bone health because of increased circulating inflammatory cytokines, malnutrition, delayed puberty, decreased
physical activity, treatment with corticosteroids, and in girls,
primary or secondary amenorrhea (247,248). Severe osteopenia
was present in 3% to 6% in UC compared with 12% to 18% in CD
(249251).
According to recently published clinical guidelines, DEXA
is the preferred screening tool for bone density measurement in
children and adolescents, provided that age- and sex-matched
z scores are used (252). Because DEXA measures BMD in 2
dimensions, it is recommended that in children with linear growth
delay (heights z score <2.0) DEXA results should also be adjusted
for height (252). It has been suggested that DEXA should be
performed in all children newly diagnosed as having IBD and
repeated in cases of severe disease course, including suboptimal
growth velocity, prolonged malnutrition, amenorrhea, delayed
puberty, and long or repeated treatments with steroids (252);
however, these recommendations are not evidence based.
Children with IBD are particularly at risk for vitamin D
deficiency, but this was not found to be associated with osteopenia
(253). Therefore, the significance of hypovitaminosis D in young
patients with UC merits further study. Nonetheless, it is widely
accepted that vitamin D levels be routinely measured and treated
when appropriate, especially in children with decreased BMD. Ageappropriate nutrition support, weight-bearing exercise, and adequate disease control using steroid-sparing strategies (248,250,252)
are also advocated to improve bone formation.
Psychosocial Support and Adherence to Therapy (100%
consensus)
1. Psychological intervention should be offered to patients
in need because it improves quality of life (QOL), coping,
and depression (Pediatric EL2b, RG B; Adults EL3b, RG C)
2. Nonadherence to medication should be also considered in
children and adolescents, particularly during unstable
disease course (Pediatric EL3a, RG B; Adults EL2a, RG B)
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Practice Points:
1. Every clinic visit made by children and adolescents with
IBD must include attention to psychological problems as part
of the consultation.
2. Pediatric IBD programs should be ready to offer psychological
interventions according to individual needs and local resources,
involving qualified specialists.
3. Adherence may be evaluated by interviews of both the
adolescent and parents, drug monitoring (eg, thiopurine
metabolite level), and prescription refill rates.
4. Adherence may be improved by providing comprehensive
information regarding the prescribed medication, keeping the
pill burden as low as possible, using single daily dosage when
possible and providing pillboxes.
Several recent SRs, including a Cochrane review, have
concluded that adolescents with IBD, especially boys, have reduced
health-related quality of life, including anxiety, depression, social
problems, and low self-esteem (254257). The problems seem to be
associated with more severe disease course, whereas most children
with mild IBD report psychosocial functioning comparable with
healthy controls (258,259). No evidence exists that psychosocial
problems contribute to the etiology of UC; however, observational
data from primarily the adult literature provide support to the
impression that psychosocial stress is a risk factor for relapse
(217). Certain drugs used for treatment of UC, such as corticosteroids, may induce change in mood and even psychiatric disturbances to which children are particularly sensitive. A Cochrane
review found that psychological interventions resulted in improvements in coping and depression among adolescents (256).
Nonadherence in IBD is an important and frequent problem,
reported in 50% to 66% of children (254,260), especially in
adolescence. The presence of nonadherence is related to increased
disease activity in adolescents (260). Individual studies among
adolescents with IBD have reported barriers identical to those
identified among adults as well as more pediatric-specific barriers:
fear of adverse events of medication, belief that the disease is
inactive, belief that the medication is not working, >1 daily
medication (254), forgetfulness, interference with other activities,
difficulty in swallowing pills (261), lack of motivation, and parent
child conflict (262).
Transitional Care (100% consensus)
1. Every adolescent should be included in transition programs that could be adapted according to the local
organization of pediatric and adult facilities [EL5, RG D]
2. The adolescent should be encouraged to assume increasing responsibility for treatment and to visit the clinic at
least once without being accompanied by the parents
[EL5, RG D]
Practice Points:
1. Whenever feasible, at least 1 joint clinic in which the adolescent
is seen by both a pediatric and an adult gastroenterologist
is recommended.
2. The time of transition should be individually adapted according
to psychosocial readiness. Most adolescents will benefit from a
transition program during the 16- to 18-year-old age period.
Pediatric IBD services differ from those for adults. Children
are usually offered endoscopy under general anesthesia and are
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Exacerbation or disease onset

Assess disease1, 2
Teach coping skills by support programs
Induction of remission
Mild disease (PUCAI 10-35)
Severe disease (PUCAI 65-85)
Moderate disease (PUCAI 40-60)
Not systemically ill
Systemically ill
Oral 5-ASA at maximal dose3;
Enemas should be offered and may
be sufficient in proctitis4
No sufficient response
in 7-14 days
Add enemas4 and/or probiotics
Prednisone 1 mg/kg
once daily up to 40 mg +
5-ASA3, 4
No sufficient
response
Sufficient response
No sufficient
in 7-14 days
response in 7-14
Taper corticosteroids
over 10 weeks5
Admission for IV steroids6
No sufficient response
7
Sufficient response
In very selected cases consider infliximab or

tacrolimus induction treatment instead of admission8
Sufficient response
Maintenance of remission
5-ASA for all patients3; Probiotics may be added. Rectal therapy4 may be sufficient in proctitis
Stepping down10
If disease is chronically active, or X2-3 annual flares, or severe attack while on 5-ASA, add thiopurines
(azathioprine 2-2.5 mg/kg once daily or mercaptopurine 1.5 mg/kg once daily)9
Stepping down10
If disease is still chronically active or frequent flares despite adequate thiopurine treatment, consider infliximab
therapy (or adalimumab in cases of failure with infliximab)11
If biologic therapy fails (including dose intensification) and other diagnosis ruled out1 consider colectomy.
Apharesis may be attempted in very selected children when applicable
FIGURE 1. Joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)-European Crohns and Colitis Organization
(ECCO) therapeutic paradigm for pediatric ulcerative colitis (UC). Medical therapies in UC should be divided into those that induce remission (5aminosalicylic acid [5-ASA], corticosteroids, anti-tumor necrosis factor [TNF] therapy, calcineurin inhibitors, and likely probiotics), and those that maintain
remission (5-ASA, thiopurines, anti-TNF therapy, and selected probiotics). 1In any state of active disease, the following must be ruled out: infectious colitis
(including cytomegalovirus [CMV] and C difficile), 5-ASA-related colitis, lactose intolerance, irritable bowel syndrome, wrong diagnosis, celiac disease, and
the like. 2Unlike in adults, endoscopic evaluation of the rectal mucosa is conceived to be more invasive for routine monitoring of disease activity and
response to therapy in children. Therefore, these should be based on noninvasive indirect markers of disease activity. Cutoff values of the Pediatric UC
Activity Index (PUCAI) for remission, mild, moderate, and severe disease activity have been previously validated in 3 independent cohorts. 35-ASA is dosed
60 to 80 mg kg1 day1 up to 4.8 g daily. In clinical practice, higher doses of up to 100 mg/kg are often used effectively but without strong supporting
evidence. Recent data in adults suggest that once-daily 3 g 5-ASA is at least as effective as twice-daily dosing. 45-ASA enemas (25 mg/kg up to 1 g) are more
effective than steroid enemas. Enemas should be administered in the left decubitus position. Liquid enemas are more difficult to tolerate than foams and
suppositories but work for more extensive colitis. 5If there is lack of improvement (ie, PUCAI decrease of <20 points) after 7 to 10 days or an increase in
PUCAI 20 points at any time, consider admission for intravenous steroids or outpatient treatment with anti-TNF therapy, or less often tacrolimus. Steroid
dependency should be declared in children achieving remission with corticosteroids but who experience return of symptoms when dosage is lowered or
within 3 months following complete taper, or if steroids cannot be stopped within 14 to 16 weeks. Maintenance therapy should be then escalated. 6Turner
et al (11) 7Response is defined as a drop in PUCAI of at least 20 points; however, the goal of induction therapy is eventually complete clinical remission
(PUCAI<10). 8For example, previous intolerance or resistance to steroids, or when infliximab is indicated anyway for maintenance treatment after failing
thiopurines. 9Measuring thiopurine methyltransferase (genotyping or enzymatic activity) at baseline, and 6-TG and 6-MMP levels after 2 to 3 months, may
aid in optimizing thiopurine dosing. 10If infliximab has been used in thiopurine-nave disease, thiopurines may be added and infliximab discontinued after
4 to 8 months if complete remission has been achieved. Stepping down to 5-ASA may be considered in selected cases, if 5-ASA did not fail previously, and
after a period of sustained complete remission. 11There is no evidence to support adding thiopurines to infliximab in thiopurine-failure children; however,
some discontinue thiopurines after 4 to 8 months of combined therapy.
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accompanied by parents or caretakers during hospital visits as well

as during making decisions for therapy. Pediatric gastroenterologists are experienced in growth and pubertal development and
the psychological aspects of puberty, and potentially also the
problems of nonadherence to medication. In general, they also
run a more child-friendly and relaxed practice. Several suggestions
for transition programs have been published, but none has been
formally evaluated (263). Most programs involve a joint clinic by
both a pediatric and an adult gastroenterologist, at least once, at ages
16 to 18 years. A dedicated IBD nurse may further improve the
process of transition.
An SR evaluated 10 transition programs (none in IBD)
focusing on the patient (educational program, skills training), staff
(joint pediatric and adult clinics), and service delivery (telephone
support and enhanced follow-up) (264). Although widely recommended, the efficacy of a specific IBD transition program remains
to be proven formally. Until then, each program can determine the
most suitable transition setup according to the local practice of
both pediatric and adult care.
SYNTHESIS AND SUMMARY

This consensus process yielded 40 formal recommendations
and 68 practice points, along with practical tables, based on SR of
the literature (Fig. 1).
Guidance for the management of pediatric UC is summarized
in an algorithm (Fig. 1). The goal of treatment in active disease
should be complete remission (as opposed to response), but usually
this can be assessed clinically without the need for endoscopic
verification. The choice of treatment in adults is a factor of both the
disease severity and disease extent (10), but because limited distal
disease is uncommon in children, pediatric treatment strategy
depends mainly on disease severity. Aminosalicylates are considered first-line therapy for inducing and maintaining remission
of mild to moderate UC. Steroids should be used only as induction
agents. If the patient does not clearly respond to oral steroids
within 1 to 2 weeks, then admission for intravenous corticosteroids
should be considered. In refractory nonsevere cases, an alternative
to admission may include outpatient treatment with infliximab
(especially in those who failed thiopurines and 5-ASA); in selected
patients, oral tacrolimus may be considered. Reasons for refractoriness include poor adherence, inadequate dosing, prescribing the
wrong drug for the clinical scenario, unrecognized complications
(eg, stenosis, superinfection), or inappropriate diagnosis (eg, IBS,
lactose intolerance, CD, celiac disease).
Most patients who received intravenous corticosteroids
should be weaned to thiopurines, and if 5-ASA nave, subsequently
to 5-ASA after a long period of complete remission. All children
with UC must be treated with a maintenance therapy indefinitely.
It should be noted that 2 studies in adults showed an increased risk
of relapse and colectomy in patients who discontinued azathioprine
(265,266). Anti-TNF is indicated for nonresponse, loss of response,
or intolerance of 5-ASA and thiopurine maintenance therapy.
Patients needing anti-TNF induction should continue this therapy
and, if thiopurine nave, may be subsequently stepped down
to thiopurines after a period of 4 to 8 months of complete remission.
5-ASA may be given as an adjuvant therapy with thiopurines and
even anti-TNF, although there is little evidence to support this
notion. Infliximab should be discontinued in those with primary
nonresponse after 2 to 3 infusions, loss of response despite dose
intensification strategies, and severe infusion reactions. Drug discontinuation may also be considered in children with sustained
remission, evidenced by clinical assessment and endoscopic evaluation, although specific timing of this is unclear. The pros and cons
of combination therapies have been discussed within each section.
354
Finally, in UC, colectomy is always a viable option that must be

discussed whenever treatment escalation is considered.
These clinical management guidelines were developed to
assist practitioners at all levels of health care, while recognizing
that each patient is unique. The recommendations may, thus, be
subject to local practice patterns, but serve as a general framework
for the management of UC in children. The development of
the guidelines should now be followed by dissemination of the
information to clinical practice.
QUALIFYING STATEMENT
These guidelines may be revised as necessary to account for
changes in technology, new data, or other aspects of clinical
practice. These guidelines are intended to be an educational device
to provide information that may assist clinicians in providing care to
patients. These guidelines are not a rule and should not be construed
as establishing a legal standard of care or as encouraging, advocating, requiring, or discouraging any particular treatment. Clinical
decisions in any particular case involve a complex analysis of the
patients condition and available courses of action. Therefore,
clinical considerations may require taking a course of action that
varies from these guidelines.
REFERENCES
1. Benchimol EI, Fortinsky KJ, Gozdyra P, et al. Epidemiology
of pediatric inflammatory bowel disease: a systematic review of
international trends. Inflamm Bowel Dis 2011;17:42339.
2. Henderson P, Hansen R, Cameron FL, et al. Rising incidence of
pediatric inflammatory bowel disease in Scotland. Inflamm Bowel
Dis 2012;18:9991005.
3. Heyman MB, Kirschner BS, Gold BD, et al. Children with earlyonset inflammatory bowel disease (IBD): analysis of a pediatric IBD
consortium registry. J Pediatr 2005;146:3540.
4. Van Limbergen J, Russell RK, Drummond HE, et al. Definition
of phenotypic characteristics of childhood-onset inflammatory bowel
disease. Gastroenterology 2008;135:111422.
5. Gower-Rousseau C, Dauchet L, Vernier-Massouille G, et al. The
natural history of pediatric ulcerative colitis: a population-based cohort
study. Am J Gastroenterol 2009;104:20808.
6. Langholz E, Munkholm P, Krasilnikoff PA, et al. Inflammatory bowel
diseases with onset in childhood. Clinical features, morbidity, and
mortality in a regional cohort. Scand J Gastroenterol 1997;32:13947.
7. Jakobsen C, Bartek J Jr, Wewer V, et al. Differences in phenotype and
disease course in adult and paediatric inflammatory bowel diseasea
population-based study. Aliment Pharmacol Ther 2011;34:121724.
8. Turner D, Walsh CM, Benchimol EI, et al. Severe paediatric ulcerative
colitis: incidence, outcomes and optimal timing for second-line
therapy. Gut 2008;57:3318.
9. Dinesen LC, Walsh AJ, Protic MN, et al. The pattern and outcome of
acute severe colitis. J Crohns Colitis 2010;4:4317.
10. Travis SPL, Stange EF, Lemann M, et al. European evidence-based
consensus on the management of ulcerative colitis: current management. J Crohn Colitis 2008;2:2462.
11. Turner D, Travis SP, Griffiths AM, et al. Consensus for managing acute
severe ulcerative colitis in children: a systematic review and joint
statement from ECCO, ESPGHAN, and the Porto IBD Working Group
of ESPGHAN. Am J Gastroenterol 2011;106:57488.
12. Wilson DC, Thomas AG, Croft NM, et al. Systematic review of the
evidence base for the medical treatment of paediatric inflammatory
bowel disease. J Pediatr Gastroenterol Nutr 2010;50:S1434.
13. IBD Working Group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition. Inflammatory bowel disease in
children and adolescents: recommendations for diagnosisthe Porto
criteria. J Pediatr Gastroenterol Nutr. 2005;41:17.
14. Levine A, Griffiths A, Markowitz J, et al. Pediatric modification of
the Montreal classification for inflammatory bowel disease: the Paris
classification. Inflamm Bowel Dis 2011;17:131421.
www.jpgn.org
JPGN
15. Bousvaros A, Antonioli DA, Colletti RB, et al. Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a
working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohns and Colitis
Foundation of America. J Pediatr Gastroenterol Nutr 2007;44:
65374.
16. Rajwal SR, Puntis JW, McClean P, et al. Endoscopic rectal sparing in
children with untreated ulcerative colitis. J Pediatr Gastroenterol Nutr
2004;38:669.
17. Glickman JN, Bousvaros A, Farraye FA, et al. Pediatric patients
with untreated ulcerative colitis may present initially with unusual
morphologic findings. Am J Surg Pathol 2004;28:1907.
18. Markowitz J, Kahn E, Grancher K, et al. Atypical rectosigmoid
histology in children with newly diagnosed ulcerative colitis. Am J
Gastroenterol 1993;88:20347.
19. Levine A, de Bie CL, Turner D, et al. Atypical disease phenotypes
in paediatric ulcerative colitis: 5-year analyses of the EUROKIDS
registry. Inflamm Bowel Dis. 2012 May 8. [Epub ahead of print]
20. Robert ME, Tang L, Hao LM, et al. Patterns of inflammation
in mucosal biopsies of ulcerative colitis: perceived differences in
pediatric populations are limited to children younger than 10 years.
Am J Surg Pathol 2004;28:1839.
21. Kim B, Barnett JL, Kleer CG, et al. Endoscopic and histological
patchiness in treated ulcerative colitis. Am J Gastroenterol 1999;94:
325862.
22. Haskell H, Andrews CW Jr, Reddy SI, et al. Pathologic features and
clinical significance of backwash ileitis in ulcerative colitis. Am J
Surg Pathol 2005;29:147281.
23. Tobin JM, Sinha B, Ramani P, et al. Upper gastrointestinal mucosal
disease in pediatric Crohn disease and ulcerative colitis: a blinded,
controlled study. J Pediatr Gastroenterol Nutr 2001;32:4438.
24. de Bie CI, Buderus S, Sandhu BK, et al. Diagnostic workup of
paediatric patients with inflammatory bowel disease in Europe: results
of a 5-year audit of the EUROKIDS registry. J Pediatr Gastroenterol
Nutr 2012;54:37480.
25. Koletzko S, Niggemann B, Arato A, et al. Diagnostic approach and
management of cows milk protein allergy in infants and children:
a practical guideline of the GI-committee of ESPGHAN. J Pediatr
Gastroenterol Nutr. 2012;55:221229.
26. Glocker EO, Frede N, Perro M, et al. Infant colitisits in the genes.
Lancet 2010;376:1272.
27. Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease
and mutations affecting the interleukin-10 receptor. N Engl J Med
2009;361:203345.
28. Begue B, Verdier J, Rieux-Laucat F, et al. Defective IL10 signaling
defining a subgroup of patients with inflammatory bowel disease. Am J
29. Stange EF, Travis SP, Vermeire S, et al. European evidence-based
consensus on the diagnosis and management of ulcerative colitis:
definitions and diagnosis. J Crohns Colitis 2008;2:123.
30. Travis SP, Schnell D, Krzeski P, et al. Developing an instrument to
assess the endoscopic severity of ulcerative colitis: the Ulcerative
Colitis Endoscopic Index of Severity (UCEIS). Gut 2012;61:53542.
31. Beattie RM, Nicholls SW, Domizio P, et al. Endoscopic assessment of
the colonic response to corticosteroids in children with ulcerative
colitis. J Pediatr Gastroenterol Nutr 1996;22:3739.
32. Colombel JF, Rutgeerts P, Reinisch W, et al. Early mucosal healing
with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011;141:1194201.
33. Gustavsson A, Jarnerot G, Hertervig E, et al. Clinical trial: colectomy
after rescue therapy in ulcerative colitis3-year follow-up of the
Swedish-Danish controlled infliximab study. Aliment Pharmacol Ther
2010;32:9849.
34. Froslie KF, Jahnsen J, Moum BA, et al. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based
cohort. Gastroenterology 2007;133:41222.
35. Gustavsson A, Jarnerot G, Hertervig E, et al. A 2-year follow-up of the
Swedish-Danish Infliximab/placebo trial in steroid resistant acute
ulcerative colitis. Gastroenterology 2007;132:A983.
36. Turner D, Mack D, Leleiko N, et al. Severe pediatric ulcerative
colitis: a prospective multicenter study of outcomes and predictors
of response. Gastroenterology 2010;138:228291.
www.jpgn.org
37. Turner D, Seow CH, Greenberg GR, et al. A systematic prospective

comparison of noninvasive disease activity indices in ulcerative colitis.
Clin Gastroenterol Hepatol 2009;7:10818.
38. Thakkar K, Lucia CJ, Ferry GD, et al. Repeat endoscopy affects
patient management in pediatric inflammatory bowel disease. Am J
39. Turner D, Otley AR, Mack D, et al. Development, validation, and
evaluation of a Pediatric Ulcerative Colitis Activity Index: a prospective multicenter study. Gastroenterology 2007;133:42332.
40. Turner D, Hyams J, Markowitz J, et al. Appraisal of the Pediatric
Ulcerative Colitis Activity Index (PUCAI). Inflamm Bowel Dis 2009;
15:121823.
41. Mack DR, Langton C, Markowitz J, et al. Laboratory values for
children with newly diagnosed inflammatory bowel disease. Pediatrics
2007;119:11139.
42. Weinstein TA, Levine M, Pettei MJ, et al. Age and family history
at presentation of pediatric inflammatory bowel disease. J Pediatr
Gastroenterol Nutr 2003;37:60913.
43. Turner D, Mack DR, Hyams J, et al. C-reactive protein (CRP),
erythrocyte sedimentation rate (ESR) or both? A systematic evaluation
in pediatric ulcerative colitis. J Crohns Colitis 2011;5:4239.
44. Schoepfer AM, Trummler M, Straumann A, et al. Ulcerative colitis:
Correlation of the Rachmilewitz endoscopic activity index with fecal
calprotectin, clinical activity, C-reactive protein, and blood leukocytes.
Inflamm Bowel Dis 2009;15:18518.
45. DInca R, Dal Pont E, Di Leo V, et al. Calprotectin and lactoferrin in
the assessment of intestinal inflammation and organic disease. Int J
Colorectal Dis 2007;22:42937.
46. Hanai H, Takeuchi K, Iida T, et al. Relationship between fecal
calprotectin, intestinal inflammation, and peripheral blood neutrophils
in patients with active ulcerative colitis. Dig Dis Sci 2004;49:143843.
47. Roseth AG, Aadland E, Jahnsen J, et al. Assessment of disease activity
in ulcerative colitis by faecal calprotectin, a novel granulocyte marker
protein. Digestion 1997;58:17680.
48. Ashorn S, Honkanen T, Kolho KL, et al. Fecal calprotectin levels and
serological responses to microbial antigens among children and
adolescents with inflammatory bowel disease. Inflamm Bowel Dis
2009;15:199205.
49. Bunn SK, Bisset WM, Main MJ, et al. Fecal calprotectin: validation as
a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001;33:1422.
50. Henderson P, Casey A, Lawrence SJ, et al. The diagnostic accuracy of
fecal calprotectin during the investigation of suspected pediatric
inflammatory bowel disease. Am J Gastroenterol 2012;107:94149.
51. Turner D, Leach ST, Mack D, et al. Faecal calprotectin, lactoferrin,
M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a
prospective multicentre comparison of predicting outcomes and
monitoring response. Gut 2010;59:120712.
52. Sylvester FA, Turner D, Draghi A 2nd, et al. Fecal osteoprotegerin
may guide the introduction of second-line therapy in hospitalized
children with ulcerative colitis. Inflamm Bowel Dis 2011;17:172630.
53. Harris MS, Lichtenstein GR. Review article: delivery and efficacy of
topical 5-aminosalicylic acid (mesalazine) therapy in the treatment of
ulcerative colitis. Aliment Pharmacol Ther 2011;33:9961009.
54. Lichtenstein GR, Kamm MA. Review article: 5-aminosalicylate
formulations for the treatment of ulcerative colitismethods of comparing release rates and delivery of 5-aminosalicylate to the colonic
mucosa. Aliment Pharmacol Ther 2008;28:66373.
55. Sutherland L, Macdonald JK. Oral 5-aminosalicylic acid for induction
of remission in ulcerative colitis. Cochrane Database Syst Rev 2006:
CD000543.
56. Sutherland L, Macdonald JK. Oral 5-aminosalicylic acid for
maintenance of remission in ulcerative colitis. Cochrane Database
Syst Rev 2006:CD000544.
57. Ford AC, Achkar JP, Khan KJ, et al. Efficacy of 5-aminosalicylates in
ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol 2011;106:60116.
58. Romkens TE, Kampschreur MT, Drenth JP, et al. High mucosal
healing rates in 5-ASA-treated ulcerative colitis patients: results of
a meta-analysis of clinical trials. Inflamm Bowel Dis 2012 Mar 14.
[Epub ahead of print]
355
Turner et al
59. Romano C, Famiani A, Comito D, et al. Oral beclomethasone
dipropionate in pediatric active ulcerative colitis: a comparison trial
with mesalazine. J Pediatr Gastroenterol Nutr 2010;50:3859.
60. Quiros JA, Heyman MB, Pohl JF, et al. Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate
active ulcerative colitis: results of a randomized, double-blind study.
J Pediatr Gastroenterol Nutr 2009;49:5719.
61. Ferry GD, Kirschner BS, Grand RJ, et al. Olsalazine versus
sulfasalazine in mild to moderate childhood ulcerative colitis: results
of the Pediatric Gastroenterology Collaborative Research Group
Clinical Trial. J Pediatr Gastroenterol Nutr 1993;17:328.
62. Heyman MB, Kierkus J, Spenard J, et al. Efficacy and safety of
mesalamine suppositories for treatment of ulcerative proctitis in
children and adolescents. Inflamm Bowel Dis 2010;16:19319.
63. Christensen LA, Fallingborg J, Jacobsen BA, et al. Bioavailability of
5-aminosalicyclic acid from slow release 5-aminosalicyclic acid drug
and sulfasalazine in normal children. Dig Dis Sci 1993;38:18316.
64. Barden L, Lipson A, Pert P, et al. Mesalazine in childhood inflammatory bowel disease. Aliment Pharmacol Ther 1989;3:597603.
65. Tolia V, Massoud N, Klotz U. Oral 5-aminosalicyclic acid in children
with colonic chronic inflammatory bowel disease: clinical and pharmacokinetic experience. J Pediatr Gastroenterol Nutr 1989;8:3338.
66. Nikfar S, Rahimi R, Rezaie A, et al. A meta-analysis of the efficacy of
sulfasalazine in comparison with 5-aminosalicylates in the induction
of improvement and maintenance of remission in patients with
ulcerative colitis. Dig Dis Sci 2009;54:115770.
67. Wiersma H, Escher JC, Dilger K, et al. Pharmacokinetics of
mesalazine pellets in children with inflammatory bowel disease.
68. Paoluzi OA, Iacopini F, Pica R, et al. Comparison of two different daily
dosages (2.4 vs. 1.2 g) of oral mesalazine in maintenance of remission
in ulcerative colitis patients: 1-year follow-up study. Aliment Pharmacol Ther 2005;21:11119.
69. Sandborn WJ, Regula J, Feagan BG, et al. Delayed-release oral
mesalamine 4.8 g/day (800-mg tablet) is effective for patients
with moderately active ulcerative colitis. Gastroenterology 2009;
137:193443.
70. Hanauer SB, Sandborn WJ, Kornbluth A, et al. Delayed-release
oral mesalamine at 4.8 g/day (800 mg tablet) for the treatment of
moderately active ulcerative colitis: the ASCEND II trial. Am J
71. Hanauer SB, Sandborn WJ, Dallaire C, et al. Delayed-release oral
mesalamine 4.8 g/day (800 mg tablets) compared to 2.4 g/day (400 mg
tablets) for the treatment of mildly to moderately active ulcerative
colitis: the ASCEND I trial. Can J Gastroenterol 2007;21:82734.
72. Kruis W, Kiudelis G, Racz I, et al. Once daily versus three times daily
mesalazine granules in active ulcerative colitis: a double-blind, doubledummy, randomised, non-inferiority trial. Gut 2009;58:23340.
73. Williams C, Panaccione R, Ghosh S, et al. Optimizing clinical use of
mesalazine (5-aminosalicylic acid) in inflammatory bowel disease.
Therap Adv Gastroenterol 2011;4:23748.
74. Kamm MA, Lichtenstein GR, Sandborn WJ, et al. Randomised trial of
once- or twice-daily MMX mesalazine for maintenance of remission in
ulcerative colitis. Gut 2008;57:893902.
75. Ford AC, Khan KJ, Sandborn WJ, et al. Once-daily dosing vs.
conventional dosing schedule of mesalamine and relapse of quiescent
ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol 2011;106:20707.
76. Loftus EV Jr, Kane SV, Bjorkman D. Systematic review: short-term
adverse effects of 5-aminosalicylic acid agents in the treatment of
77. Arend LJ, Springate JE. Interstitial nephritis from mesalazine: case
report and literature review. Pediatr Nephrol 2004;19:5503.
78. Kohli R, Melin-Aldana H, Sentongo TA. Mesalamine-induced
pneumonitis during therapy for chronic inflammatory bowel disease:
a pediatric case report. J Pediatr Gastroenterol Nutr 2005;41:47982.
79. Sentongo TA, Piccoli DA. Recurrent pericarditis due to mesalamine
hypersensitivity: a pediatric case report and review of the literature.
80. Selhub J, Dhar GJ, Rosenberg IH. Inhibition of folate enzymes by
sulfasalazine. J Clin Invest 1978;61:2214.
356
JPGN
81. Marshall JK, Irvine EJ. Rectal aminosalicylate therapy for distal
ulcerative colitis: a meta-analysis. Aliment Pharmacol Ther 1995;9:
293300.
82. Cortot A, Maetz D, Degoutte E, et al. Mesalamine foam enema versus
mesalamine liquid enema in active left-sided ulcerative colitis. Am J
83. Malchow H, Gertz B. A new mesalazine foam enema (Claversal foam)
compared with a standard liquid enema in patients with active distal
84. Gionchetti P, Ardizzone S, Benvenuti ME, et al. A new mesalazine gel
enema in the treatment of left-sided ulcerative colitis: a randomized
controlled multicentre trial. Aliment Pharmacol Ther 1999;13:3818.
85. dAlbasio G, Paoluzi P, Campieri M, et al. Maintenance treatment of
ulcerative proctitis with mesalazine suppositories: a double-blind
placebo-controlled trial. The Italian IBD Study Group. Am J Gastroenterol 1998;93:799803.
86. Hanauer S, Good LI, Goodman MW, et al. Long-term use of
mesalamine (Rowasa) suppositories in remission maintenance of
ulcerative proctitis. Am J Gastroenterol 2000;95:174954.
87. Marteau P, Crand J, Foucault M, et al. Use of mesalazine slow release
suppositories 1 g three times per week to maintain remission of
ulcerative proctitis: a randomised double blind placebo controlled
multicentre study. Gut 1998;42:1959.
88. Odera G, Giuliani B, Santini B, et al. Topical treatment with 5-ASA
and hydrocortisone. Riv Ital Pediatr 1986;12:6748.
89. Marshall JK, Thabane M, Steinhart AH, et al. Rectal 5-aminosalicylic
acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2010;CD004115.
90. Cohen RD, Woseth DM, Thisted RA, et al. A meta-analysis and
overview of the literature on treatment options for left-sided ulcerative
colitis and ulcerative proctitis. Am J Gastroenterol 2000;95:126376.
91. Regueiro M, Loftus EV Jr, Steinhart AH, et al. Medical management
of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials. Inflamm Bowel Dis 2006;12:97994.
92. Lamet M, Ptak T, Dallaire C, et al. Efficacy and safety of mesalamine
1 g HS versus 500 mg BID suppositories in mild to moderate ulcerative
proctitis: a multicenter randomized study. Inflamm Bowel Dis 2005;11:
62530.
93. Lamet M. A multicenter, randomized study to evaluate the efficacy and
safety of mesalamine suppositories 1 g at bedtime and 500 mg twice
daily in patients with active mild-to-moderate ulcerative proctitis.
Digest Dis Sci 2011;56:51322.
94. Ford AC, Khan KJ, Sandborn WJ, et al. Efficacy of topical 5aminosalicylates in preventing relapse of quiescent ulcerative colitis:
a meta-analysis. Clin Gastroenterol Hepatol 2012;10:5139.
95. Marteau P, Probert CS, Lindgren S, et al. Combined oral and enema
treatment with Pentasa (mesalazine) is superior to oral therapy alone
in patients with extensive mild/moderate active ulcerative colitis: a
randomised, double blind, placebo controlled study. Gut 2005;54:
9605.
96. Yokoyama H, Takagi S, Kuriyama S, et al. Effect of weekend
5-aminosalicylic acid (mesalazine) enema as maintenance therapy
for ulcerative colitis: results from a randomized controlled study.
97. Hyams J, Markowitz J, Lerer T, et al. The natural history of corticosteroid therapy for ulcerative colitis in children. Clin Gastroenterol
Hepatol 2006;4:111823.
98. Baron JH, Connell AM, Kanaghinis TG, et al. Out-patient treatment of
ulcerative colitis. Comparison between three doses of oral prednisone.
Br Med J 1962;2:4413.
99. Kolho KL, Raivio T, Lindahl H, et al. Fecal calprotectin remains high
during glucocorticoid therapy in children with inflammatory bowel
disease. Scand J Gastroenterol 2006;41:7205.
100. Powell-Tuck J, Bown RL, Lennard-Jones JE. A comparison of
oral prednisolone given as single or multiple daily doses for active
proctocolitis. Scand J Gastroenterol 1978;13:8337.
101. Uchida K, Araki T, Toiyama Y, et al. Preoperative steroid-related
complications in Japanese pediatric patients with ulcerative colitis.
Dis Colon Rectum 2006;49:749.
102. Rizzello F, Gionchetti P, DArienzo A, et al. Oral beclometasone
dipropionate in the treatment of active ulcerative colitis: a double-blind
placebo-controlled study. Aliment Pharmacol Ther 2002;16:110916.
www.jpgn.org
JPGN
103. Manguso F, Balzano A. Meta-analysis: the efficacy of rectal beclomethasone dipropionate vs. 5-aminosalicylic acid in mild to moderate
distal ulcerative colitis. Aliment Pharmacol Ther 2007;26:219.
104. Campieri M, Adamo S, Valpiani D, et al. Oral beclometasone
dipropionate in the treatment of extensive and left-sided active ulcerative colitis: a multicentre randomised study. Aliment Pharmacol Ther
2003;17:147180.
105. DHaens GR, Kovacs A, Vergauwe P, et al. Preliminary efficacy and
safety study of a new budesonide-MMX(R) 9 mg extended-release
tablets in patients with active left-sided ulcerative colitis. J Crohns
Colitis 2010;4:15360.
106. Miele E, Pascarella F, Giannetti E, et al. Effect of a probiotic
preparation (VSL#3) on induction and maintenance of remission in
children with ulcerative colitis. Am J Gastroenterol 2009;104:43743.
107. Burke DA, Axon AT, Clayden SA, et al. The efficacy of tobramycin
in the treatment of ulcerative colitis. Aliment Pharmacol Ther 1990;
4:1239.
108. Lobo AJ, Burke DA, Sobala GM, et al. Oral tobramycin in ulcerative
colitis: effect on maintenance of remission. Aliment Pharmacol Ther
1993;7:1558.
109. Gionchetti P, Rizzello F, Ferrieri A, et al. Rifaximin in patients with
moderate or severe ulcerative colitis refractory to steroid-treatment: a
double-blind, placebo-controlled trial. Dig Dis Sci 1999;44:12201.
110. Ohkusa T, Kato K, Terao S, et al. Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled
multicenter trial. Am J Gastroenterol 2010;105:18209.
111. Mantzaris GJ, Archavlis E, Christoforidis P, et al. A prospective
randomized controlled trial of oral ciprofloxacin in acute ulcerative
colitis. Am J Gastroenterol 1997;92:4546.
112. Turunen UM, Farkkila MA, Hakala K, et al. Long-term treatment of
ulcerative colitis with ciprofloxacin: a prospective, double-blind,
placebo-controlled study. Gastroenterology 1998;115:10728.
113. Muniyappa P, Gulati R, Mohr F, et al. Use and safety of rifaximin in
children with inflammatory bowel disease. J Pediatr Gastroenterol
Nutr 2009;49:4004.
114. Khan KJ, Ullman TA, Ford AC, et al. Antibiotic therapy in
inflammatory bowel disease: a systematic review and meta-analysis.
Am J Gastroenterol 2011;106:66173.
115. Henker J, Muller S, Laass MW, et al. Probiotic Escherichia coli Nissle
1917 (EcN) for successful remission maintenance of ulcerative colitis
in children and adolescents: an open-label pilot study. Z Gastroenterol
2008;46:8745.
116. Naidoo K, Gordon M, Fagbemi AO, et al. Probiotics for maintenance
of remission in ulcerative colitis. Cochrane Database Syst Rev 2011;
CD007443
117. Huynh HQ, deBruyn J, Guan L, et al. Probiotic preparation VSL#3
induces remission in children with mild to moderate acute ulcerative
colitis: a pilot study. Inflamm Bowel Dis 2009;15:7608.
118. Bibiloni R, Fedorak RN, Tannock GW, et al. VSL#3 probiotic-mixture
induces remission in patients with active ulcerative colitis. Am J
119. Tursi A, Brandimarte G, Papa A, et al. Treatment of relapsing mild-tomoderate ulcerative colitis with the probiotic VSL#3 as adjunctive to
a standard pharmaceutical treatment: a double-blind, randomized,
placebo-controlled study. Am J Gastroenterol 2010;105:221827.
120. Sood A, Midha V, Makharia GK, et al. The probiotic preparation,
VSL#3 induces remission in patients with mild-to-moderately active
ulcerative colitis. Clin Gastroenterol Hepatol 2009;7:12029.
121. Guslandi M, Giollo P, Testoni PA. A pilot trial of Saccharomyces
boulardii in ulcerative colitis. Eur J Gastroenterol Hepatol 2003;15:
6978.
122. Furrie E, Macfarlane S, Kennedy A, et al. Synbiotic therapy
(Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled
pilot trial. Gut 2005;54:2429.
123. Kato K, Mizuno S, Umesaki Y, et al. Randomized placebo-controlled
trial assessing the effect of bifidobacteria-fermented milk on active
124. Zocco MA, dal Verme LZ, Cremonini F, et al. Efficacy of Lactobacillus
GG in maintaining remission of ulcerative colitis. Aliment Pharmacol
Ther 2006;23:156774.
www.jpgn.org
125. Wildt S, Nordgaard I, Hansen U, et al. A randomised double-blind

placebo-controlled trial with Lactobacillus acidophilus La-5 and
Bifidobacterium animalis subsp. lactis BB-12 for maintenance of
remission in ulcerative colitis. J Crohns Colitis 2011;5:11521.
126. Oliva S, Di Nardo G, Ferrari F, et al. Randomised clinical trial: the
effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in
children with active distal ulcerative colitis. Aliment Pharmacol Ther
2012;35:32734.
127. Timmer A, McDonald JW, Macdonald JK. Azathioprine and
6-mercaptopurine for maintenance of remission in ulcerative colitis.
Cochrane Database Syst Rev 2007:CD000478
128. Gisbert JP, Linares PM, McNicholl AG, et al. Meta-analysis:
the efficacy of azathioprine and mercaptopurine in ulcerative colitis.
Aliment Pharmacol Ther 2009;30:12637.
129. Khan KJ, Dubinsky MC, Ford AC, et al. Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and
meta-analysis. Am J Gastroenterol 2011;106:63042.
130. Hyams JS, Lerer T, Mack D, et al. Outcome following thiopurine use
in children with ulcerative colitis: a prospective multicenter registry
study. Am J Gastroenterol 2011;106:9817.
131. Barabino A, Torrente F, Ventura A, et al. Azathioprine in paediatric
inflammatory bowel disease: an Italian multicentre survey. Aliment
Pharmacol Ther 2002;16:112530.
132. Kader HA, Mascarenhas MR, Piccoli DA, et al. Experiences with
6-mercaptopurine and azathioprine therapy in pediatric patients with
severe ulcerative colitis. J Pediatr Gastroenterol Nutr 1999;28:548.
133. Verhave M, Winter HS, Grand RJ. Azathioprine in the treatment
of children with inflammatory bowel disease. J Pediatr 1990;117:
80914.
134. Pozler O, Chladek J, Maly J, et al. Steady-state of azathioprine during
initiation treatment of pediatric inflammatory bowel disease. J Crohns
Colitis 2010;4:6238.
135. Ardizzone S, Maconi G, Russo A, et al. Randomised controlled trial
of azathioprine and 5-aminosalicylic acid for treatment of steroid
dependent ulcerative colitis. Gut 2006;55:4753.
136. Mate-Jimenez J, Hermida C, Cantero-Perona J, et al. 6-mercaptopurine
or methotrexate added to prednisone induces and maintains remission
in steroid-dependent inflammatory bowel disease. Eur Gastroenterol
Hepatol 2000;12:122733.
137. Mantzaris GJ, Sfakianakis M, Archavlis E, et al. A prospective
randomized observer-blind 2-year trial of azathioprine monotherapy
versus azathioprine and olsalazine for the maintenance of remission
of steroid-dependent ulcerative colitis. Am J Gastroenterol 2004;
99:11228.
138. Szumlanski CL, Weinshilboum RM. Sulphasalazine inhibition of
thiopurine methyltransferase: possible mechanism for interaction
with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol
1995;39:4569.
139. Andrews JM, Travis SPL, Gibson PR, et al. Systematic review: does
concurrent therapy with 5-ASA and immunomodulators in inflammatory bowel disease improve outcomes? Aliment Pharmacol Ther
2009;29:45969.
140. Fuentes D, Torrente F, Keady S, et al. High-dose azathioprine in
children with inflammatory bowel disease. Aliment Pharmacol Ther
2003;17:91321.
141. Kirschner BS. Safety of azathioprine and 6-mercaptopurine in
pediatric patients with inflammatory bowel disease. Gastroenterology
1998; 115:81321.
142. Sandborn WJ. A review of immune modifier therapy for inflammatory
bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and
methotrexate. Am J Gastroenterol 1996;91:42333.
143. Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infections and
mortality in association with therapies for Crohns disease: TREAT
registry. Clin Gastroenterol Hepatol 2006;4:62130.
144. Rahier JF, Ben-Horin S, Chowers Y, et al. European evidence-based
consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis
2009;3:4791.
145. De Greef E, Vandenplas Y, Veereman-Wauters G. Opportunistic
infections in paediatric inflammatory bowel disease patients.
Arch Dis Child 2011;91:57.
357
Turner et al
146. Russell RK, Wilson ML, Loganathan S, et al. A British Society of
Paediatric Gastroenterology, Hepatology and Nutrition survey of the
effectiveness and safety of adalimumab in children with inflammatory
bowel disease. Aliment Pharmacol Ther 2011;33:94653.
147. Veereman-Wauters G, de Ridder L, Veres G, et al. Risk of
infection and prevention in pediatric patients with IBD: ESPGHAN
IBD Porto Group commentary. J Pediatr Gastroenterol Nutr 2012
Feb 10. [Epub ahead of print]
148. Kandiel A, Fraser AG, Korelitz BI, et al. Increased risk of lymphoma
among inflammatory bowel disease patients treated with azathioprine
and 6-mercaptopurine. Gut 2005;54:11215.
149. Beaugerie L, Brousse N, Bouvier AM, et al. Lymphoproliferative
disorders in patients receiving thiopurines for inflammatory bowel
disease: a prospective observational cohort study. Lancet 2009;
374:161725.
150. Kotlyar DS, Osterman MT, Diamond RH, et al. A systematic review of
factors that contribute to hepatosplenic T-cell lymphoma in patients
with inflammatory bowel disease. Clin Gastroenterol Hepatol 2011;
9:3641.
151. Osterman MT, Kundu R, Lichtenstein GR, et al. Association of
6-thioguanine nucleotide levels and inflammatory bowel disease
activity: a meta-analysis. Gastroenterology 2006;130:104753.
152. Gazouli M, Pachoula I, Panayotou I, et al. Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory
bowel disease Greek patients. J Clin Pharm Ther 2010;35:937.
153. Ooi CY, Bohane TD, Lee D, et al. Thiopurine metabolite monitoring in
paediatric inflammatory bowel disease. Aliment Pharmacol Ther 2007;
25:9417.
154. Gerich ME, Quiros JA, Marcin JP, et al. A prospective evaluation of
the impact of allopurinol in pediatric and adult IBD patients with
preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine. J Crohns Colitis 2010;4:54652.
155. Rahhal RM, Bishop WP. Initial clinical experience with allopurinolthiopurine combination therapy in pediatric inflammatory bowel
disease. Inflamm Bowel Dis 2008;14:167882.
156. Oren R, Arber N, Odes S, et al. Methotrexate in chronic active
ulcerative colitis: a double-blind, randomized, Israeli multicenter trial.
Gastroenterology 1996;110:141621.
157. Onuk MD, Kaymakoglu S, Demir K, et al. Low-dose weekly
methotrexate therapy in remission maintenance in ulcerative colitis.
Gut 1996;39:A75.
158. Aloi M, Di Nardo G, Conte F, et al. Methotrexate in paediatric
ulcerative colitis: a retrospective survey at a single tertiary referral
centre. Aliment Pharmacol Ther 2010;32:101722.
159. Turner D, Griffiths AM. Acute severe ulcerative colitis in children:
a systematic review. Inflamm Bowel Dis 2011;17:4409.
160. Ziring DA, Wu SS, Mow WS, et al. Oral tacrolimus for steroiddependent and steroid-resistant ulcerative colitis in children. J Pediatr
161. Yamamoto S, Nakase H, Matsuura M, et al. Tacrolimus therapy as an
alternative to thiopurines for maintaining remission in patients with
refractory ulcerative colitis. J Clin Gastroenterol 2011;45:52630.
162. Lawson MM, Thomas AG, Akobeng AK. Tumour necrosis factor
alpha blocking agents for induction of remission in ulcerative colitis.
Cochrane Database Syst Rev. 2006;CD005112
163. Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction
and maintenance therapy for ulcerative colitis. N Engl J Med 2005;
353:246276.
164. Hyams J, Damaraju L, Blank M, et al. Induction and maintenance
therapy with infliximab for children with moderate to severe ulcerative
colitis. Clin Gastroenterol Hepatol 2012;10:3919.
165. Hyams JS, Lerer T, Griffiths A, et al. Outcome following infliximab
therapy in children with ulcerative colitis. Am J Gastroenterol 2010;
105:14306.
166. Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab
for induction of clinical remission in moderately to severely active
ulcerative colitis: results of a randomised controlled trial. Gut 2011;
60:7807.
167. Sandborn WJ, van Assche G, Reinisch W, et al. Adalimumab induces
and maintains clinical remission in patients with moderate-to-severe
ulcerative colitis. Gastroenterology 2012;142:25765.
358
JPGN
168. Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine,

or combination therapy for Crohns disease. N Engl J Med 2010;
362:138395.
169. Panaccione R, Ghosh S, Middleton S, et al. Infliximab, azathioprine or
infliximab azathioprine for treatment of moderate to severe ulcerative colitis. The UC SUCCESS trial. J Crohns Colitis 2011;5:13.
170. Lichtenstein GR, Diamond RH, Wagner CL, et al. Clinical trial:
benefits and risks of immunomodulators and maintenance infliximab
for IBD-subgroup analyses across four randomized trials. Aliment
Pharmacol Ther 2009;30:21026.
171. Van Assche G, Magdelaine-Beuzelin C, DHaens G, et al. Withdrawal
of immunosuppression in Crohns disease treated with scheduled
infliximab maintenance: a randomized trial. Gastroenterology 2008;
134:18618.
172. Fanjiang G, Russell GH, Katz AJ. Short- and long-term response to
and weaning from infliximab therapy in pediatric ulcerative colitis.
173. Chaparro M, Guerra I, Munoz-Linares P, et al. Systematic review:
antibodies and anti-TNF-alpha levels in inflammatory bowel disease.
Aliment Pharmacol Ther 2012;35:97186.
174. Afif W, Loftus EV Jr, Faubion WA, et al. Clinical utility of measuring
infliximab and human anti-chimeric antibody concentrations in
patients with inflammatory bowel disease. Am J Gastroenterol
2010;105:11339.
175. Lees CW, Ali AI, Thompson AI, et al. The safety profile of anti-tumour
necrosis factor therapy in inflammatory bowel disease in clinical
practice: analysis of 620 patient-years follow-up. Aliment Pharmacol
Ther 2009;29:28697.
176. Thanaraj S, Hamlin PJ, Ford AC. Granulocyte/monocyte adsorptive
apheresis for ulcerative colitis. Aliment Pharmacol Ther 2010;
32:1297306.
177. Sands BE, Sandborn WJ, Feagan B, et al. A randomized, double-blind,
sham-controlled study of granulocyte/monocyte apheresis for active
ulcerative colitis. Gastroenterology 2008;135:4009.
178. Tomomasa T, Kobayashi A, Kaneko H, et al. Granulocyte adsorptive
apheresis for pediatric patients with ulcerative colitis. Dig Dis Sci
2003;48:7504.
179. Kumagai M, Yamato Y, Maeda K, et al. Extracorporeal leukocyte
removal therapy for patients with ulcerative colitis. Pediatr Int 2007;
49:4316.
180. Ikeda H, Ishimaru Y, Takayasu H, et al. Efficacy of granulocyte
apheresis in pediatric patients with ulcerative colitis: a pilot study.
181. Ruuska T, Wewer V, Lindgren F, et al. Granulocyte-monocyte
adsorptive apheresis in pediatric inflammatory bowel disease: results,
practical issues, safety, and future perspectives. Inflamm Bowel Dis
2009;15:104954.
182. Martin de Carpi J, Vilar P, Prieto G, et al. Safety and efficacy of
granulocyte and monocyte adsorption apheresis in paediatric
inflammatory bowel disease: a prospective pilot study. J Pediatr
183. Tomomasa T, Tajiri H, Kagimoto S, et al. Leukocytapheresis in
pediatric patients with ulcerative colitis. J Pediatr Gastroenterol Nutr
2011;53:349.
184. Emmrich J, Petermann S, Nowak D, et al. Leukocytapheresis (LCAP)
in the management of chronic active ulcerative colitisresults of a
randomized pilot trial. Dig Dis Sci 2007;52:204453.
185. Sakata Y, Iwakiri R, Amemori S, et al. Comparison of the efficacy of
granulocyte and monocyte/macrophage adsorptive apheresis and
leukocytapheresis in active ulcerative colitis patients: a prospective
randomized study. Eur J Gastroenterol Hepatol 2008;20:62933.
186. Levine DS, Fischer SH, Christie DL, et al. Intravenous immunoglobulin therapy for active, extensive, and medically refractory idiopathic
ulcerative or Crohns colitis. Am J Gastroenterol 1992;87:91100.
187. Buning J, Homann N, von Smolinski D, et al. Helminths as governors
of inflammatory bowel disease. Gut 2008;57:11823.
188. Summers RW, Elliott DE, Qadir K, et al. Trichuris suis seems to be safe
and possibly effective in the treatment of inflammatory bowel disease.
189. Summers RW, Elliott DE, Urban JF Jr et al. Trichuris suis therapy
for active ulcerative colitis: a randomized controlled trial. Gastroenterology 2005;128:82532.
www.jpgn.org
JPGN
190. Turner D, Steinhart AH, Griffiths AM. Omega 3 fatty acids (fish oil)
for maintenance of remission in ulcerative colitis. Cochrane Database
Syst Rev. 2007:CD006443
191. Bernstein CN, Fried M, Krabshuis JH, et al. World Gastroenterology
Organization Practice Guidelines for the diagnosis and management of
IBD in 2010. Inflamm Bowel Dis 2010;16:11224.
192. Tilney HS, Constantinides V, Ioannides AS, et al. Pouch-anal
anastomosis vs straight ileoanal anastomosis in pediatric patients: a
meta-analysis. J Pediatr Surg 2006;41:1799808.
193. Seetharamaiah R, West BT, Ignash SJ, et al. Outcomes in pediatric
patients undergoing straight vs J pouch ileoanal anastomosis: a multicenter analysis. J Pediatr Surg 2009;44:14107.
194. Pakarinen MP, Natunen J, Ashorn M, et al. Long-term outcomes
of restorative proctocolectomy in children with ulcerative colitis.
Pediatrics 2009;123:137782.
195. Weston-Petrides GK, Lovegrove RE, Tilney HS, et al. Comparison of
outcomes after restorative proctocolectomy with or without
defunctioning ileostomy. Arch Surg 2008;143:40612.
196. Tjandra JJ, Fazio VW, Milsom JW, et al. Omission of temporary
diversion in restorative proctocolectomyis it safe? Dis Colon
Rectum 1993;36:100714.
197. Ahmed Ali U, Keus F, Heikens JT, et al. Open versus laparoscopic
(assisted) ileo pouch anal anastomosis for ulcerative colitis and
familial adenomatous polyposis. Cochrane Database Syst Rev.
2009;CD006267
198. Wu XJ, He XS, Zhou XY, et al. The role of laparoscopic surgery
for ulcerative colitis: systematic review with meta-analysis. Int J
Colorectal Dis 2010;25:94957.
199. Fraser JD, Garey CL, Laituri CA, et al. Outcomes of laparoscopic and
open total colectomy in the pediatric population. J Laparoendosc Adv
Surg Tech A 2010;20:65960.
200. Mattioli G, Pini-Prato A, Barabino A, et al. Laparoscopic approach for
children with inflammatory bowel diseases. Pediatr Surg Int 2011;
27:83946.
201. da Luz Moreira A, Kiran RP, Lavery I. Clinical outcomes of ileorectal
anastomosis for ulcerative colitis. Br J Surg 2010;97:659.
202. Cornish JA, Tan E, Teare J, et al. The effect of restorative proctocolectomy on sexual function, urinary function, fertility, pregnancy and
delivery: a systematic review. Dis Colon Rectum 2007;50:112838.
203. Waljee A, Waljee J, Morris AM, et al. Threefold increased risk of
infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis. Gut 2006;55:157580.
204. Mortier PE, Gambiez L, Karoui M, et al. Colectomy with ileorectal
anastomosis preserves female fertility in ulcerative colitis. Gastroenterol Clin Biol 2006;30:5947.
205. Markel TA, Lou DC, Pfefferkorn M, et al. Steroids and poor nutrition
are associated with infectious wound complications in children
undergoing first stage procedures for ulcerative colitis. Surgery
2008; 144:5405.
206. Randall J, Singh B, Warren BF, et al. Delayed surgery for acute severe
colitis is associated with increased risk of postoperative complications.
Br J Surg. 2010;97:4049.
207. Yang Z, Wu Q, Wu K, et al. Meta-analysis: pre-operative infliximab
treatment and short-term post-operative complications in patients with
208. Kappelman M, Horvath-Puho E, Sandler RS, et al. The association
between IBD and venous thromboembolism in Danish children and
adults: A population-based case-control study. Gastroenterology
2010;138:S-105 6
209. Rintala RJ, Lindahl HG. Proctocolectomy and J-pouch ileo-anal
anastomosis in children. J Pediatr Surg 2002;37:6670.
210. Alexander F, Sarigol S, DiFiore J, et al. Fate of the pouch in 151
pediatric patients after ileal pouch anal anastomosis. J Pediatr Surg
2003;38:7882.
211. Stavlo PL, Libsch KD, Rodeberg DA, et al. Pediatric ileal pouch-anal
anastomosis: functional outcomes and quality of life. J Pediatr Surg
2003;38:9359.
212. Robb BW, Gang GI, Hershko DD, et al. Restorative proctocolectomy
with ileal pouch-anal anastomosis in very young patients with
refractory ulcerative colitis. J Pediatr Surg 2003;38:8637.
213. Perrault J. Pouchitis in children: therapeutic options. Curr Treat
Options Gastroenterol 2002;5:38997.
www.jpgn.org
214. Shen B, Lashner BA, Bennett AE, et al. Treatment of rectal cuff
inflammation (cuffitis) in patients with ulcerative colitis following
restorative proctocolectomy and ileal pouch-anal anastomosis. Am J
215. Slatter C, Girgis S, Huynh H, et al. Pre-pouch ileitis after colectomy in
paediatric ulcerative colitis. Acta Paediatr 2008;97:3813.
216. Shen B, Achkar JP, Lashner BA, et al. Irritable pouch syndrome: a new
category of diagnosis for symptomatic patients with ileal pouch-anal
anastomosis. Am J Gastroenterol 2002;97:9727.
217. Biancone L, Michetti P, Travis SP, et al. European evidence based
consensus on the management of ulcerative colitis: special situations.
J Crohns Colitis 2008;2:6392.
218. Kaditis AG, Perrault J, Sandborn WJ, et al. Antineutrophil cytoplasmic
antibody subtypes in children and adolescents after ileal pouch-anal
anastomosis for ulcerative colitis. J Pediatr Gastroenterol Nutr
1998;26:38692.
219. Holubar SD, Cima RR, Sandborn WJ, et al. Treatment and prevention
of pouchitis after ileal-pouch anal anastomosis for ulcerative colitis.
Cochrane Database Syst Rev. 2010;CD001176.
220. Ferrante M, D Haens G, Dewit O, et al. Efficacy of infliximab in
refractory pouchitis and Crohns disease-related complications of the
pouch: a Belgian case series. Inflamm Bowel Dis 2010;16:2439.
221. Mimura T, Rizzello F, Helwig U, et al. Once daily high dose probiotic
therapy (VSL#3) for maintaining remission in recurrent or refractory
pouchitis. Gut 2004;53:10814.
222. Gionchetti P, Rizzello F, Venturi A, et al. Oral bacteriotherapy as
maintenance treatment in patients with chronic pouchitis: a doubleblind, placebo-controlled trial. Gastroenterology 2000;119:3059.
223. Aloi M, Cucchiara S. Extradigestive manifestations of IBD in
pediatrics. Eur Rev Med Pharmacol Sci 2009;13(suppl 1):2332.
224. Jose FA, Garnett EA, Vittinghoff E, et al. Development of
extraintestinal manifestations in pediatric patients with inflammatory
bowel disease. Inflamm Bowel Dis 2009;15:638.
225. Dotson JL, Hyams JS, Markowitz J, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation
to disease type and severity. J Pediatr Gastroenterol Nutr 2010;
51:1405.
226. Hyams JS. Extraintestinal manifestations of inflammatory bowel
disease in children. J Pediatr Gastroenterol Nutr 1994;19:721.
227. Hyams JS. Crohns disease in children. Pediatr Clin North Am
1996;43:25577.
228. Winesett M. Inflammatory bowel disease in children and adolescents.
Pediatr Ann 1997;26:22734.
229. Mamula P, Markowitz JE, Baldassano RN. Inflammatory bowel
disease in early childhood and adolescence: special considerations.
Gastroenterol Clin North Am 2003;32:96795.
230. Bonner GF, Fakhri A, Vennamaneni SR. A long-term cohort study
of nonsteroidal anti-inflammatory drug use and disease activity in
outpatients with inflammatory bowel disease. Inflamm Bowel Dis
2004;10:7517.
231. Orchard TR, Jewell DP. Conditions of the eyes and joints
associated with inflammatory bowel disease. In: Targan SR, Shanahan
F, Karp LC, eds. Inflammatory Bowel Disease: Translating Basic
Science Into Clinical Practice. Chichester, UK: John Wiley & Sons
Ltd; 2010:55361.
232. Charatcharoenwitthaya P, Lindor KD. Primary sclerosing cholangitis:
diagnosis and management. Curr Gastroenterol Rep 2006;8:7582.
233. Broome U, Lofberg R, Veress B, et al. Primary sclerosing cholangitis
and ulcerative colitis: evidence for increased neoplastic potential.
Hepatology 1995;22:14048.
234. Fevery J, Henckaerts L, Van Oirbeek R, et al. Malignancies and
mortality in 200 patients with primary sclerosering cholangitis:
a long-term single-centre study. Liver Int 2012;32:21422.
235. Cullen SN, Chapman RW. The medical management of primary
sclerosing cholangitis. Semin Liver Dis 2006;26:5261.
236. Pardi DS, Loftus EV Jr, Kremers WK, et al. Ursodeoxycholic acid as a
chemopreventive agent in patients with ulcerative colitis and primary
sclerosing cholangitis. Gastroenterology 2003;124:88993.
237. Lindor KD, Kowdley KV, Luketic VA, et al. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis.
Hepatology 2009;50:80814.
359
Turner et al
238. Eaton JE, Silveira MG, Pardi DS, et al. High-dose ursodeoxycholic
acid is associated with the development of colorectal neoplasia in
patients with ulcerative colitis and primary sclerosing cholangitis.
239. Rocha R, Santana GO, Almeida N, et al. Analysis of fat and muscle
mass in patients with inflammatory bowel disease during remission and
active phase. Br J Nutr 2009;101:6769.
240. Sawczenko A, Sandhu BK. Presenting features of inflammatory bowel
disease in Great Britain and Ireland. Arch Dis Child 2003;88:995
1000.
241. Markowitz J, Grancher K, Rosa J, et al. Growth failure in pediatric
inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1993;
16:37380.
242. Turunen P, Ashorn M, Auvinen A, et al. Long-term health outcomes
in pediatric inflammatory bowel disease: a population-based study.
243. Gonzalez-Huix F, Fernandez-Banares F, Esteve-Comas M, et al.
Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis. Am J Gastroenterol 1993;88:22732.
244. McIntyre PB, Powell-Tuck J, Wood SR, et al. Controlled trial of bowel
rest in the treatment of severe acute colitis. Gut 1986;27:4815.
245. Dickinson RJ, Ashton MG, Axon AT, et al. Controlled trial of
intravenous hyperalimentation and total bowel rest as an adjunct to
the routine therapy of acute colitis. Gastroenterology 1980;79:1199
204.
246. Barabino A, Tegaldo L, Castellano E, et al. Severe attack of ulcerative
colitis in children: retrospective clinical survey. Dig Liver Dis 2002;
34:449.
247. Bechtold S, Alberer M, Arenz T, et al. Reduced muscle mass and bone
size in pediatric patients with inflammatory bowel disease. Inflamm
Bowel Dis 2010;16:21625.
248. Werkstetter KJ, Pozza SB, Filipiak-Pittroff B, et al. Long-term
development of bone geometry and muscle in pediatric inflammatory
bowel disease. Am J Gastroenterol 2011;106:98898.
249. Gokhale R, Favus MJ, Karrison T, et al. Bone mineral density
assessment in children with inflammatory bowel disease. Gastroenterology 1998;114:90211.
250. Sylvester FA, Wyzga N, Hyams JS, et al. Natural history of bone
metabolism and bone mineral density in children with inflammatory
bowel disease. Inflamm Bowel Dis 2007;13:4250.
251. Walther F, Fusch C, Radke M, et al. Osteoporosis in pediatric patients
suffering from chronic inflammatory bowel disease with and without
steroid treatment. J Pediatr Gastroenterol Nutr 2006;43:4251.
252. Pappa H, Thayu M, Sylvester F, et al. Skeletal health of children and
adolescents with inflammatory bowel disease. J Pediatr Gastroenterol
Nutr 2011;53:1125.
360
JPGN
253. Pappa HM, Gordon CM, Saslowsky TM, et al. Vitamin D status
in children and young adults with inflammatory bowel disease.
Pediatrics 2006;118:195061.
254. Greenley RN, Stephens M, Doughty A, et al. Barriers to adherence
among adolescents with inflammatory bowel disease. Inflamm Bowel
Dis 2010;16:3641.
255. Greenley RN, Hommel KA, Nebel J, et al. A meta-analytic review
of the psychosocial adjustment of youth with inflammatory bowel
disease. J Pediatr Psychol 2011;35:85769.
256. Timmer A, Preiss JC, Motschall E, et al. Psychological interventions
for treatment of inflammatory bowel disease. Cochrane Database Syst
Rev. 2011:CD006913-CD006913.
257. Ross SC, Strachan J, Russell RK, et al. Psychosocial functioning and
health-related quality of life in paediatric inflammatory bowel disease.
258. Mackner LM, Crandall WV. Long-term psychosocial outcomes
reported by children and adolescents with inflammatory bowel disease.
259. Vaisto T, Aronen ET, Simola P, et al. Psychosocial symptoms and
competence among adolescents with inflammatory bowel disease and
their peers. Inflamm Bowel Dis 2010;16:2735.
260. Hommel KA, Denson LA, Baldassano RN. Oral medication adherence
and disease severity in pediatric inflammatory bowel disease. Eur J
Gastroenterol Hepatol 2011;23:2504.
261. Hommel KA, Baldassano RN. Barriers to treatment adherence in
pediatric inflammatory bowel disease. J Pediatr Psychol 2010;
35:100510.
262. Reed-Knight B, Lewis JD, Blount RL. Association of disease, adolescent, and family factors with medication adherence in pediatric
inflammatory bowel disease. J Pediatr Psychol 2011;36:30817.
263. Goodhand J, Hedin CR, Croft NM, et al. Adolescents with IBD: the
importance of structured transition care. J Crohns Colitis 2011;5:
50919.
264. Crowley R, Wolfe I, Lock K, et al. Improving the transition between
paediatric and adult healthcare: a systematic review. Arch Dis Child
2011;96:54853.
265. Cassinotti A, Actis GC, Duca P, et al. Maintenance treatment with
azathioprine in ulcerative colitis: outcome and predictive factors after
drug withdrawal. Am J Gastroenterol 2009;104:27607.
266. Actis GC, Fadda M, Pellicano R, et al. The 17-year single-center
experience with the use of azathioprine to maintain remission in
ulcerative colitis. Biomed Pharmacother 2009;63:3625.
267. Turner D, Otley AR, Mack D, et al. Development and evaluation of a
Pediatric Ulcerative Colitis Activity Index (PUCAI): a prospective
multicenter study. Gastroenterology 2007;133:42332.
www.jpgn.org
JPGN
Appendix 1: Predefined questions that the subgroups addressed
Appendix 3:The Pediatric Ulcerative Colitis Activity Index
Evaluation
1. The diagnosis of UC in children
2. The required investigations at baseline and differential diagnosis
3. Monitoring disease activity and remission in children
4. Predictors of severe disease course
Medical management
5. The role of antibiotics in pediatric UC (excluding pouchitis)
6. 5-ASA in pediatric UC
7. Thiopurines in pediatric UC
8. Methotrexate in pediatric UC
9. Corticosteroids in pediatric UC
10. Defining and managing steroid dependence
11. Defining and managing steroid refractoriness
12. Enemas in pediatric UC
13. Biologics in pediatric UC
14. Maintenance of remission: timing of choice of each medication
15. Probiotics in pediatric UC
16. Other investigational interventions
Surgical considerations
17. The preferred elective surgery in pediatric UC and indications
18. Ways to minimize surgical complications
19. Pouchitis in children
General considerations
20. Nutrition, growth, and bone health
21. Psychosocial support to the child and the family and transitional care
22. EIMs
23. Risks and adverse events
Item
Points
1. Abdominal pain
No pain
Pain can be ignored
Pain cannot be ignored
2. Rectal bleeding
None
Small amount only, in <50% of stools
Small amount with most stools
Large amount (>50% of the stool content)
3. Stool consistency of most stools
Formed
Partially formed
Completely unformed
4. Number of stools per 24 hours
02
35
68
>8
5. Nocturnal stools (any episode causing awakening)
No
Yes
6. Activity level
No limitation of activity
Occasional limitation of activity
Severe restricted activity
Sum of PUCAI (085)
0
5
10
0
10
20
30
0
5
10
0
5
10
15
0
10
0
5
10
For users guide and cutoff values for response, remission, mild,
moderate, and severe disease activity, refer to the original study (267).
Appendix 2: Levels of evidence and grades of recommendation based on the Oxford Centre for Evidence-based Medicine
Level
1a
1b
1c
Diagnostic study
SR with homogeneity of level 1 diagnostic studies
Validating cohort study with good reference standard
Specificity or sensitivity is so high that a positive or
a negative result rules out the diagnosis
SR with homogeneity of level >2 diagnostic studies
Exploratory cohort study with good reference standards
2a
2b
2c
3a
3b
SR with homogeneity of 3b and better studies

Nonconsecutive study; or without consistently applied
reference standards
Case-control study, poor or nonindependent reference standard
4
5
Expert opinion without explicit critical appraisal, or based

on physiology, bench research or first principles
Therapeutic study
SR with homogeneity of RCTs
Individual RCT (with narrow CI)
All or none
SR (with homogeneity) of cohort studies
Individual cohort study (including low-quality
RCT; eg, <80% follow-up)
Outcomes research; ecological studies
SR with homogeneity of case-control studies
Individual case-control study
Case series (and poor-quality cohort and casecontrol studies)
Expert opinion without explicit critical appraisal,
or based on physiology, bench research or
first principles
Grading of recommendation
A Consistent level 1 studies
B Consistent level 2 or 3 studies or extrapolations from level 1 studies
C Level 4 studies or extrapolations from level 2 or 3 studies
D Level 5 evidence or troublingly inconsistent or inconclusive studies of any level
For details, see http://www.cebm.net/levels_of_evidence.asp#refs.
www.jpgn.org
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CLINICAL GUIDELINES

Management of Pediatric Ulcerative Colitis: Joint ECCO

Alexander Potapov, Risto Rintala, jjjjjjjjjjDaniela E. Serban, Annamaria Staiano,

questions were addressed by working subgroups based on a SR of the

Received June 15, 2012; accepted June 22, 2012.

Volume 55, Number 3, September 2012

monitoring of the disease course, while acknowledging that each patient is

(JPGN 2012;55: 340361)

lcerative colitis (UC) is a chronic relapsing inflammatory

Guidelines for Management of Pediatric Ulcerative Colitis

MONITORING AND PREDICTION

Volume 55, Number 3, September 2012

TABLE 1. Main differential diagnosis of pediatric UC

Infectious colitis (frequent)

Acute onset, often with fever and occasionally

Allergic colitis (frequent in

Eczema, history of milk protein allergy,

Associated extraintestinal inflammation

Stool samples for microbial investigations including

It is beyond the scope of the present article to review all of

early-onset IBD, classical and subtle immunodeficiencies should

1. Endoscopic evaluation is recommended at diagnosis,

Volume 55, Number 3, September 2012

6. Calprotectin levels >100 to 150 mg/g indicate mucosal

Guidelines for Management of Pediatric Ulcerative Colitis

>7 to 14 days may decrease the rate of dose-dependent adverse

5-ASA delivery systems can be divided into azo-compounds

Volume 55, Number 3, September 2012

comparable with adults (63,65,67). Doses >2.4 g may be

Volume 55, Number 3, September 2012

a given child with enemas should balance the clinical benefits,

Guidelines for Management of Pediatric Ulcerative Colitis

Volume 55, Number 3, September 2012

TABLE 2. Prednisone tapering plan (numbers reflect daily milligrams)

A recent SR of RCTs suggested an overall beneficial

In other small trials, different probiotics were suggested to be

TABLE 3. Pediatric VSL#3 dosing by Miele et al (106)

Daily dose, bacteria/day

450 billion (1 sachet)

Volume 55, Number 3, September 2012

3. The determination of thiopurine methyltransferase (TPMT)

Guidelines for Management of Pediatric Ulcerative Colitis

Volume 55, Number 3, September 2012

high safety, it is not unreasonable to recommend a combined

Volume 55, Number 3, September 2012

concomitant immunomodulators reduced infusion reactions and

Guidelines for Management of Pediatric Ulcerative Colitis

Volume 55, Number 3, September 2012

Pouchitis, an idiopathic inflammation of the ileal reservoir, is

Volume 55, Number 3, September 2012

(215), and it does not necessarily confirm the diagnosis of CD.

OTHER MANAGEMENT CONSIDERATIONS

Guidelines for Management of Pediatric Ulcerative Colitis

Volume 55, Number 3, September 2012

Volume 55, Number 3, September 2012

Guidelines for Management of Pediatric Ulcerative Colitis

Exacerbation or disease onset

Severe disease (PUCAI 65-85)

Moderate disease (PUCAI 40-60)

Not systemically ill

Add enemas4 and/or probiotics

Admission for IV steroids6

In very selected cases consider infliximab or

accompanied by parents or caretakers during hospital visits as well