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eczema/
However, the most recent data from the International Study of Asthma and Allergies
in Childhood (ISAAC) Phase Three study confirms that AD is a disease with high prevalence,
affecting patients in both developed and developing countries.4 There is also a female
preponderance for AD, with an overall female/male ratio of 1.3:1.0.
The basis for this increased prevalence of AD is not well understood. However, wide
variations in prevalence have been observed within countries inhabited by similar ethnic
groups, suggesting that environmental factors are critical in determining disease expression.
Some of the potential risk factors that may be associated with the rise in atopic disease
include small family size, increased income and education both in whites and blacks,
migration from rural to urban environments, and increased use of antibiotics, that is, the socalled Western lifestyle.5,6 This has resulted in the hygiene hypothesis that allergic diseases
might be prevented by infection in early childhood transmitted by unhygienic contact with
older siblings.7 Given the increase in autoimmune diseases such as diabetes, abnormalities in
T regulatory cells have also been implicated.
TABLE 14-1
Features of Atopic Dermatitis
Major Features
Pruritus
Rash on face and/or extensors in infants and young children
Lichenification in flexural areas in older children
Tendency toward chronic or chronically relapsing dermatitis Personal or family history of atopic
disease: asthma, allergic rhinitis, atopic dermatitis
Other Common Findings
Dryness
DennieMorgan folds (accentuated lines or grooves below the margin of the lower eyelid)
Allergic shiners (darkening beneath the eyes)
Facial pallor
Pityriasis alba
Keratosis pilaris
Ichthyosis vulgaris
into the skin, they respond to chemotactic gradients established by chemokines that emanate
from sites of injury or infection.
Acute AD is associated with the production of T helper 2 type (Th2) cytokines,
notably IL-4 and IL-13,13 which mediate immunoglobulin isotype switching to IgE synthesis
and upregulate expression of adhesion molecules on endothelial cells. The important role that
Th2 cytokines play in the skins inflammatory response is supported by the observation that
transgenic mice genetically engineered to overexpress IL-4 in their skin develop
inflammatory pruritic skin lesions similar to AD, suggesting that local skin expression of Th2
cytokines plays a critical role in AD. There has also been considerable interest in IL-31,
which is a novel Th2 cytokine that induces severe pruritus and dermatitis in experimental
animals.
IL-31 has also been found to be increased in AD skin and serum levels of IL-31 correlate
with severity of skin disease.14 In chronic AD, there is an increase in the production of IL-5,
which is involved in eosinophil development and survival. Increased production of
granulocyte macrophage colony-stimulating factor in AD inhibits apoptosis of monocytes,
thereby contributing to the persistence of AD.15 The maintenance of chronic AD also
involves production of the Th1-like cytokines IL-12 and IL-18, as well as several
remodeling-associated cytokines, including IL-11 and transforming growth factor-1.16
The skin-specific chemokine, cutaneous T cell attracting chemokine [CTACK; CC
chemokine ligand 27 (CCL27)], is highly upregulated in AD and preferentially attracts skin
homing cutaneous lymphoid antigen (CLA)+ CC chemokine receptor 10+ (CCR10+) T cells
into the skin.17 CCR4 expressed on skin homing CLA+ T cells can also bind to CCL17 on the
vascular endothelium of cutaneous venules. Selective recruitment of CCR4-expressing Th2
cells is mediated by macrophage-derived chemokine and thymus and activation-regulated
cytokine, both of which are increased in AD. Severity of AD has been linked to the
magnitude of thymus and activation-regulated cytokine levels. In addition, chemokines such
as fractalkine, interferon (IFN)--inducible protein 10, and monokine induced by IFN- are
strongly upregulatedin keratinocytes and result in Th1-cell migration toward epidermis,
particularly in chronic AD.
Increased expression of the CC chemokines, macrophage chemoattractant protein-4,
eotaxin, and RANTES (regulated on activation, normal T cell expressed and secreted)
contribute to infiltration of macrophages, eosinophils, and T cells into both acute and chronic
AD skin lesions.
KEYCELL TYPES IN ATOPIC DERMATITIS SKIN
ANTIGEN-PRESENTING CELLS. DCs play an important role in detecting environmental
allergens or pathogens via pattern recognition receptors such as toll-like receptors (TLR). AD
skin contains two types of high-affinity, IgE receptor-bearing (FcR) myeloid DCs: (1) LCs
and (2) inflammatory dendritic epidermal cells (IDECs). IgE-bearing LCs appear to play an
important role in cutaneous allergen presentation to IL-4-producing Th2 cells.18 In this regard,
IgE-bearing LCs from AD skin lesions, but not LCs that lack surface IgE, are capable of
presenting allergens to T cells. These results suggest that cell-bound IgE on LCs facilitates
capture and internalization of allergens into LCs before their processing and antigen
presentation to T cells. IgE-bearing LCs that have captured allergen likely activate memory
Th2 cells in atopic skin, but they may also migrate to the lymph nodes to stimulate nave T
cells there to further expand the pool of systemic Th2 cells. Stimulation of FcRI on the
surface of LCs by allergens induces the release of chemotactic signals and recruitment of
precursor cells of IDECs and T cells in vitro. Stimulation of FcRI on IDECs leads to the
release of proinflammatory signals, which contribute to amplification of the allergic immune
response.
In contrast to other inflammatory skin diseases, such as allergic contact dermatitis or psoriasis
vulgaris, very low numbers of plasmacytoid DCs (pDCs), which play an important role in
host defense against viral infections, can be detected within the AD skin lesion. 19 pDCs in the
peripheral blood of patients with AD have been shown to bear the trimeric variant of FcRI
on their cell surface, which is occupied by IgE molecules.The modified immune function of
pDCs of patients with AD after FcRI-mediated allergen stimulation might contribute to a
local deficiency of type I IFNs, thereby contributing to increased susceptibility of AD patients
toward viral skin infections such as eczema herpeticum.20
T CELLS. Skin homing memory T cells play an important role in the pathogenesis of AD,
particularly during the acute phase of illness. This concept is supported by the observation
that primary T-cell immunodeficiency disorders are frequently associated with eczematous
skin lesions that clear after successful bone marrow transplantation.21 Furthermore, in animal
models of AD, the eczematous rash does not occur in the absence of T cells. In addition,
treatment with topical calcineurin inhibitors (TCIs), which target activated T cells,
significantly reduces the clinical skin rash of AD.
Th2-like T cells in acute AD that produce cytokines that enhance allergic skin inflammation.
During the chronic phase of AD, there is a switch to Th1-like cells that primarily produce
IFN-. These Th1-like cells induce the activation and apoptosis of keratinocytes. 23 Recently,
T regulatory (Treg) cells have been described as a further subtype of T cells that have
immunosuppressive function and cytokine profiles distinct from both Th1 and Th2 cells. 24
Treg cells are able to inhibit the development of both Th1 and Th2 responses.
Mutations in a nuclear factor expressed in Treg cells, FoxP3, result in IPEX (immune
dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome characterized by
elevated serum IgE, food allergy, and dermatitis that may be eczematous or psoriasiform. A
deficiency of resident Treg cells has also been reported in AD skin. 25 Interestingly,
staphylococcal superantigens subvert Treg cell function and may thereby augment skin
inflammation.26
There has also been considerable interest in the role of Th17 cells in the immunopathogenesis
of AD.27 These cells produce inflammatory cytokines such as IL-17 and are thought to play a
role in host defense by inducing keratinocytes to produce antimicrobial peptides as well as
promote neutrophil chemotaxis. Th17 cells are increased in the skin lesions of autoimmune
diseases, such as psoriasis, where they may promote inflammatory responses, including
neutrophil infiltration but also reduce skin infection. 28 Compared to psoriasis, AD skin lesions
have significantly fewer T cells expressing IL-17, but increased numbers of IL-4+ cells. 29
Furthermore, it has been found that the Th2 cytokines, IL-4 and IL-13, inhibit IL-17 induced
generation of antimicrobial peptides.30 Interestingly, an independent increase of IL-22
expressing cells, originally thought to be produced by Th17 cells, can be found in AD skin
and it has been suggested that these may contribute to epidermal hyperplasia.31
KERATINOCYTES. Keratinocytes play a critical role in the augmentation of atopic skin
inflammation. AD keratinocytes secrete a unique profile of chemokines and cytokines after
exposure to proinflammatory cytokines. This includes high levels of RANTES after
stimulation with TNF- and IFN-.32 They are also an important source of thymic stromal
lymphopoietin (TSLP), which activates DCs to prime nave T cells to produce IL-4 and IL-13
(i.e., promotes Th2 cell differentiation).33 The importance of TSLP in AD pathogenesis is
supported by the observation that mice genetically manipulated to overexpress TSLP in the
skin develop AD-like skin inflammation. Skinderived TSLP is also thought to trigger the
development of asthma.34,35 Keratinocytes are critical to the skins innate immune responses,
expressing Toll-like receptors, producing proinflammatory cytokines and antimicrobial
peptides (such as human defensins and cathelicidins) in response to tissue injury or
invading microbes.36 Several studies have now demonstrated that AD keratinocytes produce
reduced amounts of antimicrobial peptides and this may predispose such individuals to skin
colonization and infection with S. aureus, viruses, and fungi. However, this defect appears to
be acquired as the result of Th2-cytokine (IL-4, IL-10, and IL-13) mediated inhibition of
TNF- and IFN--induced antimicrobial peptide generation.
GENETICS
AD is a complex disease that is familially transmitted with a strong maternal
influence.37 Genome-wide linkage studies of families with AD have implicated chromosomal
regions that overlap with other inflammatory skin diseases such as psoriasis. Together with
candidate gene studies, these have provided interesting insights into the pathogenesis of AD.
Although many genes are likely to be involved in the development of AD, there has been
particular interest in the potential role of skin barrier/epidermal differentiation genes and
immune response/host defense genes. Loss-of-function mutations in FLG, which encodes the
epidermal barrier protein, filaggrin, have been demonstrated to be a major predisposing factor
for AD,38 as well as ichthyosis vulgaris, a common keratinizing disorder associated with AD
(Figs. 14-1 and 14-2). Patients with filaggrin null mutations often have early onset, severe
eczema, high level allergen sensitization, and develop asthma later in childhood.
Of note, the filaggrin gene is found on chromosome 1q21 that contains genes
(including loricrin and S100 calcium-binding proteins) in the epidermal differentiation
complex, known to be expressed during terminal differentiation of the epidermis. DNA
microarray analyses have demonstrated upregulation of S100 calcium-binding proteins and
downregulation of loricrin and filaggrin in AD. Candidate gene approaches have also
implicated variants in the SPINK5 gene, which is expressed in the uppermost epidermis
where its product, LEKT1, inhibits two serine proteases involved in desquamation and
inflammation (stratum corneum tryptic enzyme and stratum corneum chymotryptic stratum
corneum tryptic enzyme) expression is increased in AD, suggesting that an imbalance of
protease versus protease inhibitor activity may contribute to atopic skin inflammation.9
These observations establish a key role for impaired skin barrier function in the
pathogenesis of AD, as impaired skin barrier formation allows increased transepidermal water
loss and, importantly, increased entry of allergens, antigens, and chemicals from the
environment resulting in skin inflammatory responses. It is important to note that these
filaggrin mutations, and likely other mutations affecting the skin barrier, can occur in
clinically normal individuals, and in patients with ichthyosis vulgaris without clinical
evidence of skin inflammation. The majority of patients with AD outgrow their inflammatory
skin disease by adolescence. Thus, AD is a complex trait that involves interactions between
multiple gene products requiring environmental factors and the immune response to result in
the final clinical phenotype. Chromosome 5q31-33 contains a clustered family of functionally
related
cytokine
genesIL-3
IL-4,
IL-5,
IL-13,
and
granulocyte
macrophage
colonystimulating factorwhich are expressed by Th2 cells. A case control comparison has
suggested a genotypic association between the T allele of the 590C/T polymorphism of the
IL-4 gene promoter region with AD. Because the T allele is associated with increased IL-4
gene promoter activity when compared to the C allele,this suggests that genetic differences in
transcriptional activity of the IL-4 gene influence AD predisposition. In addition, an
association of AD with a gain-of-function mutation in the subunit of the IL-4 receptor has
been reported, providing further support of the concept that IL-4 gene expression plays a role
in AD. Functional mutations in the promoter region of the CC chemokines, RANTES, and
eotaxin, as well as variants in IL-13, the subunit of the high affinity cell surface receptor for
IgE (FcR1) found on basophils and mast cells suggest an overlapping of genetic basis with
other atopic diseases. Recent studies demonstrating a significant association between TSLP
gene polymorphisms and AD provide further support for the importance of Th2 polarization
in this disease.37 The involvement of T cell interferon and IL-18 genes support the role of
CD4+ T cells and dysregulation of Th1 genes in the pathophysiology of AD. As well, reports
of AD association with polymorphisms of the NOD1 gene, which encodes cytosolic pathogen
recognition receptor and toll-like receptors, suggest an important role for host defense genes
in the pathogenesis of AD. The reader is referred to Chapter 10 and reference 35 for a
detailed discussion of the genetics of AD.
BASIS OF PRURITUS IN ATOPIC DERMATITIS
Pruritus is a prominent feature of AD, manifested as cutaneous hyperreactivity and
scratching following exposure to allergens, changes in humidity, excessive sweating, and low
concentrations of irritants. Control of pruritus is important because mechanical injury from
scratching can induce proinflammatory cytokine and chemokine release, leading to a vicious
scratchitch cycle perpetuating the AD skin rash. The mechanisms of pruritus in AD are
poorly understood. Allergen-induced release of histamine from skin mast cells is not an
exclusive cause of pruritus in AD, because H1 antihistamines are not effective in controlling
the itch of AD.39 However, recent studies demonstrating a potential role for H4 receptors in
skin pathobiology suggests that histamine may play a contributory role. 40 However, the
observation that treatment with topical corticosteroids and calcineurin inhibitors is effective
at reducing pruritus suggests that the inflammatory cells play an important role in pruritus. 41,42
Molecules that have been implicated in pruritus include T-cell-derived cytokines such as IL31, stress-induced neuropeptides, and proteases which can act on protease-activated
receptors, eicosanoids, and eosinophil-derived proteins.43,44 The reader is referred to Chapter
103 for a detailed discussion of the pathophysiology of pruritus.
CLINICAL FINDINGS
The diagnosis of AD is based on the constellation of clinical features summarized in Table
14-1. AD typically begins during infancy. Approximately 50% of patients develop this illness
by the first year of life and an additional 30% between the ages of 15 years. Between 50
80% of patients with AD develop allergic rhinitis or asthma later in childhood. Many of these
patients outgrow their AD as they are developing respiratory allergy.
CUTANEOUS LESIONS
Intense pruritus and cutaneous reactivity are cardinal features of AD. Pruritus may be
intermittent throughout the day but is usually worse in the early evening and night. Its
consequences are scratching, prurigo papules (Fig. 14-3), lichenification (Fig. 14-4), and
eczematous skin lesions. Acute skin lesions are characterized by intensely pruritic,
erythematous papules associated with excoriation, vesicles over erythematous skin, and
serous exudate (Fig. 14-5). Subacute dermatitis is characterized by erythematous, excoriated,
scaling papules (Fig. 14-6). Chronic AD is characterized by (1) thickened plaques of skin, (2)
accentuated skin markings (lichenification), and (3) fibrotic papules (prurigo nodularis; Fig.
14-7). In chronic AD, all three stages of skin reactions frequently coexist in the same
individual. At all stages of AD, patients usually have dry, lackluster skin. The distribution and
skin reaction pattern vary according to the patients age and disease activity. During infancy,
the AD is generally more acute and primarily involves the face (Fig. 14-8), scalp, and the
extensor surfaces of the extremities (Fig. 14-9). The diaper area is usually spared. In older
children, and in those who have long-standing skin disease, the patient and localization of the
rash to the flexural folds of the extremities (Fig. 14-10). AD often subsides as the patient
grows older, leaving an adult with skin that is prone to itching and inflammation when
exposed to exogenous irritants. Chronic hand eczema may be the primary manifestation of
many adults with AD (Fig. 14-11). Other associated features of AD are listed in Table 14-1.
LABORATORY TESTS
Laboratory testing is not needed in the routine evaluation and treatment of uncomplicated
AD. Serum IgE levels are elevated in approximately 7080% of AD patients. This is
associated with sensitization against inhalant and food allergens and/or concomitant allergic
rhinitis and asthma.8 In contrast, 2030% of AD patients have normal serum IgE levels. This
subtype of AD has a lack of IgE sensitization against inhalant or food allergens. However,
some of these patients may possess IgE sensitization against microbial antigens such as S.
aureus toxins, and Candida albicans or Malassezia sympodialis can be detected. As well,
some of these patients show positive reactions using the atopy patch test despite negative
immediate skin tests. The majority of patients with AD also have peripheral blood
eosinophilia. Patients with AD have increased spontaneous histamine release from basophils.
These findings likely reflect a systemic Th2 immune response in AD especially those patients
who have elevated serum IgE levels. Importantly, the peripheral blood skin homing CLA+ T
cells in AD expressing either CD4 or CD8 spontaneously secrete IL-5 and IL-13, which
functionally prolong eosinophil survival and induce IgE synthesis.
DIAGNOSIS DAN DIFFERENTIAL DIAGNOSIS
Table 14-1 lists the clinical features of AD. Of the major features, pruritus and chronic
or remitting eczematous dermatitis with typical morphology and distribution are essential for
diagnosis. Other features, including allergy or elevated IgE, are variable, and some of the
associated features in the table may not be useful discriminators of individuals with AD
from the unaffected general population. Various diagnostic criteria have been proposed to
assist with clinical diagnosis, definition of patients for clinical studies, and epidemiologic
population studies.45 A refined list of diagnostic criteria suitable for epidemiologic studies has
been derived and validated by workers in the United Kingdom.46
PREDOMINANT IN INFANTS/CHILDREN
Seborrheic dermatitis
Metabolic/Nutritional
Scabies
Phenylketonuria
Psoriasis
Prolidase deficiency
Ichthyosis vulgaris
Keratosis pilaris
Dermatophytosis
CONSIDER
Asteatotic eczema
acidurias
Impetigo
DiGeorge syndrome
Drug eruptions
Hypogammaglobulinemia
Perioral dermatitis
Agammaglobulinemia
Pityriasis alba
WiskottAldrich syndrome
Ataxia-telangiectasia
porphyrias)
enteropathy,
Molluscum dermatitis
ADULTS
Omenn syndrome
Netherton syndrome
dermatoses
Lupus erythematosus
Dermatomyositis
Eosinophilic gastroenteritis
Graft-versus-host disease
Gluten-sensitive enteropathy
Pemphigus foliaceus
Dermatitis herpetiformis
Photosensitivity disorders (hydroa
Proliferative Disorders
porphyrias)
COMPLICATION
OCULAR PROBLEMS
Eye complications associated with severe AD can lead to significant morbidity. Eyelid
dermatitis and chronic blepharitis are commonly associated with AD and may result in visual
impairment from corneal scarring. Atopic keratoconjunctivitis is usually bilateral and can
have disabling symptoms that include itching, burning, tearing, and copious mucoid
discharge. Vernal conjunctivitis is a severe bilateral recurrent chronic inflammatory process
associated with papillary hypertrophy, or cobblestoning of the upper eyeliconjunctiva. It
usually occurs in younger patients and has a marked seasonal incidence, often in the spring.
The associated intense pruritus is exacerbated by exposure to irritants, light, or sweating.
Keratoconus is a conical deformity of the cornea believed to result from chronic rubbing of
the eyes in patients with AD and allergic rhinoconjunctivitis. Cataracts were reported in the
early literature to occur in up to 21% of patients with severe AD. However, it is unclear
whether this was a primary manifestation of AD or the result of the extensive use of systemic
and topical glucocorticoids, particularly around the eyes. Indeed, more recent studies suggest
that routine screening for cataracts in patients with AD may not be productive unless there is
concern about potential side effects from steroid therapy.
INFECTIONS
AD can be complicated by recurrent viral skin infections that may reflect local defects
in T-cell function.48 The most serious viral infection is herpes simplex (see Chapter 193),
which can affect patients of all ages, resulting in Kaposi varicelliform eruption or eczema
herpeticum. After an incubation period of 512 days, multiple, itchy, vesiculopustular lesions
erupt in a disseminated pattern; vesicular lesions are umbilicated, tend to crop, and often
become hemorrhagic and crusted (Fig. 14-12). Punched out and extremely painful erosions
result. These lesions may coalesce to large, denuded, and bleeding areas that can extend over
the entire body.
Although smallpox infections have been eradicated worldwide since the late 1970s,
threats of bioterrorism (with smallpox and other infectious agents) have made nations
reconsider their policies toward initiating vaccination programs. In AD patients, smallpox
vaccination (or even exposure to vaccinated individuals) (see Chapter 195) may cause a
severe widespread eruption (called eczema vaccinatum) that appears very similar to eczema
herpeticum. Thus, in patients with AD, vaccination is contraindicated unless there is a clear
risk of smallpox. In addition, decisions regarding vaccination of family members should take
into consideration the potential of eczema vaccinatum in household contacts.
Superficial fungal infections are also more common in atopic individuals and may
contribute to the exacerbation of AD. Patients with AD have an increased prevalence of
Trichophyton rubrum infections compared to nonatopic controls. There has been particular
interest in the role of M. sympodialis (Pityrosporum ovale or P. orbiculare) in AD. M.
sympodialis is a lipophilic yeast (see Chapters 188 and 189) commonly present in the
seborrheic areas of the skin. IgE antibodies against M. furfur are commonly found in AD
patients and most frequently in patients with head and neck dermatitis. In contrast, IgE
sensitization to M. sympodialis is rarely observed in normal controls or asthmatics. Positive
allergen patch-test reactions to this yeast have also been demonstrated. The potential
importance of M. sympodialis as well as other dermatophyte infections is further supported
by the reduction of AD skin severity in such patients after treatment with antifungal agents.
remission appear more frequently as the patient grows older. Spontaneous resolution of AD
has been reported to occur after age 5 years in 4060% of patients affected during infancy,
particularly if their disease is mild. Although earlier studies suggested that approximately
84% of children outgrow their AD by adolescence, more recent studies have reported that AD
disappears in approximately 20% of children followed from infancy until adolescence, but
becomes less severe in 65%. In addition, more than one-half of adolescents treated for mild
dermatitis may experience a relapse of disease as adults. Filaggrin mutations have been
associated with higher rates of persistent atopic dermatitis into later childhood and
adulthood.50 Importantly, for occupational counseling, adults whose childhood AD has been
in remission for a number of years may present with hand dermatitis, especially if daily
activities require repeated hand wetting. The following predictive factors correlate with a
poor prognosis for AD: widespread AD in childhood, associated allergic rhinitis and asthma,
family history of AD in parents or siblings, early age at onset of AD, being an only child, and
very high serum IgE levels.
TREATMENT
Successful treatment of AD requires a systematic, multipronged approach that
incorporates education about the disease state, skin hydration, pharmacologic therapy, and the
identification and elimination of flare factors such as irritants, allergens, infectious agents,
and emotional stressors (Fig. 14-13).51,52 Many factors lead to the symptom complex
characterizing AD. Thus, treatment plans should be individualized to address each patients
skin disease reaction pattern, includ- ing the acuity of the rash, and the trigger factors that are
unique to the particular patient. In patients refractory to conventional forms of therapy,
alternative antiinflammatory and immunomodulatory agents may be necessary.53
TOPICAL THERAPY
Cutaneous Hydration
Patients with AD have abnormal skin barrier function with increased transepidermal
water loss and decreased water content and dry skin (xerosis) contributing to disease
morbidity by the development of microfissures and cracks in the skin, which serve as portals
of entry for skin pathogens, irritants, and allergens. FLG gene mutations have also been
shown to result in decreased epidermal levels of natural moisturizing factor.54 This problem
can become aggravated during the dry winter months and in certain work environments.
Warm soaking baths for approximately 10 minutes followed by the application of an
occlusive emollient or topical medication to retain moisture can give such patients excellent
symptomatic relief. Bathing without emollient use may result in drier skin. 55 Use of an
effective emollient combined with hydration therapy helps to restore and preserve the stratum
corneum barrier, and may decrease the need for topical glucocorticoids. Moisturizers are
available in the form of lotions, creams, or ointments. Some lotions and creams may be
irritating due to added preservatives, solubilizers, and fragrances. Lotions containing water
may be drying due to an evaporative effect.
Hydrophilic ointments can be obtained in varying degrees of viscosity according to
the patients preference. Occlusive ointments are sometimes not well tolerated because of
interference with the function of the eccrine sweat ducts and the induction of folliculitis. In
these patients, less occlusive agents should be used.
Topical therapy to replace abnormal epidermal lipids, improve skin hydration, and
decrease skin barrier dysfunction may be useful therapeutically. Studies have shown benefits
of topical preparations with distinct compositions of lipids and ceramides, as well as a
nonsteroidal cream containing palmitamide MEA, an essential fatty acid, and a hydrolipidic
cream with glycyrrhetinic acid (MAS063ADP). 56,57 Further clinical studies to define the
benefits relative to traditional moisturizers and topical anti-inflammatory agents will be
helpful.
Hydration, by baths or wet dressings, promotes transepidermal penetration of topical
glucocorticoids. Dressings may also serve as an effective barrier against persistent scratching,
allowing more rapid healing of excoriated lesions. 58 Wet dressings, or wet wraps are
recommended for use on severely affected or chronically involved areas of dermatitis
refractory to therapy. However, overuse of wet dressings may result in maceration of the skin
complicated by secondary infection.
promote drying and fissuring of the skin if not followed by topical emollient use. Thus, wet
dressing therapy is reserved for poorly controlled AD and should be closely monitored by a
physician.
TOPICAL ANTI-INFLAMMATORY THERAPY
A recent study looked at TEWL, as well as several other parameters of epidermal
barrier including stratum corneum hydration and dye penetration. The authors found
improvement in all parameters when AD patients were treated with both a topical steroid
(betamethasone valerate 0.1% cream) and a topical calcineurin inhibitor (pimecrolimus 1%
cream) applied to paired lesions of the upper extremities. Electron microscopic evaluation of
barrier structure showed prevalently ordered stratum corneum lipid layers and regular
lamellar body extrusion in the calcineurin inhibitor treated skin but inconsistent extracellular
lipid bilayers and only partially filled lamellar bodies in the steroid-treated skin. Both
treatments normalized epidermal differentiation and reduced epidermal hyperproliferation.
Both anti-inflammatory therapies increased expression of filaggrin and involucrin in the skin.
Betamethasone valerate was superior in reducing clinical symptoms and epidermal
proliferation, but twice daily use over the 3-week period of the study led to epidermal
thinning. The authors concluded that since pimecrolimus improved the epidermal barrier and
did not cause cutaneous atrophy, it might be more suitable for long-term treatment of AD.
However,
the finding that the topical steroid was more effective in reducing clinical
symptoms and inflammation supports the use of topical steroids for acute intervention of AD
flares.
Topical Glucocorticoid Therapy
Topical glucocorticoids are the cornerstone of treatment for anti-inflammatory
eczematous skin lesions. Because of potential side effects, most physicians use topical
glucocorticoids only to control acute exacerbations of AD. However, recent studies suggest
that once control of AD is achieved with a daily regimen of topical glucocorticoid, long-term
control can be maintained in a subset of patients with twice weekly applications of topical
fluticasone to areas that have healed but are prone to developing eczema.61
Patients should be carefully instructed in the use of topical glucocorticoids to avoid
potential side effects. The potent fluorinated glucocorticoids should be avoided on the face,
the genitalia, and the intertriginous areas. A low-potency glucocorticoid preparation is
generally recommended for these areas. Patients should be instructed to apply topical
glucocorticoids to their skin lesions and to use emollients over uninvolved skin. Failure of a
patient torespond to topical glucocorticoids is sometimes due in part to an inadequate supply.
It is important to remember that it takes approximately 30 g of cream or ointment to cover the
entire skin surface of an adult once. To treat the entire body twice daily for 2 weeks requires
approximately 840 g (2 lb) of topical glucocorticoids.
There are seven classes of topical glucocorticoids, ranked according to their potency
based on vasoconstrictor assays. Because of their potential side effects, the ultrahigh-potency
glucocorticoids should be used only for very short periods of time and in areas that are
lichenified but not on the face or intertriginous areas. The goal is to use emollients to enhance
skin hydration and low-potency glucocorticoids for maintenance therapy. Midpotency
glucocorticoids can be used for longer periods of time to treat chronic AD involving the trunk
and extremities. Newer formulations of topical steroids include gel formulations without
alcohol bases that moisturize skin, and solutions, oils, foams, and shampoos that may be
useful on hair bearing surfaces.
Factors which influence topical glucocorticoid potency and side effects include the
molecular structure of the compound, the vehicle, the amount of medication applied, the
duration of application, occlusion, as well as host factors, including age, body surface area
and weight, skin inflammation, anatomic location of treated skin, and individual differences
in cutaneous or systemic metabolism. Side effects from topical glucocorticoids are directly
related to the potency ranking of the compound and the length of use, so it is incumbent on
the clinician to balance the need for a more potent steroid with the potential for side effects.
In addition, ointments have a greater potential to occlude the epidermis, resulting in enhanced
systemic absorption when compared to creams. Side effects from topical glucocorticoids can
be divided into local side effects and systemic side effects resulting from suppression of the
hypothalamicpituitaryadrenal axis. Local side effects include the development of striae,
skin atrophy, perioral dermatitis, and acne rosacea. The potential for potent topical
glucocorticoid to cause adrenal suppression is greatest in infants and young children. Several
topical steroid formulations have been specifically tested for safety and received specific US
Federal Drug Administration (FDA) approval for use in younger children such as desonide
hydrogel and nonethanolic foam, fluocinolone acetonide oil, and fluticasone 0.05% cream. 62
65
Mometasone cream and ointment are approved for children aged 2 years and older.
Because normal-appearing skin in AD shows evidence of immunologic dysregulation,
the use of topical corticosteroids as maintenance therapy has been reported in several
controlled studies.66 Once control of AD with a once daily regimen was achieved, longterm
control could be maintained with twice weekly application of fluticasone to previously
involved areas. Given recent insights into skin barrier and immunologic abnormalities and
colonization of normalappearing skin in AD by S. aureus, it is important to appreciate that
proactive therapy is an attempt to control residual disease, not just application of an active
drug to nonaffected skin.67
Topical Calcineurin Inhibitors
Topical tacrolimus and pimecrolimus have been developed as nonsteroidal
immunomodulators.68 Tacrolimus ointment 0.03% has been approved for intermittent
treatment of moderate to severe AD in children aged 2 years and older, with tacrolimus
ointment 0.1% approved for use in adults; pimecrolimus cream 1% is approved for treatment
of patients aged 2 years and older with mildmoderate AD. Both drugs have proven to be
effective with a good safety profile for treatment up to 4 years with tacrolimus ointment 69 and
up to 2 years with pimecrolimus cream. 70 A frequently observed side effect with TCIs is a
transient burning sensation of the skin. Importantly, treatment with TCIs is not associated
with skin atrophy,71 thus they are particularly useful for the treatment of areas such as the face
and intertriginous regions. Ongoing surveillance and recent reports have not shown a trend
for increased frequency of viral superinfections, especially eczema herpeticum. 72 The longterm safety of TCIs has not been established. Rare cases of skin malignancy and lymphoma
have been reported with topical tacrolimus, though the level of data quality and applicability
of these reports was judged low in the report
but
chlorine should be rinsed off immediately after swimming and the skin lubricated. Although
ultraviolet (UV) light may be beneficial to some patients with AD, sunscreens should be used
to avoid sunburn. However, because sunscreens can be irritants, care should be used to
identify a nonirritating product.
Specific Allergens
Foods and aeroallergens such as dust mites, animal danders, molds, and pollens have
been demonstrated to exacerbate AD. Potential allergens can be identified by taking a careful
history and carrying out selective skin-prick tests or specific serum IgE levels. Negative skin
tests or serum tests for allergen-specific IgE have a high predictive value for ruling out
suspected allergens. However, a normal total serum IgE level does not rule out the possibility
of allergen-specific IgE being present. Positive skin or in vitro tests, particularly to foods,
often do not correlate with clinical symptoms and should be confirmed with controlled food
challenges and elimination diets. Avoidance of foods implicated in controlled challenges
results in clinical improvement. Extensive elimination diets, which in some cases can be
nutritionally deficient, are rarely, if ever, required, because even with multiple positive skin
tests, the majority of patients react to three or fewer foods on controlled challenge. In dust
mite-allergic patients with AD, prolonged avoidance of dust mites has been found to result in
improvement of their skin disease. Avoidance measures include use of dust mite-proof
encasings on pillows, mattresses, and box springs; washing bedding in hot water weekly;
removal of bedroom carpeting; and decreasing indoor humidity levels with air conditioning.
Because there are many triggers contributing to the flares of AD, attention should be focused
on identifying and controlling the flare factors that are important to the individual patient.
Infants and young children are more likely to have food aller-gies, whereas older children and
adults are more likely to be sensitive to environmental aeroallergens. Contact allergens have
been increasingly recognized in AD. A recent study found that of children with relevant
positive reactions, 34% had a diagnosis of AD.77
Emotional Stressors
Although emotional stress does not cause AD, it often exacerbates the illness. AD
patients often respond to frustration, embarrassment, or other stressful events with increased
pruritus and scratching. In some instances, scratching is simply habitual and less commonly
associated with significant secondary gain. Psychological evaluation or counseling should be
considered in patients who have difficulty with emotional triggers or psychological problems,
contributing to difficulty in managing their disease. It may be especially useful in adolescents
and young adults who consider their skin disease disfiguring. Relaxation, behavioral
modification, or biofeedback may be helpful in patients with habitual scratching.58
Infectious Agents
Antistaphylococcal antibiotics are very helpful in the treatment of patients who are
heavily colonized or infected with S. aureus.78 Cephalosporins or penicillinase-resistant
penicillins (dicloxacillin, oxacillin, or cloxacillin) are usually beneficial for patients who are
Pruritus.
The treatment of pruritus in AD should be directed primarily at the underlying causes.
Reduction of skin inflammation and dryness with topical glucocorticoids and skin hydration,
respectively, often symptomatically reduce pruritus. Inhaled and ingested allergens should be
eliminated if documented to cause skin rash in controlled challenges. Systemic antihistamines
act primarily by blocking the H1 receptors in the dermis, there by ameliorating histamine
induced pruritus. However, histamine is only one of many mediators that can induce pruritus
of the skin. Therefore, certain patients may derive minimal benefit from antihistaminic
therapy. Some antihistamines are also mild anxiolytics and may offer symptomatic relief
through tranquilizing and sedative effects. Studies of newer, nonsedating antihistamines show
variable results in the effectiveness of controlling pruritus in AD, although they may be
useful in the subset of AD patients with concomitant urticaria or concurrent allergic rhinitis.
Because pruritus is usually worse at night, the sedating antihistamines, for example,
hydroxyzine or diphenhydramine, may offer an advantage with their soporific side effects
when used at bedtime. Doxepin hydrochloride has both tricyclic antidepressant and H1- and
H2-histamine receptor-blocking effects. It can be used in doses of 1075 mg orally at night or
up to 75 mg bid in adult patients. If nocturnal pruritus remains severe, short-term use of a
sedative to allow adequate rest may be appropriate. Treatment of AD with topical
antihistamines is generally not recommended because of potential cutaneous sensitization.
However, short-term (1 week) application of topical 5% doxepin cream has been reported to
reduce pruritus without sensitization. Of note, sedation is a side effect of widespread
application of doxepin cream, and allergic contact dermatitis has been reported.
TAR PREPARATIONS
Coal tar preparations may have antipruritic and anti-inflammatory effects on the skin,
although usually not as pronounced as those of topical glucocorticoids. 82 Tar preparations
may be useful in reducing the potency of topical glucocorticoids required in chronic
maintenance therapy of AD. Newer coal tar products have been developed that are more
acceptable with respect to odor and staining of clothes than some older products. Tar
shampoos can be beneficial for scalp dermatitis and are often helpful in reducing the
concentration and frequency of topical glucocorticoid applications. Tar preparations should
not be used on acutely inflamed skin, because this often results in skin irritation. Side effects
associated with tars include folliculitis and photosensitivity. There is a theoretic risk of tar
being a carcinogen based on observational studies of workers using tar components in their
occupations; however, epidemiologic studies do not confirm similar outcomes when used
topically.83
PHOTOTHERAPY
Natural sunlight is frequently beneficial to patients with AD. However, if the sunlight
occurs in the setting of high heat or humidity, thereby triggering sweating and pruritus, it may
be deleterious to patients. Broadband UVB, broadband UVA, narrowband UVB (311 nm),
UVA-1 (340 to 400 nm), and combined UVAB phototherapy can be useful adjuncts in the
treatment of AD. Investigation of the photoimmunologic mechanisms responsible for
therapeutic effectiveness indicates that epidermal LCs and eosinophils may be targets of UVA
phototherapy, with and without psoralen, whereas UVB exerts immunosuppressive effects via
blocking of function of antigen-presenting LCs and altered keratinocyte cytokine production.
Photochemotherapy with psoralen and UVA light may be indicated in patients with severe,
widespread AD, although studies comparing it with other modes of phototherapy are limited.
Short-term adverse effects with phototherapy may include erythema, skin pain, pruritus, and
pigmentation. Long-term adverse effects include premature skin aging and cutaneous
malignancies (see Chapters 237 and 238 for detailed discussion of phototherapy and
photochemotherapy, respectively).
HOSPITALIZATION
AD patients who appear erythrodermic or who have widespread severe skin disease
resistant to outpatient therapy should be hospitalized before considering systemic alternative
therapies (see section Systemic Therapy). In many cases, emoving the patient from
environmental allergens or emotional stresses, intense patient education, and assurance of
compliance with therapy results in a sustained improvement in their AD. Clearing of the
patients skin during hospitalization also allows the patient to undergo allergen skin testing
and appropriately controlled provocative challenges to correctly identify or rule out potential
allergens.
SYSTEMIC THERAPY
Systemic therapies discussed below were reviewed in a consensus conference.53
Systemic Glucocorticoids
The use of systemic glucocorticoids, such as oral prednisone, is rarely indicated in the
treatment of chronic AD. Some patients and physicians prefer the use of systemic
glucocorticoids to avoid the time-consuming skin care involving hydration and topical
therapy. However, the dramatic clinical improvement that may occur with systemic
glucocorticoids is frequently associated with a severe rebound flare of AD after the
discontinuation of systemic glucocorticoids. Short courses of oral glucocorticoids may be
appropriate for an acute exacerbation of AD whereas other treatment measures are being
instituted. If a short course of oral glucocorticoids is given, it is important to taper the dosage
and to begin intensified skin care, particularly with topical glucocorticoids and frequent
bathing followed by application of emollients to prevent rebound flaring of AD.
Cyclosporine
Cyclosporine is a potent immunosuppressive drug that acts primarily on T cells by
suppressing cytokine transcription. The drug binds to cyclophilin, an intracellular protein, and
this complex, in turn, inhibits calcineurin, a molecule required for initiation of cytokine gene
transcription. Multiple studies demonstrate that both children and adults with severe AD,
refractory to conventional treatment, can benefit from short-term cyclosporine treatment.
Various oral-dosing regimens have been recommended: 5 mg/kg has generally been used with
success in shortterm and long-term (1 year) use, whereas some authorities advocate bodyweight-independent daily dosing of adults with 150 mg (low dose) or 300 mg (high dose)
daily of cyclosporine microemulsion. Treatment with cyclosporine is associated with reduced
skin disease and an improved quality of life (see Chapter 233 for further discussion).
Discontinuation of treatment may result in rapid relapse of skin disease, although some
patients may have sustained remission. Elevated serum creatinine or more significant renal
impairment and hypertension are specific side effects of concern with cyclosporine use.
Antimetabolites
Mycophenolate
mofetil
is
purine
biosynthesis
inhibitor
used
as
an
immunosuppressant in organ transplantation, which has been used for treatment of refractory
inflammatory skin disorders (see Chapter 233). Open-label studies report that short-term oral
mycophenolate mofetil, 2 g daily, as monotherapy results in clearing of skin lesions in adults
with AD resistant to other treatment, including topical and oral steroids and psoralen and
UVA light. The drug has generally been well tolerated with the exception of one patient
developing herpes retinitis that may have been secondary to this immunosuppressive agent.
Dose-related bone marrow suppression has also been observed. Similar results were
previously reported in another open study of ten patients with a mean reduction in the
SCORAD (SCORing Atopic Dermatitis) index of 68% in all ten patients. Of note, not all
patients benefit from treatment. Therefore, the medication should be discontinued if patients
do not respond within 4 to 8 weeks. Dose finding and well-controlled studies are needed for
this drug.
Methotrexate is an antimetabolite with potent inhibitory effects on inflammatory
cytokine synthesis and cell chemotaxis. Methotrexate has been used for adult AD patients
with recalcitrant disease, although controlled trials are lacking. Dosing more frequently than
The typical weekly dosing for psoriasis has been advocated.84 In open-label studies, initial
improvement was observed after a period ranging from 2 weeks to 3 months (mean 9.95
weeks +/ 3.17).
Azathioprine is a purine analog with anti inflammatory and antiproliferative effects. It
has been used for severe AD, and several controlled trials have been reported in adults and
children.85,86 Myelosuppression is a significant adverse effect. Thiopurine methyl transferase
levels may predict individuals at risk.87
OTHER THERAPIES
Interferon-
IFN-
known to suppress IgE responses and down regulate Th2 cell proliferation
and function. Several studies of patients with AD, including a multicenter, double-blind,
placebo-controlled trial and two long-term open trials, have demonstrated that treatment with
recombinant human IFN-
Influenzalike symptoms are commonly observed side effects early in the treatment course.89,90
Omalizumab
Treatment of patients with severe AD and elevated serum IgE levels with monoclonal
anti-IgE has shown lack of efficacy in three adult patients 91 and significant improvement in
threeadolescent patients.92 In an open study of 11 adult patients with high IgE levels treated
with anti-IgE, some patients had very good clinical improvement, others had none and
several had worsening of their AD based on change in SCORAD. 93 To date, specific markers
have not been found to identify potential responders.
Allergen Immunotherapy
Unlike allergic rhinitis and extrinsic asthma, immunotherapy with aeroallergens has
not proven to be efficacious in the treatment of AD. There are anecdotal reports of both
disease exacerbation and improvement. A recent study of specific immunotherapy over 12
months in adults with AD sensitized to dust mite allergen showed improvement in SCORAD
as well as reduction in topical steroid use. 94
required to determine the role for immunotherapy with this disease. More recently, a
controlled study with sublingual immunotherapy showed benefit in a subset of children with
AD sensitized to dust mite allergen. 95 This data need to be reproduced in a larger pediatric
population, given the natural history of AD.
Extracorporeal Photopheresis
Extracorporeal photopheresis consists of the passage of psoralen-treated leukocytes
through an extracorporeal UVA light system. Clinical improvement in skin lesions associated
with reduced IgE levels has been reported in a few patients with severe, resistant AD who
were treated with extracorporeal photopheresis and topical glucocorticoids.96
Probiotics
Perinatal administration of the probiotic Lactobacillus rhamnosus strain GG was
shown to reduce the incidence of AD in at-risk children during the first 2 years of life. 97
Mothers were given either placebo or Lactobacillus GG daily for 4 weeks before delivery and
then either the mother (if breast-feeding) or the infant continued with daily therapy for 6
months. In a follow-up study, the same group assessed the persistence of potential to prevent
AD at 4 years.98 The results suggest that the preventive effect of Lactobacillus GG on AD
could extend beyond infancy.
In a second study, children with AD treated with two Lactobacillus strains for 6 weeks
experienced improvement of their eczema compared to placebotreated patients, although their
SCORAD index did not change significantly.99 The treatment response was found to be more
pronounced in patients with positive skin-prick tests and elevated IgE levels. Another study
of children with moderate to severe AD treated for 8 weeks with L. fermentum in a placebocontrolled study showed persistent improvement in SCORAD at 16 weeks. 100 These studies
suggest that probiotics, or at least some Lactobacillus strains, may have preventative, lasting
effects on the incidence of AD in a subset of patients. More research into subgroups of
responders, optimal therapy [route (i.e., directly to infant or via mothers milk); length of
treatment; strain of Lactobacillus], as well as mechanisms involved is clearly needed.101
A recent meta-analysis found a modest role for probiotics in children with moderately
severe disease in reducing SCORAD (mean change from baseline, 3.01; 95% confidence
interval, 5.36 to 0.66; P = .01).102 Duration of probiotic administration, age, and type of
probiotic used did not affect outcomes. Another meta-analysis found that current evidence is
more convincing for probiotics efficacy in prevention, rather than treatment of AD in
children.103 In contrast to earlier studies, supplementation with Lactobacillus GG during
pregnancy and early infancy neither reduced the incidence of AD nor altered the severity of
AD in affected children, but was associated with increased rate of recurrent episodes of
wheezy bronchitis.104 A Cochrane review concluded that probiotics are not an effective
treatment for eczema in children and that probiotic treatment carries a small risk of adverse
events.105
Chinese Herbal Medications
Several placebo controlled clinical trials have suggested that patients with severe AD
may benefit from treatment with traditional Chinese herbal therapy (see Chapter 241). They
had significantly reduced skin disease and decreased pruritus. However, the beneficial
response of Chinese herbal therapy is often temporary, and effectiveness may wear off despite
continued treatment. The possibility of hepatic toxicity, cardiac side effects, or idiosyncratic
reactions remains a concern. The specific ingredients of the herbs also remain to be
elucidated and some preparations have been found to be contaminated with corticosteroids.
At present, Chinese herbal therapy for AD is considered investigational.
Oral Vitamin D
A pilot randomized, doubleblind placebo controlled study looked at the benefit of oral
vitamin D supplementation in children with AD from February to March in Boston. 106 Eleven
pediatric patients primarily with mild AD were treated with either vitamin D (1,000 IU
ergocalciferol) or placebo once daily for a month. IGA score improved in four of six subjects
in the vitamin D group (80%), as compared to one of five subjects in the placebo group (p =
0.04). In addition, there was a greater reduction in EASI score in the vitamin D, as compared
to the placebo group, although the difference was not statistically significant. In addition, in a
controlled study, 14 healthy subjects and 14 subjects with AD were supplemented with 4,000
IU per day of oral vitamin D3 (cholecalciferol) for 3 weeks. 107 Expression of the AMP
cathelicidin was significantly increased in the skin biopsies of AD lesions, as compared to
those in healthy skin or uninvolved AD skin, suggesting a role for oral vitamin D in
improving innate immune responses in AD patients.108
EDUCATION AS INTERVENTION
Intensive