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  • Healthcare Professionals Guide to Biliary Obstruction Medication

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    otakmesum
    52 vizualizări4 pagini
    This document provides information on medications used to treat biliary obstruction. It discusses bile acid-binding resins and ursodeoxycholic acid for treating cholelithiasis when surgery is not an option. Ursodiol is mentioned as a medication that suppresses cholesterol production and absorption to dissolve gallstones. Naloxone is discussed as a potential treatment for pruritus associated with cholestasis by blocking opioid receptors. Rifampin is presented as an antibiotic that may help minimize pruritus by reducing bile salt production. Cholestyramine and colestipol are bile acid-binding resins that prevent reabsorption of bile salts from the intestine.

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    Biliary Obstruction Medication_ Gallstone Solubilizing Agents, Narcotic Antagonists, Antibiotics, Bile Acid–Binding Resins

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    This document provides information on medications used to treat biliary obstruction. It discusses bile acid-binding resins and ursodeoxycholic acid for treating cholelithiasis when surgery is not an option. Ursodiol is mentioned as a medication that suppresses cholesterol production and absorption to dissolve gallstones. Naloxone is discussed as a potential treatment for pruritus associated with cholestasis by blocking opioid receptors. Rifampin is presented as an antibiotic that may help minimize pruritus by reducing bile salt production. Cholestyramine and colestipol are bile acid-binding resins that prevent reabsorption of bile salts from the intestine.

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    © All Rights Reserved
    Descărcați ca PDF, TXT sau citiți online pe Scribd
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    52 vizualizări4 pagini

    Healthcare Professionals Guide to Biliary Obstruction Medication

    Încărcat de

    otakmesum
    This document provides information on medications used to treat biliary obstruction. It discusses bile acid-binding resins and ursodeoxycholic acid for treating cholelithiasis when surgery is not an option. Ursodiol is mentioned as a medication that suppresses cholesterol production and absorption to dissolve gallstones. Naloxone is discussed as a potential treatment for pruritus associated with cholestasis by blocking opioid receptors. Rifampin is presented as an antibiotic that may help minimize pruritus by reducing bile salt production. Cholestyramine and colestipol are bile acid-binding resins that prevent reabsorption of bile salts from the intestine.

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    © All Rights Reserved
    Descărcați ca PDF, TXT sau citiți online pe Scribd
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    din 4

    Thissiteisintendedforhealthcareprofessionals

    BiliaryObstructionMedication
    Updated:Nov27,2016
    Author:JenniferLynnBonheur,MDChiefEditor:VinayKumarKapoor,MBBS,MS,FRCS,FAMS
    more...

    MEDICATION

    MedicationSummary
    Bileacidbindingresinsandursodeoxycholicacidareusedtotreatcholelithiasiswhensurgeryis
    refusedorisinappropriate.Normalgallbladderfunctionmustbeestablishedbyoralcholecystography
    findingspriortotheinitiationofdrugtherapy.

    Gallstonesolubilizingagents
    ClassSummary
    Ursodeoxycholicacid(ursodiol)isanaturallyoccurringbileacidpresentinsmallquantitiesinhuman
    bile.Suppressesliversynthesisandsecretionofcholesterol.Inhibitsintestinalcholesterolabsorption.

    Ursodiol(Actigall)
    Viewfulldruginformation
    Usedtotreatbiliarystasisanddissolvegallstones.

    Narcoticantagonists
    ClassSummary
    Endogenousopioidsmayeffectpruriticdevelopmentassociatedwithcholestasis.Treatmentwith
    narcoticantagonistsmayattenuatepruritus.

    Naloxone(Narcan)
    Viewfulldruginformation
    Preventsorreversesopioideffects(eg,hypotension,respiratorydepression,sedation,pruritus),
    possiblybydisplacingopiatesfromtheirreceptors.

    Antibiotics
    ClassSummary

    Rifampin,inparticular,hasbeensuggestedasatreatmentforcholestasisincertainpatients.By
    reducingintestinalflora,itslowsconversionofprimarytomoretoxicsecondarybilesalts.Hasalso
    beenshowntodecreaseserumlevelsofbilirubinandALP,perhapsinpartcontributingtoits
    effectivenessinminimizingassociatedpruritus.

    Rifampin(Rifadin,RifadinIV,Rimactane)
    Viewfulldruginformation
    InhibitsDNAdependentbacterialbybindingtothebetasubunitofDNAdependentRNApolymerase,
    blockingRNAtranscription.

    Bileacidbindingresins
    ClassSummary
    Inhibitenterohepaticreuptakeofintestinalbilesalts.

    Cholestyramine(Questran)
    Viewfulldruginformation
    Actsasacholesterolloweringagent.Formsanonabsorbablecomplexwithbileacidsintheintestine,
    whichinhibitsenterohepaticreuptakeofintestinalbilesalts.

    Colestipol(Colestid)
    Viewfulldruginformation
    Bindsbileacidsintheintestine,facilitatespartialremovalofbileacidsfromenterohepaticcirculation,
    andpreventstheirreabsorption.
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