Manongsong, Joseph A.

MLS 3G
Name of the Cell

Description

Cause or Mechanism

Mistaken for/effect on WBC

differential count

Megakaryocyte
fragement

2-4 um diameter, contains granules, complex

internal structure and open canalicular system

Repeated mitosis of
megakaryocytes without
cytokines.

Leukocytes ( Falsely Increase

WBCs)

Basket cells

Ruptured leukocyte that has a network

appearance

Partial breakdown of the

immature and fragile
leukocytes

Lymphocytes(Falsely
decreased Lymphocytes)

fragmented and degenerated WBC in a peripheral

blood smear,with a bare nucleus
partially surrounded by a coarse network of splayed, red-purple
nucleoplasm

NRBCs

Have a size and a nucleus similar to that of

lymphocytes

Hypoxia stress, hemolysis,

acute infection, immature
infants

Lymphoytes ( Falsely increase

Lymphocytes)

Smudge cells

Ruptured leukocytes,

remnants of cells that lack any

identifiable cytoplasmic membrane or nuclear
structure.

Lymphocytes (Falsely
Increased Lymphocytes)

Phagocytic cells

Respond to invading bacteria, regulate the inflammatory

response, defend against parasites and play a role in
allergic reactions.

Abnormally rupture of fragile

lymphocytes due to disorders
like CLL and other
lymphoproliferative disorders.
Phagocytosis of pathogens and
other foreign materials.

Endothelial cells

Line blood vessels from the aorta to microvessels,

and form a selective blood-tissue barrier. Inhibit
coagulation of the blood

Angiogenesis, vasculogenesis,
vasoregulation, coagulation &
fibrinolysis, but also play roles
in cardiovascular disease,
metastasis & other disorders.

Inclusion body or Parasite,

Carcinoma cells
Basophils (Falsely increased
Basophils)

Abnormal WBC ( False count

on Abnormal cells)

Manongsong, Joseph A.
MLS 3G
Necrotic cells

Lacks the features of apoptosis and

autophagy, cell swells, cellular and
nuclear lysis causes inflammation.

Factors external to the cell or tissue,

such as infection, toxins, or trauma
which result in the unregulated
digestion of cell components. The
interferon-beta triggers cells to
undergo necrosis

Broken cells

Contracted cells

Radial
segmentation
Vacuolation

Pseudophagocyt
osis

formation of vacuoles within or

adjacent to cells, and, in
dermatopathology, often refers to the
basal cell-basement membrane zone
area

lumen formation in small vessels by

coalescence of intracellular vacuoles, a
view that was extended to extracellular
lumen formation by exocytosis of
vacuoles.

Basophil, Lymphocytes, (Falsely

Increased Basophils and
Lymphocytes)

Manongsong, Joseph A.
MLS 3G

References:
http://www.bloodjournal.org/content/122/26/4163?sso-checked=true
https://www.google.com.ph/search?
q=megakaryocyte+fragments+peripheral+blood&biw=1242&bih=602&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiryZjx9oLQAhVFGpQKH
b__AgkQ_AUIBigB&dpr=1.1#tbm=isch&q=megakaryocyte+fragments+mechanism&imgrc=0rQkk1lsjgAgSM%3A
http://www.free-ed.net/sweethaven/MedTech/Hematology/lessonMain.asp?iNum=0411
http://www.sysmex-europe.com/academy/knowledge-centre/sysmex-parameters/nucleated-red-blood-cells-nrbc.html
https://www.labce.com/spg48905_smudge_cells.aspx

http://medical-dictionary.thefreedictionary.com/basket+cell
https://www.reference.com Science Biology Cells
https://www.cellapplications.com/endothelial-cells