Intensive Care Med

DOI 10.1007/s00134-016-4307-6

MY PAPER 20 YEARS LATER

Therapeutic management ofperitonitis:

a comprehensive guide forintensivists
P.Montravers1*, S.Blot2,10, G.Dimopoulos3, C.Eckmann4, P.Eggimann5, X.Guirao6, J.A.Paiva7,11, G.Sganga8
andJ.DeWaele9
2016 Springer-Verlag Berlin Heidelberg and ESICM

Abstract
Purpose: The management of peritonitis in critically ill patients is becoming increasingly complex due to their
changing characteristics and the growing prevalence of multidrug-resistant (MDR) bacteria.
Methods: A multidisciplinary panel summarizes the latest advances in the therapeutic management of these critically ill patients.
Results: Appendicitis, cholecystitis and bowel perforation represent the majority of all community-acquired infections,
while most cases of healthcare-associated infections occur following suture leaks and/or bowel perforation. The microorganisms involved include a spectrum of Gram-positive and Gram-negative bacteria, as well as anaerobes and fungi.
Healthcare-associated infections are associated with an increased likelihood of MDR pathogens. The key elements
for success are early and optimal source control and adequate surgery and appropriate antibiotic therapy. Drainage,
debridement, abdominal cleansing, irrigation, and control of the source of contamination are the major steps to ensure
source control. In life-threatening situations, a "damage control" approach is the safest way to gain time and achieve
stability. The initial empirical antiinfective therapy should be prescribed rapidly and must target all of the micro-organisms likely to be involved, including MDR bacteria and fungi, on the basis of the suspected risk factors. Dosage adjustment needs to be based on pharmacokinetic parameters. Supportive care includes pain management, optimization of
ventilation, haemodynamic and fluid monitoring, improvement of renal function, nutrition and anticoagulation.
Conclusions: The majority of patients with peritonitis develop complications, including worsening of pre-existing
organ dysfunction, surgical complications and healthcare-associated infections. The probability of postoperative complications must be taken into account in the decision-making process prior to surgery.
Keywords: Peritonitis, Source control, Multidrug-resistant bacteria, Fungal infection, Postoperative complications,
Intra-abdominal hypertension
Introduction
Despite the considerable improvement in perioperative care and empirical antibiotic therapy over recent
*Correspondence: philippe.montravers@aphp.fr
1
APHP, CHU BichatClaude Bernard, Dpartement dAnesthsie
Ranimation, Universit Denis Diderot, PRESS Sorbonne Cit, Paris, France
Full author information is available at the end of the article
Take-home message: Critically ill patients with peritonitis require an
early combined operative and medical approach. The key elements
for success are appropriate anti-infective therapy (in terms of the
most appropriate drug, at an adequate dosage with satisfactory tissue
penetration to target the microorganisms concerned) and early and
optimal source control and adequate surgery, comprising a damage
control approach in life-threatening situations.

decades, community-acquired and healthcare-associated

peritonitis remain a leading cause of death, morbidity
and resource utilization in ICU patients. Their management is becoming increasingly complex because of their
changing characteristics, ageing of the population, higher
rates of comorbid conditions and the growing prevalence
of multidrug-resistant (MDR) bacteria. Several medical
specialities are involved to ensure a combined approach
to timely surgical source control and adequate anti-infective treatment. In this review, a multidisciplinary panel
summarizes the latest advances in the therapeutic management of these critically ill patients.

Epidemiology ofperitonitis inthe ICU

Peritonitis is the second leading cause of ICU admission
after complicated pneumonia, accounting for 5.810 %
of all patients [1, 2] and almost 20% of infected patients
[2]. Appendicitis, cholecystitis and bowel perforation (including colon, small bowel and gastroduodenal)
represent more than 80 % of all community-acquired
infections [35]. Most cases of healthcare-associated
infections occur following suture leaks and/or colorectal, gastroduodenal and small bowel perforation [3,
4]. Despite technical improvements, these proportions
have remained stable over recent decades. Interestingly,
recent studies have reported increasing rates (about 50%
of patients) of healthcare-associated peritonitis, mainly
related to postoperative infection [6].
Supportive andperioperative care
Supportive care of vital organs is essential in patients
with peritonitis whenever severe sepsis is suspected,
starting before the surgical procedure and continued for
as long as necessary postoperatively [710]. Supportive care includes pain management, sedation, optimization of ventilation, haemodynamic and fluid monitoring,
improvement of renal function, nutrition and anticoagulation. Patients can be stratified on the basis of risk
factors, comprising not only severity of illness (assessed
by APACHEII, SOFA or Mannheim scores) [9] but also
individual patient-related factors such as age and comorbidities (assessed by ASA or Charlson scores) in order to
tailor perioperative monitoring and management, and to
assess prognosis [2, 4, 6, 11].
Pain management depends on the extent of tissue damage. Multimodal analgesia is recommended to decrease
the adverse effects related to the use of a single agent
administered at high doses, and should be given according to adequacy of pain relief, regularly assessed by an
appropriate scale [12]. The drugs most commonly used
include non-opioid analgesics alone or combined with
opioids at doses determined by titration. Sedation is
another important issue, especially in elderly patients,
in whom close monitoring and selection of short-acting
agents could shorten the time to extubation [13].
Acute respiratory failure is frequently observed during
the postoperative care, mainly because of worsening of
the underlying disease, atelectasis, pneumonia or acute
respiratory distress syndrome [2, 4, 14]. The optimal
volume, pressure level and positive expiratory pressure
adjustments remain controversial in mechanically ventilated patients. Non-invasive positive pressure ventilation
has been proposed as an alternative option in the less
severe cases [15].
Haemodynamic monitoring and fluid management are
also challenging issues. About 10 % of all patients with

diffuse peritonitis develop septic shock, associated with

a significantly higher mortality than that observed in
haemodynamically stable patients [2, 16, 17]. The need
for fluid loading is mainly assessed by cardiac output and
oxygen delivery measurements using various devices,
none of which have been shown to be superior to the
others. The use of dynamic parameters (e.g. variations of
stroke volume or pulse pressure) and continuous measurements are sensitive methods to guide fluid therapy
and titration of vasoactive agents. Crystalloids are recommended for initial fluid resuscitation, but when large
volumes of fluid are administered, interstitial overload
and hyperchloraemic acidosis limit their prescription,
leading to the use of colloids as one of the only available
alternatives [18].
Acute kidney injury (AKI) is a common complication
resulting from functional, metabolic or haemodynamic
disorders leading to acute tubular necrosis [2, 4, 14].
Reversible causes require special attention and supportive therapies (e.g. fluids, vasoactive agents, interruption of nephrotoxic drugs) [19]. Subclinical AKI is a
clearly recognized early stage of renal failure, at which
no elevation of serum creatinine and/or decreased urinary output can be confirmed by available biomarkers
[19]. There is no evidence to support the superiority of
continuous renal replacement therapy over intermittent
haemodialysis apart from easier management of fluid
balance [9].
Nutrition support plays a crucial role by supplying
energy and preserving body proteins, but this practice
has not been extensively investigated. Enteral or parenteral nutrition can usually be implemented during the
first 48 h following ICU admission, once the patients
condition has been stabilized [20]. Enteral feeding can be
administered via various routes including placement of a
feeding tube into the bowel remnant or in the jejunum
below the anastomotic leak. Most studies recommend a
protein intake ranging between 1.2 and 3.0 g/kg/day to
improve nitrogen balance [21]. This broad range reflects
the insufficient level of available evidence as well as the
difficulty of assessing the efficacy of protein intake. Many
issues remain unresolved in ICU patients with peritonitis regarding the appropriate timing of nutrition support,
enteral versus parenteral routes, the need for micronutrients, and the use of biomarkers and scoring systems to
identify patients at risk [20].
Deep vein thrombosis prophylaxis is recommended
in septic postoperative patients [9]. Subcutaneous low
molecular weight heparin (LMWH) is the method of
choice, while unfractionated heparin or LMWH with a
low degree of renal metabolism is preferred in the presence of renal failure. The therapeutic effect must be
monitored and doses can be adjusted according to the

Table1 Step bystep approach forthe treatment ofpatients withperitonitis

Phase

Goal

Manoeuvre

Initial

Severity assessment

Applying score of sepsis

Sepsis containment

Adequate and early empirical antibiotic therapy

Preparing for surgery

Adequate haemodynamic monitoring and fluid management

SSI prevention (incisional)

Wound protection

Microbiological diagnosis

Peritoneal cultures

Decrease peritoneal inoculum

Initial abdominal cleansing

Peritonitis assessment

Looking for the source of the infection

Source control

Simple closure

Source control
1st

2nd

Resectionintestinal anastomosis
Stoma
Decrease peritoneal inoculum

Final abdominal cleansing

3rd

Abdominal closure

Primary or deferred abdominal wall closure

Final

Treatment of residual inoculum and perioperative resuscitation

Adequate empirical antibiotic therapy

Endorsement to Survival Sepsis Campaign principles

SSI surgical site infection

response. When pharmacological therapy is contraindicated, mechanical methods are used.

Importance ofsource control

The term source control was first used in the early twentieth century and has been the subject of renewed interest
with the Surviving Sepsis Campaign Guidelines [9]. Foci
of infection readily amenable to source control measures
are mainly intra-abdominal sites. Drainage of abscesses,
debridement of infected necrotic tissues, removal of
potentially infected devices, abdominal compartment
cleansing, irrigation and definitive control of a source of
ongoing microbial contamination are the usual consecutive steps to ensure source control (Table1).
Few guidelines have been published for the surgical
management of peritonitis, as most strategies depend
on intraoperative findings, severity of disease, time
to source control and underlying diseases. The surgical dilemma usually concerns conservative vs operative
management, but also laparoscopic vs open surgery.
Minimally invasive or conservative approaches including percutaneous and endoscopic treatments have been
advocated by many authors for the management of
uncomplicated cases (diverticulitis, appendicitis, cholecystitis, etc.). Percutaneous drainage may be especially
relevant in complex cases such as hostile abdomen
provided the collections are technically drainable. In
critically ill patients requiring individualized management, especially when surgery is delayed, the surgeon
must perform damage control surgery, a concept
derived from trauma and applied to sepsis, which may
include open abdomen management, exteriorization and

colostomies, drainage, stapled resections without anastomosis, etc.

The technical aspects of timely and adequate surgical
management are critical, although the quality of source
control is difficult to evaluate [22] [electronic supplementary material (ESM) TableS1]. Without adequate surgical
source control, mortality rates can reach almost 100 %.
Early management is the second key to successful treatment [23]. Short-term outcomes appear to be essentially
related to the time factor.
Surgery provides an ideal opportunity for microbiological samples, as interpretation of samples collected from
suction drains and drainage systems is difficult or misleading. Routine intraoperative cultures remain debated
in mild-to-moderate community-acquired peritonitis and
in patients with a low suspicion of multidrug resistance.
In these cases, intraoperative cultures may be useful as
a baseline measure to monitor subsequent emergence of
epidemiologically important microorganisms [8, 10]. On
the contrary, it is usually recommended to obtain peritoneal fluid cultures in the most severe patients, even with
community-acquired peritonitis, in the case of previous
antibiotic therapy and in all healthcare-associated infections [5, 7, 8, 10].
Source control can be completed by a single operation, but many studies have reported that additional
procedures are required to remove persistent clusters
of infection. Systematic reoperations are no longer recommended in routine practice [7, 8, 10]. Progression or
failure of resolution of organ dysfunction is highly suggestive of persistence of disease and requires re-evaluation [8, 10].

Organspecific management
The concepts of adequate, inadequate and difficult types
of source control depend on the specific organ constituting the source of infection (Table 2). Fresh, small
perforated duodenal ulcer is best treated by laparoscopyassisted intracorporeal suture closure. In protracted peritonitis secondary to large, chronic and/or friable peptic
ulcers in an unstable patient, quick and safe open repair
via a conservative midline incision may suffice [24, 25].
As a result of the serious consequences of protracted
infection after bariatric surgery, considerable attention
has been recently paid to early detection and treatment
(either laparoscopic or endoscopic) of any leaks [26].
Peritonitis due to small bowel perforation is not
uncommon. In faecal peritonitis or when a damage control open-abdomen technique has been used, primary
anastomosis should be delayed until improvement of the
peritoneal compartment and the patients general condition. In such circumstances, the principles of damage
control surgery with temporary ostomy should prevail
[27]. The most common abdominal source after complicated appendicitis is probably colorectal [6]. Complicated
diverticulitis is the leading cause of colonic peritonitis.
Radical source control (Hartmanns procedure) from
perforated, laparoscopic washout and intra-abdominal
drainage has raised much attention as a low-grade, easy,
straightforward approach to source control [28]. Recent
evidence is clearly against less invasive procedures in
patients with complicated diverticulitis and diffuse peritonitis [29, 30]. This policy should also be applied to leaks
following colorectal surgery with temporary ostomy.
Management ofpostoperative complications
Surgical operations can cause significant morbidity and
mortality as a result of postoperative complications [16,
17]. Peritonitis may decompensate and worsen pre-existing organ dysfunction, resulting in increased mortality.
More than 70% of these patients develop complications
[16]. The probability of postoperative complications
must be taken into account in the decision-making process prior to surgery. Several scoring systems have been
proposed to predict complications, but with disappointing results [2, 16, 17, 31]. Table 3 presents an overview
of surgical and non-surgical complications in peritonitis
and their frequency.
An association is very commonly observed between
the characteristics of the initial surgical procedure and
postoperative surgical complications [16, 17, 32]. Surgical site infections (SSI), among the most common surgical complications, are associated with the extent of stool
contamination of the wound, surgical techniques and
the patients comorbidities [17]. Superficial and deep
SSI must be treated by incision and drainage. Organ/

space SSI require more intensive intervention (CTguided drainage, relaparotomy), as SSI are usually a sign
of an occult intra-abdominal problem such as anastomotic leak. Rectal stump insufficiency, dehiscence of the
abdominal fascia and colostomy are less common complications of emergency surgery and can be repaired by
limited invasive procedures.
Surgical complications usually require reoperation.
The extent of source control interventions for complications varies substantially: from incision and drainage of a
superficial surgical site infection to CT-guided drainage
of an intra-abdominal abscess and relaparotomy comprising various types of surgical interventions. The surgical
procedure may range from simple lavage to resection of
parts of the small or large bowel and may require temporary or permanent ileostomy or colostomy, possibly leaving the abdomen open.
The role of an open abdomen technique in the management of severe peritonitis remains controversial [33]. The
abdominal contents are exposed and bowel loops are protected by placement of the omentum majus or a specific
artificial layer and a vacuum sponge. Temporary coverage
usually comprises negative pressure devices (maximum
negative pressure of minus 75mmHg) to prevent abdominal compartment syndrome (ACS) and allows a re-look
every 2448h.
Tertiary peritonitis is persistent intra-abdominal infection without a surgically treatable focus, following previous surgery and source control [14, 31]. This form of
nosocomial peritonitis is caused by a specific spectrum of
MDR microorganisms, including enterococci, Enterobacteriaceae, pseudomonas and candida. Tertiary peritonitis does not require surgery, but only a non-contributive
reoperation can confirm the diagnosis.
A high rate of healthcare-associated infections is
observed in patients with peritonitis. Up to 30 % of
patients with abdominal sepsis develop pneumonia,
which can be associated with unplanned re-intubation,
ARDS and significant mortality rates [2]. Urinary tract
infections are documented in 28% of patients with diffuse peritonitis [2, 16].

Intraabdominal hypertension
Patients with peritonitis, especially in the presence of
organ failure, present many of the known risk factors
for intra-abdominal hypertension (IAH) [34]. The two
main determinants of increased intra-abdominal pressure (IAP) may contribute to the development of IAH
and ultimately ACS: intra-abdominal volume may be
increased as a result of ischaemia/reperfusion-related
oedema, postoperative fluid accumulation and ileus,
whereas abdominal wall compliance is decreased as a
result of surgical trauma, oedema and postoperative pain.

LAP: simple closure for fresh, small and non-friable

ulcer

OPEN: simple closure

Perforated duodenal ulcer:

Accepted or adequate

Quality ofsource control

Perforated appendix with diffuse peritonitis in a patient

with previous abdominal surgery and peritoneal adhesions

Infected pancreatic necrosis

Postoperative leak of duodenal stump

Difficult/controversial management

LAP washout for perforated Hinchey III diverticulitis

OPEN resection and primary anastomosis for faecaloid
peritonitis or in septic shock

OPEN: resection and primary anastomosis in stable

patients

Mesenteric ischaemia

Resection and primary anastomosis in patients with sep- Mesenteric ischaemia

tic shock or longstanding perforation with oedematous intestine

Prolonged LAP, non-converted appendicectomy

with friable necrotic appendix, diffuse peritonitis or
patients in septic shock

Perforated appendicitis:

LAP complete cholecystectomy in patients with

shock- and/or sepsis-related intraoperative coagulopathy

Perforated cholecystitis:

LAP: simple closure for protracted, large and friable

ulcer

Perforated duodenal ulcer:

Risky or inadequate

OPEN: Hartmann procedure

Temporary stoma for neglected laceration or oedematous intestine

Resection and primary anastomosis in stable patients

LAP appendectomy in obese patients

OPEN appendectomy

Perforated appendicitis:

OPEN surgical procedure performed via laparotomy, LAP laparoscopy

Colorectal

Small bowel

Appendix

OPEN partial cholecystectomy in patients with shockand/or sepsis-related intraoperative coagulopathy

OPEN or LAP cholecystectomy in stable patients

Hepatobiliopancreatic Perforated cholecystitis:

Gastroduodenal

Infection source

Table2 Quality ofperitonitis control derived fromdifferent organ-specific infection sources

Table3 Surgical andnon-surgical infectious complications inpatients withdiffuse secondary peritonitis

Complications
Severe bleeding

Clinical setting

Frequency Treatment

Haemodynamic instability

++

Reoperation, bleeding control

+++

Incision and drainage

Significant blood loss

SSI (superficial/deep)

Putrid wound secretion

SSI (organ space)

Faecal wound secretion

Dehiscence of abdominal fascia Fascia necrosis/abdominal compartment syndrome

Intra-abdominal abscess

Evidence on imaging (CT, US)

Anastomotic leakage

Evidence on imaging, drain fluid

Rectal stump insufficiency

Putrid anal secretion following Hartmann procedure

Rupture of stoma
Tertiary peritonitis

++

Relaparotomy, source control, open wound therapy

Relaparotomy, mesh implant/open abdomen/

negative pressure therapy

+/++

CT-guided drainage

+/++

Relaparotomy, source control/drainage

(+)

Transrectal drainage, negative pressure therapy

Stool in soft tissue around stoma

(+)

Reoperation, reinsertion of stoma

Persistent abdominal infection despite adequate

source control

Antibiotic and/or antifungal treatment

Septic shock

Haemodynamic instability

++

Haemodynamic stabilization, anti-infective treatment

Pneumonia

Respiratory insufficiency, unplanned (re)intubation

+++

Antibiotic therapy

Urinary tract infection (UTI)

Lower UTI or pyelonephritis

Antibiotic therapy, source control

Source control sufficient?

Diagnostic investigations for source of infection

(+)very rare (<1%),+rare (15%), ++common (510%), +++ very common (>10%)

All these factors, particularly fluid resuscitation and surgery, may play a role in the development of IAH.
IAH has been found to impair gut perfusion [35], causing structural changes in the gut [36] and bacterial translocation [37]. In animal studies, IAH has been found to
delay healing of colonic anastomoses (ESM Fig. S1). In
summary, IAH has multiple effects that extend beyond
the abdominal cavity.
IAH should be anticipated and IAP monitoring is
advised in patients with severe sepsis or septic shock.
When IAH develops, fluid administration should be considered carefully, as parameters such as urinary output
are unreliable to assess organ perfusion.
Adequate analgesia and removal of constrictive bandages can help to increase abdominal wall compliance.
Postoperative bleeding or fluid accumulation may accentuate IAH and ultrasound may be helpful to identify
these lesions and guide drainage. Postoperative ileus and
gut distension are other common contributors to IAH,
for which nasogastric drainage and suctioning may be
required. If these interventions are unsuccessful and ACS
ensues, abdominal decompression with open abdomen
treatment may be necessary.
In some situations, an intraoperative decision to perform temporary abdominal closure may be preferable.
Consequently, postoperative IAP monitoring is mandatory to guide subsequent abdominal closure.

Microbiological considerations
The variety of pathogens isolated in the context of peritonitis represents a limited part of gastrointestinal flora.
Culture results cannot discriminate contaminating bacteria from true pathogens. The microorganisms involved
include a spectrum of Gram-positive and Gram-negative
bacteria, as well as anaerobes and fungi, with a highly
variable mix depending on several factors including the
site of perforation (ESM Fig.S2) [3]. Gram-negative and
anaerobic bacteria are increasingly involved, ranging
from about 1520 % in gastroduodenal perforation to
about 80 % in appendicitis-related peritonitis. The proportion of cultures isolating Gram-positive bacteria does
not vary substantially according to the primary source of
perforation and remains about 3040%.
Healthcare-associated infections are associated with
an increased likelihood of pathogens with reduced susceptibility to standard (first-line) antibiotic regimens.
The term MDR therefore covers methicillin-resistant
Staphylococcus aureus, coagulase-negative staphylococci,
vancomycin-resistant enterococci, extended-spectrum
beta-lactamase (ESBL)-producing Enterobacteriaceae,
quinolone-resistant Escherichia coli, and non-fermenting
Gram-negative bacteria such as Pseudomonas aeruginosa
and Acinetobacter baumannii. Factors predisposing to
MDR bacteria include corticosteroid use, recent exposure to broad-spectrum antibiotics (less than 3months),

underlying conditions such as liver disease, pulmonary

disease, organ transplantation and a length of hospitalizationgreater than 5days [3840]. However, geographical and local (in-hospital) ecology also plays a key role in
this setting, hence the critical importance of local antibiotic susceptibility testing for both bacteria and fungi.
For example, patients with a recent history of travelling
in regions known to have particular resistance problems
deserve special attention (Table4).

Antibiotic therapy inperitonitis: 10 years

ofconsensus
Over the last decade, several guidelines have been published for antibiotic therapy in community-acquired and
healthcare-associated infections (Table 5) [5, 7, 8, 10,
4143]. The most appropriate initial empirical therapy
should be prescribed early (ideally preoperatively for sepsis containment and SSI prevention) and must target all
of the microorganisms likely to be involved, including
MDR bacteria, on the basis of the suspected risk factors.
Broad-spectrum treatments are recommended in critically ill patients, but targets are different in communityacquired and healthcare-associated infections. Coverage
of enterococci and MDR bacteria is not recommended
in patients with community-acquired peritonitis, but
should be applied in patients with septic shock who have
received prolonged cephalosporin therapy, in immunosuppressed patients and in patients with recurrent intraabdominal infections. The community and/or hospital
ecology needs to be considered when starting antimicrobial therapy: the recent spread of carbapenemases in
Enterobacteriaceae has raised a serious concern worldwide, similar to that raised by the pattern of spread of
ESBL [7, 8, 10, 4143].
Dosage adjustment needs to be based on pharmacokinetic parameters reported in patients with severe sepsis
as few data are available on peritoneal diffusion of antibiotics. De-escalation has not been shown to be detrimental in patients with peritonitis. Antibacterial therapy
is usually administered for 57 days [44] after adequate
source control. Antibiotics can be discontinued once
clinical and laboratory signs of infection have resolved.
The use of procalcitonin to determine the duration of
antibiotic therapy has not been assessed in peritonitis
and remains debated [10]. Only a few guidelines have
proposed specific regimens in patients with documented
beta-lactam allergy.
Peritonitis inobese patients
While the prevalence of community-acquired peritonitis
in obese patients appears to be similar to that observed
in the overall population, a growing number of perioperative complications and postoperative or short-term

adverse outcomes following bariatric surgery have been

reported over recent years. The surgical complications
most commonly requiring ICU admission include fistulas
and anastomosis leaks [45].
Only limited pharmacological data are available in
morbidly obese patients and the appropriate doses of
anti-infective agents remain controversial. As in other
septic patients, pharmacokinetic variables may be altered
during peritonitis in obese patients (ESM TableS2). Volume of distribution (Vd) usually increases as a result of
capillary leak syndrome, increased cardiac output or
fluid resuscitation. Antibiotic clearance (Ac) may also
either increase because of increased glomerular filtration or decrease because of organ failure [46]. However,
obesity may further increase Vd as a result of increased
lean body mass and increased adipose tissue. Obesity
may also increase Ac as a result of increased kidney mass
and global filtration, or decrease Ac as a result of chronic
hypertensive or diabetic nephropathy. Hydrophilic and
lipophilic antibiotics differ in terms of their pharmacokinetics and pharmacokinetic parameters are modified by obesity [47]. Since 30% of adipose tissue is water,
an empirical, but never validated, approach is to use the
Devine formula to calculate ideal body weight (IBW), to
which is added a dosing weight correction factor of 0.4
times the difference between total body weight (TBW)
and IBW (IBW + 0.4 [TBW IBW]) to estimate
adjusted body weight, on which the dosage of hydrophilic
antibiotics should be based [47].
Standard drug regimens can therefore potentially result
in a higher rate of inadequate serum drug concentrations
in critically ill obese patients, which may be responsible
for increased treatment failure or emergence of bacterial
resistance. A study in critically ill obese patients receiving cefepime, piperacillin/tazobactam or meropenem
at standard dosing regimens demonstrated considerable variability of antibiotic concentrations, resulting in
insufficient plasma concentrations in 32 % of patients
and overdosed concentrations in 25% [48], and 35% of
obese patients treated with meropenem had concentrations below therapeutic targets. In the same study, obese
patients on continuous renal replacement therapy were
more likely to have supratherapeutic and less likely to
have insufficient beta-lactam antibiotic concentrations
[48].
High doses of piperacillin/tazobactam, at least 4.5 g
intravenously every 6 h, are commonly used in obese
patients and longer infusion times may be required [49].
The upper limit of the normal dose range of cephalosporins is recommended in these patients [50]. The upper
limit of the normal dose range of carbapenems (68 g/
day meropenem, with extended infusions over approximately 34 h) is also recommended [51], while no dose

Septic shock, failure of early surgical source control, recent

antibiotic exposure (particularly prolonged cephalosporin
treatment), immunosuppression and prosthetic heart valves
Clinical relevance uncertain
None. Methicillin-susceptible S. aureus is covered by first-line
antibiotic regimen

Coagulase-negative staphylococci

Staphylococcus aureus

None. Non-extended-spectrum beta-lactamase (ESBL)-producing strains are covered by first-line antibiotic regimen

Healthcare-associated infection, especially with length of hospital stay>5days. Recent antibiotic exposure. Chronic underlying diseases leading to immunocompromised status (e.g. due
to corticosteroid use)
None. Covered by first-line antibiotic regimen
Immunodeficiency and prolonged antibiotic exposure. Tertiary
peritonitis following failure of source control, especially in
peritonitis originating from upper GI tract perforation

Enterobacteriaceae (Escherichia coli, Enterobacter spp., Klebsiella

spp., Serratia spp., Proteus spp., etc.)

Non-fermenting Gram-negative bacteria (Pseudomonas

aeruginosa, Acinetobacter baumannii, Stenotrophomonas
maltophilia, etc.)

Anaerobe bacteria (Bacteroides fragilis, Clostridium spp., etc.)

Candida spp.

Gram-negative bacteria

None. Covered by first-line antibiotic regimen

Enterococci

Predisposing clinical condition requiring coverage

beyondstandard first-line antimicrobial therapy

Streptococci

Gram-positive bacteria

Microorganism

Table4 Potential pathogens inperitonitis

Selection towards Candida non-albicans spp. with dose-dependent susceptibility to fluconazole in patients with prior fluconazole exposure

High rates of resistance to clindamycin and cefoxitin in certain

geographical areas. Resistance to metronidazole is rare

Multidrug resistance most likely in healthcare-associated infection

ESBL-producing strains likely in healthcare-associated infection

and should be considered in patients with a history of recent
travel in regions with high prevalence (Egypt, Thailand, India).
Fluoroquinolone-resistance of E. coli may be as high as 20% in
some geographical areas

Methicillin-resistance possible in healthcare-associated infection

Methicillin-resistance likely in healthcare-associated infection

Resistance likely in healthcare-associated infections, especially

when caused by E. faecium. Ampicillin resistance and associated production of beta-lactamases are a concern in some
geographical areas, as well as glycopeptide resistance

No clinically relevant resistance problem

Resistance considerations

Piperacillin/tazobactam
At risk of ESBL infection: imipenem or
meropenem
Biliary tract infections: piperacillin/tazobactam
Biliary tract infections and at risk of ESBL
infection: piperacillin+tigecycline
Piperacillin/tazobactam+gentamicin

Mild to moderate cases: monotherapy:

cefoxitin, amoxicillin/clavulanate,
ticarcillin/clavulanate, ertapenem,
moxifloxacin, tigecycline
Combination therapy: cefuroxime,
ceftriaxone, cefotaxime or ciprofloxacin+metronidazole

2009USA [8]

2010Canada [7]

2013International [5] Amoxicillin/clavulanate, ciprofloxacin+metronidazole

At risk of ESBL infection: ertapenem or
tigecycline
Biliary tract infections and at risk of ESBL
infection: tigecycline

2015France [10]

Amoxicillin/clavulanate+gentamicin
or cefotaxime/ceftriaxone+metronidazole
In case of -lactams allergy: levofloxacin+gentamicin+metronidazole, or
tigecycline

Monotherapy: cefoxitin, ertapenem,

Monotherapy: imipenem, meropenem,
moxifloxacin, tigecycline or ticarcillin/
doripenem or piperacillin/tazobactam
clavulanate
Combination therapy: cefepime,
Combination therapy: cefazolin, cefuroxceftazidime, ciprofloxacin, or levofloxaime, ceftriaxone, cefotaxime, ciprofloxacin+metronidazole
cin or levofloxacin+metronidazole
Piperacillin/tazobactam or
Imipenem or meropenemaminoglycoside
ceftazidime or cefepime or ciprofloxacin+metronidazole
tigecycline+ciprofloxacin

Amoxicillin/clavulanate, ceftriaxone or
cefotaxime+metronidazole, ertapenem
In case of -lactams allergy: gentamicin
or aztreonam+metronidazole, tigecycline
For suspected MDR Enterobacteriaceae
ertapenem or tigecycline

2009Spain [41]

Severe or at-risk cases

Piperacillin/tazobactam+amikacinvancomycin
Allergy to -lactams: ciprofloxacin or
aztreonam+amikacin+metronidazole+vancomycin
Or tigecycline+ciprofloxacin

Piperacillin+tigecycline
Imipenem or meropenem+teicoplanin

Severe cases or patients at risk of MDR bacteria Imipenem or meropenemamikacinvancomycin

Piperacillin/tazobactam or imipenem or meropenemaminoglycoside

Ceftazidime or cefepime or ciprofloxacin+metronidazole
Tigecycline+ciprofloxacin
MRSA or enterococcal infections: vancomycin or linezolid or daptomycin or tigecycline

Piperacillin/tazobactam or imipenem, meropenemaminoglycoside

Ceftazidime or cefepime+metronidazoleaminoglycoside
MRSA infection: vancomycin

Imipenem or meropenem+linezolid or
daptomycin or glycopeptide
Tigecycline+ceftazidime or amikacin

Piperacillin/tazobactam or carbapenems
Allergy to -lactams: fluoroquinolones or aztreonam+metronidazolevancomycin

Piperacillin/tazobactam or imipenem,
Piperacillin/tazobactam or imipenem,
meropenem or tigecycline (+antipseumeropenem or tigecycline
domonal drug in case of septic shock)
In case of -lactam allergy: tigecycline
In case of -lactam allergy: tigecycline

Amoxicillin/clavulanate, cefuroxime+metronidazole
Fluoroquinolones+metronidazole

Mild tomoderate cases

Mild tomoderate cases

Severe or at-risk cases

Healthcare-associated peritonitis

Community-acquired peritonitis

2006Belgium [42]

Expert groups

Table5 Empirical antibiotic regimens proposed inrecent guidelines forcommunity-acquired andhealthcare-associated infections

Severe or at-risk cases

Piperacillin/tazobactam
Tigecycline
Meropenem
Imipenem/cilastatin
Ceftolozane/tazobactam+metronidazole
MRSA/VRE infections: add linezolid (not necessary for tigecycline)

Mild tomoderate cases

Generalized infection:
piperacillin/tazobactam
Ertapenem
Moxifloxacin
Tigecycline

Severe or at-risk cases

Mild tomoderate cases

Localized infection: cefotaxime, cefuroxime, cefztriaxone, ciprofloxacin,

levofloxacin,+metronidazole
Amoxicillin/clavulanate
Ampicillin/sulbactam
2015Germany [43]

Healthcare-associated peritonitis
Community-acquired peritonitis
Expert groups

Table5 continued

adjustment appears to be required for ertapenem [52].

Optimal dosing of fluoroquinolones is more difficult to
determine, but dosage adjustment is probably not warranted, at least for levofloxacin and moxifloxacin [47].
A loading dose of colistin should be administered and
subsequent dosing should be calculated for IBW [47].
For aminoglycosides, a loading dose should be based
on adjusted or lean body weight and subsequent doses
should be based on serum drug levels [53]. No adjustment
is needed for tigecycline [54]. For vancomycin, the loading dose is 2530mg/kg of TBW in seriously ill patients
and the maintenance dose is 1520mg/kg of TBW every
812h, without exceeding 2g per dose for patients with
normal kidney function; serum trough concentrations of
1520mg/ml are recommended; dosesgreater than 1.5g
should be infused over at least 1.5h [55].

Role of Candida inperitonitis

Non-candidemic systemic candidiasis accounts for the
majority of cases of invasive candidiasis observed in
patients with peritonitis. Up to 80 % of these patients
are colonized, but only 530 % develop intra-abdominal candidiasis requiring antifungal treatment [5658].
Combined exposure to several risk factors such as broadspectrum antibiotics, parenteral nutrition and renal
replacement therapy for 710 days is required to transform colonization into local invasion and then documented invasive infection [58].
Non-candidemic invasive candidiasis is microbiologically difficult to prove. The definition of fungal peritonitis is restrictive, based on histological criteria and cannot
be used to guide initiation of antifungal therapy [59, 60].
Experts therefore recommend that early empirical treatment be based on risk-assessment strategies, such as
colonization index, Candida scores and predictive rules.
These strategies are based on combinations of several risk
factors, such as Candida colonization, previous use of
broad-spectrum antibiotics and previous abdominal surgery. Their positive predictive values (PPV) are used for
the early prediction of invasive candidiasis. The negative
predictive values (NPV) of these scores are much higher
than their PPV. This situation has resulted in two opposing strategies: clinicians concerned by the poorer prognosis of delayed treatment start antifungal therapy early,
even in low-risk patients (especially patients with perforated gastroduodenal ulcers), leading to major overuse
of antifungals; while other clinicians, more concerned by
the negative ecological impact and the costs of antifungal
agents, delay prescription with a risk of missing patients
requiring early treatment.
The colonization index may be used to identify patients
likely to benefit from early empirical antifungal therapy,
but this strategy is work-intensive, expensive and difficult

Fig.1 Suggested approach to guide antifungal therapy in patients with peritonitis, adapted from [67]

to implement [60]. The usefulness of the Candida score

to guide empirical antifungal therapy has not been tested
in prospective clinical trials [61]. Dupont etal. developed
peritonitis scores with relatively high PPV and NPV, but
their clinical value needs to be confirmed by large prospective clinical trials [62]. Other investigators have proposed predictive scores based on combinations of risk
factors, but their clinical usefulness has not been formally demonstrated.
Biomarkers may be useful for the diagnosis of invasive
candidiasis but have yet to be confirmed by large prospective clinical trials. Candida DNA and mannan antigen/anti-mannan antibodies are of limited value. The
European Society for Clinical Microbiology and Infectious Diseases (ESCMID) guidelines considered 1,3--dglucan a very useful biomarker to rule out infection [63].
Preliminary data suggest that 1,3--d-glucan can also be
detected early in the course of non-candidemic systemic
candidiasis, including peritonitis [64]. Preliminary results
suggest that Candida albicans germ tube antibody can
also be detected early in patients with peritonitis [65].
Early empirical and pre-emptive antifungal therapy has
been suggested to decrease mortality, but this remains

highly controversial [56]. No study has ever addressed

the issue of empirical antifungal therapy in a specific
population of patients with peritonitis. Evidence-based
guidelines for proven invasive candidiasis emphasize the
need for early treatment to improve outcome but do not
provide any practical measures to guide this treatment
[56, 66], leading to major overuse of antifungal agents,
contributing to a high financial burden, and promotion of
a shift towards species and strains that are less susceptible to antifungals.
A practical two-step approach based on the use of
biomarkers could be proposed to improve the selection of patients likely to benefit from empirical antifungal therapy, while avoiding overuse of antifungal agents
(Fig.1) [67]. The first step could rule out patients at low
risk of documented fungal infection. The second step
would limit empirical antifungal therapy to patients with
increased 1,3--d-glucan levels over 80 pg/ml, as proposed by some authors [64, 65]. Alternatively, clinicians
may decide to initiate antifungal therapy (with an echinocandin) in patients with septic shock and organ failures
in the context of complications after surgery for peritonitis [8, 10]. Antifungal therapy can be continued, with

possible de-escalation to fluconazole in patients with

resolving septic shock, provided sensitive candidas are
documented [8, 10, 66].

Conclusion
Critically ill patients with peritonitis require an early
combined operative and medical approach. The key elements for success are early and optimal source control
and adequate surgery and appropriate anti-infective
therapy (in terms of the most appropriate drug, at an
adequate dosage with satisfactory tissue penetration to
target the microorganisms concerned). In life-threatening situations, a damage control approach is the safest
way to gain time and achieve stability.
Electronic supplementary material
The online version of this article (doi:10.1007/s00134-016-4307-6) contains
supplementary material, which is available to authorized users.
Author details
1
APHP, CHU BichatClaude Bernard, Dpartement dAnesthsie Ranimation,
Universit Denis Diderot, PRESS Sorbonne Cit, Paris, France. 2Department
ofInternal Medicine, Ghent University, Ghent, Belgium. 3Department ofCritical Care, University Hospital Attikon, Medical School, University ofAthens, Athens, Greece. 4Department ofGeneral, Visceral andThoracic Surgery, Klinikum
Peine, Peine, Germany. 5Department ofIntensive Care Medicine andBurn
Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
6
Department ofEndocrine andHead andNeck Surgery, Corporaci Sanitaria
del Parc Tauli, University Hospital, Sabadell, Barcelona, Spain. 7Emergency
andIntensive Care Department, Centro Hospitalar S. Joo EPE, Porto, Portugal.
8
Department ofSurgery, Catholic University ofSacred Heart, Policlinico A
Gemelli, Rome, Italy. 9Department ofCritical Care Medicine, Ghent University
Hospital, Ghent, Belgium. 10Burns, Trauma andCritical Care Research Centre,
The University ofQueensland, Brisbane, Australia. 11Department ofMedicine,
Faculty ofMedicine, University ofPorto, Porto, Portugal.
Compliance with ethical standards
Conflicts of interest
On behalf of all authors, the corresponding author states that there is no
conflict of interest.
Received: 27 January 2016 Accepted: 4 March 2016

References
1. Barie PS, Hydo LJ, Eachempati SR (2004) Longitudinal outcomes of intraabdominal infection complicated by critical illness. Surg Infect 5:365373.
doi:10.1089/sur.2004.5.365
2. De Waele J, Lipman J, Sakr Y, Marshall JC, Vanhems P, Barrera Groba C,
Leone M, Vincent JL (2014) Abdominal infections in the intensive care
unit: characteristics, treatment and determinants of outcome. BMC Infect
Dis 14:420. doi:10.1186/1471-2334-14-420
3. De Ruiter J, Weel J, Manusama E, Kingma WP, van der Voort PH (2009) The
epidemiology of intra-abdominal flora in critically ill patients with secondary and tertiary abdominal sepsis. Infection 37:522527. doi:10.1007/
s15010-009-8249-6
4. Montravers P, Lepape A, Dubreuil L, Gauzit R, Pean Y, Benchimol D,
Dupont H (2009) Clinical and microbiological profiles of communityacquired and nosocomial intra-abdominal infections: results of the
French prospective, observational EBIIA study. J Antimicrob Chemother
63:785794. doi:10.1093/jac/dkp005

5. Sartelli M, Viale P, Catena F, Ansaloni L, Moore E, Malangoni M, Moore FA,

Velmahos G, Coimbra R, Ivatury R, Peitzman A, Koike K, Leppaniemi A, Biffl
W, Burlew CC, Balogh ZJ, Boffard K, Bendinelli C, Gupta S, Kluger Y, Agresta
F, Di Saverio S, Wani I, Escalona A, Ordonez C, Fraga GP, Junior GA, Bala
M, Cui Y, Marwah S, Sakakushev B, Kong V, Naidoo N, Ahmed A, Abbas A,
Guercioni G, Vettoretto N, Diaz-Nieto R, Gerych I, Trana C, Faro MP, Yuan
KC, Kok KY, Mefire AC, Lee JG, Hong SK, Ghnnam W, Siribumrungwong B,
Sato N, Murata K, Irahara T, Coccolini F, Segovia Lohse HA, Verni A, Shoko
T (2013) 2013 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg 8:3. doi:10.1186/1749-7922-8-3
6. Inui T, Haridas M, Claridge JA, Malangoni MA (2009) Mortality for intraabdominal infection is associated with intrinsic risk factors rather than the
source of infection. Surgery 146:654661. doi:10.1016/j.surg.2009.06.051
(discussion 661652)
7. Chow AW, Evans GA, Nathens AB, Ball CG, Hansen G, Harding GK, Kirkpatrick AW, Weiss K, Zhanel GG (2010) Canadian practice guidelines for surgical intra-abdominal infections. Can J Infect Dis Med Microbiolo 21:1137
8. Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ,
ONeill PJ, Chow AW, Dellinger EP, Eachempati SR, Gorbach S, Hilfiker M,
May AK, Nathens AB, Sawyer RG, Bartlett JG (2010) Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 50:133164. doi:10.1086/649554
9. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM,
Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally
ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman
CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno
R (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med
39:165228. doi:10.1007/s00134-012-2769-8
10. Montravers P, Dupont H, Leone M, Constantin JM, Mertes PM, Laterre
PF, Misset B, Bru JP, Gauzit R, Sotto A, Brigand C, Hamy A, Tuech JJ (2015)
Guidelines for management of intra-abdominal infections. Anaesth Crit
Care Pain Med 34:117130. doi:10.1016/j.accpm.2015.03.005
11. Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon
AC, Holloway PA, Chiche JD, Bion J, Stuber F, Garrard C, Hinds CJ (2014)
Patients with faecal peritonitis admitted to European intensive care units:
an epidemiological survey of the GenOSept cohort. Intensive Care Med
40:202210. doi:10.1007/s00134-013-3158-7
12. Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S,
Brennan T, Carter T, Cassidy CL, Chittenden EH, Degenhardt E, Griffith S,
Manworren R, McCarberg B, Montgomery R, Murphy J, Perkal MF, Suresh
S, Sluka K, Strassels S, Thirlby R, Viscusi E, Walco GA, Warner L, Weisman
SJ, Wu CL (2016) Management of postoperative pain: a clinical practice
guideline from the American Pain Society, the American Society of
Regional Anesthesia and Pain Medicine, and the American Society of
Anesthesiologists Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 17:131157. doi:10.1016/j.
jpain.2015.12.008
13. Klompas M, Li L, Szumita P, Kleinman K, Murphy MV (2015) Associations between different sedatives and ventilator-associated events,
length-of-stay, and mortality in mechanically ventilated patients. Chest.
doi:10.1378/chest.15-1389
14. Montravers P, Dufour G, Guglielminotti J, Desmard M, Muller C, Houissa
H, Allou N, Marmuse JP, Augustin P (2015) Dynamic changes of microbial
flora and therapeutic consequences in persistent peritonitis. Crit Care
19:70. doi:10.1186/s13054-015-0789-9
15. Jaber S, Delay JM, Chanques G, Sebbane M, Jacquet E, Souche B, Perrigault PF, Eledjam JJ (2005) Outcomes of patients with acute respiratory
failure after abdominal surgery treated with noninvasive positive pressure
ventilation. Chest 128:26882695. doi:10.1378/chest.128.4.2688
16. Saze Z, Miyata H, Konno H, Gotoh M, Anazawa T, Tomotaki A, Wakabayashi G, Mori M (2015) Risk models of operative morbidities in 16,930
critically ill surgical patients based on a Japanese nationwide database.
Medicine 94:e1224. doi:10.1097/md.0000000000001224
17. Zonta S, De Martino M, Podetta M, Vigano J, Dominioni T, Picheo R,
Cobianchi L, Alessiani M, Dionigi P (2015) Influence of surgical technique,
performance status, and peritonitis exposure on surgical site infection
in acute complicated diverticulitis: a matched case-control study. Surg
Infect 16:626635. doi:10.1089/sur.2014.231

 18. Lameire N, Hoste E (2014) Whats new in the controversy on the renal/
tissue toxicity of starch solutions? Intensive Care Med 40:427430.
doi:10.1007/s00134-013-3191-6
19. KDIGO Workgroup Kidney Disease (2012) Improving Global Outcomes
(KDIGO) Acute Kidney Injury Work Group: KDIGO clinical practice guideline
for acute kidney injury. Kidney Int Suppl 2:1138. doi:10.1038/kisup.2012.1
20. Casaer MP, Van den Berghe G (2014) Nutrition in the acute phase of critical illness. New Engl J Med 370:12271236. doi:10.1056/NEJMra1304623
21. Hoffer LJ, Bistrian BR (2012) Appropriate protein provision in critical
illness: a systematic and narrative review. Am J Clin Nutr 96:591600.
doi:10.3945/ajcn.111.032078
22. Solomkin JS, Ristagno RL, Das AF, Cone JB, Wilson SE, Rotstein OD, Murphy BS, Severin KS, Bruss JB (2013) Source control review in clinical trials
of anti-infective agents in complicated intra-abdominal infections. Clin
Infect Dis 56:17651773. doi:10.1093/cid/cit128
23. Azuhata T, Kinoshita K, Kawano D, Komatsu T, Sakurai A, Chiba Y, Tanjho K
(2014) Time from admission to initiation of surgery for source control is a
critical determinant of survival in patients with gastrointestinal perforation with associated septic shock. Crit Care 18:R87. doi:10.1186/cc13854
24. Sanabria A, Villegas MI, Morales Uribe CH (2013) Laparoscopic repair
for perforated peptic ulcer disease. Cochrane Database Syst Rev.
doi:10.1002/14651858.CD004778.pub3
25. Soreide K, Thorsen K, Soreide JA (2014) Strategies to improve the
outcome of emergency surgery for perforated peptic ulcer. Br J Surg
101:e51e64. doi:10.1002/bjs.9368
26. Nguyen NT, Armstrong C (2015) Management of gastrointestinal leaks
and fistula. In: Nguyen NT, Blackstone RP, Morton JM, Ponce J, Rosenthal R
(eds) The ASMBS textbook of bariatric surgery, vol 1. Springer, New York,
pp 221227
27. Waibel BH, Rotondo MF (2012) Damage control for intra-abdominal
sepsis. Surg Clin North Am 92:243257. doi:10.1016/j.suc.2012.01.006
28. Angenete E, Thornell A, Burcharth J, Pommergaard HC, Skullman S,
Bisgaard T, Jess P, Lackberg Z, Matthiessen P, Heath J, Rosenberg J,
Haglind E (2015) Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results
from the randomized controlled trial DILALA. Ann Surg. doi:10.1097/
sla.0000000000001061
29. Vennix S, Musters GD, Mulder IM, Swank HA, Consten EC, Belgers EH, van
Geloven AA, Gerhards MF, Govaert MJ, van Grevenstein WM, Hoofwijk
AG, Kruyt PM, Nienhuijs SW, Boermeester MA, Vermeulen J, van Dieren
S, Lange JF, Bemelman WA (2015) Laparoscopic peritoneal lavage or
sigmoidectomy for perforated diverticulitis with purulent peritonitis:
a multicentre, parallel-group, randomised, open-label trial. Lancet
386:12691277. doi:10.1016/s0140-6736(15)61168-0
30. Schultz JK, Yaqub S, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald
P, Korner H, Dahl FA, Oresland T (2015) Laparoscopic lavage vs primary
resection for acute perforated diverticulitis: the SCANDIV randomized
clinical trial. JAMA 314:13641375. doi:10.1001/jama.2015.12076
31. Eckmann C, Dryden M, Montravers P, Kozlov R, Sganga G (2011) Antimicrobial treatment of complicated intra-abdominal infections and
the new IDSA guidelines? A commentary and an alternative European
approach according to clinical definitions. Eur J Med Res 16:115126
32. Eckmann C, Bassetti M (2014) Prognostic factors for mortality in
(fecal) peritonitis: back to the roots! Intensive Care Med 40:269271.
doi:10.1007/s00134-013-3155-x
33. Sartelli M, Abu-Zidan FM, Ansaloni L, Bala M, Beltran MA, Biffl WL, Catena
F, Chiara O, Coccolini F, Coimbra R, Demetrashvili Z, Demetriades D, Diaz
JJ, Di Saverio S, Fraga GP, Ghnnam W, Griffiths EA, Gupta S, Hecker A, Karamarkovic A, Kong VY, Kafka-Ritsch R, Kluger Y, Latifi R, Leppaniemi A, Lee
JG, McFarlane M, Marwah S, Moore FA, Ordonez CA, Pereira GA, Plaudis H,
Shelat VG, Ulrych J, Zachariah SK, Zielinski MD, Garcia MP, Moore EE (2015)
The role of the open abdomen procedure in managing severe abdominal
sepsis: WSES position paper. World J Emerg Surg 10:35. doi:10.1186/
s13017-015-0032-7
34. Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain ML, De
Keulenaer B, Duchesne J, Bjorck M, Leppaniemi A, Ejike JC, Sugrue M,
Cheatham M, Ivatury R, Ball CG, Reintam Blaser A, Regli A, Balogh ZJ,
DAmours S, Debergh D, Kaplan M, Kimball E, Olvera C (2013) Intraabdominal hypertension and the abdominal compartment syndrome:
updated consensus definitions and clinical practice guidelines from the

35.
36.
37.
38.

39.

40.

41.

42.

43.
44.

45.
46.
47.
48.

49.

50.
51.

52.

World Society of the Abdominal Compartment Syndrome. Intensive Care

Med 39:11901206. doi:10.1007/s00134-013-2906-z
Diebel LN, Dulchavsky SA, Wilson RF (1992) Effect of increased intraabdominal pressure on mesenteric arterial and intestinal mucosal blood
flow. J Trauma 33:4548 (discussion 4849)
Gong G, Wang P, Ding W, Zhao Y, Li J (2009) Microscopic and ultrastructural changes of the intestine in abdominal compartment syndrome. J
Invest Surg 22:362367
Diebel LN, Dulchavsky SA, Brown WJ (1997) Splanchnic ischemia and bacterial translocation in the abdominal compartment syndrome. J Trauma
43:852855
Seguin P, Fedun Y, Laviolle B, Nesseler N, Donnio PY, Malledant Y (2010)
Risk factors for multidrug-resistant bacteria in patients with postoperative peritonitis requiring intensive care. J Antimicrob Chemother
65:342346. doi:10.1093/jac/dkp439
Seguin P, Laviolle B, Chanavaz C, Donnio PY, Gautier-Lerestif AL, Campion
JP, Malledant Y (2006) Factors associated with multidrug-resistant bacteria
in secondary peritonitis: impact on antibiotic therapy. Clin Microbiol
Infect 12:980985. doi:10.1111/j.1469-0691.2006.01507.x
Swenson BR, Metzger R, Hedrick TL, McElearney ST, Evans HL, Smith RL,
Chong TW, Popovsky KA, Pruett TL, Sawyer RG (2009) Choosing antibiotics for intra-abdominal infections: what do we mean by high risk? Surg
Infect 10:2939. doi:10.1089/sur.2007.041
Guirao X, Arias J, Badia JM, Garcia-Rodriguez JA, Mensa J, Alvarez-Lerma F,
Borges M, Barberan J, Maseda E, Salavert M, Llinares P, Gobernado M, Garcia Rey C (2009) Recommendations in the empiric anti-infective agents of
intra-abdominal infection. Rev Esp Quimioter 22:151172
Laterre PF, Colardyn F, Delmee M, De Waele J, Legrand JC, Van Eldere J,
Vergison A, Vogelaers D (2006) Antimicrobial therapy for intra-abdominal
infections: guidelines from the Infectious Disease Advisory Board (IDAB).
Acta Chir Belg 106:221
Eckmann C (2016) Antimicrobial therapy of intra-abdominal infections in the era of multiresistance. Chirurg 87:2633. doi:10.1007/
s00104-015-0106-9
Sawyer RG, Claridge JA, Nathens AB, Rotstein OD, Duane TM, Evans HL,
Cook CH, ONeill PJ, Mazuski JE, Askari R, Wilson MA, Napolitano LM,
Namias N, Miller PR, Dellinger EP, Watson CM, Coimbra R, Dent DL, Lowry
SF, Cocanour CS, West MA, Banton KL, Cheadle WG, Lipsett PA, Guidry
CA, Popovsky K (2015) Trial of short-course antimicrobial therapy for
intraabdominal infection. New Engl J Med 372:19962005. doi:10.1056/
NEJMoa1411162
Montravers P, Ribeiro-Parenti L, Welsch C (2015) Whats new in postoperative intensive care after bariatric surgery? Intensive Care Med 41:1114
1117. doi:10.1007/s00134-015-3686-4
Goncalves-Pereira J, Povoa P (2011) Antibiotics in critically ill patients:
a systematic review of the pharmacokinetics of beta-lactams. Crit Care
15:R206. doi:10.1186/cc10441
Al-Dorzi HM, Al Harbi SA, Arabi YM (2014) Antibiotic therapy of pneumonia in the obese patient: dosing and delivery. Curr Opin Infect Dis
27:165173. doi:10.1097/qco.0000000000000045
Hites M, Taccone FS, Wolff F, Cotton F, Beumier M, De Backer D, Roisin S,
Lorent S, Surin R, Seyler L, Vincent JL, Jacobs F (2013) Case-control study
of drug monitoring of beta-lactams in obese critically ill patients. Antimicrob Agents Chemother 57:708715. doi:10.1128/aac.01083-12
Cheatham SC, Fleming MR, Healy DP, Chung CE, Shea KM, Humphrey ML,
Kays MB (2013) Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion
in obese patients. Int J Antimicrob Agents 41:5256. doi:10.1016/j.
ijantimicag.2012.09.004
Rich BS, Keel R, Ho VP, Turbendian H, Afaneh CI, Dakin GF, Pomp A, Nicolau DP, Barie PS (2012) Cefepime dosing in the morbidly obese patient
population. Obes Surg 22:465471. doi:10.1007/s11695-011-0586-8
Kays MB, Fleming MR, Cheatham SC, Chung EK, Juenke JM (2014)
Comparative pharmacokinetics and pharmacodynamics of doripenem
and meropenem in obese patients. Ann Pharmacother 48:178186.
doi:10.1177/1060028013512474
Zakrison TL, Hille DA, Namias N (2012) Effect of body mass index on treatment of complicated intra-abdominal infections in hospitalized adults:
comparison of ertapenem with piperacillin-tazobactam. Surg Infect
13:3842. doi:10.1089/sur.2010.095

 53. Ross AL, Tharp JL, Hobbs GR, McKnight R, Cumpston A (2013) Evaluation
of extended interval dosing aminoglycosides in the morbidly obese
population. Adv Pharmacol Sci 2013:194389. doi:10.1155/2013/194389
54. Pai MP (2014) Serum and urine pharmacokinetics of tigecycline in obese
class III and normal weight adults. J Antimicrob Chemother 69:190199.
doi:10.1093/jac/dkt299
55. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL,
Karchmer AW, Levine DP, Murray BE, Talan DA, Chambers HF (2011) Clinical practice guidelines by the Infectious Diseases Society of America for
the treatment of methicillin-resistant Staphylococcus aureus infections
in adults and children: executive summary. Clin Infect Dise 52:285292.
doi:10.1093/cid/cir034
56. Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O,
Meersseman W, Akova M, Arendrup MC, Arikan-Akdagli S, Bille J, Castagnola E, Cuenca-Estrella M, Donnelly JP, Groll AH, Herbrecht R, Hope WW,
Jensen HE, Lass-Florl C, Petrikkos G, Richardson MD, Roilides E, Verweij
PE, Viscoli C, Ullmann AJ (2012) ESCMID guideline for the diagnosis and
management of Candida diseases 2012: non-neutropenic adult patients.
Clin Microbiol Infect 18(Suppl 7):1937. doi:10.1111/1469-0691.12039
57. Bassetti M, Marchetti M, Chakrabarti A, Colizza S, Garnacho-Montero J,
Kett DH, Munoz P, Cristini F, Andoniadou A, Viale P, Rocca GD, Roilides
E, Sganga G, Walsh TJ, Tascini C, Tumbarello M, Menichetti F, Righi E,
Eckmann C, Viscoli C, Shorr AF, Leroy O, Petrikos G, De Rosa FG (2013) A
research agenda on the management of intra-abdominal candidiasis:
results from a consensus of multinational experts. Intensive Care Med
39:20922106. doi:10.1007/s00134-013-3109-3
58. Montravers P, Dupont H, Eggimann P (2013) Intra-abdominal candidiasis:
the guidelines-forgotten non-candidemic invasive candidiasis. Intensive
Care Med 39:22262230. doi:10.1007/s00134-013-3134-2
59. Playford EG, Eggimann P, Calandra T (2008) Antifungals in the ICU. Curr
Opin Infect Dis 21:610619. doi:10.1097/QCO.0b013e3283177967
60. Eggimann P, Pittet D (2014) Candida colonization index and subsequent
infection in critically ill surgical patients: 20years later. Intensive Care Med
40:14291448. doi:10.1007/s00134-014-3355-z
61. Leon C, Ruiz-Santana S, Saavedra P, Galvan B, Blanco A, Castro C, Balasini
C, Utande-Vazquez A, Gonzalez de Molina FJ, Blasco-Navalproto MA,
Lopez MJ, Charles PE, Martin E, Hernandez-Viera MA (2009) Usefulness

62.

63.

64.

65.

66.

67.

of the Candida score for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a
prospective multicenter study. Crit Care Med 37:16241633. doi:10.1097/
CCM.0b013e31819daa14
Dupont H, Guilbart M, Ntouba A, Perquin M, Petiot S, Regimbeau JM,
Chouaki T, Mahjoub Y, Zogheib E (2015) Can yeast isolation be predicted
in complicated secondary non-postoperative intra-abdominal infections?
Crit Care 19:60. doi:10.1186/s13054-015-0790-3
Cuenca-Estrella M, Verweij PE, Arendrup MC, Arikan-Akdagli S, Bille J,
Donnelly JP, Jensen HE, Lass-Florl C, Richardson MD, Akova M, Bassetti M,
Calandra T, Castagnola E, Cornely OA, Garbino J, Groll AH, Herbrecht R,
Hope WW, Kullberg BJ, Lortholary O, Meersseman W, Petrikkos G, Roilides
E, Viscoli C, Ullmann AJ (2012) ESCMID guideline for the diagnosis and
management of Candida diseases 2012: diagnostic procedures. Clin
Microbiol Infect 18(Suppl 7):918. doi:10.1111/1469-0691.12038
Tissot F, Lamoth F, Hauser PM, Orasch C, Fluckiger U, Siegemund M,
Zimmerli S, Calandra T, Bille J, Eggimann P, Marchetti O (2013) Betaglucan antigenemia anticipates diagnosis of blood culture-negative
intraabdominal candidiasis. Am J Respir Crit Care Med 188:11001109.
doi:10.1164/rccm.201211-2069OC
Leon C, Ruiz-Santana S, Saavedra P, Castro C, Ubeda A, Loza A, MartinMazuelos E, Blanco A, Jerez V, Ballus J, Alvarez-Rocha L, Utande-Vazquez
A, Farinas O (2012) Value of beta-d-glucan and Candida albicans germ
tube antibody for discriminating between Candida colonization and
invasive candidiasis in patients with severe abdominal conditions. Intensive Care Med 38:13151325. doi:10.1007/s00134-012-2616-y
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel
JD (2015) Clinical practice guideline for the management of candidiasis:
2016 update by the Infectious Diseases Society of America. Clin Infect
Dis. doi:10.1093/cid/civ933
Pagani JL, Revelly JP, Que YA, Eggimann P (2015) The role of biomarkers for starting antifungals in the intensive care unit. Clin Pulm Med
22:286293. doi:10.1097/CPM.0000000000000118