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75 Lawrence G. Lenke
classifications possible, when one uses the modularity of this help guide the surgeon to appropriate surgical decisions for
system and determines the curve type (1 to 6), coronal lumbar patients with operative AIS.
modifier (A, B, or C), and sagittal thoracic modifier (, N, or
) then joins them together, this system is much more user-
CURVE TYPES
friendly and easy to understand.
While this radiographic classification system is fairly descrip- Curve Type 1
tive, because of the thorough radiographic analysis performed,
In type 1 MT curve patterns, the major curve is in the MT
there are certainly many additional factors that play an
region and the PT and TL/L regions are nonstructural
extremely important role in deciding on the actual regions of
minor curves (Fig. 75.3). Thus, the suggested treatment is
the spine to fuse as well as determining specific fusion levels.14
anterior or posterior correction and fusion of the MT region
Simplistically, the treatment guidelines of the Lenke system rec-
only. In the past 10 years, the use of an anterior spinal fusion
ommend that one should consider fusing the major curve as
(ASF) approach for a type 1 MT curve has diminished sig-
well as the structural minor curve(s) but not the nonstructural
nificantly at our institution and throughout North America.1,12
minor curve(s). However, there are other aspects of the radio-
Simultaneous with this, there has been an increased use of
graphic and clinical presentation that are important in this
posterior spinal fusion (PSF) procedures with pedicle screw
decision process. These factors include the ratio of radio-
instrumentation.9,21,10 The upper instrumented vertebra
graphic parameters, the level of skeletal maturity, preoperative
(UIV) is typically T3, T4, or T5, while the lowest instru-
shoulder alignment, thoracic and lumbar prominences, trunk
mented vertebra (LIV) will vary considerably between T11
balance, athleticism of the patient, and personal desires and
(rarely) and L4 or even L5-sacrum (rarely).
wishes of the patient.20 Thus, in combination with this classifi-
Correction maneuvers of type 1 MT curves include a variety
cation system these various additional radiographic and clinical
of options such as cantilever, in situ contouring, in situ transla-
factors, as well as the prior operative experience of the surgeon
tion, apical derotation using pedicle screws, and selective com-
pression and distraction forces applied in an attempt to maxi-
mally translate the apex and horizontalize the LIV when
appropriate. In the pedicle screw era, the use of apical derota-
tion maneuvers has become common with subsequent improve-
ment of rib prominences obviating a thoracoplasty procedure
in the majority of patients.9 For those patients who have a severe
apical lordotic component to their curve, the use of ligament
releases or formal periapical Pont or Smith-Petersen osteoto-
mies may be necessary to improve this sagittal plane malalign-
ment thereby restoring a more physiologic kyphosis across
these apical segments. Also, in large and stiff deformities
(upright coronal Cobb 75, with side bending 50), these
apical releases will be helpful to allow maximum correction
while minimizing the bone/screw interface stresses during
correction.22
Advantages of Lenke et al
TABLE 75.2
Classification System of AIS
Comprehensive
Two-dimensional
Reliable
Modular (curve type, lumbar, and sagittal modifiers)
Figure 75.1. Anteroposterior and lateral X-rays demonstrating the Treatment recommendations (fuse major and structural
proximal thoracic, main thoracic, and the thoracolumbar/lumbar minor curves)
regions.
The selection of the LIV is strongly correlated with the coro- long as there is no TL junctional kyphosis present. However, for
nal lumbar modifier. For coronal lumbar modifier A curve pat- coronal lumbar modifier C curves, the stable vertebra (typically
terns, the LIV selected is usually the most cephalad vertebra in T11, T12, or L1) located in the TL junction is selected as the
the TL/L region that is at least intersected by the CSVL on the LIV when a selective thoracic fusion is performed.
upright coronal radiograph and is neutral in rotation (Case The type 1C curve pattern is highly controversial.2 Even
75.1). This typically is one-level caudad to the lower end verte- though the TL/L region completely deviates off the CSVL at
bra (LEV) of the MT curve and one or two levels cephalad to the apex, the TL/L curve side bends to less than 25 and lacks
the true stable vertebra. For coronal lumbar modifier B curve a true junctional kyphosis. Thus, a selective thoracic fusion is
patterns, this same rule for the LIV seldom holds true. Typically, recommended for most 1C curves. However, the selection of
the last vertebra touched by the CSVL is a safe LIV selection as patients with a 1C curve pattern suitable for a selective thoracic
fusion will necessitate additional evaluation beyond the Lenke
Classification System.23 Analysis of radiographic and clinical
ratios of the thoracic to the lumbar spine deformity is also
imperative.18 In this regard, evaluating the ratio of thoracic to
lumbar Cobb measurements, apical vertebral rotation (AVR),
and apical vertebral translation (AVT) is performed. When
these ratios are greater than 1.2 and ideally close to 2.0, espe-
cially the AVT ratio, then a selective thoracic fusion can typi-
cally be successfully performed (Table 75.3). In addition, it is
necessary to evaluate the patients upright, prone, and forward
bend clinical posture in order to document that a thoracic
lumbar clinical prominence is present. In the suitable patient,
typically a thoracic trunk shift will outweigh any lumbar shift
3A 3B 3C
4A 4B 4C
Figure 75.5. Schematic of type 3 double major curves with 3A, 3B,
and 3C represented. General rule: posterior spinal fusion/PSSI span- Figure 75.6. Schematic of type 4 triple major curves with 4A, 4B,
ning both main thoracic and the thoracolumbar/lumbar curves. and 4C represented. General rule: posterior spinal fusion/PSSI all
three structural curves (proximal thoracic, main thoracic, and the
thoracolumbar/lumbar).
wedging of the L3-4 disc or translation of L3 off the CSVL,
centering of L3 on a push-prone and/or side-bending radio- performed if radiographic and clinical conditions will allow for
graphs, and presence of an L5 and/or S1 fixed obliquity. These a shorter fusion.
radiographic factors will all play a role in the success of stop-
ping at the L3 level in these curve patterns (Case 75.4).
Curve Type 5
Most type 3 DM curves are associated with a lumbar C modi-
fier; however, those that have a lumbar A or B modifier usually A type 5 TL/L curve pattern has the major curve located in the
have an extremely large MT curve angle, which makes the TL/L region with nonstructural PT and MT regions (Fig. 75.7).
residual TL/L curve structural on side bending but not as Thus, this single curve pattern can be treated with an isolated
translated from the CSVL. Alternatively, TL/L junctional ASF or PSF in the TL/L region. Traditionally, our institution has
kyphosis of 20 or greater creates a type 3 DM curve pattern treated these curves anteriorly, most recently with a dual rod5
even when the coronal flexibility would predict a nonstructural instrumentation construct from the UEV to the LEV of the
TL/L region as in a 1C pattern. Occasionally, there are 3C pat- TL/L curve (Case 75.5). However, as we and others are finding,
terns that one may consider for a selective thoracic fusion.2 a PSF over the same instrumentation levels can often be per-
When applying the radiographic and clinical ratio criteria as formed using pedicle screw instrumentation and apical derota-
described for a 1C pattern, if the ratios are favorable, one may tion maneuvers. The choice between an ASF and PSF is currently
treat the larger thoracic radiographic and clinical deformity controversial, but the use of segmental pedicle screw fixation is
leaving the lumbar curve unfused. However, one must carefully imperative if one chooses a posterior approach for these curves
select these rare 3C curve patterns for a selective thoracic to try to obtain the same amount of correction and positioning
fusion, and perform appropriate instrumentation techniques of the UIV and LIV as with an anterior procedure. Technically,
to allow optimal coronal and sagittal alignment and clinical the goal is usually to horizontalize the LIV and potentially keep
posture postoperatively (see Case 75.2). some residual tilt to the UIV based on the amount of scoliosis
deformity present in the thoracic spine. This is analogous to the
performance of a selective thoracic fusion where the residual tilt
Curve Type 4
is left on the LIV of the MT curve. It is also imperative to evalu-
A type 4 triple major (TM) curve has a major curve in the MT ate the nonstructural MT curve radiographically and clinically,
or TL/L region with the other two regions including the PT for in some circumstances it will be required to treat the tho-
region structural minor curves (Fig. 75.6). Thus, these rare racic curve even in a 5C pattern. Typically, the rib prominence
curves typically require that all three regions PT, MT, and TL/L in the thoracic region, a junctional kyphosis between the MT
be included in a PSF procedure. The UIV is selected in accor- and TL/L curves, and/or shoulder malalignment may necessi-
dance with the rules of the type 2 DT curve pattern, while the tate including the thoracic curve as well.
LIV is selected in accordance with the rules of the type 3 DM
curve pattern. Thus, this curve pattern usually requires an
Curve Type 6
extremely long instrumentation and fusion from T2 or T3 down
to L3 or L4. However, just as mentioned in the previous three A type 6 TL/L-MT curve has the major curve in the TL/L
curve types, selecting the major curve for isolated treatment and region, with a structural MT curve, but a nonstructural PT
leaving one or both of the minor curve(s) unfused may be curve (Fig. 75.8). Both regions are treated with a PSF similar to
5C 6C
Figure 75.7. Schematic of a type 5 thoracolumbar/lumbar (TL/L) Figure 75.8. Schematic of a type 6 thoracolumbar/lumbar (TL/L)-
curve with a 5C curve pattern depicted. General rule: anterior spinal main thoracic (MT) curve with a 6C curve pattern depicted. General
fusion/ASSI or posterior spinal fusion/PSSI TL/L curve alone. rule: posterior spinal fusion/PSSI both curves (MT and TL/L).
a type 3 DM curve pattern. In rare circumstances, a selective regions of the spine to be included in the instrumentation and
TL/L fusion can be performed based on the structural criteria fusion.20 However, it must be stressed that personal experi-
comparing the TL/L region with the MT region. Thus, the ence, additional radiographic analysis, and the patients clini-
ratio of TL/L to MT Cobb measurement, AVR, and AVT as well cal deformity are extremely important in this decision process
as the clinical deformity will show a definite larger TL/L defor- as well. In addition, the level of skeletal immaturity plays an
mity.5 In this circumstance, a selective TL/L fusion can be per- important role in the operative approach and the LIV selec-
formed either anteriorly or posteriorly as described above.26 tion process as adding-on and crankshaft are adverse clinical
Occasionally, any of the curve patterns may be associated with outcomes that should be avoided. It is well accepted that selec-
extremely large Cobb angles of the MT or less commonly TL/L tion of the UIV and LIV as well as the performance of specific
region. Because of the large major curve, the other minor curves intraoperative correction maneuvers in various sequences are
become structural based on sheer curve magnitude alone due to highly individualistic among surgeons and are part of the art
residual Cobb measurements of greater than 25 on side bend- of scoliosis surgery.13,25 Because of the wide variety of fusion
ing. Currently these large and stiff curves are treated with multi- levels chosen and techniques utilized to correct these spinal
level posterior-based osteotomies or even three-column osteoto- deformities it is necessary to have a classification system that
mies such as a pedicle subtraction or a vertebral column resection allows outcomes assessment of similar curve patterns treated
procedure (Case 75.6). These procedures are technically chal- differently. Thus, for the specific curve patterns described by
lenging and should be performed by scoliosis surgeons who are this classification system, various treatment methods can thus
comfortable treating severe deformities. These posterior osteot- be compared via multicenter analysis in order to eventually
omy procedures have provided safe and optimal deformity cor- select the optimal treatment of each specific curve pattern.
rection without any formal anterior approach. However, we still This will be important for not only radiographic assessment,
utilize preoperative halo-gravity traction for thoracic-based defor- but also clinical assessment using outcome questionnaires such
mities to aid in safely stretching the spine and chest wall thereby as the Scoliosis Research Society (SRS) instrument as well as
improving pulmonary function as well. functional assessments with pulmonary function tests, gait,
and range of motion analysis. Ultimately, multicenter analysis
of large numbers of similar curve patterns treated differently
SUMMARY should help sort out the best treatment of each particular
curve pattern, thus optimizing the surgical treatment of
The use of the Lenke Classification System of AIS has provided patients with AIS.
a template for analysis of the radiographic component of sco- Lastly, knowing that scoliosis is a three-dimensional (3D)
liosis, as well as basic treatment guidelines with respect to the deformity, classifying AIS in three dimensions will be necessary.
The SRS has a dedicated committee working on 3D curve anal- together. At that point, prospective analysis will provide assess-
ysis and potential classification of AIS. Hopefully in the future, ment of the 3D correction achieved with various surgical treat-
3D analysis for scoliosis patients will be the norm, and with a 3D ments to optimize these patients radiographic and clinical
classification system we will be able to group similar curves deformity postoperatively.
CASE EXAMPLES
CASE 75.1
(A) Patient is a 134-year-old girl with a 40 PT, 74 MT, and 42 TL/L curve. On left side bending, the PT
curve bends to 3 and the TL/L curve to 2, thus both are nonstructural. T5-T12 kyphosis is 25; therefore,
the curve classification is 1AN. (B) She was treated with a PSF with a pedicle screw construct from T4 to L2,
the lowest vertebra touched by the CSVL in the preoperative coronal radiograph. At 5 years postoperative,
there is excellent coronal and sagittal alignment. (continued)
C
(C) Pre- and postoperative upright and forward bend clinical photographs demonstrate the chest wall correc-
tion afforded by the pedicle screw construct with active derotation forces applied.
CASE 75.2
(D) The patient underwent a PSF from T4 to L1 with a segmental pedicle screw construct and
undercorrection of the coronal curve down to the stable vertebra L1. At 3 years postoperative,
there is excellent coronal and sagittal alignment. (E) Postoperative clinical photographs dem-
onstrate the marked improvement of the trunk and chest wall following the selective thoracic
E fusion.
CASE 75.3
CASE 75.4
B
(A) 158-year-old girl with a 25 PT, 60 MT, and 53 TL/L curve. On left side bending, the TL/L curve
bends out to only 25 and thus is structural. T5-T12 kyphosis is 7, thus the complete curve classification is
3C-. (B) The patient underwent a PSF from T4-L3 with segmental pedicle screw fixation. At 2 years postopera-
tive, the coronal plane LIV at L3 is completely horizontal, central, and neutral in position. In this case, a selec-
tive thoracic fusion was not performed due to the patients dissatisfaction with her waistline asymmetry preop-
eratively due to her lumbar translation.
CASE 75.5
CASE 75.6
A
(A) 165-year-old girl with an 80 PT, 138 MT, and a 60 TL/L curve. On left side bending, the PT curve
bends out to 65 thus is structural, while the TL/L curve bends to 22 and is nonstructural. T5-T12 kyphosis is
58, thus the complete curve classification is 2A. (continued)
B
(B) (Continued) The patient underwent a PSF from T2 to L4 with a T10 posterior vertebral column resection.
Postoperative radiographs demonstrate marked correction of the coronal and sagittal planes. (continued)
13. Lenke LG, Betz RR, Clements D, et al. Curve prevalence of a new classification of operative
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