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CHAPTER

Alpesh A. Patel

128 Alexander R. Vaccaro


Paul A. Anderson

Classification of Cervical
Spine Injury

INTRODUCTION disease, and the Arbeitsgemeinschaft fr Osteosynthesefragen


(AO) Pilon fracture that, when tested, have proven unreliable
Cervical spine injuries are a common clinical condition observed and unsatisfactory for decision making.4,5,15,16
across a wide spectrum of the population. Traumatic injury to Six attributes of a quality classification system have been
the cervical spine, especially when associated with spinal cord described by Mirza et al.11 The system should aid in the identi-
injury, has a profound impact on the individual patient as well fication of injury and provide a description. It should reflect
as society. Despite the frequency and implications of cervical the injury mechanism and pathogenesis, and therefore guide
spine trauma, there remains little consensus as to the classifica- treatment. The classifications should be based on easily deter-
tion and treatment of cervical fractures and dislocations. mined clinical and radiographic characteristics, which should
Classification systems are widely utilized across medical and also allow differentiation from other injury types. The system
surgical specialties, from trauma to oncology to blood pressure should account for, and quantify, neurologic injury. The skele-
management. Although injury and disease occur on a contin- tal injury should be graded for both bony and ligamentous
uum, the use of classification systems is critical. Classification integrity. Finally, a classification should provide an estimate of
systems serve many functions in defining traumatic injury. First, the prognosis for healing and adverse events such as chronic
classification improves communication between health care pain and/or deformity.
providers. Second, classification can guide medical decision The vast majority of current classification systems fall short
making. Third, a well-structured classification system can deter- of these expectations (Table 128.1). They are often convoluted
mine injury prognosis. Lastly, classification allows for valid and systems based upon inferred, mechanistic descriptors of bony
reliable research using a standard, universal language. injury. They do not account for potential intervertebral disc or
Classification systems are generalizations or estimates of a ligamentous injury. They all ignore the clinical status of the
highly variable morphologic and biomechanical structure. patient, specifically the presence of neurological injury. Because
These generalizations sacrifice data that can result in decreased of these factors, none of the current classification systems has
precision, from attempting to place into categories of injury, stood out as a gold standard.
which in reality are continuous variables across a spectrum. The purpose of this chapter is to review current cervical
Attempting to increase the precision by utilizing more catego- spine trauma classification systems, to review the critical con-
ries decreases reliability and makes the system more confusing cepts in cervical spine trauma, and to describe two new quanti-
and not usable. tative classification systems.
An ideal classification system, therefore, provides both
descriptive and prognostic information. The descriptive com-
ponent relays information about the traumatic condition, orga- CLASSIFICATION SYSTEMS
nized by injury severity, based upon consistent radiographic
and clinical parameters, in an easily understood, reproducible A number of classification schemes have been described in an
language. The prognostic component of an ideal system affects attempt to better define spine trauma and spinal instability.
clinical decision making by accounting for natural history and Many of these systems have added to the collective understand-
known injury outcomes to guide treatment. Lastly, this system ing and vocabulary of spinal trauma, but none has distinguished
must be reproducible, incorporate commonly used clinical itself as the best.
parameters and be readily implemented into regular clinical The concept of spinal stability and instability is one that has
practice. proven difficult to define. Nicoll defined functional spinal sta-
To aid physicians in caring for patients, classification systems bility based upon return to work after thoracolumbar spinal
must be valid and reliable. Reliability is the reproducibility by the fracture in a group of 152 Welsh miners.13 Contrary to the prior
observer (intraobserver) and between observers (interobserv- teachings of Bohler and Watson-Jones, Nicoll demonstrated
ers). Many classic classification systems including Gardens hip that functional outcomes did not correlate with radiographic
fracture, Neers proximal humerus fracture, Catteralls Perthes appearance, most notably in individuals without neurological

1381

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1382 Section XII Trauma

TABLE 128.1 Classification Systems for Subaxial Cervical Injuries

Classification System Strengths Weaknesses


Nicoll Functional outcomes Retrospective
Lacks details
No neurological assessment
Holdsworth Posterior ligament complex Limited descriptors
Ignores anterior soft tissues (disc, ALL, PLL)
No neurological assessment
Louis Conceptually simple Anatomic description only
Ignores soft tissues (anterior and posterior)
No neurological assessment
White and Panjabi Neurological assessment Intricate radiographic criteria
Point based Stretch test
Limited assessment of soft tissues (anterior and posterior)
Allen et al Comprehensive Mechanisticinferred description and assessment of stability
Harris et al Organized by severity Large number of subgroups
No neurological assessment
Poor to fair reliability
AO Comprehensive Large, complex number of subgroups
Organized by severity No neurological assessment
Universal language Poor to moderate reliability
Cervical Spine Injury Quantifies instability No neurological or morphologic assessment
Severity Score Proven reliable and valid
Subaxial Injury Directs treatment Unproven reliability
Classification (SLIC) Comprehensive by including Indeterminate group difficult to define
and Severity Scale neurologic function

ALL, anterior longitudinal ligament; AO, Arbeitsgemeinschaft fr Osteosynthesefragen; PLL, posterior longitudinal ligament

injury.3,19 While this supports nonoperative treatment, the defi- The White and Panjabi system is the first to designate neuro-
nition of stability is broad, overlooking many of the details logic status as a component of cervical stability and the first to
involved with the management of acute cervical trauma and provide radiographic measurements as criteria for instability. The
acute neurological injury. In addition, it is a purely retrospec- system is limited in its usefulness, however, by the stretch test,
tive description, based upon functional outcomes and, there- which is now rarely required due to current imaging technologies
fore, provides no prognostic information. and an improved understanding of soft tissue disruptions. It is
Holdsworth, through a review of more than 1000 patients, further limited by the number of radiographic criteria present,
divided fractures into two large groups (stable and unstable) the disproportionate weight given to radiographic criteria over
based primarily upon disruption of the posterior ligament ligamentous and neurological status, and unproven reliability.
complex.7 Stable patterns included wedge fractures, burst frac- Whereas others had classified injuries based on concepts of
tures, and extension injuries; unstable patterns included dislo- stability, Allen et al developed a mechanistic classification sys-
cation, rotational-fracture dislocation, and shear injuries. tem.1 Based upon a review of 165 patients with subaxial cervical
Although based solely on radiographs, Holdsworth astutely trauma, the authors divided injuries into groups based upon a
identified the critical importance of the posterior cervical liga- common mechanism of injury with emphasis on a progression
ments in spinal stability. His description fell short, however, due of severity within each mechanism. Six main categories were
to a lack of anatomic fracture detail and by not accounting for derived based upon inferred force vectorscompressive flex-
the neurologic status of the patient. ion, vertical compression, distractive flexion, compressive
Louis defined cervical spinal stability upon three anatomic extension, distractive extension, and lateral flexion. This was
pillars (columns)one anterior (vertebral body, intervertebral later modified by Harris et al to include rotational vectors in
disc) and two posterior (each lateral mass).9 Although concep- both flexion and extension.6
tually easy to understand, this remains primarily a descriptor of The system is comprehensive, detailing an array of potential
bony injury location, without accounting for spinal alignment cervical injuries. The system is also appropriately organized by
or ligamentous injury and without any implication as to injury severity and can, therefore, aid in injury stratification. The sys-
severity. tem is, however, also handcuffed by the multitude of options.
White and Panjabi through a review of clinical cases and in Furthermore, the system is fundamentally limited because it is
vitro biomechanical testing have suggested a point-based clas- based upon mechanisms that are inferred from the recoil posi-
sification system for cervical trauma.20 Radiographic criteria, tion of the spine on radiographic imaging. This leaves the clas-
physical examination (including neurological status), and a sification open to interpretation and has been reflected in the
stretch test are required and have an assigned point system. poor to fair reliability of this system.17
The stretch test, involving sequential traction, aims to quantify The AO classification of spinal trauma defines injuries into
disc or ligamentous disruption through radiographic changes. one of three large categories (A, B, C) with nine subgroups.10

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Chapter 128 Classification of Cervical Spine Injury 1383

Type A injuries are compression injuries of the anterior col- The reliability of the system was tested on 35 cervical spine
umn; type B injuries involve distraction injuries, with or without injured patients.2 The radiographs and computed tomography
angulation; type C injuries additionally involve a translational (CT) scans were reviewed by 15 investigators of varying experi-
or rotational component. Subgroups are further defined ence and the CSISS measured. The reliability was assessed by
according to the standard AO 3 3 system. determining the mean intraobserver and interobserver differ-
The AO system provides a well-defined, well-organized ences using intraclass correlation coefficients (ICCs). For this
means of describing a broad array of injury patterns. metric, any score greater than 0.75 indicates excellent reliabil-
Classification is based upon severity of injury and can thereby ity. The intraobserver ICC was 0.98, and the interobserver ICC
guide treatment. The system also allows for a universal lan- was 0.88, both indicating excellent reliability. No difference was
guage that can improve communication between treating phy- noted based on experience of the examiner. The worst cases
sicians. The complexity of the AO system, specifically the array with the greatest variance in scores where in patients with anky-
of subgroups, limits its usefulness in routine clinical care. The losed spines or those with subtle ligamentous injury.
large AO categories (A, B, C) have additionally demonstrated Validity indicates that the test or instrument is correctly
only poor to moderate reliability, with results worsening when gauging reality. In most cases, this requires that the results be
AO subcategories are tested.14,21 compared with a gold standard. Validity was tested by compar-
ing the CSISS to the presence of neurologic injury and whether
surgery was performed (Figs. 128.2A to D). All 14 patients with
MODERN CLASSIFICATION SYSTEMS scores of 7 or greater had surgery whereas only 3 out of 20
with scores below 7 had surgery (Figs. 128.3A to D). All three
THE CERVICAL SPINE INJURY SEVERITY SCORE of these patients had a neurologic deficit. Furthermore, 65% of
patients with scores greater than 7 had neurologic deficits
The Cervical Spine Injury Severity Score (CSISS) was devel-
compared with only 15% with lower than 7 scores.
oped to quantify the degree of traumatic instability.2,12 The sys-
In summary, the CSISS causes the surgeon to critically exam-
tem is based on a four-column model of the cervical spine and
ine all components of the injury and can reliably measure the
an analog scale to assess injury of each column (Figs. 128.1A
degree of instability. It is easy to use and can be based on com-
and B). The four columns are anterior, each lateral pillar, and
puted tomography (CT) and magnetic resonance imaging
the posterior osseous ligamentous complex (Fig. 128.1A). The
(MRI).
anterior column consists of the body, disc and annulus, and the
anterior and posterior longitudinal ligaments. Each lateral pil-
lars includes the pedicles, lateral masses with facet articulations, SUBAXIAL CERVICAL INJURY CLASSIFICATION
and facet capsules. The posterior column includes the lamina,
spinous processes, ligamentum flavum, and all the nuchal liga- The Subaxial Cervical Injury Classification (SLIC) system and
ments. severity score have been described by Vaccaro et al as a novel
Each column is scored independent of the others using an system to define subaxial cervical trauma (C3-C7).17 It is an
analog scale from 0 to 5 (Fig. 128.1B). A zero is no injury and adaptation of a thoracolumbar injury classification system
five is the worst injury that could occur to that column. Scores described by Vaccaro et al in an attempt to standardize
in-between are based on degree of displacement. For example, approaches to and descriptors of spine trauma across anatomic
a nondisplaced fracture is graded as a 1, while a subluxation regions.18
of 3 mm would be graded as a 3. Fractional values can be The SLIC system describes the injury by spinal level, injury
used. The score for each column is summed giving a potential morphology, bony description, discoligamentous status, and
score from 0 to 20. neurological examination. The SLIC system identifies three

Figure 128.1. The Cervical Spine Injury Severity


Score. (A) Four columns of the cervical spine. Each col-
umn will be scored independently using analog scale.
(B) Analog scoring ranging from 0 to 5. Zero is no
injury and a 5 is the worst injury possible of that col-
umn. A 1 is a nondisplaced fracture and the remain-
ing scores are based on increasing displacement of bony
fractures or from ligamentous disruption. Fractional val-
A
ues can be used.

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1384 Section XII Trauma

A B

C D

Figure 128.2. (A) A 27-year-old man with facet fracture of C6 and C7 body and right facet. The sagittal
computed tomography (CT) demonstrates the body fractures and opening between spinous processes
(arrows). His anterior column is scored 2.0 for slightly fractures without vertebral subluxation. The posterior
column is disrupted and scored 4.0. (B) Axial CT. Arrow indicates body fracture of C7. (C) Left pillar was
scored 2.0 for facet subluxation (arrow). (D) Right pillar was scored 3.0 for having both subluxation and supe-
rior facet fracture. The overall Cervical Spine Injury Severity Score was 11.0, and the patient was treated by
posterior fusion.

critical components in subaxial cervical spine trauma: injury advanced imaging characteristic. Injury morphology is classi-
morphology, discoligamentous injury, neurological status. fied as compression, distraction, or rotation/translation.
Compression injuries are defined by a visible loss of height
of the vertebral body or disruption through the vertebral end
Injury Morphology
plate. This includes traditional compression and burst frac-
The injury morphology defines the structural relationship of tures, sagittal or coronal plane fractures of the vertebrae, and
the vertebral bodies to each other in terms of anterior ana- teardrop, or flexioncompression fractures.
tomical support, soft tissue structures, facet relationships, and The distraction injury pattern is readily identified by
overall alignment as determined by plain radiographic and anatomical dissociation in the vertical axis. A representative

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Chapter 128 Classification of Cervical Spine Injury 1385

A B

Figure 128.3. (A) A 35-year-old womans


sagittal computed tomography (CT) demon-
strating a flexion distraction injury. The ante-
rior column is significantly translated into
canal and scored a 3.5 interspinous widening
is noted (arrow). (B) The axial CT shows dis-
placement of bilateral laminar fractures. The
posterior column is disrupted and scored 5.
(C) Left pillar is minimally involved with only
questionable diastasis of C4-5 facet and scored
0.5. (D) Right lateral mass of C3 is fractured,
and there is dislocation of the C3-4 facet artic-
ulation. The right pillar is scored 5.0. Overall
the Cervical Spine Injury Severity Score is
14 and the patient was treated by anterior
C D
posterior fusion.

example would be a hyperextension injury causing disruption The rotation/translation injury is defined by horizontal dis-
of the anterior longitudinal ligament (ALL) with subsequent placement of one vertebral body of the subaxial cervical spine
widening of the anterior disc space. Posterior element fractures with respect to another other. Biomechanical work suggests that
(facet, lamina, spinous process) may also be present. Bilateral adequate thresholds for stability are less than 3.5 mm of displace-
perched facets or other kyphotic deformities of the spine, ment or relative angulation of less than 11.20 It is typified by
through a tensile failure of the ligamentous restraints, repre- unilateral and bilateral facet dislocations or fracture-dislocations,
sent another clinical example of the distraction morphology. fracture separation of the lateral mass (floating lateral mass)

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1386 Section XII Trauma

with vertebral subluxation, and bilateral pedicle fractures with Injury Severity Score
vertebral subluxation (traumatic spondylolisthesis).
A numeric value has been assigned to each descriptor within
these three critical components. Injury patterns that are known
Discoligamentous Complex to result in worse outcomes or require urgent surgical interven-
The discoligamentous complex (DLC) component is based tion (spinal instability, neurological injury) are weighted to
upon integrity of the intervertebral disc, anterior and posterior receive greater point values. These three numbers are summed
longitudinal ligaments, interspinous ligaments, facet capsules, to provide an overall SLIC score. The resultant score can then
and ligamentum flavum. This is a descriptor unique to the be used to guide treatment of that particular injury. Surgical
SLIC system and is divided into three categories: intact, inde- versus nonsurgical treatment is determined by a threshold
terminate, and disrupted. Disruption of the DLC may be repre- value of the SLIC severity score. If the total score is less than
sented by abnormal facet alignment (articular apposition four (1 to 3), nonoperative treatment is suggested. If the total
50% or diastasis 2 mm through the facet joint), abnormal is greater than or equal to five (5), operative treatment is rec-
widening of the anterior disc space either on neutral or exten- ommended. This may consist of realignment, neurological
sion radiographs, translation or rotation of the vertebral bod- decompression (if indicated), and stabilization. A total score of
ies, or kyphotic alignment of the cervical spine. Indeterminate four (4) may be treated operatively or nonoperatively (Figs.
injury may exist when radiographic disruption of the DLC is 128.4A to D).
not otherwise obvious on radiographic or CT imaging but a In instances of multiple levels of cervical trauma, each level
hyperintense signal is found through the posterior ligamentous is treated as a separate injury and SLIC scores are calculated
regions on T2-weighted MRI images, suggesting edema and independently for each level. If a single level has multiple injury
injury. Intact DLC is defined by a lack of radiographic evidence patterns, only the most severe injury is considered for scoring.
of abnormal spinal alignment in addition to normal disc space For example, if the injured level showed signs of both compres-
and ligamentous appearance. sion and rotation, morphology would be scored as rotation/
translation. The descriptive identifiers and the point scores for
each SLIC category are summarized in Table 128.2.
Neurological Status
The neurologic status of the patient is often the most influen-
tial component of medical decision making. In addition, it can CLINICAL USE OF MODERN
be inferred that neurologic injury is a critical indicator of the CLASSIFICATION SYSTEMS
degree of spinal column injury. The neurologic status, another
unique component of the SLIC system, is defined as one of These two classification systems are designed to aid treatment
the following: root injury, complete cord injury, or incomplete decisions as presented in Figure 128.5. Greater scores generally
cord injury. An additional modifier, continuous cord compres- indicate that surgery is indicated as attested by the primary
sion, is described in the setting of either complete or incom- authors of the system. However, the reader should consider
plete spinal cord injury with ongoing spinal cord compression these systems as tools and that each patient should be evaluated
due to disc, bone, ligamentum flavum, hematoma, or other on its own merits. Both systems require further validation to
structures. establish their role in evaluating spinal injured patients.

TABLE 128.2 Subaxial Injury Classification (SLIC) and Severity Scale

Points
Morphology No Abnormality 0
Compression 1
Burst 1 2
Distraction (e.g., facet perch, hyperextension) 3
Rotation/translation (e.g., facet dislocation, unstable teardrop, or advanced 4
staged flexion compression injury)
Discoligamentous Complex (DLC) Intact 0
Indeterminate (e.g., isolated interspinous widening, MRI signal change 1
only)
Disrupted (e.g., widening of anterior disc space, facet perch or dislocation, 2
kyphotic deformity)
Neurological Status Intact 0
Root injury 1
Complete cord injury 2
Incomplete cord injury 3
Continuous cord compression (in setting of a neurologic deficit) 1

MRI, magnetic resonance imaging.

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Chapter 128 Classification of Cervical Spine Injury 1387

A B

C D

Figure 128.4. Subaxial Cervical Injury Classification (SLIC): Translational C4-C5 bilateral facet disloca-
tion with disruption of the discoligamentous complex, complete spinal cord injury. (A) Sagittal computed
tomography (CT) shows greater than 50% vertebral translation and wide interspinous distraction. (B) Axial
CT demonstrating bilateral facet dislocation. (C, D) Ventral cord compression and disruption of interverte-
bral disc and posterior ligamentous structures are seen on (C) T2 and (D) short TI inversion recovery
(STIR) magnetic resonance imaging (MRI). SLIC Severity Scale:
Morphology
Rotation/Translation 4 pts
DLC
Disrupted 2 pts
Neurological Status
Complete Spinal Cord Injury 2 pts
SLIC Score 4 2 2 8 (operative)

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1388 Section XII Trauma

History
Physical examination
Neurologic examination

Plain radiographs
CT scan (with reconstructions) MRI
Unexplained neurologic deficits
Possible ligamentous injury
Neurologic deterioration
Preoperative evaluation
Injury type

Cervical spine injury severity score Subaxial cervical injury classification


Four columns Injury morphology
0-5 Rating Neurological status
Discoligamentous complex

<5 5-7 0-3 =4


Nonoperative Either 7 Nonoperative Either 5
treatment Operative treatment Operative Figure 128.5. Flowchart of cervical
classification.

MORPHOLOGIC DESCRIPTIONS Discoligamentous injuries can be more subtle and are


underrecognized. These occur most commonly from hyperex-
Despite limitations of morphologic classification systems, they tension injuries and result in tensile failure of the ALL,
are of value as they are descriptive of most injury patterns. disc annulus, and the posterior longitudinal ligament.
Unfortunately, morphologic descriptions often use mechanistic Morphologically the disc is distracted anteriorly and there may
terms without actual basis, and therefore at times can be con- be small amounts of retrolisthesis of the vertebral body.
fusing. Arbitrarily, we have grouped injuries into categories Occasionally, there will be a small avulsion fracture of the ante-
based on which is commonly thought of as the most injured rior vertebral body that can be confused with the teardrop in a
segment. In reality, most injuries occur globally across all seg- flexion-distraction injury. MRI will demonstrate increased sig-
ments. In each column, injuries may be isolated to that column nal in the disc and failure of the ALL. These injuries occur
and are usually stable, or may be part of a multicolumn injury more commonly in the spondylotic spines where the disc is
and are potentially unstable. most likely narrowed before injury but after is open and not
appreciated as injured. Also, this is a common injury in patients
with ankylosed spines either from inflammatory disease, spon-
ANTERIOR COLUMN dylosis, diffuse idiopathic spinal hyperostosis (DISH), or sur-
Anterior column injuries include any vertebral body fracture or gery. Rarely a patient may have an isolated traumatic disc her-
major injury to the intervertebral disc and annulus, without sig- niation without other skeletal involvement.
nificant facet subluxation. Vertebral body injuries include com-
pression fractures where the anterior body is fractured but the
LATERAL PILLARS
posterior body wall remains intact. Burst fractures are where
the entire body is fractured and radially dispersed. The hall- Injuries that involve primarily the lateral pillars have a wide
mark of a burst fracture is the retropulsion of a fragment of the variety of mechanisms, morphologic patterns, and stability. We
posterior wall into the spinal canal. Both a compression and divide them into fractures of the lateral mass, facet articula-
burst fracture can be associated with varying amounts of poste- tions, and subluxations and dislocations.
rior ligamentous injury. Lateral mass fractures are common injuries resulting from
The flexion-axial loading injury or the so-called teardrop lateral compression or extension. Kotani divided them into
fracture is sometimes confused with a burst fracture. In this four types.8 Type 1 is a fracture separation of the lateral mass.
injury, the body is sheared in a coronal plane leaving an ante- This is caused by ipsilateral fractures of the pedicle and lamina
rior inferior small triangular fragment attached to the caudal creating a free-floating lateral mass. Rotation of the loose lat-
disc (teardrop), and the remaining body is rotated posteriorly eral mass can allow facet subluxation at one or both facet artic-
into the spinal canal. In addition, there is often a significant ulations. Type 2 injuries are severely comminuted fractures of
injury to posterior osseousligamentous complex. the lateral mass and facet articulations. Type 3 is a split type

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Chapter 128 Classification of Cervical Spine Injury 1389

where there is an invagination of the superior facet into a coro- CONCLUSION


nal split fracture in the inferior facet. Type 4 is traumatic spon-
dylolysis where bilateral pedicle fractures separate the posterior Classification systems of subaxial cervical trauma have a broader
element from the body, which may be associated with vertebral impact on the quality of health care delivered to patients. An
subluxation. effective system can reproducibly define the injury to improve
Facet fractures occur to the superior, inferior, or both facets communication between health care providers. A strong system
and may involve varying amounts of the articular surface. Often will also address the clinical status of the patient and provide
they are associated with facet subluxation or dislocation. prognostic information about injury severity and outcomes to
However, even nondisplaced fractures should be viewed suspi- help guide treatment. Overall, a truly effective classification sys-
ciously as progressive instability can occur with these injuries. tem will bring consistency to the evaluation and management
The degree of facet involvement may have a role in prediction of cervical trauma that is, otherwise, severely lacking.
of late displacement. The CSISS and the SLIC system offer a systematic, reproduc-
Unilateral facet dislocations occur in isolation; or with frac- ible means of defining cervical spine trauma. Future investiga-
ture of the facet articulation; or from fracture separation of the tions will help determine the clinical impact of these systems on
lateral mass. These will result in a malrotational and forward slip- trauma care and treatment outcomes.
page of the vertebral body up to 25%. The presence and degree
of subluxation may be related to the amount of associated injury
to the disc and posterior osseous ligamentous complex.
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