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Vaskularni glatki mii kontroliu:

1. simpatiki nervi
2. vaskularni endotel
3. cirkuliui hormoni

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1. Uticaj VNS na tonus glatke muskulature krvnih sudova

e Dilation predominates in situ owing to metabolic autoregulatory mechanisms.

f Over the usual concentration range of physiologically released circulating epinephrine, the
receptor response (vasodilation) predominates in blood vessels of skeletal muscle and liver;
receptor response (vasoconstriction) in blood vessels of other abdominal viscera. The
renal and mesenteric vessels also contain specific dopaminergic receptors whose activation
causes dilation.
h The endothelium of most blood vessels releases NO, which causes vasodilation in response to
muscarinic stimuli. However, these muscarinic receptors are not innervated and respond only
to exogenously added muscarinic agonists in the circulation.
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2. Uloga endotela u kontroli tonusa glatke

muskulature krvnih sudova
Endotel oslobaa razliite vazoaktivne
supstance:
Prostanoide: PGI2 i PGE2 (relaksacija), PGG2 i
PGH2 (kontakcija)
NO (EDRF): relaksacija (posredovana cGMP)
Peptide: endotelin (ET), angiotenzin II
(kontracija), C-natriuretski peptid (relaksacija)
Hiperpolarizirajue faktore poreklom iz
endotela (EDHF) (relaksacija)

Veinavazodilatatornih supstanci (ACh,

bradikinin) i nekolicina lekova deluje preko
NO.
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3. Uloga RAAS u kontroli tonusa ks

Cirkuliui RAAS

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