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Analysis of IGFs and IGFBPs in levels of this IGF in tumor tissue was
tumor compared with plasma not even detectable (ND). IGF-IIE[68-
88] and IGFBP-6 levels inside the
before surgery
tumor are even higher than the
abundance already seen in the patients
Preoperative IGF system proteins
blood before resection. Total IGF-II and
already tend to have extreme values.
IGFBP-3 are both substantially
Analysis of tumor material show in
increased. IGFBP-2 is the only
some cases even more peculiar values,
measured binding protein to be more
as seen in table 2. IGF-I levels in
concentrated in plasma than in tumor
preoperative plasma of the patient are
fluid.
very low (see table 1), however the
Concentration of multiple IGFBPs pmol/mg protein (mean SD) in
in tumor and control tissue control fibroblasts to 0.112 0.021
pmol/mg protein in tumor tissue.
The different IGFBP RIAs have been IGFBP-3 is even more depressed to
used in order to assess changes of approximately 6.5-times in tumor tissue
IGFBP levels in tumor tissue by as opposed to controls. IGFBP-3 levels
comparing them with healthy skin are 6.430 1,82 pmol/mg protein (mean
fibroblast, as shown in figure 1. IGFBP- SD) in fibroblasts but only reach
2 concentrations are 1.6-fold decreased 0.990 0.149 pmol/mg protein in the
in neoplasm tissue, from 0,179 0,061 non beta cell tumor. IGFBP-6 is the
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