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There are two adrenal glands, located one above each kidney. The adrenal
glands are really two endocrine (ductless or hormone producing) glands in
one. The inner part of the adrenal gland produces epinephrine. The absence
of the adrenal medulla and epinephrine does not cause disease. The outer
portion of the adrenal gland, the cortex, is more critical. The adrenal cortex
makes two important steroid hormones, cortisol and aldosterone.
http://www.nadf.us/diseases/addisons.htm#what
Cortisol mobilizes nutrients, modifies the body's response to inflammation,
stimulates the liver to raise the blood sugar, and also helps to control the
amount of water in the body.
Aldosterone regulates salt and water levels which affects blood volume and
blood pressure. Cortisol production is regulated by another hormone,
adrenocorticotrophic hormone (ACTH), made in the pituitary gland which is
located just below the brain.
If the patient is very sick and Addison's disease is suspected, treatment can
be initiated while the diagnostic tests are being done. Once the diagnosis of
Addison's disease is established, an effort should be made to find the cause
by checking for tuberculosis and other infections through skin tests and X-
rays. Tuberculosis (TB), an infection which can destroy the adrenal glands,
accounts for about 20% of cases of primary adrenal insufficiency in
developed countries. When adrenal insufficiency was first identified by Dr.
Thomas Addison in 1849, TB was found at autopsy in 70 to 90% of cases.
As the treatment for TB improved, however, the incidence of adrenal
insufficiency due to TB of the adrenal glands has greatly decreased.
Antibodies to adrenal tissue, especially to 21OH can now be measured, and
are specific to autoimmune Addison’s.
Other lab work may include glucose, nitrogen balance, WBC (decreased),
CRH, BUN (increased), Alb, Mg2+ (increased), HbAlc. Apart from these,
Addison’s disease is diagnosed by the conduction of stimulation tests of
CRH and ACTH.
References
Sylvia Escott-Stump: Nutrition Diagnosis Related Care, 6th Edition, Lippincott-Williams & Wilkins, 2007
http://www.lib.uiowa.edu/HARDIN/md/addisons.html
http://www.nadf.us/diseases/addisons.htm#what
http://www.mayoclinic.com/health/addisons-disease/DS00361