Pathophysiology

Modifiable Factors Non Modifiable Factors

Lack of physical activity Age: 62 years old

Diet: high in fat Gender: Male

Diabetes Mellitus II

Hypertension

Acute Myocardial Infarction

(2009)

ATHEROSCLEROSI

Disrupted atherosclerotic
plaque

Stimulates platelet
aggregation and

Blood flow is obstructed and

Coronary blood supply less than

demand

Decreased Increased
oxygen CO levels

Ischemia of tissue in the region supplied by

the artery

Impaired myocardial
perfusion
Anaerobic Lactic acid
Glycolysis

Myocardial cell death Chest Pain

 Decreased
Altered contractility Myocardial
repolarization of irritability
the myocardium
Increased Dysryth
Elevated ST Myocardial oxygen
requirements

Decreased left
ventricular

Decreased
cardiac

Decreased renal
perfusion

Compensatory
RAAS

ADH

Increased
myocardial
preload and
workload