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gastric juice
About 99% gastric juice mass is water, while
the remaining consists of both organic and
inorganic matter.
The organic matter consists of
Mucins,
Pepsinogens[precursors Of Pepsins]
Gastric Lipase
Intrinsic factor
A trace of lactic acid
The most important inorganic constituent is
HCl.
Other inorganic constituents are
Na+
K+
Phosphate
pH
1.3 to 2.6
Secretion /day
Two to three liters
1. HCI:
(i) lt activates pepsinogen to pepsin.
(ii) It lowers the pH of the gastric juice so that
pepsin can have a favorable pH for digestion of
proteins.
(iii) lt has an antiseptic action which prevents
the growth of microorganisms in the stomach.
When gastric juice is low in HCL
(hypochlorhydria) or when HCI is totally absent
(achlorhydria), there occurs microbial growth
in the stomach as shown by an increased lactic
(iv) It helps in the absorption of iron as it helps
in the release of iron from its bound form in
food ; moreover, it has a role in converting
ferric to ferrous form which is easily absorbed.
(v) When the gastric contents enter the
duodenum, the HCl contained in them
stimulates the release of a hormone namely
secretin into the blood stream.
HCl increase:
Acetylcholine
Histamine
Gastrin
HCl decrease:
Prostaglandin (PG)
Somatostatin
2. Pepsin:
lt is secreted in the inactive zymogen form
called pepsinogen which is initially activated to
pepsin by the HCl present in the gastric juice;
activation occurs rapidly at a pH below 2.