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The project aims to write (create) a synthetic DNA rather than reading a DNA
HGP-Write seeks to reduce the cost of engineering DNA segments
synthetically in the laboratory
Potential applications: Growing transplantable human organs, engineering
cancer resistance, engineering immunity to viruses and accelerating vaccine
& drug development using human cells and organs
Concerns: This project raises concern over the extent to which human life
can or should be engineered. It also raises troubling ethical concerns as this
project has potential of creating children with no biological parents
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HUMAN GENOME PROJECT
The Human Genome Project (HGP) was a large, international and multi-institutional
effort that took 13 years [1990-2003] and $2.7 billion to produce a blueprint of the
sequence of genes and spaces between genes that make up a typical human genome.
In 2016 Human Genome Projectwrite (HGP-write) is now underway to synthesise a
human genome from scratch.
The original HGP was a read in that it used chemicals and instruments to decipher the
genome for the first time.
The new project is to write or build an artificial human genome with sophisticated
bioengineering tools.
The potential benefits of HGP-write to India include providing new solutions to diseases
like malaria, dengue and chikungunya.
The tools, techniques and technologies that are going to be developed through
HGP-write will be universally applicable to all organisms, especially at an
earlier stage for organisms with smaller genomes (for example, viruses),
towards building individual genes and genomes efficiently and in an
inexpensive manner.
USAGE - for eg. sending sterile mosquitoes into the environment, incapable of
producing offspring after mating with their wild type mates and/or by building
pathogen resistance in mosquitoes, both by genome engineering. Results from
the initial experiments following field trials to release sterile mosquitoes have
been very encouraging.
CONCERNS - sterile, genetically-rewritten mosquitoes could create imbalances in
ecological niches and wipe out entire populations of insects. Then there are the
unintended side- effects of releasing modified mosquitoes into the wild, who
which could transfer their genes to non-target species.
The human genome sequence is like a map of the human body. Through this
map, we can tell what leads to what. We can use this map to predict
mutations in the gene, like predicting how a certain person may get a certain
disease. We can predict for instance, who will get the common bipolar disease
or single nuclear polymorphism.
PROJECT - ReAnima
looks for signs of neurological reactivation. Their focus will be on
the upper spinal cord, which is the lowermost part of the brain
stream that controls a persons cardiorespiratory functions
breathing and a beating heart, primarily.
The project is a joint-venture between the Philadelphia-based
biotech company Bioquark Inc, Revita Life Science and Anupam
Hospital in Rudrapur, Uttarakhand.
plans to inject the central nervous system of around 20 brain-
dead people with stem cells and give laser and median nerve
stimulation. These techniques have sometimes revived patients
from coma.
SCIENCE & TECH