Source: http://effbot.org/zone/python-register.

htm

Adding Python Information to the

Windows Registry
February 19, 2003 | Fredrik Lundh

Some Python distributions add information to the Windows registry when installed. This
information is used by certain tools, such as the win32all installer and Windows
installers generated by the distutils (dead link) package.

If youre using an unregistered Python environment, youll usually end up with an

empty list of alternatives on the installers Select Python installation to use screen.

The following script registers the current interpreter. The script should work for Python
2.0 and later.

Note that there can be only one registered interpreter for each major Python release (e.g.
2.0, 2.1, 2,2 etc).

Register a Python Interpreter

#
# script to register Python 2.0 or later for use with win32all
# and other extensions that require Python registry settings
#
# written by Joakim Lw for Secret Labs AB / PythonWare
#
# source:
# http://www.pythonware.com/products/works/articles/regpy20.htm

import sys

from _winreg import *

# tweak as necessary
version = sys.version[:3]
installpath = sys.prefix

regpath = "SOFTWARE\\Python\\Pythoncore\\%s\\" % (version)

installkey = "InstallPath"
pythonkey = "PythonPath"
pythonpath = "%s;%s\\Lib\\;%s\\DLLs\\" % (
installpath, installpath, installpath
)

def RegisterPy():
try:
reg = OpenKey(HKEY_LOCAL_MACHINE, regpath)
except EnvironmentError:
try:
reg = CreateKey(HKEY_LOCAL_MACHINE, regpath)
SetValue(reg, installkey, REG_SZ, installpath)
SetValue(reg, pythonkey, REG_SZ, pythonpath)
CloseKey(reg)
 except:
print "*** Unable to register!"
return
print "--- Python", version, "is now registered!"
return
if (QueryValue(reg, installkey) == installpath and
QueryValue(reg, pythonkey) == pythonpath):
CloseKey(reg)
print "=== Python", version, "is already registered!"
return
CloseKey(reg)
print "*** Unable to register!"
print "*** You probably have another Python installation!"

if __name__ == "__main__":
RegisterPy()

(To download, triple-click on the first line to select the entire script, and copy the text
into your favourite text editor.)

Unregistering the interpreter

If you need to reverse the above, you can add the following function to the script (code
provided by Martin Lamar):

Unregister a Python Interpreter

def UnRegisterPy():
try:
reg = OpenKey(HKEY_LOCAL_MACHINE, regpath)
except EnvironmentError:
print "*** Python not registered?!"
return
try:
DeleteKey(reg, installkey)
DeleteKey(reg, pythonkey)
DeleteKey(HKEY_LOCAL_MACHINE, regpath)
except:
print "*** Unable to un-register!"
else:
print "--- Python", version, "is no longer registered!"