Documente Academic
Documente Profesional
Documente Cultură
Isabel Serrano
Dr. Bruce
15 March 2017
Purpose
Our review aims to compare dDry-eEye dDisease diagnostic techniques and, emphasizeing the
mathematical approaches used to measure optical tear film thicknesses, which is an essential
Introduction
The eyes tear film is composed of three layers: the lipid, aqueous, and mucus layers. Tears
function to provide eyes with moisture and protection (King-Smith, Fink, & Fogt, 1999).
However, dry-eye diseases, such as Dry-Eye Disease, can manifest when a tear shortage exists
(Lu, Wang, Wang, & Shen, 2014). The tear film layers thicknesses influence the rate of tears
evaporation (King-Smith, Fink, & Fogt, 1999). Thus, tear supply is correlated to the layers
thicknesses. Due to this connection, various methods have been developed to measure tear film
invasive techniques, which disturb the tear film, were utilized. However, these disturbances can
interferometric methods, are popularly used as they offer more precise results. The current body
of literature concerning optical film measuring techniques provides a wide range of thickness
Serrano 2
estimates. Due to the lack of consensus, this review aims to compare these techniques in the
Carniglia, C.K. (1978). Scalar scattering theory for multilayer optical coatings. Optical
Purpose: Carniglia introduces two models to measure the surface roughness of the eyes film
layers and identify the layers distinct refractive indices role in scattering light.
Presently, techniques dependent on lights reflection are popularly used to measure the eyes tear
film thickness, as shown in Fogt et al. and Lu et al.s studies. However, scattered light is essential
in accurately converting reflected light values into thickness measurements. While Lu et al.s
work acknowledges the layers varying refractive indices, the study does not account for
scattered light in their calculations. Thus, Carniglias work will be used in our conclusion to
Lu, H., Wang, M.R., Wang, J., & Shen, M. (2014). Tear film measurement by optical
doi:10.1117/1.JBO.19.2.027001.
Purpose: Lu et al. developed a tool to measure film thickness by mathematically translating the
In tracing the evolution of tear film measuring techniques, we will be referring to this studys
methods and comparing them to established measuring tools, namely interferometric techniques.
Notably, Lu et al. do not rely on the effect of wavelengths collisions to interpret film thickness,
distinguishing their approach from Fogt et al.s methods. We will compare the assumptions
surrounding both studies to note underlying discrepancies and report the more effective
methodology.
Fogt, N., King-Smith, P.E., & Tuell, G. (1998). Interferometric measurement of tear film
techniques by broadening the range of wavelengths used to calculate tear film layers
thicknesses.
Our work will highlight this studys methods and contrast them to other measuring techniques. In
particular, we will compare this study to other works that sought to improve interferometric
techniques. In stark contrast to Lu et al. who rely on the amount of light reflected off of the tear
film, Fogt et al. emphasize the reflected light waves oscillations in their film measurements. In
other words, Lu et al. translate the amount of light reflected while Fogt et al. convert the light
waves characteristics into thickness measurements. Overall, we will compare these models and
Mishima, S. (1965). Some physiological aspects of the precorneal tear film. Archives of
Purpose: This work aims to describe the properties of the eyes tear film layers, including the
As our review aims to trace the development of optical film measuring techniques, incorporating
the initial measuring approaches described in Mishimas study is essential in contextualizing the
improvements made in these techniques. Thus, we will reference Mishimas use of invasive
techniques, or methods that disturb the tear film, to demonstrate the improved accuracy in Fogt
Additional Source (Source Cited in the Introduction as it offered general information, but
King-Smith, P.E., Fink, B.A., & Fogt, N. (1999). Three interferometric methods for measuring
the thickness of layers of the tear film. Optometry and Vision Science, 76, 19-32.