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Example:
normal bacteria in the gastrointestinal tract have
beneficial effects, assisting in the production of
vitamins and the breakdown of foods
The Facts!!!!
can produce desirable and undesirable responses
within the host.
Example:
Pathogenic organisms enter the body through oral
ingestion, inhalation, trauma, surgical procedures, or
any body opening, the result is an unwanted host-
pathogen response, termed an infection.
Defenisi
Antimikroba Obat pembasmi mikroba
dapat berasal dr bahan alam termasuk
mikroorganisme maupun hasil sintesis
MIC
(Minumum Inhibit Concentration)
Site of Infection
Enter CSF When Do Not Enter CSF
Readily Enter CSF Inflammation Adequately to Treat
Present Infection
Chloramphenicol Penicillin G Cefazolin
Sulfonamides Ampicillin Cefoxitin
Trimethoprim Piperacillin Erythromycin
Rifampin Oxacillin Clindamycin
Metronidazole Nafcillin Tetracycline
Cefuroxime Gentamicin
Cefotaxime Tobramycin
Ceftriaxone Amikacin
Ceftazidime
Aztreonam
Ciprofloxacin
Vancomycin
Meropenem
Cefepime
Combination
Why???
To treat a life-threatening infection
To treat a polymicrobial infection
Empiric therapy when no one agent is active against potential
pathogens
To achieve synergy (obtain enhanced antibacterial activity)
To prevent the emergence of resistant bacteria
To permit the use of a lower dose of one of the antimicrobial
agents
Bacterial Resistance
Menghambat sintesis
Dinding peptidoglikan
Sel Ex: gol Betalaktam
Mengganggu keutuhan
Membran membran sel
sel Ex: nistatin
Pembagian AM berdasarkan tempat Kerja
Menghambat
Asam sintesis DNA, mRNA
nukleat Ex: Rifampisin
Menghambat
Ribosom sintesis protein
Ex: kloramfenikol
THaNk U
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