Scribd Logo
Încărcați

Bine ați venit la Scribd!

  • Hemostasis Blok Hemato 2015

    Încărcat de

    herry
    11 vizualizări15 pagini
    The document summarizes the major components and mechanisms of hemostasis. It discusses the three primary components: 1) vasoconstriction, 2) platelet activation and the coagulation cascade, and 3) fibrinolysis. It then describes how endothelial cells normally inhibit thrombus formation through multiple mechanisms and secreting factors like prostacyclin and nitric oxide. The coagulation cascade involves the intrinsic and extrinsic pathways leading to thrombin and fibrin formation. Finally, it discusses the fibrinolytic pathway and inhibitors that regulate clot breakdown.

    Descriere originală:

    xfvs

    Drepturi de autor

    © © All Rights Reserved

    Formate disponibile

    PDF, TXT sau citiți online pe Scribd

    Vi se pare util acest document?

    Este necorespunzător acest conținut?

    Raportați acest document
    The document summarizes the major components and mechanisms of hemostasis. It discusses the three primary components: 1) vasoconstriction, 2) platelet activation and the coagulation cascade, and 3) fibrinolysis. It then describes how endothelial cells normally inhibit thrombus formation through multiple mechanisms and secreting factors like prostacyclin and nitric oxide. The coagulation cascade involves the intrinsic and extrinsic pathways leading to thrombin and fibrin formation. Finally, it discusses the fibrinolytic pathway and inhibitors that regulate clot breakdown.

    Drepturi de autor:

    © All Rights Reserved
    Descărcați ca PDF, TXT sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    11 vizualizări15 pagini

    Hemostasis Blok Hemato 2015

    Încărcat de

    herry
    The document summarizes the major components and mechanisms of hemostasis. It discusses the three primary components: 1) vasoconstriction, 2) platelet activation and the coagulation cascade, and 3) fibrinolysis. It then describes how endothelial cells normally inhibit thrombus formation through multiple mechanisms and secreting factors like prostacyclin and nitric oxide. The coagulation cascade involves the intrinsic and extrinsic pathways leading to thrombin and fibrin formation. Finally, it discusses the fibrinolytic pathway and inhibitors that regulate clot breakdown.

    Drepturi de autor:

    © All Rights Reserved
    Descărcați ca PDF, TXT sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    din 15

    HEMOSTASIS

    BIOCHEMISTRY DEPARTMENT
    UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
    Major Components of Hemostasis
    Vasoconstriction (vascular phase)
    Platelet activation

    Coagulation cascade/ antithrombotic control


    mechanisms

    Fibrinolysis
    Endothelial cells normally inhibit thromus
    formation through multiple mechanism:
    1. Secretion of prostacyclin inhibits
    platelet activation and aggregation
    2. Secretion of nitric oxide vasodilates
    and inhibits platelet activation
    aggregation
    3. Expression of heparine sulfate
    activates antithrombin
    4. Thrombomodulin changes thrombins
    affinity away from activation of
    proclotting factors, and toward
    activation of anticoagulants factors
    5. Tissue factor pathway inhibitor
    inhibits the Tf/viiA/Xa complex
    Vasoconstriction reduce blood getting out

    Cells around area send signals


    Nerve reflex

    Myogenic spasm

    Smooth muscle constriction


    Primary
    hemostatic
    mechanism
    Coagulation
    Intrinsic
    and extrinsic pathway (clotting factors), lead to
    prothrombinase (prothrombine activator)
    Prothrombinase and calsium catalyze prothrombine
    thrombine
    Thrombine and calsium acts as an enzyme to convert
    fibrinogen fibrin

    Erythrocyte, platelet, fibrin meshwork stable clot


    Proteins of Blood Coagulation
    A cell-based model of coagulation
    THE FIBRINOLYTIC PATHWAY. Plasminogen is converted enzymatically to plasmin by t-PA or by u-
    PA. Plasmin cleaves fibrin and fibrinogen into fibrin degradation products. Major inhibitors of the
    fibrinolytic pathway are depicted. PAI-1 and PAI-2 inhibit t-PA. Plasmin activity is inhibited by 2-
    AP. Abbreviations: t-PA, tissue plasminogen activator; u-PA, urokinase; PAI-1, plasminogen activator
    inhibitor 1; PAI-2, plas- minogen activator inhibitor 2; 2-AP, 2 antiplasmin. = inhibition
    Screening tests of coagulation and the coagulation parameters
    they measure. Ptt, partial thromboplastin time; pt, prothrombin
    time.

    S-ar putea să vă placă și