DRUG MOA PK CI ADR

Antimonial: Amastigote Absorbed from Stiffness of

SODIUM enzyme reduces M.I. excreted injected
STIBOGLUCONATE pentavalent SB unchanged from muscle
of SSG to toxic urine Sterile
trivalent form abscess
Promotes efflux Pancreatitis
of glutathione Liver and
and exposes it kidney
to oxidative damage
damage But seldom
severe

Diamidine: Interacts with TOXIC causes Acute:

PENTAMIDINE kinetoplast DNA histamine release Fall in BP
and inhibits CVS
topoisomerase collapse
II Dyspnea
Palpitation
Liver
damage

Antifungal : Bind to High toxicity Fever and

Amphotericin B ergosterol and Delivers drug in chills
KETOCONAZOLE forms pores and reticuloendothelial Renal
disrupts cells impairment
membrane Hypotension
function by anemia
leaking
electrolyte and
leads to cell
death
PAROMOMYCIN Aminoglycosidic G.I distress
antibiotic Unabsorbed from diarrhea
Causes leakage G.I.
on cell
membrane of
leishmania

DRUGS FOR FILARIASIS Targets Does not cross In Fever

glutamate gated BBB meningitis Headache
IVERMECTIN cl channel Given oral patient as Dizziness
receptors BBB more somnolence
Enhanced cl permeable
influx
Leads to Pregnancy
paralysis of
worm
DIETHYLCARBAMAZINE Immobilize Rapidly absorbs Urinary Malaise
microfilariae Oral alkalosis Rash
And render administration Renal Myalgia
them Excreted in urine impairment athralgia
susceptible to may
host defense require
mechanism drug
reduction