Aspirin

Chemistry
Final Project

By: Nattanicha Siamnikorn 1106

Teacher
Patraphorn Sanguansat

Mahidol University International

Demonstration School
Purposes & Application
Aspirin or Acetylsalicylic acid is one of the type of drugs
used to treat patients who suffering from pain. This painkiller
drug will relieve mild to moderate pain as well as treat cancer
diagnosis such as colon cancer and breast cancer. Aspirin is a
Nonsteroidal Anti-inflammatory Drug and Platelet Aggregation
Inhibitor. It is well-known as a personal care product which
usually consumed by tablets. [1] However, by consuming
regular aspirin over a 15-year period would lead to an absolute
increase in major bleeding events of between 0.16% and
0.81%. Not only healing pain but aspirin can prevent the
development of cancer if the person consume 600 mg of aspirin
a day up to four years will prevent colorectal and other cancers
associated with Lynch syndrome (a hereditary condition which
predisposes to cancer development). [2]
Chemical & Physical Properties [1]

Property Name Property Value

Molecular Weight 180.159 g/mol
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 3
Complexity 212
Topological Polar Surface Area 63.6 A^2
Monoisotopic Mass 180.042 g/mol
Exact Mass 180.042 g/mol
XLogP3 1.2
Compound Is Canonicalized True
Formal Charge 0
Heavy Atom Court 13
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Isotope Atom Count 0
Covalently-Bonded Unit Count 1

References
[1]
Aspirin. (2004, September 16). Retrieved May 22, 2017, from
https://pubchem.ncbi.nlm.nih.gov/compound/aspirin#section=Chemical-Vendors

[2]
Robman, L. (2017, June). Age-related macular degeneration in a randomized controlled trial
of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Retrieved May
22, 2017, from http://www.sciencedirect.com/science/article/pii/S2451865416301156