5/13/2017 USMLE World pharmacology (uworld pharm) Flashcards | Memorang

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What can be used to prevent

Leucovorin (folinic acid)--converted into THF
methotrexate toxicity?

what degrades 6-mercaptopurine? xanthine oxidase

how do you acquire resistance to

mutations in DNA gyrase
uoroquinolones?

transfer actyl/adenyl/phosphate groups onto

how do you acquire resistance of
aminoglycoside to inhibit binding to ribosomal
aminoglycosides?
subunits

what to drugs that are metabolized by

lupus-like syndrome
n-acetylation put you at risk for?

which antiviral drug does not require

foscarnet
intracellular activation by kinases?

what is given for n. gonnorhea? ceftriaxone

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inhibit tubulin polymerization (reduces neutrophil

what the mechanism of colchicine
Search chemotaxis)
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what is the adverse e ect of

Create diarrhea
colchicine?
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what muscle relaxant cannot be depolarizing NMJ blockers such as succinylcholine

Favorites reversed by anticholinesterase
agents? (can't be reversed)

Playlists what type of muscle relaxant is used depolarizing NMJ blockers such as succhinylcholine -
for rapid induction? rapid induction

Power-Ups what anti- u drug prevents virion

particle release/neuraminidase
(/marketplace/) oseltamivir
inhibitor?

what anti- u drug prevents uncoating? amantidine

what comes rst in rx of gouty

nsaids
arthritis?

which methods of drug administration

IV, sublingual and rectal administration
bypass rst pass metabolism?

what is suggested by frequent

urination, suprapubic pain, dysuria and hemorrhagic cystitis due to clyclophosphamide
hematuria after chemotherapy?

what is used to prevent hemmorhagic

mesna
cystitis

what is the mechanism of

trimethoprim, methotrexate and inhibit dihydrofolate reductase
pyrimethamine?

what antibiotic binds to PBPs and can

be used with cilastatin to prevent imipenem
renal metabolism?

what antiemetic blocks 5-HT3 and be

odansetron
used after chemo?

what is an example of a TNFalpha

etanercept, in ixamab, andalimumab
inhibitor used in RA?

what needs to be checked before

PPD skin test
starting etanercept rx?

which HIV drugs cause lipodystrophy,

hyperglycemia and inhibition of protease inhibitors such as inidavir
cytochrome p450?

what HIV drug causes bone marrow

zidovudine (NRTI)
toxicity?

what causes medication induced fat

HAART and glucocorticoids
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5/13/2017 USMLE World pharmacology (uworld pharm) Flashcards | Memorang
what causes medication induced fat
HAART and glucocorticoids
redistribution?
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what drug is an estrogen agonist in

raloxifene
bone and antagnoist in breast?

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what is meant by bacteroid? gram - anaerboe

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(/create/)
what drug is a ected by acetylation
isoniazid
variation?
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what induces single strand breaks? topoisomerase I

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what induced double strand breaks? topoisomerase II

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what is used to chelate copper? panicillamine

what is used to chelate lead? dimercaprol and EDTA

what is used to chelate iron? deferoxamine

what is used to treat cirrhosis-related

lactulose
hepatic encephalopathy?

what is an example of a beta lactamse

inhibitor that can be used clauvonic acid, sulbactam, tazobactam
concamitantly with penicillins?

what is the main side e ect of

neurotoxicity-numbness and tingling in ngers
vincristine?

what part of the cell cycle does

mitosis (microtubule inhibitor)
vincristine inhibit?

what anti-protozoal drug causes

metronidazole
disulfram like reaction?

what is used to treat post-op urinary

bethanechol (muscarinic agonist)
retention?

what should CMV retinitis be treated

ganciclovir
with?

what might muscle weakness and

hypokalemia
cramping suggest?

what chemotherapy drug works by

cisplatin
DNA crosslinking?

what is the primary toxicity of

nephrotoxicity
cisplatin?

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what can be taken to prevent cisplatin
amifostine
induced nephrotociviity?

Search what does colchicine inhibit? neutrophil chemotaxis

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Create what kinds of drugs have can be

(/create/) highly lipophilic with high volume of distribution
cleared by liver?

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what is a side e ect of many
liver toxicity
hypolipidemics, especially statins?

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what are bisphosphonates analogs of? pyrophosphate

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