HISTOLOGY OF

THE GASTRO-
INTESTINAL
TRACT
Part 2: Colon

Kriziaoumo P. Orpia, RMT, MED-1C

Batch 2018
COLON: Division

MUCOSA

SUBMUCOSA

MUSCULARIS EXTERNA
 PLATE 1: Mucosa
GOBLET CELLS LAMINA PROPRIA
GLANDS OF LIEBERKUHN

MUCOSA

SUBMUCOSA

MUSCULARIS MUCOSAE
 Glands of Lieberkuhn

Lamina propia

LYMPH NODULE
Goblet cells and
Colonocytes

LYMPH
NODULE

Muscularis
mucosae
Lamina propria
Arterial Vessels

submucosa
APPENDIX
 APPENDIX
Muc- mucosa
Submuc- submucosa
LN LN- Lymph nodule
Gc
ME- Muscularis Externa
Gc- Germinal Center

Muc Submuc
en
ME
Lu m

LN
Gc

LN
Gc
TEST: Identify:

1.
2. 1
3.
4.
5.
5

4
TEST: Identify:
1. Germinal Center
2. Crypt of Langerhan/Mucosa Layer
3. Lymph Nodule
4. Muscularis Externa
5. Submucosa
1

4
Netters Histology

1. Mesoappendix
2. Lumen
3.Lymph nodule
4. Germinal Center
5. Intestinal Crypt
6. Adipose tissue
7. Muscularis mucosae
Recto-Anal Junction
Notice the Shift from Columnar to Stratified
Squamous tissue:
Vascular MUCOSA
Intestinal glands
Rich in blood vessels

ANAL REGION
RECTAL REGION
Netters Histology Card

4. Lumen of
Rectum
5. Goblet Cells
6.Stratified
Squamous tissue
of anal canal
7. Lymph nodule
ASSOCIATE ORGANS OF THE
DIGESTIVE SYSTEM
PANCREAS
Black Arrow: Islets of Langerhans (ENDOCRINE GLANDS
RED ARROW- Islets of Langerhans (ENDOCRINE GLANDS)
BLUE ARROW- acini(Acinar cells (peri) and Centroacinar Cells (central
 IL- Islets of Langerhans
CA- Centroacinar Cells
CT- Connective Tissue Septa
AC- Acinus
Try it yourself
ENDOCRINE PANCREAS:

Resembles the parotid gland

Contains ZYMOGEN GRANULES
Contains various pancreatic enzymes
Unlike the PAROTID, it does not have STRIATED DUCT
Secretion is controlled by Cholecystokinin (Acinar) and Secretin
(Ductal) as well as Acetylcholine (from the ENS)
 Cells of the Islets
Cell Type Percent Product Mallory Azons Stain

Alpha 15-20% Glucagon RED

Beta 60-70% Insulin BROWNISH
Delta 5-10% Somatostatin BLUE

Minor Cell Types of the Pancreatic Islets

Cell Type % Product -

PP - Pancreatic Polypeptide -

Vasoactive Intestinal
D1 - Peptide (VIP)
-

Secretin, Motilin,
EC - Substance P
-

Epsilon - Ghrelin -
G-cell Gastrin -
ZYMOGEN GRANULE CONTENTS

PROTEOLYTIC ENDOPEPTIDASE
Trypsinogen
Chymotrypsinogen
PROTEOLYTIC EXOPEPTIDASE
Procarboxypeptidase
Proaminopeptidase
AMYLOLYTIC ENZYME
LIPASE
NUCLEOLYTIC ENZYMES
LIVER
2015-3-25
THE PORTAL AREA:

KpoRMT
VivaMedisina2018
Pointed: Hepatic Artery Branch (Arteriole)

BD

PV

KpovRMT
VivaMedisina2018
BILE DUCT (Pointed Structure)

PV
HA

KpoRMT
VivaMedisina2018
Portal Vein

KpoRMT
VivaMedisina2018

Portal Vein
Kupffer Cell
Identify (SLU Slide 20):

KpoRMT
VivaMedisina2018
 KpoRMT

Identify: (SLIDE 20) VivaMedisina2018

PORTAL LOBULE
Portal
Area

Portal
Area

Portal
Area

Central Vein

HEPATIC ACINUS

CLASSIC LOBULE Portal

Area Portal
Area
C: central venule
A: arteriole
D: Bile Duct
V: Venule
Identify Structures:
BD: Bile Duct
CT: Connective Tissue
CV: Central Vein
HA: Hepatic Artery
HV: Hepatic Vein
L: Lymphatic nodule
PV: Portal Vein
*: blood sinusoids
---: approximates the limit
of a lobule
CLINICAL CORRELATION:
GALLBLADDER
 GALL BLADDER:
LP: Lamina Propria
M: Muscularis
A: Adventitia
arrows: simple columnar
epithelium
ROKITANSKY-ASCHOFF
SINUSES
Gall Bladder (s20):
identify Structures

KpoRMT
VivaMedisina2018
 More Ways Than One

To you, more ways than one

You feed me with those curves from your smile
You look at me with those oh submissive eyes
You make me high, you make me run
You make me sing, you make problems fit in a bun
You make me happy until the setting of a rising sun
You make my heart melt, in more ways than one
Ill keep saying this, over and over
You are special, Till the last cell of my body lyse
and the end of forever

-Kriziaoumo Orpia, RMT, MED 1C

HAPPY REVIEWING!!
References

Junqueiras Basic Histology Text and Atlas by Anthony Mescher 12th

Edition
Histology A Text and Atlas Histology by Ross 6th Edition
Bloom and Fawcetts Histology
Practical Illustrated Histology by Radcliffe
Lippincotts Atlas to Histology by Dongmei Cui
diFiores Atlas to Histology with Clinical Correlations

SLIDE BOX 20