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ABSTRACT
Background: Silver diamine fluoride (SDF) is approved by the Food and Drug
Administration for the reduction of dentinal hypersensitivity, and has been shown to
prevent and arrest caries. While dental hygienists (DHs) are licensed to use SDF in
patient care, their knowledge, attitudes, and behaviors regarding use of SDF are
unknown.
Purpose: To assess DHs knowledge, attitudes, and behaviors regarding the use of SDF
during patient care for caries management in the United States (US).
Methods: The study used a cross-sectional and quantitative, email distributed survey of
a random sample of 10,000 licensed US dental hygienists in the American Dental
Hygienists Association member database. The 57-item questionnaire assessed DHs
knowledge, attitudes, and behaviors about the use of SDF in patient care. Responses
were analyzed using frequencies (percentages), chi-square tests, and analysis of
variance to describe and determine significant differences between groups of responses
using Qualtrics and SAS software.
Results: 1219 completed the survey for a 12% response rate. Knowledge: Over half of
the respondents (55%) were familiar with SDF use in patient care and 91-98% were
knowledgeable regarding SDFs mechanism of action and use for caries arrest. Attitudes:
77% agreed that application of SDF lies within the scope of DH practice, and 83% agreed
that the advantages of SDF outweigh the disadvantages. Behaviors: Majority (86%)
reported the likelihood of recommending SDF for caries arrest, but 75-88% have not
used SDF primarily because they do not have SDF available in their employment setting.
Conclusion: The knowledge among dental hygienists regarding use of SDF in patient
care was inconsistent. Although many think highly of the variety of benefits that SDF can
provide, the use of SDF is still lacking.
This study supports the NDHRA priority area, Clinic Level: Basic science (new therapies
and prevention modalities).
1
INTRODUCTION
Dental caries is one of most prevalent and chronic oral diseases spreading across
our globe.1 According to the Centers for Disease Control and Prevention (CDC), the
prevalence of untreated caries for children ages 5 through 19 is 17.5% and 27.4% for
adults between the ages of 20 and 44.2 CDC also reported that one in five adults aged 65
and older have untreated caries.3 Traditionally, management of a carious lesion has
access to care has been difficult for certain populations.4 Fortunately, dental caries are
highly preventable with use of fluoride treatments, which help decrease acid solubility,
aid in the remineralization of tooth structure, and inhibit bacterial enzyme activity. 1,4,6
Many fluoride products are effective at the superficial layer of the tooth, but few have
shown efficacy once the caries advance into the dentin layer.7 A potential solution exists
in the use of silver diamine fluoride (SDF), an inexpensive topical medicament that has
the ability to arrest the caries process and simultaneously prevent the formation of new
SDF has been widely used to treat caries in Japan and other countries for over 80
years.4-6 In August 2014, the Food and Drug Administration (FDA) approved the first 38%
SDF product for reducing tooth sensitivity in the United States (US).5 Its off label use is
being promoted for caries arrest and prevention.5 Many clinical studies have shown the
2
root caries in the geriatric population.12-13,16 Systematic reviews of clinical trials on
children and elderly adults reveal SDF is highly effective in arresting dentin caries when
applied every 6 months for a period of 2 to 3 years.9 While these clinical trials have
shown a successful arrest rate with bi-annual applications, some trials suggested that
annual applications proved to be just as effective.13,16 One major drawback to use of SDF
is the appearance of black stains on the treated carious lesion which may cause esthetic
concerns.9
With the recent growing promotion of SDF among the dental professional
community in the US, it is uncertain how dental hygienists will adopt its use in their
patient care. Their knowledge, attitudes, and behaviors surrounding its use are also
unknown. However, dental care professionals, i.e., dental hygienists (DH), are equipped
with the knowledge and skills to perform and teach best practices to achieve optimal
oral health and to stop the progression of dental caries.9 Since SDF is cleared as a topical
agent, DH may apply it in accordance with their current licensed duties once a dentist
provides a diagnosis of caries or, in the treatment plan, indicates its use as a preventive
measure.9-10
After conducting an exhaustive search using the following search engines and
key search terms: PubMed for silver diamine fluoride AND dental hygienist or
dental assistant AND (silver diamine fluoride/exp OR silver diamine fluoride), and
3
Cochrane for silver diamine fluoride, no references were found regarding studies of
dental hygienists knowledge, attitudes, and behaviors of the use of SDF in patient care.
and behaviors of the use of SDF for caries management using an online survey.
Therefore, the research questions asked for more specific information regarding: (1)
DHs knowledge about SDF in patient care in terms of familiarity, knowledge sources,
and indication for use, (2) DHs attitudes about the use of SDF in patient care in terms of
scope of practice, types of patients, advantages and disadvantages, and (3) DHs
behaviors toward the use of SDF in their practice in terms of recommendations and
frequency of use.
4
METHODS
The target study population consisted of licensed DHs working as clinicians in the
US. A sample of 10,000 participants was randomly selected from a population of 35,000
DHs in the American Dental Hygienists Association (ADHA) email database. Assuming a
10% response rate, a sample size of 1,000 respondents was estimated to be adequate
for determining statistical significance, based on the conservative expectation that 50%
of the DHs will not have familiarity with the use of SDF in patient care.17 Participants
who reported they had never heard of SDF were excluded. The ADHA approved and
the Master of Science in Dental Hygiene program and 1 dentist currently studying SDF at
UCSF for acceptability and feasibility. Following this feedback, the survey was modified
ADHA to potential respondents using email addresses acquired from the ADHA member
database. The invitation described the purpose of the study and provided information
for giving informed consent as well as links to the survey instrument. The email also
Access to the survey was accomplished by selecting the Yes box, indicating participant
5
consent. Follow-up email messages were sent at 3, 25, and 31 days to encourage non-
responders to participate.18
and behaviors of DHs concerning use of SDF for caries management was accomplished
by creation of a 57-item survey which addressed the following areas: the knowledge of
DHs concerning various uses of SDF in patient care (12 items), the attitudes of DHs
regarding uses of SDF for patient care (16 items), what recommendations concerning
SDF are DHs giving patients and, if DHs are using SDF, what purposes are being satisfied
with its use (9 items), and lastly, the demographic and practice-related characteristics of
the respondents (20 questions). The survey was distributed using Qualtrics, a web-based
qualifying item (2 questions); 5-point fixed Likert scale items (24 questions);
dichotomous items, with 4 true and false and 7 yes and no items (11 questions);
and demographic items (21 questions). The scales of measurement included nominal,
Knowledge of SDF in patient care was addressed by questions asking about the
participants familiarity with using SDF in patient care, what sources the participant had
used to gain knowledge of SDF, and whether the participant knew SDFs mechanism of
Concerning the participants attitudes about the use of SDF, the survey asked the
participants whether they believed that SDF is within their scope of practice, that SDF
6
can enhance the oral health of various types of patients, that SDF provides advantages
for patients when they accept SDF as a treatment, that disadvantages would prevent
patients from accepting SDF for treatment, and whether the advantages of SDF
recommending SDF treatments for patients, participants use of SDF for its 3 indications
in the last year, and if participants have SDF in their employment setting.
state(s) in which he/she was licensed to practice in the past 6 months, approximate age
group of the patients he or she treated during the last 6 months, average hours of
clinical practice per week during the last 6 months, and the types of DH license held by
participant.
QualtricsTM and the SAS Software were used to tabulate the responses and
calculate the response frequency for each survey item. Chi-square analysis was
statistically significant when P-values was less than or equal to 0.05. Lastly, Analysis of
variance (ANOVA) was conducted to compare the selected demographic and practice-
7
related characteristics of dental hygienists and their responses for the knowledge
variable.
8
RESULTS
The results are derived from a random sample of 10,000 dental hygienists
working in the US and with email addresses in ADHAs member database. The online
survey was completed by 1,219 dental hygienists, resulting in a 12% response rate.
The age range for almost half (49%) of the respondents was 50-64. Fifty-three
percent also graduated from their respective dental hygiene program in 1994 or earlier
and more than half (58%) have been licensed for over 20 years. The highest dental
hygiene degree reported was 38-39% for an Associate or Bachelor degree and 22% for a
Masters degree. In addition to having an RDH license, 4% were also licensed for
alternative practice (RDHAP) and 3% for extended functions (RDHEF). The majority of
respondents (59%) were employed in private practice, and the remaining respondents
independently. The region where the respondent was licensed to practice was
distributed similarly, (20-29%) among four regions in the US: Northeast, Midwest, South,
and West. The majority of respondents (76-91%) treated a wide age range of patients
aged from infancy to 65 years and older (Results not shown). The average hours of
patient care practiced by the respondents during the last 6 months were also
distributed similarly (31-39%) among three categories: 1-16 hours, 17-32 hours, and
9
Approximately half (55%) of the respondents were familiar with the use of SDF in
patient care while 29% have heard of SDF, but were uncertain of its use in patient care
(Table II). The respondents who reported, never heard of SDF (16%) were excluded
from the rest of the questionnaire. There were no significant relationships found when
comparing the respondents familiarity with SDF by regions of the US (Results not
shown). Among the other responses concerning knowledge of SDF, the majority (91-
98%) answered correctly when asked about the mechanism of action and its use for
caries arrest. The remaining respondents (33-43%) did not have knowledge concerning
its indication for dentinal hypersensitivity or prevention of caries (Table III). We found a
significant relationship (p <0.01) between when the graduation year and knowledge of
SDF (Table IV). No significant relationships were found when comparing any other
given 9 sources of dental information and developments to choose from and asked
which had provided them with their knowledge concerning SDF (Table V): the 3 most
statements on the use of SDF using a Likert scale. Three-fourths (77%) strongly agreed
or agreed that the application of SDF was within their scope of practice (Table VI). There
were no significant relationships found when comparing any other demographic and
strongly agreed or agreed that SDF treatment could enhance the oral health of the
10
following patient types: geriatric patients, patients living in undeserved areas, patients
with disabilities that reduce their capacity for oral self-care, pediatric patients with
challenges, patients with low income, patients with advanced carious lesions that
cannot be treated in one appointment, and patients with high dental anxiety (Table VII).
settings (85-98%) had a greater percentage of agreement that SDF could enhance the
oral health of various types of patients than any other employment settings (74-97%)
(Results not shown). Among the perceived advantages of SDF, 86-95% of respondents
strongly agreed or agreed that SDF is less expensive than restorative treatment, more
time efficient, and can be an alternative to arrest caries without using a dental drill
(Table VIII). Ninety-five percent of respondents reported the most frequent advantage
of SDF was not requiring the use of local anesthesia. When reporting on the greatest
SDFs property of staining a carious lesion black, patients lack of knowledge of SDF, and
the multiple visits recommended for re-applications (Table IX). Although respondents
reported a high level of agreement with the disadvantages of SDF, 83% strongly agreed
use of SDF using a Likert scale and a multiple-choice question. Among the 3 indications
for treatment with SDF, 86% of respondents were extremely likely or likely to
recommend SDF for arresting caries (Table XI). In comparing respondents likelihood of
recommending SDF with various employment settings, (64-67%) were extremely likely
11
to recommend for arresting caries in the independent, public health or government, and
other employment groups (Table XII). Less than half (45-46%) of respondents were
found (Results not shown). The majority of respondents (75-88%) have not reported use
of SDF for any of the indicated treatments of caries arrest, caries prevention, and
treatment of dentinal hypersensitivity in the past year (Table XIII). Overall, 72% of
respondents do not have SDF at their current employment setting (Table XIV). A
significant relationship exists when examining the presence of SDF in the employment
12
DISCUSSION
This study indicated that approximately half of the respondents were unfamiliar
with SDF and its use in patient care. This is not surprising since SDF was recognized as a
new chemotherapeutic option for caries management in recent years, but was not
commercially available in the US until 20155. Before SDFs approval in the US, it was
used extensively in other countries such as Japan, Australia, and Argentina for caries
prevention, and the value of silver ions in the treatment of dental caries has been
regarding SDFs indication for caries arrest, two-fifths did not have such knowledge
concerning its indication for caries prevention. One may speculate that respondents are
already familiar with other preventive interventions, e.g., daily 225-800 ppm fluoride
rinse, chlorhexidine, and fluoride varnish that are commonly used in the US for
preventing caries. Consider also that half of the respondents are employed in private
practice, where SDF is not available to them, according to their responses. This is
unfortunate, since studies show that SDF has always been more effective in preventing
caries compared to other preventive interventions for populations that are at greater
caries risk19.
Dentist and dental hygienists may not always agree on who is ultimately
responsible for the application of SDF. Although the majority of respondents agreed that
the application of SDF is within their DH scope of practice, one fourth did not.
Respondents who may be uncertain about their DH duties may need to examine their
13
states dental board regulations to determine which dental providers can lawfully place
SDF.20. In addition, the term to arrest caries may raise concerns since dental hygienists
may see their primary role as preventive rather than treatment-based. The diagnosis of
a caries is also not in DH scope of practice and therefore, a dentist must evaluate if SDF
would consider accepting SDF treatment for a number of reasons. First, SDF does not
require the use of local anesthesia and can be an alternative to arrest caries without
using a dental drill to place a restoration. Individuals with dental phobia will typically
avoid dental treatments based upon a fear of dental injections and dental drills. 21 Since
SDF is applied like a varnish when indicated, however, there is no need for local
anesthesia or use of a drill. Secondly, SDF is less expensive than a restorative treatment.
Although preventive measures such as SDF incur some cost, the cost may be
reduce the future need for more aggressive and more costly restorative measures.
cavities in their molars between ages 7 and 12 will require more than $1,000 in services
treatment, a bottle (8 mL) of SDF will only cost the provider $149.00. One bottle has
approximately 250 drops, which is sufficient to treat 125 sites with a site defined as up
to 5 teeth.23 And, in January 2016, the current dental terminology (CDT) billing code
14
1354 for interim caries arresting medicament application became active and Medicaid
In contrast, the majority of respondents also agreed that the greatest perceived
disadvantage that would prevent patients from accepting SDF treatment for dental
caries was SDFs property of black staining on a carious lesion. However, the advantages
of SDF may outweigh the disadvantages. In a 2017 survey, parents of children at New
York University Pediatric Dentistry Clinic and several private clinics in New Jersey
reported that SDF staining on posterior teeth was more acceptable than on the anterior
parents preferred this option over the use of advanced behavioral techniques such as
SDF do not practice with it. This is not surprising since half of the respondents are
employed in private practice and their employer might not be familiar with SDF or
accept the efficacy of SDF treatment. In this study, more than 70% of respondents
reported not having SDF available where they practice dental hygiene.
and 1 dentist studying SDF at UCSF to access questionnaire acceptability and feasibility.
To the best of our knowledge, this may be the first study to assess DHs knowledge,
This study may be limited and may not be generalized to all US dental hygienists
based on the 12% response rate. Given that only 12% of the total population responded
15
to the survey, it is possible that response bias has skewed the results unfavorably
against the use of SDF. Of the 88% of non-respondents, there could be a stronger
population of DH who believe in the positive effects of SDF. The exclusion of participants
who Never heard of SDF may be another limitation to our study. These participants
could possibly have provided us with valuable data and insight to our study. Lastly, some
terms may have been ambiguous and affected the results. For example, separating the
clarity. Respondents who work in a public health setting may not be employed in
governmental work.
16
CONCLUSION
Results of this study suggest that the knowledge surrounding the use of SDF in
patient treatment and care was inconsistent among a large sector of practicing dental
oral preventive care to the community. This knowledge can be obtained by reading
journal articles related to the topic or by attending continuing education courses. Most
respondents did agree to the substantial benefits SDF can offer to variety of patients
with different types of challenges; however, the reason for SDFs lack of use in practice
is still unclear. Further studies may need to address potential barriers that may prevent
DH from implementing SDF, but to also consider the employers interest of offering SDF
in their practice.
17
REFERENCE
1. Petersen PE, Ogawa H. Prevention of dental caries through the use of fluoride-the
2. CDC: Untreated Dental Caries (Cavities) in Children Ages 5-19 and in Adults Ages 20-
44, United States [Internet]. Centers for Disease Control and Prevention;
https://www.cdc.gov/features/dsuntreatedcavitieskids/
3. Dye BA, Thornton-Evans G, Li X, Iafolla TJ. Dental caries and tooth loss in adults in
the United States, 2011-2012. NCHS data brief, no 197. Hyattsville, MD: National
5. Horst JA, Ellenikiotis H, Milgrom PM, UCSF Silver Caries Arrest Committee. UCSF
protocol for caries arrest using silver diamine fluoride: rationale, indications and
8. Duffin S. Back to the future: the medical management of caries introduction. J Calif
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Dent Assoc. 2012; 40(11):852858.
10. The California Dental HygienistS Association Promotes The Use Of Silver Diamine
Fluoride As A Means To Halt Decay And Treat Dentinal Hypersensitivity. 1st ed.
11. Gao SS, Zhao IS, Hiraishi N, Duangthip D, Mei ML, Lo ECM, Chu CH. Clinical trials
12. Li R, Lo EC, Liu BY, Wong MC, Chu CH. Randomized clinical trial on arresting
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prevent and arrest root caries among community-dwelling elders. Caries Res
2013;47(4):284-90.
14. Llodra JC, Rodriguez A, Ferrer B, et al. Efficacy of silver diamine fluoride for caries
15. Gao SS, Zhang S, Mei ML, Lo EC, and Chu CH. Caries remineralisation and
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16. Tan HP, Lo EC, Dyson JE, Luo Y, Corbet EF. A randomized trial on root caries
17. Salant, P., & Dillman, D. A. (1994). How to conduct your own survey. New
York: Wiley.
18. Dillman DA, Smyth JD, Christian LM. Internet, phone, mail, and mixed-mode
surveys: the tailored design method. John Wiley & Sons; 2014 Aug 6.
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2016;14(07):61-64.
UK specialist unit for dental phobia and outcomes of treatment. Br Dent J. 2015
Nov 27;219(10):501-6.
22. Dental Dental Insurance. The true cost of a cavity. [Internet]. Available from:
https://www.deltadentalins.com/about/community/cavity-cost.html
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http://www.elevateoralcare.com/dentist/AdvantageArrest/Advantage-Arrest-
Silver-Diamine-Fluoride-38
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24. Crystal YO, Janal MN, Hamilton DS, Niederman R. Parental perceptions and
acceptance of silver diamine fluoride staining. J Am Dent Assoc. 2017 Apr 27. pii:
S0002-8177(17)30273-8.
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DATA TABLES
Practice-related Characteristics
Year graduated from dental hygiene program (N=941)
1994 or earlier 495 (53)
1995 - 2005 202 (22)
2006 - 2011 119 (13)
2012 or later 125 (13)
22
Independent 42 (5)
Other^ 100 (11)
Percentages may not add up to 100 due to rounding
*Participant may select more than one
^Other includes: retired, corporate, volunteer, sales, assisted living facility, research
Note: Northeast Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island,
Vermont, Delaware, New Jersey, New York, Pennsylvania; Midwest - Illinois, Indiana,
Michigan, Ohio, Wisconsin, Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota,
South Dakota; South - Florida, Georgia, Maryland, North Carolina, South Carolina, West
Virginia, Alabama, Kentucky, Mississippi, Tennessee, Arkansas, Louisiana, Oklahoma,
Texas; West - Arizona, Colorado, Idaho, Nevada, New Mexico, Utah, Wyoming, Alaska,
California, Hawaii, Oregon, Washington
23
Knowledge Results.
Table II: Respondents familiarity of silver diamine fluoride
Heard of SDF but unsure of its uses in patient care 354 (29)
Table III: Responses to true statements regarding knowledge of silver diamine fluoride
24
Table IV: Differences in the mean sample score of correct knowledge statements by the
year graduated from the dental hygiene program
Respondents knowledge
scores regarding SDF
Year graduated from Mean Std Dev
DH program
P-value 0.0099
Percentages may not add up to 100 due to rounding
SDF silver diamine fluoride
BOLD significant differences between groups (p< 0.05)
25
Table V: Respondents sources of knowledge about silver diamine fluoride
26
Attitude Results.
Table VI: Respondents level of agreement towards their scope of practice
Table VII: Respondents level of agreement towards silver diamine fluoride treatment
Challenging pediatric patients 669 (70) 213 (22) 60 (6) 13 (1) 7 (1)
(N=962)
Patients with low income 657 (68) 227 (24) 63 (7) 8 (1) 7 (1)
(N=962)
Patients with high dental 512 (53) 213 (22) 193 (20) 30 (3) 13 (1)
anxiety (N=961)
Percentages may not add up to 100 due to rounding
SDF silver diamine fluoride
27
Table VIII: Respondents level of agreement to whether they agree to the advantages of
silver diamine fluoride
28
Table IX: Respondents level of agreement to whether they agree to the disadvantages
of silver diamine fluoride
Patients lack of knowledge about 333 (35) 403 (43) 126 (13) 75 (8) 9 (1)
SDF (N=946)
Table X: Respondents level of agreement that the advantages of silver diamine fluoride
outweigh the disadvantages.
The advantages of
SDF outweigh the 443 (47) 342 (36) 143 (15) 17 (2) 4 (<1)
disadvantages (N=949)
Percentages may not add up to 100 due to rounding
SDF silver diamine fluoride
29
Behavior Results.
Table XI: Respondents degree of likelihood of recommending silver diamine fluoride to
patients for the following treatments.
Dental hypersensitivity 129 (14) 278 (31) 227 (25) 191 (21) 69 (8)
(N= 894)
Percentages may not add up to 100 due to rounding
SDF silver diamine fluoride
30
Table XII: Respondents likelihood of recommending silver diamine fluoride by
employment setting
31
Table XIII: Respondents reported behavior towards the use of silver diamine fluoride in
the past year
Table XIV: Respondents response to having silver diamine fluoride present at their
employment setting
32
Table XV: Respondents response to having silver diamine fluoride present at their
office/work setting by state regions
33