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B. LEVELS OF LIFE **"The human embryo has, therefore, from the very beginning,
1. Plant Life (Vegetative Life) the dignity proper to a person." (from Dignitas Personae, 2008)
Characteristics common to all living beings:
Organism II. Stages of Life in Embryo
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o Individual can distinguish a certain organism as A. EMBRYONIC PERIOD (from conception to 8 week)
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different from another 1. Early embryo: Pre-organogenic Phase (1 2 weeks)
o Integrated
Responsiveness Week 1:
o Responds to external stimuli Includes fertilization, cleavage & morulation, blastocyst
o Easy to see in animals but less apparent in plants formation, implantation
but still present (ex. sunlight heliotropism) Ovulation
Growth not stagnant, there is an ongoing process o Ovum comes out of the ovary and is caught by the
Reproduction for the continuation of species fallopian tube.
Fertilization
2. Animal Life o Occurs at the fallopian tube during the first 12-24
Characteristics: all of the above, plus: hours
Mobility ability to move Cleavage/mitosis
Moderate intellect, concrete thinking o Form morula by the time the fertilized zygote reaches
o Can determine that a particular experience is opening to the fallopian tube towards cavity of the
harmful or pleasurable uterus.
Instinctive Behavior
Transcribers: Pagtalunan, Palacio, Pangilinan, Parado, Paypa
Editors:
2 Tolentino, D.
[HLC][Life in Utero]
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Once it enters the uterine cavity, it further differentiates to Figure 2. A. Implantation site at the end of the second week. B.
form a blastocyst Representative view of the germ disc at the end of the second week of
o Has fluid inside development. The amniotic cavity has been opened to permit a view of
the dorsal side of the epiblast. The hypoblast and epiblast are in
o Preparing itself to be implanted on the wall of the contact with each other, and the primitive streak forms a shallow
endometrial lining of the uterus by the end of the 1st groove in the caudal region of the embryo. (Langmans)
week
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2. Late Embryo: Organogenesis (3 -8 week)
Week 3:
Embryonic period proper
Gastrulation: Formation of the 3 definitive germ layers "
trilaminar germ disc
o Migration of epiblast cells via primitive streak to form:
# Endoderm (Lining of GIT and Respiratory Tract)
# Mesoderm (Musculoskeletal, Cardiovascular and
Urogential System)
# Ectoderm (Epidermis and CNS)
2. Environmental Factors
Alcohol
o Slight intake (2 shots/ day) " can lower IQ by 7
o Binge drink (>5 per sitting) " increased risk for
orofacial defects
o Fetal Alcohol Syndrome delayed growth,
mental retardation, facial deformities; most
common preventable
Smoking
o Reduced oxygen, CO " fetal circulation of
nicotine & other toxins " fetal RR & fetal HR
o (if chronic) risk of miscarriage, infant mortality,
Figure 4. Exposure to harmful substances and event during specific IUGR, mental retardation & developmental delay
periods could increase risk for the development of particular
deformities and malformations. Exposure during the embryonic period Radiation
when the organ systems are still being developed (red bars) would o Birth defects depending on dose and stage of
increase risk for major morphological abnormalities. After the organ development at time of exposure
systems are formed, exposure to maturation (yellow bars) may lead to
o Exposure during the embryonic period does not
functional defects and minor morphological abnormalities. Note that a
woman may be exposed to harmful substances and events at a time automatically lead to major malformations.
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when she may not even know she is pregnant (before 6 week) and
may produce major malformations in the embryo and fetus. IV. Developmental Origins of Health and Diseases
(DOHAD)
1. Maternal Factors David Barker, MD, PhD
Maternal Illness British physician
o Diabetes congenital defects and neonatal 1989: reported relationship between birth weight & death
hypoglycemia rates from coronary heart disease in both men & women in
# Baby is exposed to too much glucose while a poor district in Birmingham, UK
inside the mother " adjusts the insulin level Hypothesized that poor prenatal nutrition led to diversion
to maintain normal levels " when born, of nutrients to the brain, while skimping on other parts of
there is a drop in glucose levels due to the body, predisposing them to weakened heart
disconnection of glucose supply from mother Met with ridicule (heart disease perceived as due to
" baby still has high level of insulin " genetics and affluent lifestyle)
hypoglycemia Subsequent studies, even by detractors, replicated his
findings.