m o l e c u l a r s p e c t r o s c o p y

DXR Raman Microscope

Precision Raman Microscopy

Point-and-shoot Raman microscopy

Exceptional spatial resolution

Powerful analytical tool focused on results

Three excitation laser frequencies

Part of Thermo Fisher Scientific

 F O C U S O N R E S U LT S DXR R A M A N M I C R O S C O P E

Packaging Forensics Fibers Gems/Geology Art Restoration Nanotechnology

The DXR Raman microscope delivers

uncompromising 1-micron spatial resolution
and true confocal depth profiling for the
most demanding analytical challenges.
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly
FT-IR microscopy, Thermo Fisher Scientific
Your Applications and Raman Microscopy
and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and
to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications
microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in:
Top Quality Results Made Easy instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In Dyes and Chemicals Fibers
unique software features optimize signal-to-noise includes patented technology to take
Patent g addition, the DXR Raman microscope gives you Pharmaceuticals Nanotechnology
Pendin to reveal even the finest details in a spectrum of the guesswork out of achieving optimal true confocal depth profiling abilities, enabling Packaging Polymers
Tyrian Purple pigment. performance routinely and reproducibly. Paper Manufacturing Forensics
you to look for evidence of inclusions or impurities
This is the Raman microscope that the busy and characterize multi-layer polymer films. Gemstones Geology
analytical lab cannot afford to be without. Art Restoration and the Study of Cultural Artifacts
Raman provides many benefits:
Raman microscopy is employed at many stages in the
Autofocus Rapid and non destructive
No sample preparation manufacturing process from research to final product QC:
optimizes the focus to
No water interference easy to measure Methods Development R&D
maximize the Raman
aqueous samples QA/QC Reverse Engineering
signal automatically.
Complementary to FT-IR Failure and Defect Analysis
Easy access to low vibrational frequencies,
Smart making it easy to analyze inorganic molecules
Background
Automatic Fluorescence Correction
the DXR Raman
automatically corrects for fluorescence interference.
microscope collects
background data
Available for all excitation lasers. The DXR Raman Microscope
during instrument The DXR Raman microscope is a research-quality tool designed specifically for todays multi-purpose
downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of
the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire Patented autoalignment
has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal
performance
resolution that is as good or better than any instrument on the market,
True point-and-shoot Raman
Autoexposure the DXR Raman together with unique features designed to make it as easy as
capability
microscope calculates the exposure time and possible to get high quality results.
Exceptional spatial resolution
number of exposures for optimal sensitivity. Superb visual quality

Laser Power Regulator compensates for Automatic Intensity Correction

changes in laser power output and guarantees consistent compensates for detector wavelength dependence.
Raman response.
Legend:
Zone A: The Laser Power Regulator controls the laser power
reaching the sample to ensure reproducible results.
Zone B: As the laser power declines over its lifetime,
measurements become non-reproducible on instruments
lacking a Laser Power Regulator.
Zone C: Beyond the expected laser lifetime. The DXR Raman
microscope can still be used reproducibly at lower power
levels, however the laser should be replaced in order to
obtain maximum power output.
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly
FT-IR microscopy, Thermo Fisher Scientific
Your Applications and Raman Microscopy
and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and
to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications
microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in:
Top Quality Results Made Easy instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In Dyes and Chemicals Fibers
unique software features optimize signal-to-noise includes patented technology to take
Patent g addition, the DXR Raman microscope gives you Pharmaceuticals Nanotechnology
Pendin to reveal even the finest details in a spectrum of the guesswork out of achieving optimal true confocal depth profiling abilities, enabling Packaging Polymers
Tyrian Purple pigment. performance routinely and reproducibly. Paper Manufacturing Forensics
you to look for evidence of inclusions or impurities
This is the Raman microscope that the busy and characterize multi-layer polymer films. Gemstones Geology
analytical lab cannot afford to be without. Art Restoration and the Study of Cultural Artifacts
Raman provides many benefits:
Raman microscopy is employed at many stages in the
Autofocus Rapid and non destructive
No sample preparation manufacturing process from research to final product QC:
optimizes the focus to
No water interference easy to measure Methods Development R&D
maximize the Raman
aqueous samples QA/QC Reverse Engineering
signal automatically.
Complementary to FT-IR Failure and Defect Analysis
Easy access to low vibrational frequencies,
Smart making it easy to analyze inorganic molecules
Background
Automatic Fluorescence Correction
the DXR Raman
automatically corrects for fluorescence interference.
microscope collects
background data
Available for all excitation lasers. The DXR Raman Microscope
during instrument The DXR Raman microscope is a research-quality tool designed specifically for todays multi-purpose
downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of
the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire Patented autoalignment
has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal
performance
resolution that is as good or better than any instrument on the market,
True point-and-shoot Raman
Autoexposure the DXR Raman together with unique features designed to make it as easy as
capability
microscope calculates the exposure time and possible to get high quality results.
Exceptional spatial resolution
number of exposures for optimal sensitivity. Superb visual quality

Laser Power Regulator compensates for Automatic Intensity Correction

changes in laser power output and guarantees consistent compensates for detector wavelength dependence.
Raman response.
Legend:
Zone A: The Laser Power Regulator controls the laser power
reaching the sample to ensure reproducible results.
Zone B: As the laser power declines over its lifetime,
measurements become non-reproducible on instruments
lacking a Laser Power Regulator.
Zone C: Beyond the expected laser lifetime. The DXR Raman
microscope can still be used reproducibly at lower power
levels, however the laser should be replaced in order to
obtain maximum power output.
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly
FT-IR microscopy, Thermo Fisher Scientific
Your Applications and Raman Microscopy
and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and
to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications
microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in:
Top Quality Results Made Easy instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In Dyes and Chemicals Fibers
unique software features optimize signal-to-noise includes patented technology to take
Patent g addition, the DXR Raman microscope gives you Pharmaceuticals Nanotechnology
Pendin to reveal even the finest details in a spectrum of the guesswork out of achieving optimal true confocal depth profiling abilities, enabling Packaging Polymers
Tyrian Purple pigment. performance routinely and reproducibly. Paper Manufacturing Forensics
you to look for evidence of inclusions or impurities
This is the Raman microscope that the busy and characterize multi-layer polymer films. Gemstones Geology
analytical lab cannot afford to be without. Art Restoration and the Study of Cultural Artifacts
Raman provides many benefits:
Raman microscopy is employed at many stages in the
Autofocus Rapid and non destructive
No sample preparation manufacturing process from research to final product QC:
optimizes the focus to
No water interference easy to measure Methods Development R&D
maximize the Raman
aqueous samples QA/QC Reverse Engineering
signal automatically.
Complementary to FT-IR Failure and Defect Analysis
Easy access to low vibrational frequencies,
Smart making it easy to analyze inorganic molecules
Background
Automatic Fluorescence Correction
the DXR Raman
automatically corrects for fluorescence interference.
microscope collects
background data
Available for all excitation lasers. The DXR Raman Microscope
during instrument The DXR Raman microscope is a research-quality tool designed specifically for todays multi-purpose
downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of
the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire Patented autoalignment
has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal
performance
resolution that is as good or better than any instrument on the market,
True point-and-shoot Raman
Autoexposure the DXR Raman together with unique features designed to make it as easy as
capability
microscope calculates the exposure time and possible to get high quality results.
Exceptional spatial resolution
number of exposures for optimal sensitivity. Superb visual quality

Laser Power Regulator compensates for Automatic Intensity Correction

changes in laser power output and guarantees consistent compensates for detector wavelength dependence.
Raman response.
Legend:
Zone A: The Laser Power Regulator controls the laser power
reaching the sample to ensure reproducible results.
Zone B: As the laser power declines over its lifetime,
measurements become non-reproducible on instruments
lacking a Laser Power Regulator.
Zone C: Beyond the expected laser lifetime. The DXR Raman
microscope can still be used reproducibly at lower power
levels, however the laser should be replaced in order to
obtain maximum power output.
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE S I M P LY T H E B E S T

Raman Spectrometer
Class I laser safe; safe to use in the open lab (Class IIIb optional)
The Performance You Need Invaluable Now and into the Future Effortless Maintenance 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Convenient storage container for additional lasers, gratings and filters
The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its
Spectrometer with no moving parts for dependable performance
This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1,
maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution*
Precision a
High Brightness Lasers
Fiber optics for remote sampling
routine instrument maintenance into standard lab operating procedures. High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1
focus all of the laser energy (fingerprint region)
on the target for better DIC and fluorescence for greater SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port
contrast and no wasted flexibility in sample imaging
b Smart components report identity and serial numbers for compatibility checking,
laser power. The absence traceability and laser lifetime tracking
of scatter from material Pre-aligned Smart Components factory-aligned components permit lasers, Patented Autoalignment procedure to ensure optimal alignment and precision sampling
surrounding the target gratings and filters to be exchanged easily.
Rapid automated calibration to ensure validity of results
guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial
Low Brightness High Brightness
Laser Power Regulator
Choice of Spectral Resolution number and wavelength. OMNIC software checks for component compatibility.
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
choose standard spectral resolution
c for routine analysis. For hard-to-
resolve bands high resolution gratings Sampling
are available for all three lasers. Easy-to-maintain Software-controlled motorized microscope stage for automated data collection
Spectrograph and sample mapping (manual stage optional)
no moving parts, unique Multi-well adapter for automated multi-well plate sampling
Exceptional Spatial Resolution design optimizes perform-
Spacious microscope stage compartment for large samples, heated, cooled
analyze the smallest sample features with confidence. ance at all wavelengths.
and other specialty stages
(a) and (b): SEM of spatial resolution target and Raman User-replaceable Components
Optional tube and vial sampling accessory
map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser.
demonstrating better than 1-micron resolution. Fiber optic probe sampling option
Smart Lasers
Add objectives for additional versatility
automatically track laser lifetime. Software
Patented Comprehensive OMNIC software suite for full instrument control and data processing
Fully Automated Confocal Microscopy Autoalignment
Switch to brightfield OMNIC Array Automation provides automated data collection from sample arrays
Patented 2-micron resolution for depth profiling and inclusion or darkfield keeps the excitation laser,
Ra r and post-collection data processing
ma se Autoalignment analysis. Depth profile of food packaging.
n La illumination the Raman scattering,
Sc on
att ati precision sampling OMNIC Atls software permits sample mapping and image analysis
er xcit and the visual light paths
E
with minimum Superior Visual Imaging precisely aligned to the TQ Analyst with chemometrics for comprehensive data analysis
Visual Light Path

Multiple Lasers Be ready for any sample. Expand the

interference from same sampling point Extensive Raman libraries and easy to use search capabilities
capabilities of the DXR Raman microscope by adding a second
surrounding for maximum sampling
or third excitation laser. Minimize fluorescence interference, or
materials. precision. No manual Light Microscope
enhance sensitivity by up to 10-fold. Facilities with more than
alignment necessary. Research grade microscope
one DXR microscope or SmartRaman can share lasers, gratings
and filters between instruments for even greater versatility. 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield,
Trinocular
oil immersion, and long working distance options
Full range of Olympus microscope options Components are automatically recognized by Smart technology
and pre-aligned so there is no need for a service call. Standard and brightfield/darkfield illuminators
Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results Digital video camera for video data capture
Trinocular for visual and video imaging (binocular or video only optional)
SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple
Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance
with up to three different excitation wave- spectra; grating exchanged between each collect). Single beam-path spectrometer for robustness and simple alignment
Single USB Connection
lengths at 532, 633 and 780 nm. The lasers, full instrument control from Spectrograph with no moving parts for high reliability
together with the appropriate filters and either a desktop or laptop Minimal service requirements
gratings, lock into place using SmartLock computer through a single All consumables, including lasers, are
technology for precisely reproducible results. USB port. Laser Power Regulator user-replaceable
OMNIC software recognizes each component, compensates for changes Software-controlled alignment and calibration
records the serial numbers and checks for Automated Calibration spectrograph, laser and Raman in laser power output and performed routinely by the user
compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power
using standards located in the alignment/calibration tool. Fine-adjust Mirrors software-controlled mirror Validation
is provided for when the components are not at the sample.
SmartLock Lasers adjustments to maintain peak performance.
in use. ValPro System Qualification package for full
validation to meet all regulatory requirements
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE S I M P LY T H E B E S T

Raman Spectrometer
Class I laser safe; safe to use in the open lab (Class IIIb optional)
The Performance You Need Invaluable Now and into the Future Effortless Maintenance 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Convenient storage container for additional lasers, gratings and filters
The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its
Spectrometer with no moving parts for dependable performance
This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1,
maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution*
Precision a
High Brightness Lasers
Fiber optics for remote sampling
routine instrument maintenance into standard lab operating procedures. High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1
focus all of the laser energy (fingerprint region)
on the target for better DIC and fluorescence for greater SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port
contrast and no wasted flexibility in sample imaging
b Smart components report identity and serial numbers for compatibility checking,
laser power. The absence traceability and laser lifetime tracking
of scatter from material Pre-aligned Smart Components factory-aligned components permit lasers, Patented Autoalignment procedure to ensure optimal alignment and precision sampling
surrounding the target gratings and filters to be exchanged easily.
Rapid automated calibration to ensure validity of results
guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial
Low Brightness High Brightness
Laser Power Regulator
Choice of Spectral Resolution number and wavelength. OMNIC software checks for component compatibility.
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
choose standard spectral resolution
c for routine analysis. For hard-to-
resolve bands high resolution gratings Sampling
are available for all three lasers. Easy-to-maintain Software-controlled motorized microscope stage for automated data collection
Spectrograph and sample mapping (manual stage optional)
no moving parts, unique Multi-well adapter for automated multi-well plate sampling
Exceptional Spatial Resolution design optimizes perform-
Spacious microscope stage compartment for large samples, heated, cooled
analyze the smallest sample features with confidence. ance at all wavelengths.
and other specialty stages
(a) and (b): SEM of spatial resolution target and Raman User-replaceable Components
Optional tube and vial sampling accessory
map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser.
demonstrating better than 1-micron resolution. Fiber optic probe sampling option
Smart Lasers
Add objectives for additional versatility
automatically track laser lifetime. Software
Patented Comprehensive OMNIC software suite for full instrument control and data processing
Fully Automated Confocal Microscopy Autoalignment
Switch to brightfield OMNIC Array Automation provides automated data collection from sample arrays
Patented 2-micron resolution for depth profiling and inclusion or darkfield keeps the excitation laser,
Ra r and post-collection data processing
ma se Autoalignment analysis. Depth profile of food packaging.
n La illumination the Raman scattering,
Sc on
att ati precision sampling OMNIC Atls software permits sample mapping and image analysis
er xcit and the visual light paths
E
with minimum Superior Visual Imaging precisely aligned to the TQ Analyst with chemometrics for comprehensive data analysis
Visual Light Path

Multiple Lasers Be ready for any sample. Expand the

interference from same sampling point Extensive Raman libraries and easy to use search capabilities
capabilities of the DXR Raman microscope by adding a second
surrounding for maximum sampling
or third excitation laser. Minimize fluorescence interference, or
materials. precision. No manual Light Microscope
enhance sensitivity by up to 10-fold. Facilities with more than
alignment necessary. Research grade microscope
one DXR microscope or SmartRaman can share lasers, gratings
and filters between instruments for even greater versatility. 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield,
Trinocular
oil immersion, and long working distance options
Full range of Olympus microscope options Components are automatically recognized by Smart technology
and pre-aligned so there is no need for a service call. Standard and brightfield/darkfield illuminators
Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results Digital video camera for video data capture
Trinocular for visual and video imaging (binocular or video only optional)
SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple
Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance
with up to three different excitation wave- spectra; grating exchanged between each collect). Single beam-path spectrometer for robustness and simple alignment
Single USB Connection
lengths at 532, 633 and 780 nm. The lasers, full instrument control from Spectrograph with no moving parts for high reliability
together with the appropriate filters and either a desktop or laptop Minimal service requirements
gratings, lock into place using SmartLock computer through a single All consumables, including lasers, are
technology for precisely reproducible results. USB port. Laser Power Regulator user-replaceable
OMNIC software recognizes each component, compensates for changes Software-controlled alignment and calibration
records the serial numbers and checks for Automated Calibration spectrograph, laser and Raman in laser power output and performed routinely by the user
compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power
using standards located in the alignment/calibration tool. Fine-adjust Mirrors software-controlled mirror Validation
is provided for when the components are not at the sample.
SmartLock Lasers adjustments to maintain peak performance.
in use. ValPro System Qualification package for full
validation to meet all regulatory requirements
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE S I M P LY T H E B E S T

Raman Spectrometer
Class I laser safe; safe to use in the open lab (Class IIIb optional)
The Performance You Need Invaluable Now and into the Future Effortless Maintenance 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Convenient storage container for additional lasers, gratings and filters
The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its
Spectrometer with no moving parts for dependable performance
This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1,
maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution*
Precision a
High Brightness Lasers
Fiber optics for remote sampling
routine instrument maintenance into standard lab operating procedures. High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1
focus all of the laser energy (fingerprint region)
on the target for better DIC and fluorescence for greater SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port
contrast and no wasted flexibility in sample imaging
b Smart components report identity and serial numbers for compatibility checking,
laser power. The absence traceability and laser lifetime tracking
of scatter from material Pre-aligned Smart Components factory-aligned components permit lasers, Patented Autoalignment procedure to ensure optimal alignment and precision sampling
surrounding the target gratings and filters to be exchanged easily.
Rapid automated calibration to ensure validity of results
guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial
Low Brightness High Brightness
Laser Power Regulator
Choice of Spectral Resolution number and wavelength. OMNIC software checks for component compatibility.
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
choose standard spectral resolution
c for routine analysis. For hard-to-
resolve bands high resolution gratings Sampling
are available for all three lasers. Easy-to-maintain Software-controlled motorized microscope stage for automated data collection
Spectrograph and sample mapping (manual stage optional)
no moving parts, unique Multi-well adapter for automated multi-well plate sampling
Exceptional Spatial Resolution design optimizes perform-
Spacious microscope stage compartment for large samples, heated, cooled
analyze the smallest sample features with confidence. ance at all wavelengths.
and other specialty stages
(a) and (b): SEM of spatial resolution target and Raman User-replaceable Components
Optional tube and vial sampling accessory
map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser.
demonstrating better than 1-micron resolution. Fiber optic probe sampling option
Smart Lasers
Add objectives for additional versatility
automatically track laser lifetime. Software
Patented Comprehensive OMNIC software suite for full instrument control and data processing
Fully Automated Confocal Microscopy Autoalignment
Switch to brightfield OMNIC Array Automation provides automated data collection from sample arrays
Patented 2-micron resolution for depth profiling and inclusion or darkfield keeps the excitation laser,
Ra r and post-collection data processing
ma se Autoalignment analysis. Depth profile of food packaging.
n La illumination the Raman scattering,
Sc on
att ati precision sampling OMNIC Atls software permits sample mapping and image analysis
er xcit and the visual light paths
E
with minimum Superior Visual Imaging precisely aligned to the TQ Analyst with chemometrics for comprehensive data analysis
Visual Light Path

Multiple Lasers Be ready for any sample. Expand the

interference from same sampling point Extensive Raman libraries and easy to use search capabilities
capabilities of the DXR Raman microscope by adding a second
surrounding for maximum sampling
or third excitation laser. Minimize fluorescence interference, or
materials. precision. No manual Light Microscope
enhance sensitivity by up to 10-fold. Facilities with more than
alignment necessary. Research grade microscope
one DXR microscope or SmartRaman can share lasers, gratings
and filters between instruments for even greater versatility. 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield,
Trinocular
oil immersion, and long working distance options
Full range of Olympus microscope options Components are automatically recognized by Smart technology
and pre-aligned so there is no need for a service call. Standard and brightfield/darkfield illuminators
Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results Digital video camera for video data capture
Trinocular for visual and video imaging (binocular or video only optional)
SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple
Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance
with up to three different excitation wave- spectra; grating exchanged between each collect). Single beam-path spectrometer for robustness and simple alignment
Single USB Connection
lengths at 532, 633 and 780 nm. The lasers, full instrument control from Spectrograph with no moving parts for high reliability
together with the appropriate filters and either a desktop or laptop Minimal service requirements
gratings, lock into place using SmartLock computer through a single All consumables, including lasers, are
technology for precisely reproducible results. USB port. Laser Power Regulator user-replaceable
OMNIC software recognizes each component, compensates for changes Software-controlled alignment and calibration
records the serial numbers and checks for Automated Calibration spectrograph, laser and Raman in laser power output and performed routinely by the user
compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power
using standards located in the alignment/calibration tool. Fine-adjust Mirrors software-controlled mirror Validation
is provided for when the components are not at the sample.
SmartLock Lasers adjustments to maintain peak performance.
in use. ValPro System Qualification package for full
validation to meet all regulatory requirements
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 1

PERFORMANCE WITHOUT COMPROMISE S I M P LY T H E B E S T

Raman Spectrometer
Class I laser safe; safe to use in the open lab (Class IIIb optional)
The Performance You Need Invaluable Now and into the Future Effortless Maintenance 532-, 633- and 780-nm high-brightness lasers; factory aligned, user-interchangeable
Convenient storage container for additional lasers, gratings and filters
The DXR Raman microscope is designed from start to finish as a robust analytical tool. The DXR Raman microscope is the platform that expands to meet your changing needs. A fully calibrated and aligned instrument delivers reproducible results dependably. With its
Spectrometer with no moving parts for dependable performance
This means no compromises on the performance features that matter. deceptively simple design and minimal moving parts, the DXR Raman microscope is easy to Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1,
maintain. Patented autoalignment, calibration and other features make it easy to incorporate 5 cm-1 spectral resolution*
Precision a
High Brightness Lasers
Fiber optics for remote sampling
routine instrument maintenance into standard lab operating procedures. High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1
focus all of the laser energy (fingerprint region)
on the target for better DIC and fluorescence for greater SmartLock technology for reproducibly mounting lasers, gratings, filters, fiber port
contrast and no wasted flexibility in sample imaging
b Smart components report identity and serial numbers for compatibility checking,
laser power. The absence traceability and laser lifetime tracking
of scatter from material Pre-aligned Smart Components factory-aligned components permit lasers, Patented Autoalignment procedure to ensure optimal alignment and precision sampling
surrounding the target gratings and filters to be exchanged easily.
Rapid automated calibration to ensure validity of results
guarantees true confocality. Lasers, gratings, filters, fiber launcher identify themselves by serial
Low Brightness High Brightness
Laser Power Regulator
Choice of Spectral Resolution number and wavelength. OMNIC software checks for component compatibility.
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
choose standard spectral resolution
c for routine analysis. For hard-to-
resolve bands high resolution gratings Sampling
are available for all three lasers. Easy-to-maintain Software-controlled motorized microscope stage for automated data collection
Spectrograph and sample mapping (manual stage optional)
no moving parts, unique Multi-well adapter for automated multi-well plate sampling
Exceptional Spatial Resolution design optimizes perform-
Spacious microscope stage compartment for large samples, heated, cooled
analyze the smallest sample features with confidence. ance at all wavelengths.
and other specialty stages
(a) and (b): SEM of spatial resolution target and Raman User-replaceable Components
Optional tube and vial sampling accessory
map, respectively; (c) cross-section of the Raman map, no service calls required to replace a laser.
demonstrating better than 1-micron resolution. Fiber optic probe sampling option
Smart Lasers
Add objectives for additional versatility
automatically track laser lifetime. Software
Patented Comprehensive OMNIC software suite for full instrument control and data processing
Fully Automated Confocal Microscopy Autoalignment
Switch to brightfield OMNIC Array Automation provides automated data collection from sample arrays
Patented 2-micron resolution for depth profiling and inclusion or darkfield keeps the excitation laser,
Ra r and post-collection data processing
ma se Autoalignment analysis. Depth profile of food packaging.
n La illumination the Raman scattering,
Sc on
att ati precision sampling OMNIC Atls software permits sample mapping and image analysis
er xcit and the visual light paths
E
with minimum Superior Visual Imaging precisely aligned to the TQ Analyst with chemometrics for comprehensive data analysis
Visual Light Path

Multiple Lasers Be ready for any sample. Expand the

interference from same sampling point Extensive Raman libraries and easy to use search capabilities
capabilities of the DXR Raman microscope by adding a second
surrounding for maximum sampling
or third excitation laser. Minimize fluorescence interference, or
materials. precision. No manual Light Microscope
enhance sensitivity by up to 10-fold. Facilities with more than
alignment necessary. Research grade microscope
one DXR microscope or SmartRaman can share lasers, gratings
and filters between instruments for even greater versatility. 4X, 10X, 20X, 50X and 100X microscope objectives, with brightfield/darkfield,
Trinocular
oil immersion, and long working distance options
Full range of Olympus microscope options Components are automatically recognized by Smart technology
and pre-aligned so there is no need for a service call. Standard and brightfield/darkfield illuminators
Fluorescence and DIC light microscopy options
SmartLock Technology for Reproducible Results Digital video camera for video data capture
Trinocular for visual and video imaging (binocular or video only optional)
SmartLock Filters SmartLock Grating Ensures reproducible spectra even with multiple
Users can configure the DXR Raman microscope grating exchanges (plot shows an overlay of 150 Maintenance
with up to three different excitation wave- spectra; grating exchanged between each collect). Single beam-path spectrometer for robustness and simple alignment
Single USB Connection
lengths at 532, 633 and 780 nm. The lasers, full instrument control from Spectrograph with no moving parts for high reliability
together with the appropriate filters and either a desktop or laptop Minimal service requirements
gratings, lock into place using SmartLock computer through a single All consumables, including lasers, are
technology for precisely reproducible results. USB port. Laser Power Regulator user-replaceable
OMNIC software recognizes each component, compensates for changes Software-controlled alignment and calibration
records the serial numbers and checks for Automated Calibration spectrograph, laser and Raman in laser power output and performed routinely by the user
compatibility. A convenient storage container intensity calibrations are completely automated by OMNIC software guarantees consistent power
using standards located in the alignment/calibration tool. Fine-adjust Mirrors software-controlled mirror Validation
is provided for when the components are not at the sample.
SmartLock Lasers adjustments to maintain peak performance.
in use. ValPro System Qualification package for full
validation to meet all regulatory requirements
DXR Micro Interior 1-23-08 1/23/08 7:43 PM Page 2

ANSWERS YOU CAN TRUST T HE R AMAN M ICROSCOPE D ESIGNED W ITH Y OU I N M IND

Results Made Easy From the Experts in Raman Microscopy

The DXR Raman microscope lets the user focus on the results, not on learning new techniques With many years of experience in Raman and Unlock the power of Raman microscopy, effortlessly
FT-IR microscopy, Thermo Fisher Scientific
Your Applications and Raman Microscopy
and procedures. At Thermo Scientific, we design instruments that take care of the details. has designed the DXR Raman microscope You are going to find yourself relying on your Raman microscopy is of critical value in industrial and
to encompass all the benefits of Raman DXR Raman microscope for many of your most non-industrial environments alike. New applications
microscopy in one simple, easy-to-use challenging applications. For small particle analysis, are being discovered daily in:
Top Quality Results Made Easy instrument. The DXR Raman microscope the 1-micron spatial resolution is invaluable. In Dyes and Chemicals Fibers
unique software features optimize signal-to-noise includes patented technology to take
Patent g addition, the DXR Raman microscope gives you Pharmaceuticals Nanotechnology
Pendin to reveal even the finest details in a spectrum of the guesswork out of achieving optimal true confocal depth profiling abilities, enabling Packaging Polymers
Tyrian Purple pigment. performance routinely and reproducibly. Paper Manufacturing Forensics
you to look for evidence of inclusions or impurities
This is the Raman microscope that the busy and characterize multi-layer polymer films. Gemstones Geology
analytical lab cannot afford to be without. Art Restoration and the Study of Cultural Artifacts
Raman provides many benefits:
Raman microscopy is employed at many stages in the
Autofocus Rapid and non destructive
No sample preparation manufacturing process from research to final product QC:
optimizes the focus to
No water interference easy to measure Methods Development R&D
maximize the Raman
aqueous samples QA/QC Reverse Engineering
signal automatically.
Complementary to FT-IR Failure and Defect Analysis
Easy access to low vibrational frequencies,
Smart making it easy to analyze inorganic molecules
Background
Automatic Fluorescence Correction
the DXR Raman
automatically corrects for fluorescence interference.
microscope collects
background data
Available for all excitation lasers. The DXR Raman Microscope
during instrument The DXR Raman microscope is a research-quality tool designed specifically for todays multi-purpose
downtime, so that analytical labs. This is the microscope for the user who needs the high spatial resolution, ease of
the user never sample preparation and power of Raman microscopy, and who has neither the time nor the desire Patented autoalignment
has to wait. to become a Raman expert. The DXR Raman microscope delivers spatial system for guaranteed optimal
performance
resolution that is as good or better than any instrument on the market,
True point-and-shoot Raman
Autoexposure the DXR Raman together with unique features designed to make it as easy as
capability
microscope calculates the exposure time and possible to get high quality results.
Exceptional spatial resolution
number of exposures for optimal sensitivity. Superb visual quality

Laser Power Regulator compensates for Automatic Intensity Correction

changes in laser power output and guarantees consistent compensates for detector wavelength dependence.
Raman response.
Legend:
Zone A: The Laser Power Regulator controls the laser power
reaching the sample to ensure reproducible results.
Zone B: As the laser power declines over its lifetime,
measurements become non-reproducible on instruments
lacking a Laser Power Regulator.
Zone C: Beyond the expected laser lifetime. The DXR Raman
microscope can still be used reproducibly at lower power
levels, however the laser should be replaced in order to
obtain maximum power output.
The Answers You Need
Whether its library searches to identify unknowns, data interpretation
for large collections of samples, or mapping the distribution of key
components, the DXR Raman microscope and the OMNIC software
suite make it easy to focus on the answers.

Identify Unknowns

Sophisticated Spectral Analysis

InterpretIR+ identifies key spectral
features in a nylon fiber sample.

The most extensive Raman libraries

Sophisticated Mapping and Data Analysis

OMNIC Atls mapping software combines
hyperspectral mapping with image analysis Overlay of chemical and video map to show
algorithms and chemometric tools. Analyze distribution of components
sample cross-sections, extract sample
component information using MCR then map
and quantify the distribution of components.
Add mapping capability to the DXR Raman
microscope for ever more sophisticated
applications.

Distribution of the two major tablet

components generated by MCR analysis
Atls generates an information-rich map of a painkiller tablet of the hyperspectral Atls map
Laboratory Solutions Backed by Worldwide Service and Support In addition to these offices, Thermo
Fisher Scientific maintains a network
With its user-friendly patented autoalignment and calibration, plus its user-replaceable of representative organizations
lasers, gratings and lters, the DXR Raman microscope has been designed to need throughout the world.
little service attention. However, we know that in todays busy, multifunctional
laboratories you cannot afford to be without your workhorse instruments for even Africa
the shortest time. With the most extensive world-wide organization of eld service +43 1 333 5034 127 analyze.emea@thermo.com
Australia
engineers, you can count on us to keep you up and running. +61 2 8844 9500 analyze.au@thermo.com
Austria
First class service and support allow you to get the most out of your microscope +43 1 333 50340 analyze.at@thermo.com
Belgium
and samples. With our expertise in applications support, we offer comprehensive +32 2 482 30 30 analyze.be@thermo.com
training to take you to the next level. Canada
+1 800 530 8447 analyze.ca@thermo.com
China
+86 10 5850 3588 analyze.cn@thermo.com
The Thermo Scientic Family of Raman Spectrometers Denmark
+45 70 23 62 60 analyze.dk@thermo.com
Nicolet Almega XR Europe-Other
The Thermo Scientific Nicolet Almega XR is a high- +43 1 333 5034 127 analyze.emea@thermo.com
performance dispersive Raman spectrometer. Fully France
automated and with micro and macro sampling combined +33 1 60 92 48 00 analyze.fr@thermo.com
in one instrument, the Almega XR offers the ultimate in Germany
performance, automation and flexibility. The Almega XR +49 6103 408 1014 analyze.de@thermo.com
is ready for any sample and meets the needs of even the India
+91 22 6742 9434 analyze.in@thermo.com
most demanding applications.
Italy
+39 02 950 591 analyze.it@thermo.com
Japan
+81 45 453 9100 analyze.jp@thermo.com
Latin America
+1 608 276 5659 analyze.la@thermo.com
NXR FT-Raman Series Middle East
The Nicolet NXR FT-Raman spectrometer uses 1064- +43 1 333 5034 127 analyze.emea@thermo.com
or 976-nm excitation lasers for radical reduction in Netherlands
+31 76 587 98 88 analyze.nl@thermo.com
fluorescence interference. With the most extensive
sampling accessories available, including the FT-Raman South Africa
+27 11 570 1840 analyze.sa@thermo.com
MicroStage for microscopic analysis, the NXR FT-Raman
spectrometer can be configured either as a dedicated, Spain
+34 914 845 965 analyze.es@thermo.com
stand-alone system or as an accessory for FT-IR
Sweden / Norway / Finland
spectrometers.
+46 8 556 468 00 analyze.se@thermo.com
Switzerland
+41 61 48784 00 analyze.ch@thermo.com
DXR SmartRaman UK
Built on the same platform as the DXR Raman microscope, +44 1442 233555 analyze.uk@thermo.com
the DXR SmartRaman spectrometer is dedicated to bulk USA
sample analysis. It is intended for use in busy multi-purpose +1 800 532 4752 analyze.us@thermo.com
analytical labs, where the users are looking for reproducible
and accurate results from a dependable, low maintenance www.thermo.com
instrument.

Thermo Electron Scientific Instruments LLC,

Madison, WI USA is ISO Certified.
The DXR Raman microscope is a Class IIIb laser-safe
product, unless installed with the Class I Laser Safety
Enclosure. Installation of a fiber optic probe launcher
and fiber probe will convert all microscopes to Class IIIb
laser-safe, even with the Laser Safety Enclosure installed.
2008 Thermo Fisher Scientific Inc. All rights reserved.
All trademarks are the property of Thermo Fisher
Scientific Inc. and its subsidiaries.
Specifications, terms and pricing are subject to change.
Not all products are available in all countries. Please
consult your local sales representative for details.

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