I'm building a spreadsheet to calculate the dose of a drug called Carboplatin for patients.

I have the basic

spreadsheet built out, but I need help or someone to add the below parameters to the spread sheet. The
clinician will enter the patient's AGE, HEIGHT, WEIGHT, SEX, DESIRED AUC, and SERUM CREATININE and
the spreadsheet will calculate the dose base on the Calvert Equation. T

The formula is as follows:

Carboplatin Dose = AUC x (Creatinine Clearance + 25)

The formula only has two variables, which are defined below. Pretty simple, but its major variable
(Creatinine Clearance) is based on another formula that takes in user inputs and has limit.

DEFINITION OF VARIABLES:
AUC = Area under the curve. It is a number between 0-8 only.

Creatinine Clearance (CrCL): Calculated by the following formula:

CrCl = Sex * ((140 - Age) / (Serum Creatinine)) * (Weight / 72)

RULES FOR CrCl FORMULA

Sex: Ideally, I would like a drop down menu for the user to select MALE or FEMALE, where MALE = 1
and FEMALE = 0.85. Basically, the CrCl is 85% if a female is selected.

MAXIMUM CREATININE CLEARANCE IS 125. Default to 125 automatically.

Age: user inputed integer

Serum Creatinine (SCr)= user inputed value...but there is a limit. If the value is less than 0.7, then 0.7
is automatically used as the minimum value. I would like a message to appear as a note in the results
that states that a minimum SCr of 0.7 was used to tally this result.

Weight: user inputed weight in kilograms. There are special rules that needs to be followed about
what is the correct weight to use in the CrCl formula:

RULES FOR WEIGHT:

1. User will input height (in centimeters) and weight (in kilograms).
2. The spreadsheet will calculate and display the Ideal Body Weight
3. The formula for IBW is:
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.
4. If a patient's weight is 30% above IBW, then calculate the ADJUSTED body weight and use that
value in place of weight.
5. The formula for is:
Adjusted Body Weight = ((Actual Body Weight - Ideal Body Weight) x 0.40) + IBW
6. Otherwise use weight entered Max dose of Carboplatin: Because the CrCl is capped at 125mL,
each AUC level will have a corresponding max dose. Thus, if an AUC = 2 for a MALE, AGE = 25, SCR =
0.7, HEIGHT = 170 cm and WEIGHT = 75 kg, the max dose should be 300mg

RESULTS: On the results, please display the carboplatin dose, weight used (Adjusted or entered weight) and
if the Scr was rounded to 0.7
DELIVER BY: 24hrs from the time of acceptance. Thanks!