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Downloaded from nejm.org on August 27, 2015. For personal use only. No other uses without permission.
Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org on August 27, 2015. For personal use only. No other uses without permission.
Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org on August 27, 2015. For personal use only. No other uses without permission.
Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org on August 27, 2015. For personal use only. No other uses without permission.
Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org on August 27, 2015. For personal use only. No other uses without permission.
Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine
Downloaded from nejm.org on August 27, 2015. For personal use only. No other uses without permission.
Copyright 1991 Massachusetts Medical Society. All rights reserved.