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Name ______________________________

Non-Mendelian Inheritance: Multiple Alleles

Blood type is a special type of inherited trait that is governed by multiple alleles, or gene variants.

Blood Type Genotype Can donate blood to: Can receive blood from:
(Phenotype)

O ii A, B, AB and O O
(universal donor)

AB IAIB O, AB A, B, AB and O
(universal acceptor)

A IAIA or IAi AB, A O, A

B IBIB or IBi AB, B O, B

1. Write the genotype for each person based on the description:

a. Homozygous for blood type B ______


b. Heterozygous for blood type A ______
c. Blood type O ______
d. Blood type A who had a blood type O parent ______
e. Blood type AB ______
f. Blood type that can be donated to anybody ______
g. Blood type that can only get blood from a type O donor ______

2. Pretend that Brad Pitt is homozygous for the blood type B, and Angelina Jolie is blood type
O. What are all the possible blood genotypes types of their baby? _________________________
3. Fill in the Punnett square below showing all the possible blood types for the offspring
produced by a blood type O mother and a blood type AB father.

4. Mrs. Clink is blood type A and Mr. Clink is blood type O. They have three children named
Matthew, Mark, and Luke. Mark is blood type O, Matthew is blood type A, and Luke is blood
type AB. Luke is not their biological child. Based on this information:

a. Mr. Clink must have the genotype ______.


b. Mrs. Clink must have the genotype ______.
c. Luke cannot be the child of these parents because neither parent has the allele _____.

5. Two parents think their baby was switched at the hospital. Its 1968, so DNA fingerprinting
technology does not exist yet. The mother has blood type O, the father has blood type AB,
and the baby has blood type B.

a. Mothers genotype: _______


b. Fathers genotype: _______
c. Babys genotype: ______ or ________
d. Fill in the Punnett square below showing all possible genotypes for children
produced by this couple.

e. Was the baby switched? _____________


6. Two other parents think their baby was switched at the hospital. The mother has blood
type A, the father has blood type B, and the baby has blood type AB.

a. Mothers genotype: _______ or ________


b. Fathers genotype: _______ or ________
c. Babys genotype: ______
d. Fill in the Punnett square below that shows the babys genotype as a possibility:

e. Was the baby switched? ______________

7. Based on the information in this table, which man or men could not be the father of the
baby with blood type B? ____________________________________
Justify your answer by filling in the Punnett square below; showing mother and baby.

Name Blood Type


Mother Type A
Baby Type B
Sammy the Type O
player
George the Type AB
sleeze
The waiter Type A
The cable guy Type B
8. Based on the information in this table, which man or men could not be the father of the
baby with blood type AB? ________________________________________
Justify your answer by filling in the Punnett square below; showing mother and baby.

Name Blood Type


Mother Type O
Baby Type AB
Bartender Type O
Guy at the club Type AB
Cabdriver Type A
Flight Type B
attendant

9. Analysis Question: Explain why blood type data cannot prove who the father of a baby is,
and can only prove who the father is not (refer back to the tables in questions #7 & #8 to
help you answer this question).

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