Datasheet of AV-412(MP-412)

Detailed information:
http://www.sun-shinechem.com/Details/AV-412(MP-412)/1626/451493-31-5(tosylate);451492-95-8(free-base).html

USD250.0/50.0mg;
Price USD400.0/100.0mg
Please send your email to sales@sun-shinechem.com for other package.

Product Name AV-412(MP-412)

N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-
Chemical Name
yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate)

Synonyms MP-412;MP 412;MP412;AV-412;AV 412;AV412.

CAS No. 451493-31-5 Catalog No 100501

Molecular Weight 507.00

OH O N
O S O
Molecular Formula C41H44ClFN6O7S2 O S O NH OH
N
F NH

Cl N
Other information N/A N

Items Specifications Results

Appearance Off-white solid Complies

HNMR 400MHz,d6-DMSO Complies

Analysis
HPLC 98.0% Complies

Storage condition Kept under dry and cool condition

The above substance has been tested according to In house Standards, and it
Conclusion
meets requirements.

No.8 Rd, The Great Wall Park, Donghu High-Tech District 430074, Wuhan, China
Tel: 0086-27-59253327||Email:sales@sun-shinechem.com||Web:www.sun-shinechem.com
 AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential
antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the
epidermal growth factor receptor (EGFR) and the human epidermal growth factor
Description receptor 2 (HER2), which may result in the inhibition of tumor growth and
angiogenesis, and tumor regression in EGFR/HER2-expressing tumors.

No.8 Rd, The Great Wall Park, Donghu High-Tech District 430074, Wuhan, China
Tel: 0086-27-59253327||Email:sales@sun-shinechem.com||Web:www.sun-shinechem.com