MAPA INSTITUTE OF TECHNOLOGY

SCHOOL OF CHEMICAL ENGINEERING AND CHEMISTRY (INTRAMUROS)

VISION
Mapua shall be among the best universities in the world.

MISSION

1. The Institute shall provide a learning environment in order for its students to acquire the
attributes that will make them globally competitive.
2. The Institute shall engage in economically viable research, development, and innovation.

3. The Institute shall provide state-of-the-art solutions to problems of industries and communities.

PROGRAM EDUCATIONAL OBJECTIVES MISSION

1 2 3
Within the five years after graduation, the graduates of the Chemical
Engineering program shall have:
1. Undertaken, singly or in teams, projects that show ability to solve
problem in Chemical Engineering or related fields.
2. Had substantial involvement in projects that take into consideration
safety, health, environmental concerns and the public welfare, partly
through adherence to required codes and laws.
3. Demonstrated professional success via promotions and/or positions of
increasing responsibility.
4. Demonstrated life-long learning via progress toward completion of an
advanced degree, professional development/continuing education
courses, or industrial training courses.
5. Exhibited professional behavior and attitude in practice of Chemical
Engineering or related fields.
6. Initiated and implemented actions toward the improvement of practice
of Chemical Engineering or related fields.

COURSE SYLLABUS

1. Course Code: CHE142-1

2. Course Title: BIOCHEMICAL ENGINEERING

3. Pre-requisite: BIO149, CHE143-1

4. Co-requisite: None

5. Credit: 3

6. Course Description:

The course deals with bioreactor design for processing of biological materials and processing using
biological agents such as microbial cells and enzymes.

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7. Student Outcomes and Relationship to Program Educational Objectives

PEOs
Student Outcomes
1 2 3 4 5 6
an ability to apply knowledge of mathematics, science, and
(a)
engineering
an ability to design and conduct experiments, as well as to
(b)
analyze and interpret from data
an ability to design a system, component, or process to
(c)
meet desired needs
(d) an ability to function on multidisciplinary teams

an ability to identify, formulate, and solve engineering

(e)
problems

(f) an understanding of professional and ethical responsibility

(g) an ability to communicate effectively

the broad education necessary to understand the impact of

(h)
engineering solutions in the global and societal context

a recognition of the need for, and an ability to engage in life-

(i)
long learning
(j) a knowledge of contemporary issues

an ability to use the techniques, skills, and modern

(k)
engineering tools necessary for engineering practice
knowledge and understanding of engineering and
(l) management principles as a member and leader in a team,
to manage projects in multidisciplinary environments

8. Course Outcomes (COs) and Relationship to Student Outcomes

Course Outcomes Student Outcomes*

After completing the course, the student must be able to: a b c d e f g H i j k l
1. Describe the scope and applications of biochemical
engineering, and how enzymes work (including its basic R R
kinetics and mechanistic model).
2. Describe the mechanisms of enzyme inhibition and
R R
activations) and solve problems pertaining to it;
3. Explain the principles involved in enzyme immobilization
R R
(heterogeneous catalysis) and solve problems related to it.
4. Solve problems on batch and continuous operation modes of
R R
bioreactors; and solve stoichiometric problems related to it.
5. Explain the concepts and applications of sterilization and
R R
downstream processing.
* Level: I- Introduced, R- Reinforced, D- Demonstrated

9. Course Coverage

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 COURSE
Week TOPIC TLA AT
OUTCOMES
1-2 CO1 Orientation and Introduction to the Peer discussion Exam 1
Course on Vision,
Mapas Vision and Mission; Departments Mission and
Specific Objectives; Course Policies and Course
Guidelines; Nature and Scope of the Objectives
Course

Introduction: What is a bioprocess

engineer?
Biotechnology and Bioprocess Engineering;
Biologists and Engineers Differ in Their
Approach to Research; Bioprocesses:
Regulatory Constraints Lecture
Learning
Enzymes I Task 1
Exam 1
How Enzymes Work; Enzyme Kinetics:
Mechanistic Models for Simple Enzyme
Kinetics, Experimentally Determining Rate
Parameters for Michaelis-Menten Type
Kinetics;
3 CO2 Enzyme Inhibition Lecture Learning
Problem Solving Task 1
Regulation of enzyme activity; Kinetic Exam 1
models for different inhibitions; Models for
More Complex Enzyme Kinetics, Effects of
pH and Temperature

EXAMINATION 1
46 CO3 Enzyme Immobilization Lecture Learning
Problem Solving Task 2
Immobilized Enzyme Systems: Methods of
Immobilization, Diffusional Limitations in Exam 2
Immobilized Enzyme Systems; Derivation of
the differential equation and its solution,
heterogeneous catalysis.

EXAMINATION 2
78 CO4 Biological Reaction Kinetics: Reactor Lecture Learning
Engineering Problem Solving Task 3
Exam 3
-10 CO5 Lecture Learning
Student class Task 4
Sterilization
presentations Exam 3
Downstream Processing (presentation of
learning tasks by
the assigned
student groups)
EXAMINATION 3
Problem
Solving
11 CO1, CO2, Summative Assessment Final Exam
CO3, CO4
Final Examination

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10. Lifelong-Learning Opportunities

Students are also exposed to new scientific finding in the field bioprocessing through journal readings.

11. Contribution of Course to Meeting the Professional Component

Engineering Topics - 90%

General Education - 10%

12. Textbook

Doran, P. M., Bioprocess Engineering Principles, 2nd ed., Elsevier Pte Ltd. (2013).

13. Course Evaluation

Student performance will be rated based on the following:

Assessment Tasks Weight Minimum Average for

Satisfactory
Performance
CO 1 Exam1 10.0% 60.00%
Exam 5.0% 60.00%
Learning Task 1 1.5% 60.00%
CO 2 Exam 1 10.0 % 60.00%
Exam 5.0% 60.00%
Learning Task 1 1.5% 60.00%
CO 3 Exam 2 20.0% 60.00%
Exam 10.0% 60.00%
Learning Task 2 3.0% 60.00%
CO 4 Exam 3 15.0% 60.00%
Exam 7.0% 60.00%
Learning Task 3 2.0% 60.00%
CO 5 Exam 3 5.0% 60.00%
Exam 3.0% 60.00%
Learning Task 4 2.0% 60.00%
TOTAL 100.0% 60.00%

The final grades will correspond to the weighted average scores shown below

Average Grade Average Grade

0 - 59.99 5.00 78.00 - 80.99 2.00
60.00 - 64.99 3.00 81.00 - 84.99 1.75
65.00 - 69.99 2.75 85.00 - 89.99 1.50
70.00 - 73.99 2.50 90.00 - 93.99 1.25
74.00 - 77.99 2.25 94.00 - 100.00 1.00

13.1. Other Course Policies

a. Attendance
According to CHED policy, total number of absences by the students should not be more than
20% of the total number of meetings or 9 hrs for a three-unit-course. Students incurring more

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 than 9 hours of unexcused absences automatically gets a failing grade regardless of class
standing.

b. Assessment Tasks
Assessment Tasks are activities to supplement the lecture discussion, usually a set of problems
the students need to solve. The learning tasks will be graded based on the presentation and
correctness of the solution. Late submissions of learning tasks will not be accepted.

c. Written Examination
There will be 4 long written examinations (including the finals) covering the four major clusters
of topics (see course coverage). The final examination will cover all topics of the course. Test
booklet will be used as answer sheet on all written examinations. All exams are announced.
There will be no make-up exams. For those who missed an exam, the equivalent grade in the
final examination will be applied as the grade in that missed exam. A grade of zero will be given
to the succeeding missed exams.

d. Course Portfolio
Selected problem sets and examinations are to be compiled and collected before the end of the
term. The selection is based on statistical data gathering (lowest, median, and highest).
Learning tasks and examinations with marks lowest, median, and highest must be scanned and
compiled. The compilation must be place on a CD and be submitted to the instructor for course
portfolio keeping.

e. Language of Instruction
Lectures, discussion, and documentation will be in English. Written and spoken work may
receive a lower mark if it is, in the opinion of the instructor, deficient in English.

f. Honor, Dress and Grooming Codes

All of us have been instructed on the Dress and Grooming Codes of the Institute. We have all
committed to obey and sustain these codes. It will be expected in this class that each of us will
honor the commitments that we have made.
For this course the Honor Code is that there will be no plagiarizing on written work and no
cheating on exams. Proper citation must be given to authors whose works were used in the
process of developing instructional materials and learning in this course. If a student is caught
cheating on an exam, he or she will be given zero mark for the exam. If a student is caught
cheating twice, the student will be referred to the Prefect of Student Affairs and be given a failing
grade.

g. Consultation Schedule
Consultation schedules with the Professor are posted outside the ChE-Chm Faculty room and in
the Schools web-page (http://che-chm.mapua.edu.ph ). It is recommended that the student first
set an appointment to confirm the instructors availability.

14. Other References

14.1. Books

Mathews, C., Biochemistry, Benjamin Cummings, (2000).

Shuler, M. L. and F. Kargi. Bioprocess Engineering: Basic Concepts, 2nd ed., (2002).
Steel, R., Biochemical Engineering Fundamentals, McGraw Hill, (1986).

14.2. Websites

http://student.ccbc.cc.md.us/biotutorials/dna/dna_index.html
http://www.ncbi.nlm.nih.gov
http://www.stn-international.de/stndatabases/databases/genbank.html
http://www.ncbi.nlm.nih.gov/entrez/
http://www.ncbi.nlm.nih.gov/BLAST/
http://www.expasy.ch
http://www.rcsb.org/pdb/
http://www.ncbi.nlm.nih.gov/Structure/
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15. Course Materials

15.1. Course goals and instructional objectives

15.1. Course schedule for lectures and exams

16. Committee Members

CAPARANGA, ALVIN (R)

DE JESUS, MEDARLO (BUENAVENTURA)
DE VERA, FLORDELIZA (COSME)
DOMA JR, BONIFACIO (T.)
LERON, RHODA (BALASADAS)
MARQUEZ, ARIZIEL RUTH (DIZON)
SORIANO, ALLAN (NANA)

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