Wound infections Possible therapeutic alternatives

Wound: Infected, Common Uncomplicated (mild or moderate)

post-op or trauma, pathogens Bactrim DS orally twice daily OR
without sepsis. (Not
Gastrointestinal tract Cephalexin 500mg orally 4 times daily OR
or female genital
tract.) Augmentin 875/125 mg orally twice daily
OR500/125mg three times daily or
Augmentin XR* 1000/62.5 mg 2 tablets orally
twice daily OR

*AUGMENTIN XR is contraindicated in patients

with a creatinine clearance of < 30 mL/min. and
in hemodialysis patients.
Doxycycline 100mg orally twice daily OR
Clindamycin 300mg to 450mg orally four
times daily
Complicated (Severe)
Ticarcillin-clavulanic acid 3.1 grams IV
every 6 hours OR
Piperacillin-tazobactam 3.375 grams IV
every 6 hours OR
Ertapenem 1 gram q24h

PLUS
Vancomycin 1 gram ivpb q12h (patient-specific
dosing required)

Wound infection + Common Ampicillin-sulbactam 1.5 - 3 grams IV

sepsis. (does not pathogens every 6 hours OR
include surgery
involving GI or female Ticarcillin-clavulanic acid 3.1 grams IV
genital tract) every 6 hours OR
Piperacillin-tazobactam 3.375 grams IV
every 6 hours OR
Cefazolin 1 gram IV every 8 hours.
Postop wound Common Piperacillin-tazobactam 3.375 grams IV
(surgery involving pathogens every 6 hours OR
gastrointestinal tract
or female genital Ticarcillin-clavulanic acid 3.1grams IV
tract) (all regimens every 6 hours OR
must cover
anaerobes) Ampicillin-sulbactam 1.5-3g ivpb q6h OR
[ (Cefotaxime 1g ivpb q8h or
Ceftriaxone1-2g ivpb q24h )
+ Metronidazole 500mg ivpb q6-8h] OR
Imipenem 500mg ivpb q6h.