A Drug Study on Aztreonam

In Partial Fulfillment of the Requirements

in Clinical Education 1

Submitted to:
Mr. Lloyd Deocades
Clinical Instructor

Submitted by:
John-Francis B. Ycong
Group 5

Date Submitted:
Brand Name: Azactam
Generic Name: Aztreonam
Classification: Antibiotic
Mode of Action: Aztreonam is a bactericidal agent that acts by inhibition of bacterial
cell wall synthesis it is a monobactam antibiotic used primarily to treat infections caused
by gram-negative bacteria
Dosage:
Powder for Reconstitution:
Oral inhalation (75 mg)
>7 years: 75 mg 3x/day x 28 days
Do not repeat for 28 days after completion
Indications: Aztreonam is an antibiotic that fights severe or life-threatening infection
caused by bacteria. It is used to treat severe infections of the urinary tract, lower
respiratory tract, skin, stomach, female reproductive organs, and other body systems.

Contraindications: This preparation is contraindicated in patients with known

hypersensitivity to aztreonam or any other component in the formulation.
Side Effects:
Cough
mild stomach pain
Nasal congestion
sore throat
Vomiting
Pain at injection site

Adverse Effects:
Cough
Severe allergic reactions
Increase in serum transaminases
Neutropenia
Diarrhea
Nausea
Vomiting
Drug Interaction:
BCG Vaccine aztreonam decreases effects of bcg vaccine live by
pharmacodynamic antagonism.
Cholera vaccine pharmacodynamic antagonism. Avoid coadministration of
cholera vaccine with systemic antibiotics since these agents may be active against the
vaccine strain.
Typhoid vaccine live oral decreases effects of bcg vaccine live by
pharmacodynamic antagonism.
amoxicillin - increase effects of the other by pharmacodynamic synergism
combination may be used synergistically against enterobacteriaceae
aztreonam will increase the level of effect of digoxin by altering intestinal flora

RT Management:
In patients with impaired hepatic or renal function, appropriate monitoring is
recommended during therapy
.
Patients should be counseled that antibacterial drugs including Aztreonam for
injection should only be used to treat bacterial infections. They do not treat viral
infections (e.g., the common cold).

You should use a bronchodilator (eg, albuterol) before you use Aztreonam
Inhalation. Contact your doctor for instructions on how and when to use a
bronchodilator before using Aztreonam Inhalation.

Do not use Aztreonam Inhalation if it is cloudy, contains particles, or if it has been

stored at room temperature for more than 28 days.

To clear up your infection completely, use Aztreonam Inhalation for the full
course of treatment. Keep using it even if you feel better in a few days.

Aztreonam Inhalation is usually used for 28 days on the medicine followed by at

least 28 days off the medicine. Follow the dosing schedule given to you by your
doctor carefully.
 If you miss a dose of Aztreonam Inhalation, use it as soon as possible. If it is less
than 4 hours until your next dose, skip the missed dose and go back to your
regular dosing schedule. Do not use 2 doses at once.