IV.

PATHOPHYSIOLOGY

Predisposing factors:
Precipitating factors: Frequently eating
decrease urinary frequency junkfoods
and output Unhygienic habits

Legend: Invasion of exogenous streptococcal

Saprophyticus in the body

-Disease Process
Release of antigen-antibody complexes
in the circulation

-Signs and
symptoms Exogenous streptococcal bacteria goes
to the renal system (glomeruli)

Entrapment of exogenous streptococcal

bacteria in the endothelial lining of the
glomeruli

Immune complex
reaction in the glomerular
capillary

Proliferation of epithelial cells lining

glomerulus & cells between
endothelium & epithelium of capillary
membrane

Impairment to release
Inflammatory response erythropoeitin

Vasodilation of the renal arteries Inability to stimulate

supplying the glomeruli red bone marrow to
increase production of
RBC
 Increase perfusion of blood going to
the glomeruli
Decrease
RBC: 3.26
Hgb; 8.4
Swelling capillary membrane & Hct: 26.2
infiltration with leukocytes Pallor skin and
conjunctivae
restless

Reduction of glomelular membranes

capacity for selective permeability

Occlusion of the capillaries of the insufficient tissue perfusion going

glomeruli vasospasm of afferent to the kidneys
ventrioles

Leakage of large and small particles

- Hematuria such as RBC and protein. - decrease
- Proteinuria urine output
and frequency

↓ Glomerular filtration rate

↓ Ability to form filtrate from

glomeruli plasma flow

Third-space fluid shifting

from intravascular to
interstitial compartment in Retention of water and Ansarca
the peritoneal cavity waste products Restless
Increase BUN of
35.9
Increase of
Occurrence of
creatinine of
descending infection
1.30

Increase Invasion of the bacteria to the

abdominal girth ureter and bladder
of 77 cm
Increase
respiratory rate
of 32 cpm.

Increase
- pus cells in
WBC count
the urine
of 18.0