Expression of specific chemokines and chemokine receptors in

the central nervous system of multiple sclerosis patients

Torben L. Srensen,1,2 Marie Tani,1 Jakob Jensen,2 Virginia Pierce,1 Claudia Lucchinetti,3 Virginia A.
Folcik,1 Shixin Qin,4 Jim Rottman,4 Finn Sellebjerg,2 Robert M. Strieter,5 Jette L. Frederiksen,2 and Richard M.
Ransohoff1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC408141/

FIRST GROUP OBTAINED BY LUMBAR PUNCTURE

MULTIPLE SCLEROSIS
1000
900
1, 936
800
700
DIAGNOSIS

600
500 2, 620
4, 536
400
300
200
100
0 3, 103
6, 50 7,731
1 2 3 4 5,50 6
IP-10, MIG, RANTES, MCP-1, MIP-1, IL8, GRO

CONTROLLED
800 745

700
600
464
DIAGNOSIS

500
400 319
300
200
100 29 30
2 0
0
1 2 3 4 5 6 7
IP-10, MIG, RANTES,MCP-1, MIP-1, IL-8,GRO
 OTHER NEUROGICAL DISEASE CONTROL
900 801
800
700
586 574
600
DIAGNOSIS

500
400
300
200
100 40 36 48
0
0
1 2 3 4 5 6 7
IP-10,MIG,RANTES,MCP-1,MIP-1,IL-8,GRO

MS vs. CON
0.06
0.05
0.05

0.04
RELATIVITY

0.03

0.02

0.01
0.001 0.001 0.001 0 0 0
0
1 2 3 4 5 6 7
IP-10,MIG,RANTES,MCP-1,MIP-1,IL-8,GRO
 MS vs. OND
0.0012
0.001
0.001

0.0008
RELATIVITY

0.0006

0.0004

0.0002
0 0 0 0 0 0
0
1 2 3 4 5 6 7
IP-10,MIG,RANTES,MCP-1,MIP-1,IL-8,GRO

CXCR3 EXPRESSIONA BY CD4 AND CD8 CELLS IN BLOOD AND CSF

CD4

CD4
900 100
800 90
700 80
600 70
60
500
50
400
40
300 30
200 20
100 10
0 0
1 2 3 4 5 6 7

PATIENT ID Blood csf

CD8
 CD8
900 102
800 100
700
98
600
500 96
400 94
300
92
200
100 90

0 88
1 2 3 4 5 6 7

PATIENT ID BLOOD CSF