Exercise 4: Endocrine System Physiology: Activity 4: Measuring Cortisol and Adrenocorticotropic Hormone Lab Report

Pre-lab Quiz Results

You scored 100% by answering 5 out of 5 questions correctly.

1. Cortisol
You correctly answered: d. is a hormone important in the body's response to stress.

2. ACTH
You correctly answered: d. is a tropic hormone that stimulates cortisol release.

3. CRH
You correctly answered: b. has a tropic effect on the anterior pituitary gland.

4. Cushing's syndrome refers to

You correctly answered: c. a hypercortisolism, which could be iatrogenic.

5. A condition of hypocortisolism
You correctly answered: d. refers to low levels of cortisol in the blood.

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Experiment Results
Stop & Think Questions:
Normally high levels of cortisol would inhibit release of
You correctly answered: c. both ACTH and CRH

Which hormone(s) stimulate(s) the pituitary gland to release ACTH?

You correctly answered: a. CRH

Experiment Data:

Patient Cortisol High/Low ACTH High/Low

(mcg/dl) (pg/ml)
1 3.91 Low 16.95 Low
2 30.62 High 13.07 Low
3 41.31 High 83.82 High
4 2.30 Low 97.10 High
5 51.45 High 19.72 Low

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Post-lab Quiz Results
You scored 83% by answering 5 out of 6 questions correctly.

1. Under normal conditions, if the amount of secreted CRH increases, then

You correctly answered: c. the amount of secreted ACTH will increase.

2. Under normal conditions, if the amount of secreted ACTH increases, then

You correctly answered: d. the amount of secreted CRH will likely decrease.

3. Under normal conditions, if the amount of secreted cortisol increases, then

You correctly answered: b. the amount of secreted ACTH will likely decrease.

4. If a hypersecreting pituitary tumor develops, then an expected outcome is

You correctly answered: a. a diagnosis of Cushing's disease.

5. If a hypersecreting adrenal cortex tumor develops, then an expected outcome is

You correctly answered: b. abnormally low levels of CRH due to negative feedback.

6. A patient's chart lists the diagnosis of Addison's disease. Therefore, you expect
Your answer: c. abnormally low levels of CRH.
Correct answer: b. abnormally high levels of ACTH.

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Review Sheet Results
1. Which patient would most likely be diagnosed with Cushing's disease (view Table 4.1 in Experiment Results)? Why?
Your answer:
pasien 3
karena kadar kortisol dalam darahnya mengalami peningkatan, dan juga terjadi peningkatan kadar ACTH, sehingga pasien
ini mengalami "hypercortisolism", yang merupakan tanda klinis dari "Cushing's disease".

2. Which two patients have hormone levels characteristic of Cushing's syndrome (view Table 4.1 in Experiment Results)?
Your answer:
pasien 2 dan 5

3. Patient 2 is being treated for rheumatoid arthritis with prednisone. How does this information change the diagnosis (view
Table 4.1 in Experiment Results)?
Your answer:
pasien 2 ditangani menggunakan prednisone yang merupakan hormon glukokortikoid, sehingga pemberiannya dapat
meningkatkan kadar kortisol dalam darah, dan karenanya pasien didiagnosis mengalami iatrogenic cushing's syndrome.

4. Which patient would most likely be diagnosed with Addison's disease (view Table 4.1 in Experiment Results)? Why?
Your answer:
pasien 4
karena addison's disease ditandai dengan hipokortisolism yg dikarenakan oleh insufisiensi dari korteks adrenal yang tidak
dapat menghasilkan kortisol, sehingga terjadi penimbunan ACTH yang tidak dapat diproses lebih lanjut oleh korteks
adrenal.

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