PATHOPHYSIOLOGY OF OVARIAN CANCER

PRECIPITATING FACTORS: CONTRIBUTORY FACTORS:

PREDISPOSING FACTORS:
Smoking (6-7 sticks; 30 yrs.) Family history (Colon cancer
Age (45 y/o)
Polycystic Ovary Syndrome uncle)
Gender (Female)
Comorbidities (HTN, DM) Previous intake of oral
contraceptives

Alteration to genetic structure of

cellular DNA

Cellular mutation

Abnormal cells fail to

undergo apoptosis

Cancer cells proliferate

(hyperplasia)

MANAGEMENT:
Total Abdominal Tumor formation in the right ovary Female hormone Failure of egg
Hysterectomy Bilateral (+) 4x3.8 cm palpable mass, RLQ area; affectation cells to mature
Salpingo-oophorectomy pain
(TAHBSO)
Tumor release pro-inflammatory
cytokines, lactate, and Tumor angiogenesis factor (TAF) promote Irregular
parathormone-related peptide blood and nutrients to cancer cells menstrual cycles
substances that alter nutrition

Acts on the Hematogenous spread Cancer cells seed into

hypothalamus to the surface of the
suppress hunger peritoneal cavity

Metastasis to other
organs
Metastasis to peritoneal
Early satiety
lymph nodes
Anorexia
Weight loss
BMI: 15 (+) palpable node in

Pale conjunctiva the LUQ of the breast Release of mediators

Cancer cells compress (histamine) to promote
lymphatic channels and inflammatory response
impair lymph drainage

T: 38.9C (fever)
Slow fluid reabsorption PR: 113 bpm
RR: 26 bpm

Progressive abdominal
Fluid accumulation in enlargement
Increased pressure
peritoneum (ascites) AC: 68 cm
Bloating
Bulging flanks with (+)
Impaired venous fluid wave
return Fluid escapes through
transdiaphragmatic
lymphatic channels

Pooling of blood
Grade 2 bipedal edema Effusion to the
pleural cavity

Lagging on the L heme-diaphragm

Decreased tactile fremiti on the L
Decreased breath sounds on the L
Dyspnea
(+) nasal flaring with intercostal
retraction
RR: 26 bpm