Sepsis Antibiotics

Skin and Skin Structures

Goals of Therapy: Toxic Shock Syndrome
Obtain appropriate cultures Host (IVIG* 1g/kg with first Necrotizing Fasciitis
Determine appropriate coverage and dosing dose of antibiotics)
Administer within less than 1 hour of patient identification All: Normal,
Immunocompromised,
vancomycin and
Institutionalized/Recently meropenem*
Community Acquired Pneumonia clindamycin
Hospitalized, & Febrile
Host Antibiotic Neutropenic
azithromycin and ceftriaxone
Normal
moxifloxacin alone if allergic to beta lactams Abdominal Infection
azithromycin and ceftriaxone piperacillin/tazobactam
Immunocompromised Normal
moxifloxacin alone if allergic to beta lactams metronidazole & aztreonam if allergic to beta lactams

vancomycin and Immunocompromised piperacillin/tazobactam

Institutionalized/ Recently meropenem* alone if allergic to beta lactams
Hospitalized EITHER piperacillin/tazobactam or
ceftazidime Institutionalized/ Recently piperacillin/tazobactam
vancomycin and azithromycin and Hospitalized meropenem* alone if allergic to beta lactams
Febrile Neutropenic
meropenem
Febrile Neutropenic meropenem and vancomycin
Meningitis
Everyone: dexamethasone 0.4mg/kg (IBW if > 100kg) IV every 12 hours
after first dose of antibiotic Urosepsis
ceftriaxone and vancomycin Normal ceftazidime OR ciprofloxacin
add ampicillin if > 50 years old Immunocompromised ceftazidime OR ciprofloxacin
Normal
meropenem* & vancomycin if allergic to beta lactams
Institutionalized/ Recently piperacillin/tazobactam
Hospitalized/ Catheterized/
ciprofloxacin & vancomycin if allergic to beta lactams
Immunocompromised/ ampicillin and vancomycin and Instrumented
Recent Neurosurgery meropenem * Febrile Neutropenic meropenem and vancomycin
ampicillin and vancomycin and
Institutionalized/ Recently ceftriaxone
Hospitalized meropenem * & vancomycin if allergic to beta lactams

ampicillin and vancomycin and

Febrile Neutropenic
ceftriaxone * requires approval by Infectious Disease
meropenem * & vancomycin if allergic to beta lactams attending

ONLINE 11/06 (supersedes 10/05) Accompanies PO-7156 DO NOT SCAN