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DEPARTMENT OF PHARMACOLOGY - Model questions THEORY

MBBS 3rd term March 2006

Long essay
1. Discuss the various sources of drugs with suitable examples. Add a note on
rational drug use and the concept of essential drug list.
2. Mention the various injectable routes with suitable examples. Discuss the
advantages and disadvantages of intravenous route.
3. Mention the different phases of pharmacokinetics. Discuss the mechanisms of
passage of drugs across biological membranes with suitable examples.
4. Define the terms bioavailability and bioequivalence. Discuss the factors
influencing drug absorption and bioavailabilty by oral route with suitable
examples.
5. Define the term volume of distribution of drugs and explain its pharmacokinetic
significance. Discuss the factors, which influence drug distribution with suitable
examples.
6. Define the term biotransformation of drugs and explain its purpose. Mention the
important types of biotransformation reaction with suitable examples. Discuss the
factors influencing the biotransformation of drugs.
7. Define the term half-life of drugs. Mention the different types of half-lives and
explain their clinical significance. Discuss the methods of prolonging drug actions
with suitable examples.
8. Explain the terms actions and effects of drugs. Discuss the various mechanisms of
drug action with suitable examples.
9. Mention the various factors influencing drug response. Discuss the
pharmacological factors influencing drug response with suitable examples.
10. Define the term drug allergy. Discuss the various types of allergic reactions with
suitable examples and a note on their management.
11. Name the different types of histamine receptors and mention their agonists and
antagonists. Discuss the pharmacological actions and adverse effects and
therapeutic uses of H1 blockers.
12. Classify the anticoagulants. Discuss the mechanism of action, adverse effects,
therapeutic uses and drug interactions of oral anticoagulants.
13. What are hematinics? Mention the oral and parenteral iron preparations and
indications for parenteral iron therapy. Add a note on the management of acute
iron poisoning.
14. Classify the anticholinesterase drugs. Discuss the pharmacological actions,
adverse effects and therapeutic uses of reversible antichlolinesterases.

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15. Classify the drugs used in cardiac failure, explaining the rationale for the use each
class of drugs. Discuss the pharmacological actions, adverse effects, therapeutic
uses and contraindications of digitalis.
16. Classify the antiarrythmic drugs. Discuss the pharmacological actions,
pharmacokinetics, adverse effects and therapeutic uses of quinidine.

17. Classify the anti-anginal drugs. Discuss the mechanism of action,


pharmacokinetis, adverse effects and therapeutic uses of nitrates.

18. Classify the calcium channel blockers. Discuss the pharmacological actions,
adverse effects and therapeutic uses of dihydropyridines.

19. Classify the Adrenergic drugs based on their chemical structure and clinical
utility. Discuss the pharmacological actions and therapeutic uses of
catecholamines.

20. Classify the local anesthetics and explain their mechanism of action. Discuss the
various techniques of local anesthesia and their clinical utility. Mention the
adverse effects and complications of local anesthetics.

21. Name the various types of adrenergic receptors and their physiological functions.
Discuss the pharmacological actions, adverse effects & therapeutic uses of
selective beta-2 agonists.

II. Short notes

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1. Over the Counter Medications 16. Drug dependence
2. Advantages of drug prescribing 17. Cumulative effect of drugs
in 18. Pathological factors influencing
3. generic names drug response
4. Patient compliance 19. Tachyphylaxis
5. Pharmacopoeias 20. Rectal administration of drugs
6. Transdermal administration of 21. Cholinergic receptors
drugs 22. Secondary prophylaxis of MI
7. Placental transfer of drugs 23. Class III anti-arrhythmic drugs
8. Drug prescribing during lactation 24. Parenteral ionotropic agents
9. Microsomal enzyme induction 25. Therapeutic uses of
10. Pharmacogenetics prostaglandins
11. Pulmonary route of drug 26. Sub-lingual administration of
administration drugs
12. Selective distribution of drugs 27. 5-HT antagonists
13. Kinetics of clearance 28. Drugs used for PSVT
14. Placebo 29. LMW heparin
15. Idiosyncrasy
30. Fibrinolytic agents 42. Receptor regulation
31. Pharmacoeconomics 43. Appetite suppressants
32. Hemopoetic growth factors 44. Drugs influencing CA
33. Lignocaine as antiarrythmic Biosynthesis
agent 45. Immuno-complex reactions
34. Therapeutic uses of anti-platelet 46. Laboratory control of anti-
drugs coagulant
35. Styptic agents Therapy
36. Adenosine 47. Drug antagonism
37. Anti-fibrinolytic agents 48. Potency and efficacy of drugs
38. Therapeutic index of drugs 49. Delayed hypersensitivity
39. Treatment of pernicious anemia 50. Intramuscular injection
40. Orphan drugs 51. Nasal decongestants
41. Folic acid

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52. Therapeutic uses of alpha local anesthetics
blockers 54. Cholinomimetic alkaloids
53. Advantages & disadvantages of 55. Oximes
combining vasoconstrictors with
& release

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