DEPARTMENT OF PHARMACOLOGY, KIMS

IAE THEORY- MODEL QUESTIONS

MBBS 3rd term Aug 2008
Long essay

1) Discuss the various sources of drugs with suitable examples. Add a note on rational drug
use and the concept of essential medicine list. GP

2) Mention the various injectable routes with suitable examples. Discuss the advantages and
disadvantages of intravenous route. Name the drugs always used by I.V. route. GP

3) Mention the different phases of pharmacokinetics. Discuss the mechanisms of passage of

drugs across biological membranes with suitable examples. GP

4) Define the terms bioavailability and bioequivalence. Discuss the factors influencing drug
absorption and bioavailability by oral route with suitable examples. GP

5) Define the term volume of distribution of drugs and explain its pharmacological
significance. Discuss the factors which influence drug distribution with suitable examples.
GP

6) Define the term drug biotransformation and explain its purpose. Mention the important
types of biotransformation reactions with suitable examples. Discuss the factors
influencing drug biotransformation. GP

7) Define the term half-life of drugs. Mention the different types of half-lives and explain
their clinical significance. Discuss the methods of prolonging drug actions with suitable
examples. GP

8) Explain the terms actions and effects of drugs. Discuss the various mechanisms of drug
action with suitable examples. GP

9) Mention the various factors influencing drug response. Discuss the pharmacological
factors influencing drug response with suitable examples. GP

10) Define the term drug allergy. Discuss the various types of allergic reactions with suitable
examples and a note on their management. GP

11) Name the different types of histamine receptors and mention their agonists and
antagonists. Discuss the pharmacological actions, adverse effects and therapeutic uses of
H 1 blockers. Autacoids

12) Classify the local anesthetics and explain their mechanism of action. Discuss the various
techniques of local anesthesia and their clinical utility. Mention the adverse effects and
complications of local anesthetics. PNS

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 13) Mention the various routes of drug excretion. Discuss the mechanisms of renal excretion
of drugs and factors influencing them with suitable examples. GP

14) Classify the drugs used in cardiac failure, explaining the rationale for the use each class
of drugs. Discuss the pharmacological actions, adverse effects, therapeutic uses and
contraindications of digitalis. CNS

15) Classify the anticoagulants. Discuss the mechanism of action, adverse effects,
therapeutic uses and drug interactions of oral anticoagulants. BLOOD

16) What are hematinics? Mention the oral and parenteral iron preparations and indications
for parenteral iron therapy. Add a note on the management of acute iron poisoning.
BLOOD

17) Classify the drugs used in Bronchial Asthma and explain their mechanism of action and
purpose of use. Outline the management of an acute attack, recurrent attacks & status
asthmaticus RESPIRATORY

II. Short notes

1. Non-prescription drugs GP 25. Entero hepatic recycling of drugs GP

2. Advantages of drug prescribing in 26. Therapeutic index of drugs GP
generic names GP 27. Orphan drugs GP
3. Patient compliance GP 28. Receptor regulation GP
4. Pharmacopoeias GP 29. Immuno-complex reactions GP
5. Transdermal administration of drugs GP 30. Drug intolerance GP
6. Placental transfer of drugs GP 31. Drug antagonism GP
7. Drug prescribing during lactation GP 32. Potency and efficacy of drugs GP
8. Microsomal enzyme induction GP 33. Repository preparations GP
9. Pharmacogenetics GP 34. Delayed hypersensitivity GP
10. Pulmonary route of administration GP 35. Drug dependence GP
11. Selective distribution of drugs GP 36. Intramuscular injection GP
12. Kinetics of clearance GP 37. Advantages & disadvantages of
13. Placebo GP combining vasoconstrictors with
14. Idiosyncrasy GP local anesthetics GP
15. Advantages & disadvantages of oral route 38. Redistribution of drugs GP
GP 39. Parenteral ionotropic agents CNS
16. Cumulative effect of drugs GP 40. Teratogenicity of drugs GP
17. Pathological factors influencing drug 41. Sumatriptan AUTACOIDS
response GP 42. Antifibrinolytics BLOOD
18. Tachyphylaxis GP 43. Topical hemostatics BLOOD
19. Rectal administration of drugs GP 44. Antiplatelet agents BLOOD
20. 5-HT antagonists AUTACOIDS 45. LMW heparin BLOOD
21. Non-sedating H 1 blockers AUTACOIDS 46. Fibrinolytics BLOOD
22. Sub-lingual administration of drugs GP 47. Drugs used for migraine prophylaxis
23. Bupivacaine PNS AUTACOIDS
24. Pharmacoeconomics GP 48. Hemopoietic growth factors BLOOD
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49. Drugs used for megaloblastic anaemia
BLOOD
50. Therapeutic uses of prostaglandins
AUTACOIDS