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This is called glial activation and upon repeated destruction of the OG cells
and myelin sheath this process leads to scar-like plaques that developed
around the damaged neurons (5).
Additionally, MS is characterized by a breakdown in the blood brain barrier
(which protects the brain from toxins, infectious microorganisms and our own
immune system) and T lymphcytes which are normally unable to cross the
blood brain barrier are able to enter into the neurological tissue. These T
lymphocytes agitate more inflammatory mechanisms and promote swelling
and further tissue destruction.
Immune Modulation:
Chronic inflammatory disorders are characterized by a hyper responsive
immune system. There are several key factors that must be addressed to
regulate and better coordinate the immune system.
The AGEs destroy cell membrane function and damage insulin receptor
activity creating a vicious cycle of elevated blood sugar and inflammatory
stress. AGEs cause massive destruction throughout the body and have an
affinity for neurological tissue.
When the blood sugar drops too low (hypoglycemia), it causes the blood
brain barrier to become more permeable in order to get more sugar into the
neurological tissue. Part of this characterization is a reduction in Interleukin-
25 (19).
This permeability opens the door for toxic debris and inflammatory molecules
(such as TNF-alpha) to get into the brain tissue and cause major problems.
This is a serious problem in the pathogenesis of multiple sclerosis (20)
The most common food based culprits include all processed foods, artificial
sweeteners/preservatives and gluten containing products. Soy, peanuts,
pasteurized dairy, corn and eggs are often not tolerated well.
The nightshadefamily of eggplant, potatoes and tomatoes are often
challenging on the system as well.
Mitochondrial Dysfunction:
Every cell of the body has mitochondria within it that produce energy for the
cell. The mitochondria are the battery packs of the cell and they are
extremely important. High levels of oxidative stress wear down the
mitochondria and cause a dysfunctional state.
Mitochondria are one of the main cellular sources of reactive oxygen species
(ROS) and reactive nitrogen species (RNS) and play a pivotal role in many
neuro-pathological conditions. Mitochondrial dysfunction leading to
excessive production of ROS and RNS plays a significant role in the
pathogenesis of MS, particularly in loss of myelin/oligodendrocyte complex
(30, 31).
Supporting the mitochondria with clinically effective doses of mitochondrial
nutrients such as CoQ10, L-carnitine, N-acetyl cysteine and lipoic acid has
been shown to be extremely effective for improving mitochondrial health and
MS (32, 33, 34).
Organ meats such as grass-fed liver, heart, etc. are rich in mitochondrial
support nutrients. Powerful herbs such as turmeric, ginger, garlic, onion,
rosemary, thyme, cinnamon, & oregano among others should be used as
much as possible to improve immune coordination.
Consuming lots of sulfur based onions, garlic, cruciferous veggies on a daily
basis and getting high quality seaweed in the form of kelp can be extremely
helpful. Using purified fish oils to boost up omega 3 levels is also very
important.
Upper Cervical Subluxation and MS:
People with MS are highly likely to have neurological dysfunction in their
upper neck. Subluxation, or neurological interference, at the bottom of the
skull, C1 & C2 alters blood supply, stress hormone release and immune
modulation throughout the body. Research has found this problem to be very
common in MS patients (38)
Upper cervical subluxation leads to increased states of pain, fatigue, anxiety
and accelerated stress as well as mal-coordinated immunity (39).
Well trained chiropractors can analyze these regions of the spine and give
specific corrective adjustments to restore balance and optimal neurological
expression in these regions. This reduces the stress response and improves
endorphin release. This improves the individuals pain levels, stress
tolerance, immune function and overall well-being (40).