Target Target

Nama Sumber Fungsi

receptors cells
T helper cells co-stimulation
B cells maturation & proliferation
macrophages, B cells, CD121a/IL1R1,
IL-1 NK cells activation[
monocytes,dendritic cells CD121b/IL1R2
macrophages, inflammation small amounts induce acute
endothelium, other phase reaction, large amounts induce fever
stimulates growth and differentiation of T
cell response. Can be used in
activatedT cells and B
CD25/IL2RA, immunotherapy to treat cancer or
cells, NK cells,
IL-2 Th1-cells CD122/IL2RB, suppressed for transplant patients. Has also
macrophages,
CD132/IL2RG been used in clinical trials (ESPIRIT.
oligodendrocytes
Stalwart) to raise CD4 counts in HIV
positive patients.
differentiation and proliferation of myeloid
activated T helper hematopoietic stem
CD123/IL3RA, progenitor cells to e.g. erythrocytes,
IL-3 cells,[35] mast cells, NK cells, cells
CD131/IL3RB granulocytes
endothelium, eosinophils
mast cells growth and histamine release
proliferation and differentiation, IgG1 and
Th2 cells, just activated activated B cells IgE synthesis. Important role in allergic
naive CD4+ cell, memory CD124/IL4R, response (IgE)
IL-4
CD4+ cells, mast cells, CD132/IL2RG
T cells proliferation
macrophages
endothelium
Th2 cells, mast cells, CD125/IL5RA, eosinophils production
IL-5
eosinophils CD131/IL3RB B cells differentiation, IgA production
activated B cells differentiation into plasma cells
plasma cells antibody secretion
macrophages, Th2 cells, B
CD126/IL6RA, hematopoietic stem
IL-6 cells, astrocytes, differentiation
CD130/IR6RB cells
endothelium
induces acute phase reaction, hematopoiesis,
T cells, others
differentiation, inflammation
differentiation and proliferation of lymphoid
pre/pro-B cell,
Bone marrow stromal cells CD127/IL7RA, progenitor cells, involved in B, T, and NK
IL-7 pre/pro-T cell, NK
and thymus stromal cells CD132/IL2RG cell survival, development, and homeostasis,
cells
proinflammatory cytokines
macrophages, lymphocytes, neutrophils,
IL-8 or CXCR1/IL8RA,
epithelial cells, endothelial basophils, Neutrophil chemotaxis
CXCL8 CXCR2/IL8RB/CD128
cells lymphocytes
Th2 cells, specifically by Potentiates IgM, IgG, IgE, stimulates mast
IL-9 CD129/IL9R T cells, B cells
CD4+ helper cells cells
macrophages cytokine production
B cells activation
monocytes, Th2 cells, CD8+
CD210/IL10RA, mast cells
IL-10 T cells, mast cells,
CDW210B/IL10RB inhibits Th1 cytokine production (IFN-,
macrophages, B cell subset Th1 cells
TNF-, IL-2)
Th2 cells Stimulation
acute phase protein production, osteoclast
IL-11 bone marrow stroma IL11RA bone marrow stroma
formation
differentiation into Cytotoxic T cells with IL-
dendritic cells, B cells, T CD212/IL12RB1, activated [35] T cells,
IL-12 2,[35] IFN-, TNF-, IL-10
cells, macrophages IR12RB2
NK cells IFN-, TNF-
Stimulates growth and differentiation of B
cells (IgE), inhibits TH1-cells and the
activated Th2 cells, mast TH2-cells, B cells,
IL-13 IL13R production of macrophage inflammatory
cells, NK cells macrophages
cytokines (e.g. IL-1, IL-6), IL-8, IL-10, IL-
12
T cells and certain controls the growth and proliferation of B
IL-14 activated B cells
malignant B cells cells, inhibits Ig secretion
 mononuclear phagocytes
(and some other cells),
T cells, activated B
IL-15 especially macrophages IL15RA Induces production of Natural killer cells
cells
following infection by
virus(es)
lymphocytes, epithelial cells, CD4+ T cells (Th-
IL-16 CD4 CD4+ chemoattractant
eosinophils, CD8+ T cells cells)
CDw217/IL17RA, epithelium, osteoclastogenesis, angiogenesis,
IL-17 T helper 17 cells (Th17)
IL17RB endothelium, other inflammatory cytokines
Induces production of IFN, NK cell
IL-18 macrophages CDw218a/IL18R1 Th1 cells, NK cells
activity
IL-19 IL20R
regulates proliferation and differentiation of
IL-20 IL20R
keratinocytes
costimulates activation and proliferation of
CD8+ T cells, augment NK cytotoxicity,
activated T helper cells, All lymphocytes,
IL-21 IL21R augments CD40-driven B cell proliferation,
NKT cells dendritic cells
differentiation and isotype switching,
promotes differentiation of Th17 cells
Activates STAT1 and STAT3 and increases
production of acute phase proteins such as
IL-22 IL22R serum amyloid A, Alpha 1-
antichymotrypsin and haptoglobin in
hepatoma cell lines
Increases angiogenesis but reduces CD8 T-
IL-23 IL23R
cell infiltration
Plays important roles in tumor suppression,
IL-24 IL20R wound healing and psoriasis by influencing
cell survival.
Induces the production IL-4, IL-5 and IL-13,
IL-25 LY6E
which stimulate eosinophil expansion
Enhances secretion of IL-10 and IL-8 and
IL-26 IL20R1 cell surface expression of CD54 on epithelial
cells
Regulates the activity of B lymphocyte and T
IL-27 IL27RA
lymphocytes
Plays a role in immune defense against
IL-28 IL28R
viruses
IL-29 Plays a role in host defenses against microbes
IL-30 Forms one chain of IL-27
IL-31 IL31RA May play a role in inflammation of the skin
Induces monocytes and macrophages to
IL-32
secrete TNF-, IL-8 and CXCL2
Induces helper T cells to produce type 2
IL-33
cytokine
IL-35 regulatory T cells Suppression of T helper cell activation

IL-36 Regulates DC and T cell responses