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Horm Behav. 2008 May;53(5):716-28. doi: 10.1016/j.yhbeh.2008.01.014. Epub 2008 Feb 15.

Androgen regulation of axon growth and

neurite extension in motoneurons.
Fargo KN1, Galbiati M, Foecking EM, Poletti A, Jones KJ.

Author information

Abstract

Androgens act on the CNS to affect motor function through interaction with a widespread distribution
of intracellular androgen receptors (AR). This review highlights our work on androgens and process
outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons
involve the generation of novel neuronal interactions that are mediated by the induction of androgen-
dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the
androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured
immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We
place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries.

PMID:
18387610
PMCID:

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Androgen regulation of axon growth and neurite extension in m... file:///Users/chrisgroves/!gear/Androgen regulation of axon gro...

PMC2408920
DOI:
10.1016/j.yhbeh.2008.01.014

[Indexed for MEDLINE]

Free PMC Article

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