https://en.wikipedia.

org/wiki/Brown_tumor

Brown tumor
From Wikipedia, the free encyclopedia
Brown tumor

Brown tumours of the hands in a patient with

hyperparathyroidism.
Classification and external resources
ICD-9-CM 252.01
DiseasesDB 30721
MeSH D010002
[edit on Wikidata]

The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as
hyperparathyroidism. It is not a true neoplasm, as the term "tumor" suggests; however, it may
mimic a true neoplasm.[1] Brown tumours are radiolucent on x-ray.

Contents
1 Pathology
2 Epidemiology
3 See also
4 References

Pathology
Micrograph of a brown tumor (left of image). H&E stain.

Brown tumours consist of fibrous tissue, woven bone and supporting vasculature, but no
matrix. The osteoclasts consume the trabecular bone that osteoblasts lay down and this front
of reparative bone deposition followed by additional resorption can expand beyond the usual
shape of the bone, involving the periosteum thus causing bone pain. The characteristic brown
coloration results from hemosiderin deposition into the osteolytic cysts. Hemosiderin
deposition is not a distinctive feature of brown tumors; it may also be seen in giant cell
tumors of the bone.[2][3]

Brown tumors may be rarely associated with ectopic parathyroid adenomas.[4]

Epidemiology
Age and gender have an effect on the incidence of these lesions; they are more prevalent in
women than men (though still common in both genders), and they appear more frequently
with age. Due to the standard of medical care and screening in developed countries, it is
increasingly rare for primary hyperparathyroidism to present with accompanying bone
disease. This is not the case in less developed nations, however, and the two conditions are
more often seen together.[5]

See also
Osteitis fibrosa cystica

References
1.

Meydan N, Barutca S, Guney E, et al. (June 2006). "Brown tumors mimicking bone
metastases". J Natl Med Assoc. 98 (6): 9503. PMC 2569361 . PMID 16775919.
Aoki, J.; Moriya, K.; Yamashita, K.; Fujioka, F.; Ishii, K.; Karakida, O.; Imai, S.; Sakai,
F.; et al. (1991). "Giant cell tumors of bone containing large amounts of hemosiderin: MR-
pathologic correlation". J Comput Assist Tomogr. 15 (6): 10247. doi:10.1097/00004728-
199111000-00023. PMID 1939753.
Matsushige, T.; Nakaoka, M.; Yahara, K.; Kagawa, K.; Miura, H.; Ohnuma, H.; Kurisu,
K. (Aug 2008). "Giant cell tumor of the temporal bone with intratumoral hemorrhage". J Clin
Neurosci. 15 (8): 9237. doi:10.1016/j.jocn.2007.03.013. PMID 18554912.
Sharma, Ravi; Mathan Mohan; R S Neelakandan; D Siddharth (October 2013). "An
unusual case of brown tumor of hyperparathyroidism associated with ectopic parathyroid
adenoma". European Journal of Dentistry. 7 (4): 500503. doi:10.4103/1305-7456.120657.
Retrieved 2013-10-28.

5. http://www.bonetumor.org/tumors-disorder-metabolism/brown-tumor

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v
t
e

Bone and joint disease (M80M94, 730733)

Osteitis fibrosa cystica
endocrine: o Brown tumor

Osteomyelitis
o Sequestrum
Inflammation o Involucrum
Sesamoiditis
infection:
Brodie abscess
Periostitis
Vertebral osteomyelitis

Bone density
Osteoporosis
o Juvenile
Metabolic Osteopenia
Osteomalacia
Bone Paget's disease of bone

Osteolysis
Bone Hajdu-Cheney syndrome
resorption Ainhum

Ischaemia
o Avascular necrosis
o Osteonecrosis of the jaw
Algoneurodystrophy
Hypertrophic pulmonary osteoarthropathy
Nonossifying fibroma
Other
Pseudarthrosis
Stress fracture
Fibrous dysplasia
o Monostotic
o Polyostotic
Skeletal fluorosis
 bone cyst
o Aneurysmal bone cyst
Hyperostosis
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Pycnodysostosis

Relapsing polychondritis
Chondritis
Joint
Tietze's syndrome
Other

Osteochondritis dissecans
Osteochondritis

hip
o LeggCalvPerthes syndrome
tibia
o Osgood-Schlatter disease
leg: o Blount's disease
foot
o Khler disease
Combined o Sever's disease
Child

spine o Scheuermanns disease

wrist
o Kienbock's disease
arm: elbow
o Panner disease

Categories:

Skeletal disorders