Abstracts e99
Objective: We aimed to compare prolonged hypotension following moderate-
intensity continuous exercise (MICE), high-intensity interval exercise (HIIE) in
dry land or HIIE in immersed condition, using 24-h ambulatory blood pressure
monitoring (ABPM).
Design and method: Forty-two individuals (Table 1) suffering from hypertension
or with a baseline blood pressure (BP) > = 130/85 mmHg (systolic/diastolic, SBP/
DBP), were randomly assigned to performing one of the three following exercises
on a stationary cycle: MICE (24-min at 50% peak power output (PPO)) or HIIE
in dry land (two sets of 10-min with phases of 15-sec at 100% PPO interspersed
by 15-sec of passive recovery) or HIIE in up-to-the-chest immersed condition.
ABPM and ambulatory pulse wave velocity (PWV) were assessed during the 24-h
after.
Results: While MICE modified none of the 24-h average hemodynamic vari-
ables, dryland HIIE induced a 24-h BP decrease (SBP: 3.6 5.7/DBP: 2.8
3.0 mmHg, P < 0.05) and, to a much greater extent, immersed HIIE (SBP: 6.8
9.5/DBP: 3.0 4.5 mmHg, P < 0.05). The one condition that modified 24-h
PWV was immersed HIIE (0.21 0.30 m/s, P < 0.05).
Conclusions: HIIE performed on a stationary cycle in immersed condition, ap-
peared more effective than HIIE in dry land and MICE in improving 24-h ABPM.
In addition, cycling in water alleviated 24-h arterial stiffness.
OP.8A.05 REGULAR PHYSICAL ACTIVITY ATTENUATES
THE ASSOCIATION BETWEEN COFFEE
CONSUMPTION AND CARDIOVASCULAR EVENTS
IN HYPERTENSION. THE HARVEST
L. Mos1, C. Fania2, F. Saladini2, A. Mazzer3, S. Cozzio4, A. Bortolazzi5,
G. Garavelli6, E. Casiglia2, P. Palatini2. 1Town Hospital, San Daniele del Friuli,
ITALY, 2University of Padua, Padua, ITALY, 3Town Hospital, Vittorio Veneto, ITA-
LY, 4Town Hospital, Trento, ITALY, 5Town Hospital, Rovigo, ITALY, 6Town Hospi-
tal, Cremona, ITALY
Objective: Coffee consumption has been found to predict the risk of cardiovas-
cular events (CVE) in hypertension. Aim of the present study was to ascertain
whether the strength of the coffee-CVE association is modulated by regular physi-
cal activity.
Design and method: The analysis was made in 1204 participants from the HAR-
VEST, a prospective cohort study of non-diabetic subjects aged 1845 years,
screened for stage 1 hypertension. Among the participants, 26.2% were abstain-
ers, 62.8% were moderate coffee drinkers (13 cups/day) and 10.0% were heavy
coffee drinkers (>3 cups/day). For physical activity level, 61.1% were categorized
as sedentary (class 0), 14.9% as mild exercisers (class 1), 14.9% as amateurs
(class 2), and 9.1% as competitive athletes (class 3).
Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.
Results: The frequency of coffee drinkers was higher among the sedentary
(77.4%) than the active (67.9%) subjects (p < 0.001). During a 12.6 year follow-
up 70 participants developed a CVE. The rate of CVE was higher among the
coffee drinkers (7.1%) than the abstainers (2.2%, p = 0.001) and was higher in the
sedentary (7.2%) than the active (3.6%) subjects (p = 0.01). In a 2x2 sub-table the
coffee-related difference in CVE was significant among the sedentary (p = 0.006)
but not the active subjects (p = 0.22) with a Mantel-Haenszel Chi-Square = 8.3 (p
= 0.004). In a multivariable Cox analysis, including age, sex, parental CVE, smok-
ing, alcohol use, total cholesterol, follow-up hypertension, and a coffee-physical
activity interaction term, coffee consumption was a significant predictor of CVE
in heavy coffee drinkers (Hazard ratio, 95% CI; 3.3, 1.28.9) and was a borderline
predictor in moderate drinkers (HR, 95% CI; 2.0, 0.94.5). In addition, a bor-
derline negative interaction was found between coffee consumption and physical
activity habits on risk of CVE (p = 0.05).
Conclusions: These data confirm that coffee use is associated with increased risk
of CVE in young-to-middle age subjects with stage 1 hypertension. However, the
effects of coffee on risk of CVE is modulated by the individual level of physical
activity. Regular physical activity seems to counteract the long-term deleterious
effect of caffeinated coffee on the cardiovascular system.
OP.8A.06 CARDIAC REHABILITATION IN HYPERTENSIVE
PATIENTS: COMPARISON BETWEEN TWO
PROTOCOLS
L.B. Parreira1, P.C.B. V. Jardim1, A.L.L Sousa1, T.S.V. Jardim1, W.M. Sousa2,
A.F.O. Justo2, W.K.S.B. Souza1, P.V.O. Vitorino1,2. 1Liga de Hipertenso Arterial
da Universidade Federal de Gois, Goinia, BRAZIL, 2Mestrado em Ateno
Sade da Pontifcia Universidade Catlica de Gois, Goinia, BRAZIL
Objective: To compare clinical and functional parameters in hypertensive patients
who underwent two cardiac rehabilitation protocols: supervised and partially su-
pervised.
Design and method: This randomized clinical trial included patients with stage
I or II hypertension, > 18 years, with no contraindication to physical exercise,
who did not use beta blockers and used at least three antihypertensive drugs and
also did not have limited voluntary ambulation. Group 1 participated in partially
supervised cardiac rehabilitation and group 2, supervised rehabilitation. All par-
ticipants did warm-up exercises, physical conditioning, resistance training, and
cool-downs three days a week with sessions lasting 45 minutes over a period of
three months. Before and after the intervention, the patients underwent physical
evaluation, a six-minute walking test, treadmill exercise test, metabolic exams,
and central and peripheral measures of blood pressure.
Results: We evaluated 61 patients (30 in group 1/31 in group 2) with a mean age
of 60.3 11.3 years; 78.7% were women. In the initial evaluation, the groups
were homogenous with regard to all parameters except for mean body mass index
values, which were 30.1 5.5 Kg/m2 in group 1 and 26.6 7.0 Kg/m2 in group
2 (p = 0.040). After the intervention, both groups were able to walk farther in the
six-minute walking test: group 1 increased mean distance by 30.6 meters (p =
0.004) and group 2 increased by 55.0 meters (p < 0.001). In addition, group 2 had
higher values for weight bearing achieved in muscular strength tests, advancing
from 2.3 0.7 Kg to 3.0 0.7 for upper limbs (p < 0.001) and from 3.4 0.9 Kg to
3.8 0.8 Kg for the lower limbs (p < 0.001). Gains were also seen in the maximal
consumption of oxygen, from 24.7 8.6 mlO2/Kg/min to 28.4 7.5 mlO2/Kg/
min (p = 0.003). Adherence to the intervention was similar for both groups: 77.5
11% (G1) and 82 10% (G2) (p = 0.124).
Conclusions: The partially supervised cardiac rehabilitation program resulted in
significant improvements in the distance covered in the six-minute walking test.
The supervised cardiac rehabilitation program yielded, in addition to this gain,
significant improvements in muscular strength and maximal consumption of oxy-
gen. Adherence was satisfactory in both groups.