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The Most Promising Antioxidant You Never Heard Of

By Hank Campbell | May 19th 2014 06:02 PM | 6 comments | Print | E-mail | Track Comments

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There is a discovery out there that has shown some success with multiple sclerosis, with
amyotrophic lateral sclerosis (ALS - Lou Gehrig's Disease), and has even improved the function of
aging hearts but despite all that, you have probably never heard of it.

No, this is not a story about how a revolutionary breakthrough got bought up by some giant
corporation and stuck in a warehouse to protect their profits - it is instead a story about how
potentially good products may never see the light of day for lots of reasons. It happens more
often than you think.

In 2013, we covered a study on Science 2.0 which suggested a cure for a mouse version of
multiple sclerosis. A few weeks ago a study came out which showed improvements in the
arteries of old mice. This month Elsevier published a study showing improvements in
ALS. Another study last year showed improvement in Inflammatory Bowel Disease (IBD).

They all had one thing in common an antioxidant called MitoQ.

*****

Antioxidants are widely criticized because some companies in the supplements business are
correlating all kinds of health benefits without being any more specific than that they contain
'antioxidants'. The $35 billion organic food marketing machine claims locally-grown organic
tomatoes have more antioxidants and are therefore superior to regular-priced tomatoes. It's
okay to be skeptical of miracle health claims, I know I am.

But long before the hype, there was science happening and there still is today. Antioxidants are
intriguing because oxidative phosphorylation, our metabolic pathway, impacts how the energy
stored in food can be used within our cells. As we age, mitochondria, an organelle in cells that
uses oxygen to turn carbohydrates and into energy, are less able to carry out their core function
of making adenosine triphosphate (ATP). When cells age, we age. Obviously, when antioxidants
talk about slowing aging it is going to get attention but, as GlaxoSmithKline has discovered with
resveratrol, proving it is difficult.

And some cynicism is warranted. Joe Mercola gushes about antioxidants, which is a red flag for
everyone in science, so how can the public separate the salesmanship from the evidence? And if
antioxidants impact how cells create energy, why not just take more vitamin E, since antioxidant
activity is its most important benefit? Or vitamin C?

Why indeed. But there may be a bigger benefit than selling better health. Under the radar, away
from CNN headlines about antioxidants and red wine, scientists think a particular antioxidant
may be the key to unlocking answers to a lot of disease problems. And the company behind it
may never see anything for their efforts.

That takes us back to ALS, MS, heart disease and the MitoQ at the heart of all those studies. It
leads to an obvious question; why isn't this in clinical trials? The answer is intriguing.

*****

MitoQ is appropriately named because it is a mitochondria-targeted antioxidant descended

from discoveries of Coenzyme Q that started in 1957. Coenzyme Q, commonly called CoQ10, is a
molecule made inside the mitochondria as a component of the electron transport chain, to
enable cellular respiration and ATP. Its oily and sticky and that is fine inside mitochondria
because it doesn't need to exit or enter the membrane but coming from the outside, like with a
supplement, it doesnt penetrate very well. Because the antioxidants didnt actually get to
mitochondria, people who took a CoQ10 supplement didn't get much benefit, just like eating
more fruits isnt enough. It turns out, a CoQ10 supplement only ends up having about 5 percent
bioavailability.

Credit: MitoQ.

A decade and a half ago, Professor Michael P. Murphy and Professor Robin A.J. Smith of the
University of Otago found a way to change that, by introducing a phosphonium (salt) ion. You
are aware that a lot of our bodily functions are electrical in nature. Mitochondria are negatively
charged and, as you know from school, opposites attract. By adding a phosphonium group to
the Coenzyme Q quinone group they introduced a positive charge and discovered that the
antioxidant could still be quickly reduced to active quinol form by cells - but at levels 800-1200
times greater than CoQ10.

By doing so, Murphy and Smith solved the puzzle as to why just eating more fruits didn't prevent
cells from becoming less efficient as we age and perhaps how to fix that.
Accumulation of MitoQ10 into cells and mitochondria. MitoQ10 will first pass through the plasma
membrane and accumulate in the cytosol driven by the plasma membrane potential (Dyp). From
there it will be further accumulated several-hundred fold into the mitochondria, driven by the
mitochondrial membrane potential (Dym). There it will be reduced to the active antioxidant
ubiquinol. In preventing oxidative damage it will be oxidised to the ubiquinone which will then be
re-reduced. ( Murphy, MP, Smith, RAJ, 'Targeting antioxidants to mitochondria by conjugation to
lipophilic cations', ANNU REV PHARMACOL TOXICOL Volume: 47 Pages 629-656 2007)

There are about 200 conditions associated with mitochondria dysfunction and now an
antioxidant could be delivered directly into the mitochondria at levels that were really
meaningful.

For obvious reasons, they got patents on it, and research continued. Clinical trials began.
Optimism was high.
*****

Clinical trials are almost as old as society itself. There is a clinical trial in The Bible (the Book of
Daniel) but a more famous example is recent, when James Lind used a clinical trial to show that
citrus fruit cured scurvy - a disease that leads to open wounds, rotting teeth and lethargy,
primarily in sailors - in 1747. Since then, clinical trials have become the norm.

We hear a lot about Phase II and Phase III and other terms when it comes to clinical trials so
here is a short primer. Research is often done on animal models and, if the results are
promising, they will go to a clinical trial. All clinical trials share a few traits in common - informed
consent, statistical power and a placebo group. A Phase I trial is looking for side effects that
haven't been found in animal tests and to figure out dosing. If things look promising, as in it
could be a commercial product, a Phase II trial recruits larger numbers to really see that it
works, that there are no side effects, and that it is better than a placebo.

Phase III is where things get really exciting because it compares the new treatment with the best
currently available treatment. In todays drawn out regulatory environment, a Phase III trial will
often be an exit for a small company because conducting it requires a lot of money and a larger
company may be confident enough in its potential that they are willing to pay for the product
right now.

Trials are absolutely required to get government approval and what many people do not realize
is that, while the government makes the rules about how trials are conducted, companies have
to pay for them. "Industry-funded" is the biggest misnomer among critics of science - all studies
are industry-funded by law. You can't sell your drug unless you first prove it is safe and does
something useful, the local pharmacy cannot be your lab and taxpayers shouldn't have to pay to
find out if something is safe.

Trials are expensive and so no company undertakes them unless they are convinced they have a
winner. The risk/reward ratio is lopsided but someone has to be adventurous enough take a
chance.
Thats where venture capital comes in.

MitoQ was exciting and so a company named Antipodean Pharmaceuticals raised money and
bought up the patents. The investors were intrigued by its possible benefits for Parkinson's
Disease. It did well in studies, until the Phase II results didn't show the outcome they were
looking for.

Venture capitalists immediately lost interest.

That's not a knock on VCs - VCs see a lot of losses before they see any wins and they are a huge
boon to society and especially drug discovery. But when an investment doesn't work they check
out, for one reason that makes sense to everyone - the clock is still ticking on the patent.

A company that has a product that doesn't meet expectations in a Phase II trial may have a
great thing on their hands somewhere else - but they are not going to own the patent for long
to be able to start over. Expecting venture capitalists to spend a lot of money proving the worth
of a compound only to lose it and then reset, start all over and pay for new trials is unrealistic.

But sometimes products fail in a clinical trial and then have other benefits. Viagra is a good
example of a product that didnt succeed with its original target but was found to have a benefit
elsewhere. MitoQ had that too - it actually seemed to work for aging and all those studies had
shown MitoQ was safe. Murphy and Smith got a patent for a "Lipophilic cation-mitochondrially
targeted antioxidant compositions for skin care" in 2009.

Today, the MitoQ compound is being marketed by a company fittingly called MitoQ. They sell
supplements and skin care and avoid any discussion of medical uses because regulatory bodies
frown on that sort of thing when there are no clinical trial results. But the animal model
research is right there, its hard to miss. They have to be at least a little excited about that.

I contacted MitoQ CEO Greg Macpherson to ask the obvious questions about how so much
research is still finding results - and if MitoQ is ever going to see any money from it.
He says they are thrilled that its still being studied extensively. " I also think the research
coming out from various sources on issues relating to broad spectrum antioxidants is very
interesting. We now know that free radicals have beneficial effects as well - like helping the
body identify and remove cells that are infected or unhealthy or to capture the benefits of
exercise in terms of breaking down and rebuilding new muscle. Broad spectrum antioxidants
appear to negate these positive pro-oxidant signaling mechanisms. Something a targeted
antioxidant like MitoQ, that goes into the mitochondria within minutes, avoids."

I asked him if, given the volume of studies coming out showing positive results in animal models,
if perhaps creative people were self-experimenting and using the supplements off-label for
conditions they read about in studies. He wasn't biting on that but if you search the Internet,
people with MS claim it helps, people with heart disease say it helps. And the clinical trials
showed it can't hurt.

No matter what results happen in animal models this year or next, with only 10 years of patent
life remaining and such a lopsided risk/reward landscape for drug development, the window is
too small to turn MitoQ into another Glaxo. But Macpherson is surprisingly upbeat regardless of
that.

"MitoQ has incredible potential to help with lots of conditions associated with oxidative stress
imbalances and mitochondrial dysfunction, be it primary or secondary to another condition.
When we optimize mitochondrial function we are improving the energy production in a cell and
more energy means that the cell is able to function optimally. Because our bodies are essentially
self repairing machines, when we get optimal cellular function we are providing the energy a cell
needs to repair itself. MitoQ also slows the oxidative stress related damage that occurs slowly to
our cells over the years. This includes damage to DNA, telomeres and other cellular machinery.

And if things do change in the regulatory future?

 "Someone in the future is going to make a killing going back through all these compounds and
cross checking their activity vs the various genotypes to assess function and toxicity profiles."

In the meantime, researchers continue to study MitoQ. Macpherson is happy about that,
obviously they believe in it, and a page on their site even carries links to the latest research.

The science is very strong and safety is well established so we are regularly approached by
research scientists and universities around the world who want to investigate its effects in the
various disease models they are studying. We have made MitoQ available for this research and
there is some amazing research being undertaken by leading scientists that will surface over the
next few years.

So Mitoq was a loss for VCs but may still end up being a win for society.

Science 2.0

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 I want to do an experiment with this. Where do I get it?

'Who can give up essential liberty to obtain a little temporary safety, deserve neither liberty nor safety' Benjamin
Franklin

Martin Vlaskamp | 05/20/14 | 01:29 AM

Link

I think if they are going to take you seriously enough to approve you in the experimenter requests they curate, it
might help if they know you read the article first.

Hank Campbell | 05/20/14 | 09:38 AM

Link
One might wonder whether there would be any need for 'mitochondrial permeating supplemental antioxidants' if
one were to control the amount of iron allowed to accumulate in the mitochondria.
"Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells"
Thereby allowing food bound quinols and phosphates, vitamin E and chaff as examples, to naturally accomplish
what supplemental MitoQ is intended to accomplish?
"Mitochondria as Possible Pharmaceutical Targets for the Effects of Vitamin E and its Homologues in Oxidative
Stress-Related Diseases"

"It is suggested that pulse doses of iron chelators that easily penetrate membranes could be used to diminish
lipofuscinogenesis"

ironjustice (not verified) | 05/20/14 | 09:13 AM

Link

Very interesting article Hank. I have been taking a daily supplement of Coenzyme Q10 for over 30 years ever since
I read a newspaper article when I was about 20 years old in which thousands of white coat laboratory technicians
were interviewed about what supplements if any they were taking after them often being in a unique position of
being able to observe first hand the effects of the many drugs and supplements they were testing on thousands of
laboratory animals. At the time it was claimed that coenzyme Q10 had been seen to double the life expectancy of
some laboratory mice and as a result of this and maybe their own observations quite a high percentage of these
lab technicians were found to be taking Coenzyme Q10 supplements daily but nothing much else of any
significance, like aspirin for example.
 Occasionally I forget to take my Coenzyme Q10 but then I usually notice a mild craving to take it later on in the
day which may be just a psychological craving not a physical one, I'm not sure.

Last month I went for a pap smear and a relatively young lady doctor who was not my normal doctor performed
this test because my regular doctor is a man and I felt a bit uncomfortable about him doing it. She took the
sample and then filled out the details ready to send it off for analysis. When she asked me my birth date for the
form she acted very amazed and said she thought I was more than 10 years younger and kept asking me 'what's
the secret?' I told her that a lot of people say I look 10 years younger than I am and ask me that same question
and often I just think they are being polite but that if its true then maybe the daily Coenzyme Q10 is having some
sort of anti-aging effect on me and also maybe causing me to have a late menopause? I guess I will never know
but one thing is for sure I am going to keep taking the coenzyme Q10 ;)

My 5 min film 'Hidden Dangers for ALS' entry in the AAN #2015Neurofilm Festival is listed no. 21 of 65 entries
at https://www.youtube.com/playlist?list=PLYNSC2T2aPD7GH6pVWI7I6DjzwbbBKCWK

Helen Barratt | 05/20/14 | 18:41 PM

Link
The little known amino acid L-ergothioneine found in mushrooms is a natural mitochondrial antioxidant. I'd love to
see it tested against MitoQ. L-erg meets the definition for a vitamin but hasn't yet been recognized as such. Still
while MitoQ passively enters mitochondria L-erg is actively transferred into mitochondria since it has specific
transporters as is common with vitamins. So I predict L-erg outperforms MitoQ.

https://www.ncbi.nlm.nih.gov/pubmed/19911007

Nerissa Belcher (not verified) | 05/21/14 | 02:47 AM

Link
Greetings All,

If you think MitoQ is "interesting" then you will love SKQ1.

Google: SKQ1 Skulchev

" It's the Mitochondria ! Stupid"

Albert Thompson III circa 1990

https://www.consumerlab.com/answers/Is+MitoQ+a+better+form+of+CoQ10/MitoQ_vs_CoQ1
0/

Question:
Is MitoQ a better form of CoQ10?

Answer:
MitoQ (by MitoQ Limited) is a form of CoQ10 promoted as a "more effective" antioxidant than
regular CoQ10 because it is shown to be absorbed by the mitochondria of cells - where many
oxidative reactions take place. It also appears to achieve higher levels in the blood compared to
regular CoQ10 - although a number of formulations of CoQ10 also offer enhanced absorption
over regular CoQ10. More information about MitoQ and other CoQ10 formulations is found in
the CoQ10 and Ubiquinol Supplements Review >>
 See other recent and popular questions >>

COMMENTS

Add Comment

Louis1762 June 4, 2015

I've always heard that CoQ10 was absorbed in the mitochondria of cells thus strengthening and protecting
the interior and nucleus of the cell. So does it have to be MitoQ to accomplish this, or are you saying that
MitoQ is more effective at doing this?

Comment on Post

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Benefits
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Description
MitoQ is a patented antioxidant that targets the mitochondria, our cellular power plant, to support
healthy organ and cell function. MitoQ can boost cellular energy levels, and helps to reduce the
cellular free radical damage that, over time, contributes to many of the symptoms of aging and various
health disorders.
Levels of Cellular CoQ10 (aka ubiquinone or ubiquinol) start to decline from our thirties, so many
people supplement with CoQ10 to assist energy levels, support certain health conditions, and when
taking medicines that deplete CoQ10 (like statins for heart disease). Unfortunately, most CoQ10
formulas do not reach the mitochondria at levels that are needed.

Benefits of taking MitoQ 5mg

MitoQ is different. It has been designed to replenish antioxidant levels inside the mitochondria, and in
so doing assist the cell with repair and normal function. MitoQ acts as an antioxidant reservoir to
reduce the damage that excess free radicals cause to DNA and cell membranes.
MitoQ, when taken with a good diet and regular exercise, will support healthy aging.
To learn more about MitoQ, mitochondria, aging, and the use of MitoQ to support health conditions
associated with mitochondrial dysfunction or high levels of oxidative stress, visit MitoQ University.
Supplement facts:
Adult dose: 2 capsules each morning on an empty stomach.
Do not exceed dose unless directed by your physician. Consult your physician if you are pregnant or
nursing.
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Peter

Reviewed on 11/03/2017

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 MitoQ is great! I have used it for 18 months, and have significant energy increase, much improved
skin condition, and great mental clarity! Well done guys! My one problem is NZ Post shipping, which
takes up to 2 months to reach me! They need to use DHL or FedEx....otherwise great product!!

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HATE RUNNING OUT OF IT

Heidi

Reviewed on 4/03/2017

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It's one of those products that you don't appreciate until you're out of it. I am now resolved never to be
without it again. I have an inherited neurological condition and find that with MITOQ my balance and
strength are improved. I am also less exhausted with the product. It's awesome indeed!

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I HAVE A MUSCULOSKELETAL CONDITION AND THIS CHANGED MY LIFE

Jayne

Reviewed on 2/02/2017

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After 3 days I felt a difference. My energy levels are so good that I have gone from spending days on
the sofa to flying to New Zealand from the uk. Thank you for creating this amazing Mitoq. My 85
year old mother has also found she has more energy. A life changer

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ENERGIZING!
Melissa (Lovely with Lupus)

Reviewed on 17/01/2017

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When I started taking oral MitoQ, I did not expect to feel much, particularly in the way of increased
energy, because many supposedly energizing supplements have disappointed me. I had come to the
resigned conclusion that in the stormy ocean that is fatigue associated with my condition, most
supplements are like a tiny drop of water I can barely see or feel. MitoQ is different. It works for me.
Over the first weeks of taking MitoQ, I gradually noticed an improvement in my energy, stamina, and
alertness. Eventually, I could not deny that I felt a lot better since starting the supplement. Better yet,
 as the weeks have continued, I have continued the improvement in my vitality and daily energy has
not waned. Taking MitoQ has cleared away so much fog and fatigue. Fortunately (since I like its
effects so much), the supplement is easy to swallow and has never caused me any digestive troubles,
even on an empty stomach.

With MitoQ, I feel more like I did before my condition was a part of my life, before fatigue became
such a hurdle. I cannot promise it will work this well for everyone, but it has for me, and I am not easy
to energize. Although I was initially skeptical, there is no denying that MitoQ truly makes a difference
in my day to day life and helps me have the energy I need to be (closer to) the kind of wife and mother
I aspire to be. You can bet that I will continue to take MitoQ as part of my daily regimen; I consider
my MitoQ supplement a vital investment in my own optimal vitality and well-being. MitoQ is at the
top of my best-supplements-ever list.

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HIGHLY RECOMMEND
Mac

Reviewed on 11/11/2016

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Starting taking this about 2 years ago while going through menopause. What a difference to my
memory not to mention my wellbeing. Feel so much more confident that I can take on life head on.

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NEW START
sandy

Reviewed on 1/06/2016

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I work to the early hours of the morning 5 days a week, i always wake up feeling unhealthy, tired,my
skin never looked good, i just never had much energy in the morning.I had read many times about
mitoQ but it was quite expensive . I finally got around to buying them. i took the two a day and after 1
week even with just 5-6 hours sleep a day i was waking up feeling energized , healthy , awake and my
skin looked much better, also the sun spots i had on my face faded after 3 weeks . I even got my sister
on them. I will most definitely be purchasing some more.

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HELPED WITH MY FIBRO RELATED FATIGUE

 Cindy

Reviewed on 5/03/2016

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It took nearly the whole month before i felt a change but one day i realized i was cleaning after work
instead of sleeping! Each day i go home and can do a little more than I could before the MITOQ. It
has made a big difference! Thank you MITOQ folks!

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HELPS ME
Ian

Reviewed on 10/02/2016

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I have fatigue problems and have been using 5mg for over 6 months I started with 2per day but felt
agitated and dropped to one. Not a total solution but it does help. I have also found improvement in
my dry nails.

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LOVE IT
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Reviewed on 5/02/2016

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I have been taking for 6 days and today I can feel that it's working.

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WORKS QUITE WELL

Natalie

Reviewed on 1/02/2016

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I have been chronically ill my whole life (31 years old) so this past year I learned a lot of genetics and
biochemistry. I basically fixed almost everything wrong with me and function nearly normally, but I
was still having issues with energy. MitoQ changed all that AND seemed to improve my liver, heart,
and immune function as well. The effect was noticeable from the first day and just scaled up more
with use, to the point where I did not feel I had energy issues at ALL anymore. It's amazing. The day I
ran out, I got quite sleepy. I'm glad I have more on the way. I wish they could make it cheaper,
though.

https://www.mitoq.com/mitoq-curcumin.html

Active Ingredients per dose (2 capsules):

Mitoquinol mesylate equiv. Mitoquinol: 10mg
Longvida Optimized Curcumin Extract (Curcuma longa) (root) (min. 80mg curcuminoids): 400mg
MitoQ + Curcumin also contains:
Lecithin, Stearic Acid, Maltodextrin, Ascorbyl Palmitate, Microcrystalline Cellulose, Magnesium
Stearate, Silica. Contains Soy.
MitoQ + Curcumin contains no animal products or gluten.
Made in New Zealand
LONGVIDA extract is patented under US9192644 & EP1993365 (other patents pending) and
LONGVIDA is a registered trademark of Verdure Sciences Inc.

Description
MITOQ + Curcumin is a double-action super supplement which supports normal immune response
pathways and key organ health, including the brain and the digestive system.
What is MitoQ + Curcumin?
MitoQ + Curcumin is the only product in the world to combine the 3rd generation antioxidant power
of MitoQ with Longvida Optimized Curcumin, a highly bioavailable, optimized curcumin extract.
Curcumin is the most active constituent of Turmeric and is one of the most researched natural
compounds available.
MitoQ is a special patented formulation of the antioxidant CoQ10 with significantly superior
absorption compared to standard CoQ10/ubiquinol. MitoQ is the only CoQ10 formula to specifically
target and enter mitochondria, the energy-producing powerhouses of your cells, making it hundreds of
times more effective than other CoQ10 or Ubiquinol products.
Longvida Optimized Curcumin Extract is a breakthrough ingredient that is 65-100 times more
bioavailable than standard curcumin. Curcumin has been shown to have a multitude of health benefits,
including supporting brain, digestive, heart, metabolic and skin health.
How does MitoQ + Curcumin work?
Both of the active ingredients in MitoQ + Curcumin have been shown to cross the brains protective
barrier known as the blood brain barrier, making them particularly effective at supporting brain
health compared to other supplements that are unable to cross this barrier.
MitoQ is rapidly absorbed into the mitochondria of brain (and other) cells where it immediately goes
to work neutralizing free radicals and supporting normal mitochondrial function. The result is reduced
free radical damage and optimal energy production which helps the brains cells function.
Longvida Optimized Curcumin is also a powerful ingredient which can support normal immune
responses to the damage caused by mitochondrial dysfunction and other harmful stimuli. There are a
number of digestive and brain health issues that can arise when our immune system is out of balance,
hence the importance of supporting the normal immune response.
MitoQ + Curcumin is an excellent support product for digestive health issues: both ingredients have
been individually shown to support normal gastrointestinal health and function. Because it is taken by
mouth, curcumin is highly bioavailable to the digestive tract. The optimized absorption of Longvida
also allows a significant proportion to enter the blood stream and have a systemic supportive effect on
the bodys immune response pathways. In these ways, curcumin can help to support normal responses
and a balanced immune system, which, in turn, supports normal gastrointestinal function and digestive
health. At the same time, MitoQ targets the mitochondria in digestive system tissues, reducing
oxidative damage from free radicals and allowing for optimal cellular energy production for growth
and repair.
Who is MitoQ + Curcumin suitable for?
People who want to support brain health and stay mentally sharp
Those who need digestive system support
Anyone looking for a double-action super supplement to support improved energy and stamina,
healthy organ function, and long-term health and wellbeing.
MitoQ + Curcumin supplement facts:
Adult dose: 2 capsules each morning on an empty stomach
Always read the label and use as directed. Do not exceed dose unless directed by your physician.
Consult your physician if you are pregnant or nursing. If symptoms persist see your healthcare
professional.
LONGVIDA extract is patented under US9192644 & EP1993365 (other patents pending) and
LONGVIDA is a registered trademark of Verdure Sciences Inc.

Frequently Asked Questions

Is Curcumin the same as Turmeric?

No, Curcumin is the most active constituent of Turmeric, so the benefits are much more concentrated
and much smaller doses are required.

Is MitoQ + Curcumin suitable for vegetarians?

MitoQ + Curcumin contains no animal products or gluten, but it does contain soy.

When should I take this supplement?

We recommend that MitoQ + Curcumin be taken in the morning on an empty stomach. For best
absorption rates, take at least 30 minutes before breakfast.
What is the difference between MitoQ + Curcumin and other Curcumin products on the
market?
MitoQ + Curcumin contains world renowned MitoQ, a special patented formulation of the
antioxidant CoQ10, along with Longvida Optimized Curcumin. No other Curcumin product contains
MitoQ. MitoQ has significantly superior absorption compared to standard CoQ10/ubiquinol, and is the
only CoQ10 formula which specifically targets and enters mitochondria, the energy-producing
powerhouses of your cells. This makes MitoQ hundreds of times more effective than other CoQ10
products.
The Longvida Optimised Curcumin contained in MitoQ + Curcumin is significantly superior to
other Curcumin formulations. It is a breakthrough formula of this natural antioxidant using patented
SLCP (Solid Lipid Curcumin Particle) technology, which optimizes it to deliver curcumin into target
tissues, and makes it 65 100 times more bioavailable than unformulated curcumin.

Is MitoQ + Curcumin safe for children?

We recommend MitoQ + Curcumin is taken by adults only. If you are considering giving MitoQ +
Curcumin to children or teenagers, please consult your doctor first.
What can I expect?
Everyone will experience MitoQ + Curcumin differently, depending on your age, your fitness, and
whether you have a health condition. As different cells and organ systems re-energise at different
speeds it can take days, weeks or months for you to experience the full effect of increased levels of
energy and health.
Are there any side effects?
At higher doses than usual (more than twice the recommended dose), a small number of people may
experience mild stomach upset and/or nausea. You should avoid taking MitoQ + Curcumin if you
are allergic to turmeric or CoQ10.
Does MitoQ + Curcumin interact with any medicines?
MitoQ has been extensively tested for safety but not for interactions with prescription medicines.
Curcumin is also considered very safe, but a few drug interactions have been noted. Please consult
with your physician before taking MitoQ + Curcumin if you are taking a prescription medicine.
Can I take a dose thats higher than you recommend?
The recommended dose of MitoQ + Curcumin is two capsules per day. It is possible to gradually
increase this to potentially gain extra support for certain health conditions, but we recommend you
consult with a health professional before doing so.
Can I take MitoQ with other supplements?
MitoQ can be taken in combination with your other supplements.
Is MitoQ natural?
MitoQ is derived from naturally occurring CoQ10, and has been modified to target cellular
mitochondria more effectively.