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Mucin antigen
Using a two-site solid phase immunoassay:
Sensitivity = 42%
Specificity = 97%
Positive predictive value = 98%
In combination with CEA, sensitivity is slightly improved
Chemical markers of colorectal cancer
CA 19-9
TPS
CAM 17.1
CA 19-9
Sialylated Lexa
Secreted by gastric, colonic, endometrial, and salivary
epithelia
Lea-b- individuals (5%) do not make Ca 19-9
Clinical performance
Sensitivity = 80%
Specificity = 60-100% (depending on control group)
Low positive predictive value in a screening scenario
Chemical markers of pancreatic cancer
CA 19-9
TPS
CAM 17.1
TPS
CA 19-9
TPS
CAM 17.1
CAM 17.1