Harrison'sPrinciplesofInternalMedicine,19e,2015>EnlargementofLymphNodesandSpleen

DennisKasper,AnthonyFauci,StephenHauser,DanLongo,J.LarryJameson,JosephLoscalzo+
TABLE79-1DiseasesAssociatedwithLymphadenopathy

1. Infectiousdiseases

1. Viralinfectiousmononucleosissyndromes(EBV,CMV),infectioushepatitis,herpessimplex,herpesvirus-6,varicella-zostervirus,rubella,measles,adenovirus,HIV,epidemickeratoconjunctivitis,vaccinia,
-herpesvirus-8
2. Bacterialstreptococci,staphylococci,cat-scratchdisease,brucellosis,tularemia,plague,chancroid,melioidosis,glanders,tuberculosis,atypicalmycobacterialinfection,primaryandsecondarysyphilis,
diphtheria,leprosy,Bartonella
3. Fungalhistoplasmosis,coccidioidomycosis,paracoccidioidomycosis
4. Chlamydiallymphogranulomavenereum,trachoma
5. Parasitictoxoplasmosis,leishmaniasis,trypanosomiasis,filariasis
6. Rickettsialscrubtyphus,rickettsialpox,Qfever
2. Immunologicdiseases

1. Rheumatoidarthritis
2. Juvenilerheumatoidarthritis
3. Mixedconnectivetissuedisease
4. Systemiclupuserythematosus
5. Dermatomyositis
6. Sjgrenssyndrome
7. Serumsickness
8. Drughypersensitivitydiphenylhydantoin,hydralazine,allopurinol,primidone,gold,carbamazepine,etc.
9. Angioimmunoblasticlymphadenopathy
10. Primarybiliarycirrhosis
11. Graft-versus-hostdisease
12. Silicone-associated
13. Autoimmunelymphoproliferativesyndrome
14. IgG4-relateddisease
15. Immunereconstitutioninflammatorysyndrome(IRIS)
3. Malignantdiseases

1. HematologicHodgkinsdisease,non-Hodgkinslymphomas,acuteorchroniclymphocyticleukemia,hairycellleukemia,malignanthistiocytosis,amyloidosis
2. Metastaticfromnumerousprimarysites
4. LipidstoragediseasesGauchers,Niemann-Pick,Fabry,Tangier
5. Endocrinediseaseshyperthyroidism
6. Otherdisorders

1. Castlemansdisease(giantlymphnodehyperplasia)
2. Sarcoidosis
3. Dermatopathiclymphadenitis
4. Lymphomatoidgranulomatosis
5. Histiocyticnecrotizinglymphadenitis(Kikuchisdisease)
6. Sinushistiocytosiswithmassivelymphadenopathy(Rosai-Dorfmandisease)
7. Mucocutaneouslymphnodesyndrome(Kawasakisdisease)
8. HistiocytosisX
9. FamilialMediterraneanfever
10. Severehypertriglyceridemia
11. Vasculartransformationofsinuses
12. Inflammatorypseudotumoroflymphnode
13. Congestiveheartfailure

Abbreviations:CMV,cytomegalovirus;EBV,Epstein-Barrvirus.

Dateofdownload:11/30/17fromAccessMedicine:accessmedicine.mhmedical.com,CopyrightMcGraw-HillEducation.Allrightsreserved.