Huntingtons Disease

Huntingtons Disease Protein synthesis

Genetic disease
Affects b rain, nerves
Symptoms: jerky movement, poor mental
abilities, coordination, mood
Affects Huntingtin protein (Nerve creation and
long term memory storage) (36+ glutamine
residues)
Likely through genetics (dominant)
Still rare ( 4-15 in every 100,000 persons of
European descent)
Treatments: supportive care
Cure: None
Research on cure through gene splicing
http://www.rcsb.org/pdb/explore/jmol.do?structureId=3IOV&bionumber=1
1. DNA has code for starting and stopping of
transcription
2. RNA polymerases split the DNA, and copy it,
creating a new strand. This is occurs in the
nucleus. The major components are the DNA, the
mRNA, and RNA polymerase. Replaces Thymine
with Uracil.
3. mRNA travels to cytoplasm through nucleus.
4. A ribosome binds to the mRNA. This ribosome
reads mRNA in group of 3 called codons. An
anti-codon will link to these codons according
to their base pairs. These anti-codons carry an
amino acid, which gets added to the previous
amino acid until the ribosome reaches the end of
the mRNA, where the polypeptide chain
detaches.
5. Polypeptides make up helix and sheets, which
create domains. Domains combine to create
proteins. This happens in the cytoplasm. The
important components are the helix the
sheets, and the polypeptide.