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I. Introduction
In order to appreciate the complexities of the human body, one must be knowledgeable in both its anatomy
and physiology. Anatomy is defined as a branch of biology that deals with the study of body structures and
its parts. Physiology is the study of the various functions of living things in relation to its parts as a whole.
The size, shape, and structure of each part are related to the functions it performs. For example, the pouch-
like shape of the stomach containing hydrochloric acid, functions in the breakdown of food particles into
smaller molecules. These are then distributed by the blood via a vast network of arteries and veins to
various tissues in the body, supplying them with the nutrients it needs. Homeostasis refers to the body’s
ability to maintain a steady state of equilibrium. Any disruption in homeostasis results in the body’s
inability to function appropriately thus leading to disease or even death.
kidneys, ureters, urinary bladder Maintain volume and Regulation of body chemistry in
Urinary and urethra composition of body coordination with the endocrine
fluids within normal System.
limits
Male: Penis, testicles, prostate, Maintenance of secondary sex
seminal vesicles, epididymis, characteristics. Passing of
Cowper glands and prostate. Reproduction genetic characteristics.
Female: Vulva, vagina, uterus,
fallopian tubes, ovaries, Skene
Reproductive glands and Bartholin.
Shape of fibers Elongated, cylindrical, Elongated, spindle shaped, Elongated, cylindrical, fibers
and blunt ends pointed ends branch and fuse
Striations Present Absent Present
HUMAN DISEASES
Nomenclature and Classification of Diseases
There are several different ways diseases are named. The following section outlines these. It is important to
remember, though, that disease names formed with Greek suffixes have fairly predictable patterns of
meaning, such as:
Hyperacute Refers to a disease with a very short onset or course Hyperacute skin graft
has reached a high level of morbidity and mortality Acute fulminant dysentery
End-stage Referring to a continually worsening condition which End-stage Renal Failure
has reached a point of functional organ impairment
Acquired A disease which has not been genetically passed down Acquired
from one generation to another; one that has Immunoglobulinemia
originated and developed during the course of an
individual s life
Congenital absence of limbs
Congenital Referring to a condition present at birth but
not necessarily inherited Congenital cataracts
Recurring/ a condition which reap ears after symptoms Recurrent peptic ulcer
Recurrent/ had largely or entirely resolved disease
Relapsing
Relapsing fever
.
Functional pathology resulting to a disturbance function even Functional dysmenorrhea
without evidence of structural or chemical
abnormality
Onset The period within which the signs or symptoms of a disease first appeared
Prodrome a period during which constitutional symptoms of fever or malaise precede the
appearance of typical signs and symptoms of a disease
Life-threatening a prognosis that a disease or injury may prove lethal in spite of aggressive
treatment.
TNM classification a formal mode of staging that is used for many malignant diseases; (T
— tumor, N (lymph) nodes; M, metastases.)
Symptomatic Giving treatment that is intended to relieve symptoms rather than abolish their
cause
Supportive A treatment regiment with goals to preserve the patient’s comfort, hydration, and
nutritional status without affecting the underlying disease.
Radical A drastic treatment plan (medical or surgical) with a high risk of adverse effects,
justified only by the severity of the patient’s condition or the unfavorable
Conservative Treatment mode applied that is either medical or surgical, and has a low risk of
causing serious adverse effects, but also less likelihood of affecting a cure than
more aggressive methods
Therapeutic trial Experimental administration of a drug in a effort not only to relieve symptoms
but also to confirm the working diagnosis
Monodrug therapy Treatment of a condition with a single drug, rather than a combination of drugs
Synergism A positive interaction between two or more drugs in which each boosts the effect
of the others
Physical therapy Treatment involving application of physical modalities to reserve the body’s
physiologic function
Regimen A course of treatment for the over-all well-being of the organism, including diet,
and drug theraphy.
LABORATY DIAGNOSTICS
Pathology as a Science
Pathology is defined as the branch of medicine that deals with changes, both structural and functional,
observed in the living body as a result of injury or disease process
A. Branches of Pathology
1. Anatomic Pathology — deals with the gross and microscopic changes observed in living human tissues
brought about by disease.
2. Clinical Pathology — concerned with laboratory examination of body fluids, such as blood and
cerebrospinal fluid and waste products such as urine, and feces.
3. Forensic Pathology — involves the application of principles of both anatomic and clinical pathology to
civil and criminal law.
2. FALSE NEGATIVE - normal or negative result despite the presence of a disease or condition in a
subject that is expected to produce an abnormal or positive test result
*Characteristics of a valid and reliable, test result:
• ACCURACY - ability to yield a test result that truly measures or reflects the condition under
investigation.
• REPRODUCIBILITY - ability to yield the same result time after time when performed on the
same specimen or material
• SENSITIVITY - ability to yield abnormal results consistently when performed on abnormal
material usually expressed as a percentage.
• SPECIFICITY - ability to reflect only a specific abnormality and not influenced by other factors;
also expressed as percentage.
PHARMACOLOGY
Pharmacology is defined as the science of interaction between chemical substances (like drugs) and the
living organism. It includes medical pharmacology— the science of materials used to prevent, diagnose,
and treat disease and toxicology
Drugs are primarily used for therapeutic, prophylactic, or diagnostic use.
TERM DEFINITION
It is essentially the effect of the drug on the body; the study of the
Pharmacodynamics changes in the body brought about by the drug.
It is the study of the effect of the body on the drug, dealing with the
Pharmacokinetics
absorption, distribution, biotransformation, and excretion of substance.
Deals with the use of drugs in the prevention and treatment of disease.
Pharmacotherapeutics Therapeutics studies the uses of drugs with regards to prevention,
diagnosis, and treatment of diseases.
The study of the chemical structure of drugs at the molecular level; it
Molecular pharmacology
deals with the mechanism of action of drugs at the enzymatic level.
It is the study of the toxic or poisonous effects of drugs with particular
emphasis on the dosage of the medication; it primarily deals with the
Toxicology
prevention, diagnosis, and management of adverse effects of drugs in
living beings.
Drug Forms
The different foams of a drug are appropriate for different routes of administration. There are some drugs
that are ineffective when administered in a certain form or by a certain route; other drugs may cause serious
injury to the patient if administered in a certain form or by a certain route.
Forms of drugs: tablets (lozenge, troche), capsule, powder, pills, suppository, liquid, syrups, suspensions,
gel, cream, lotion, injections, sprays, ointment, patch, bead or pellets.
*pharrnacokinetics (the study of what the body does to the drug) and pharrnacodynaics (the study of
what the drug does to the body).
MECHANISM OF DESCRIPTION
ACTION (MOA)
Analgesic A drug that relieves pain without causing loss of consciousness or
anesthesia.
Anesthetic, general A drug used either parenterally or by mask that render the subject
unconscious and incapable of perceiving pain.
Anesthetic, local A drug that prevents perception of pain at the site of
administration.
Antibiotic A drug that is indicated in cases of infection. It may either kill
(bactericidal) or inhibit the growth (bacteriostatic) of the bacteria
involved.
Anticholinergic A drug that works antagonistically against acetylcholine.
Anitemetic A drug that prevents or arrests vomiting.
Antifungal A drug indicated for fungal infections.
Antihistamine A drug that works antagonistically with histamine which is
released during allergic reactions.
Antihypertensive A drug indicated for high blood pressure.
Antiinflammatory A drug that inhibits the release of prostaglandins which is
responsible
for causing symptoms of inflammation.
Antineoplastic A drug used to treat neoplasm or cancer.
Antipruritic A drug that is used to prevent or relieve itching.
Antiseptic A drug that prevents the growth of infectious agents
Antispasmodic A drug given to stop muscle spasm.
Antitussive A cough suppressing drug.
Antiviral A drug used for treating viral infections
Bronchodilator A drug used to relax bronchial smooth muscles therefore dilating
them that lead to increased respiratory airflow.
Cholinergic Receptor of the PNS that is acted upon by acetylcholine.
Decongestant Drug that decongests the mucous membranes of the sinuses and
nose.
Disinfectant An agent that is used for killing microorganisms on surfaces and
instruments.
Diuretic A drug that causes the kidneys to excrete more water and sodium.
Mydriatic A drug that dilates the pupils of the eye.
Vasodilator A drug that relaxes the smooth muscles of blood vessels so as to
decrease blood pressure
Vasopressor A drug that constricts the smooth muscles of blood vessels so as to
increase blood pressure.
3. Laminectomy is a somewhat prone (lying on 7. Prone is a position with the patient chest and
stomach) and lateral position to expose the face down as he lies on his abdominal area. This
vertebral spine for laminectomies involving, for position is primarily used for surgeries involving
example, slipped discs. the back area.
Surgical instruments are classified based on their function. They are divided into four major groups:
CUTTING AND DISSECTING (SHARPS)
These instruments include scissors, scalpels, bone cutters or osteotomes, curettes, chisels, biopsy punches,
saws, drills, and needles.
GRASPING AND CLAMPING
A clamp is defined as any surgical instrument that grabs body tissues between its jaws.
RETRACTING
To hold tissues or organs away from the working area of the surgeon, retractors are used.
hand-held retractor — physically manipulated by the surgeon and / or his assistant throughout the duration
of the surgery, e.g., Army-Navy and Richardson retractors.
Self-retaining retractor — apparatus that remains steadily and mechanically extended after being set-up
manually by the surgeon, e.g., Balfour retractor.
PROBING AND DILATING
These particular instruments are stainless rods of differing diameters and lengths whose ends are blunted
for the purposes of probing surgical areas for investigation..
HEALTHCARE RECORDS
Standard healthcare forms that become a part of the patient chart include the Admitting Notes, Chart Notes,
Consultative Letters, Diagnostic & Laboratory Reports, Radiologic Interpretations, Histopathological
Reports, Operative Procedures which may include the Anesthesiology Report, and Discharge Summaries.
More specialized notes would include those from, for example, the Departments of Obstetrics &
Gynecology, Pediatrics, Psychiatry, and Physical Therapy.
The SOAP
SOAP is a four-part mini-report divided into the subjective (written alongside the left margin as S>),
Objective (0>), Assessment (A>), and Plan (P>) portions. It represents a brief description of the illness of
the patient, with the physician’s impressions and proposed treatment which may include laboratory
requests.