Due to the funding limitation in government community

health protection schemein 2014, quality control and medical

cost are the important factor to be concerned.
Therefore the application in pharmacoeconomic study in
choosing the effectiveand efficient medication has an
important roles.

Objective : To know the cost-minimalization analysis general

anesthesiabetween propofol target controlled infusion and
anastehsia inhalationin major operationpatient at Sanglah
hospital.

Methods : A Consecutive Randomized Controlled Trial study

of 40 patient that undergo a major operation at central
operating theather Sanglah hospital, divided into two groups.
Group A is patient with propofol target controlled infusion
and
group B is patient with anesthesia inhalation isoflurane. The
collected data wasstatistically analyzed with Shapiro Wilk,
Lavene Test and independent sample T-test (P < 0.05).

Results : In this study, the drug usage ratio perminute in group

A is 8,54 mg (±2,04 mg) and 0,42 ml (±0,09 ml) in group B.
The drug cost in general anesthesia group A is Rp. 800,85
(±Rp. 127,99) per minute and in group B isRp.1.266,32 (
± Rp. 227,26) per minute (P < 0.001).

Conclusion : the cost-minimalization analysis in general

anesthesia drug using propofol TCI siginificantly cheaper than
anesthesia inhalation
isofluran.
 Keywords: cost-minimalization analysis, general anesthesia
drug, TCI propofol,isoflurane

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